Gestational Trophoblastic Disease

This page contains recent news articles, when available, and an overview of Gestational Trophoblastic Disease but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

News: Gestational Trophoblastic Disease

Residual lung lesions after completion of chemotherapy for gestational...  -  Oct 5, 2005
Nature.comKohorn EI (2001) The new FIGO 2000 staging and risk factor scoring system for gestational trophoblastic disease: description and critical assessment. ...

Does This Woman Have Gestational Trophoblastic Disease?  -  Nov 17, 2006
Cancer NetworkThe University of Colorado Health Sciences Center holds weekly second opinion conferences focusing on cancer cases that represent most major sites of the ...

Gestational trophoblastic disease  -  Sep 11, 2006
Waco Tribune-Herald - Waco Tribune HeraldGestational trophoblastic disease is a quick growing form of cancer that occurs in a woman's uterus after a pregnancy, miscarriage, or abortion. ...

A comparison of patients with relapsed and chemo-refractory gestationa...  -  Nov 23, 2006
Nature.comGestational trophoblastic disease comprises a spectrum of disorders ranging from the ... Fisher RA, Newlands ES (1998) Gestational trophoblastic disease. ...

Placental-site trophoblastic tumors: a case of resistant pulmonary …  -  Feb 13, 2007
Nature.comBently RC (2003) Pathology of gestational trophoblastic disease. Clin Obstet Gynecol 46: 513–522 | Article | PubMed | ...

External validation of serum hCG cutoff levels for prediction of...  -  Sep 5, 2008
Nature.comHuman chorionic gonadotropin (hCG) is a sensitive marker in monitoring trophoblastic activity in gestational trophoblastic disease (GTD; Delfs, 1957). ...

… ; Galectins -1 and -3 may play role in gestational trophoblastic...  -  Jan 1, 2005
Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones..."Immunoreactivity for both galectin-1 and galectin-3 in gestational trophoblastic disease is increased (significant differences at p < 0.05, Mann-Whitney ...

The significance of the time interval between antecedent pregnancy...  -  Jul 13, 2006
Nature.comKohorn EI (2001) The new FIGO 2000 staging and risk factor scoring system for gestational trophoblastic disease: description and critical assessment. ...

Molar pregnancy  -  Nov 6, 2009
CNNMolar pregnancy is a type of gestational trophoblastic disease (GTD). In a complete molar pregnancy, there's no embryo or normal placental tissue. ...

Metastatic Choriocarcinoma to the Pancreas  -  May 20, 2005
RedOrbitGestational trophoblastic disease (GTD) is composed of a group of aggressive, highly invasive neoplasms derived from the placenta. The classification of GTD ...

Reproductive Issues in the Gynecologic Cancer Patient  -  Apr 30, 2007
Cancer Network...arise out of pregnancy, as is the case with gestational trophoblastic disease. Parenthood has been cited as an important aspect of cancer survivorship. ...

Gynecologic Oncologist hasTreatment Of Women's Cancers Using …  -  May 9, 2008
ParamusPost.comGestational trophoblastic disease arises during early pregnancy from tissues that develop into the placenta. The tumor can be benign or malignant and spread ...

Playing with a different kind of pain, Wife's battle with cancer...  -  Jun 18, 2006
Pay-Per-View - Newsday - ProQuest ArchiverIt's called gestational trophoblastic disease, which occurs when a tumor is formed in the uterus. It is typically cured with immediate surgery - four out of ...

Sepulveda v. Stiff, No. 4:05cv167 (EDVa. 11/13/2006)  -  Nov 13, 2006
$2.95 - U.S. District Court, Eastern District... - VersusLaw...for proper and timely treatment, which negligence led to the development of gestational trophoblastic disease, which became metastatic choriocarcinoma. ...

'I'd lost my dream of a baby and what I saw looked alien'  -  Mar 5, 2007
WalesOnline...anymore children then in some instances a hysterectomy maybe carried out to ensure that the woman does not develop gestational trophoblastic disease. ...

Trophoblastic Tumors; Placental site trophoblastic tumor prognosticato...  -  May 8, 2006
Pay-Per-View - OBGYN & Reproduction Week - Factiva, from Dow JonesKeywords: New York, New York, United States, Extravillous Trophoblast, Gestational Trophoblastic Disease, Gonadotropins, Gynecology, ...

I'd lost my dream of a baby and what I saw just looked alien  -  Feb 19, 2007
WalesOnline...anymore children then in some instances a hysterectomy maybe carried out to ensure that the woman does not develop gestational trophoblastic disease. ...

Cancer Risk Factors; Persistent low human chorionic gonadotropin...  -  Sep 26, 2006
Pay-Per-View - Life Science Weekly - Factiva, from Dow JonesAccording to the report, "The remaining 157 patients had false-positive hCG, quiescent gestational trophoblastic disease (quiescent GTD), or pituitary hCG ...

Molar Pregnancy Overview: Types, Causes, Risks, Symptoms, and …  -  Oct 29, 2007
WebMDSome molar pregnancies lead to abnormal cell growth called gestational trophoblastic disease. About 15% to 20% of complete molar pregnancies develop ...

Molar Pregnancy - Treatment Overview  -  Oct 29, 2007
WebMDIf you have no future plans to become pregnant, you may consider a hysterectomy, which reduces the chance of developing gestational trophoblastic disease ...

Molar Pregnancy (Hydatidiform Mole): Symptoms and Treatment  -  Jun 13, 2009
BuzzleMedically referred to as hydatidiform mole, molar pregnancy is a type of gestational trophoblastic disease (GTD). The article throws light on molar ...

Obstetrics; Treatment regimens using methotrexate for gestational …  -  Aug 28, 2006
Pay-Per-View - OBGYN & Reproduction Week - Factiva, from Dow JonesKeywords: Lyon, France, Gestational Trophoblastic Disease, Gestational Trophoblastic Tumors, Methotrexate, Pregnancy, Pregnancy Complications, ...

Tumour markers  -  Dec 21, 2005
Malaysia StarHCG is increased markedly in gestational trophoblastic disease (GTD), a group of conditions in which there is abnormal growth of cells in the pregnant ...

Likelihood Of Placental-Site Trophoblastic Tumors Linked To The...  -  Jun 24, 2009
Medical News Today - Medical News Today (press release)They are the rarest form of gestational trophoblastic disease (GTD) accounting for only 0.2 percent of all GTDs. Trophoblasts are cells which provide ...

Stage-adapted management of placental-site trophoblastic tumors …  -  Jun 29, 2009
HemOncTodayBetween 1976 and 2006, 35550 women with gestational trophoblastic disease were registered in the United Kingdom; 62 were diagnosed with placental-site ...

Article: Teen is held on murder.(News) - The People (London, England)...  -  Jul 29, 2007
Pay-Per-View - The People - HighBeam ResearchThe researchers ... additional information, contact A.K. Lim, Charing Cross Hospital, Dept. of Imaging and Charing Cross Gestational Trophoblastic Disease ...

Significado biologico del eje hormona de crecimiento (GH) / factor de...  -  Mar 1, 2006
Free with registration - Revista de la Academia Colombiana de... - AccessMyLibrary.comKey words: GH, IGF-I, IGF-II, lymphocytes, gestational trophoblastic disease. La interaccion entre diferentes sistemas celulares es esencial para la ...

Washington Supreme Court Reports - RUFER v. ABBOTT LABS., 154 Wn. …  -  Jun 30, 2005
Pay-Per-View - Washington Supreme Court Reports - Loislaw...chroionic gonadotropin (hCG) in Jennifer's blood led to the eventual diagnosis of a deadly cancer known as gestational trophoblastic disease (GTD). ...

30-Year Study Uncovers Predictor of Survival in Patients With...  -  Jun 22, 2009
DG NewsThey are the rarest form of gestational trophoblastic disease (GTD) accounting for only 0.2% of all GTDs. PSTTs were diagnosed in 1 per 20000 women in the ...

Survivor will get to meet life-saver  -  Oct 17, 2005
$2.95 - Kansas City Star - NewsBankShe had a baby in the spring, but her eight-week checkup revealed she had gestational trophoblastic disease, a rare form of cancer that develops in the ...

New Year Honours: Yorkshire's great and good receive recognition  -  Dec 31, 2008
Yorkshire PostHe is an expert in lymphoma, gestational trophoblastic disease and biological therapy. He has authored or edited eight books – including Cancer Care in the ...

Health: News, articles, tips, fitness, nutrition, medical resources...  -  Mar 22, 2007
Palm Beach PostThis cancer, called gestational trophoblastic disease, is responsive to an aggressive, multi-agent chemotherapy regimen. It is very treatable, even at later ...

Cancer patient, 8, off to Midwest for possible marrow transplant  -  Oct 28, 2006
San Francisco ChronicleWetle has been diagnosed with gestational trophoblastic disease, a rare cancer that develops in the uterus immediately after a woman conceives a child. ...

Article: Cancer centre to open at Charing Cross Hospital ; NEWS IN …  -  Jan 22, 2008
Pay-Per-View - Evening Standard - London - HighBeam ResearchThe researchers ... additional information, contact A.K. Lim, Charing Cross Hospital, Dept. of Imaging and Charing Cross Gestational Trophoblastic Disease ...

People on the Move: July 20  -  Jul 20, 2009
Washington Business Journal...preinvasive and invasive disease of the vulva, vagina and cervix, gestational trophoblastic disease, and advanced laparoscopic and robotic surgery. ...

Absence of Y chromosome in human placental site trophoblastic tumor  -  Jul 20, 2007
Nature.com...a comparatively more common gestational trophoblastic disease with uniparental disomy of the paternal genome and an exclusive paternal X chromosome. ...

Professor retires after 35 years caring for patients  -  Jul 17, 2009
Star - The StarHe is an expert in lymphoma, gestational trophoblastic disease, and biological therapy, has authored or edited eight books including Cancer Care in the ...

Article: Struggling teaching hospital may shut. - The Evening...  -  Apr 11, 2005
Pay-Per-View - Evening Standard - HighBeam ResearchThe researchers ... additional information, contact A.K. Lim, Charing Cross Hospital, Dept. of Imaging and Charing Cross Gestational Trophoblastic Disease ...

Mayo Clinic expertise  -  Feb 16, 2009
MayoClinic.comEpidemiology, clinical manifestations and diagnosis of gestational trophoblastic disease. http://www.uptodate.com/home/index.html. Accessed Feb. 10, 2009. ...

Article: Row over closure plan for teaching hospital. - The Evening …  -  Apr 11, 2005
Pay-Per-View - Evening Standard - HighBeam ResearchThe researchers ... additional information, contact A.K. Lim, Charing Cross Hospital, Dept. of Imaging and Charing Cross Gestational Trophoblastic Disease ...

What are contraindications to IUDs?(misconceptions on intra-uterine …  -  Aug 1, 2006
Free with registration - Journal of Family Practice - AccessMyLibrary.com...by patients with recent postpartum endometritis, gynecologic malignancy, genital bleeding of unknown cause, and gestational trophoblastic disease. ...

New Zealand Doctor Online - Medical News for GPs  -  Dec 19, 2007
New Zealand Doctor OnlineHistology of the “products� should be requested to exclude gestational trophoblastic disease. For breast infections, flucloxacillin is indicated early to ...

Death becomes her | Sunshine Coast Community | Stories about People …  -  Jul 29, 2007
Sunshine Coast DailyEleven years ago, when her eldest daughter was three years old, Chris was diagnosed with gestational trophoblastic disease – a cancer which occurs when ...

Helicobacter pylori seropositivity and stool antigen in patients with...  -  Jan 1, 2006
Free with registration - Infectious Diseases in Obstetrics and... - AccessMyLibrary.comPatients with known thyroid disease, multiple gestation, gestational trophoblastic disease, psychological and gastrointestinal disorders were excluded. ...

Article: Peer's 'relief' after crash.(News) - Sunday Mail (Glasgow,...  -  Jun 24, 2007
Pay-Per-View - Sunday Mail - HighBeam ResearchThe researchers ... additional information, contact A.K. Lim, Charing Cross Hospital, Dept. of Imaging and Charing Cross Gestational Trophoblastic Disease ...

What are contraindications to IUDs?(misconceptions on intra-uterine …  -  Aug 1, 2006
$4.95 - Journal of Family Practice - ECNext...by patients with recent postpartum endometritis, gynecologic malignancy, genital bleeding of unknown cause, and gestational trophoblastic disease. ...

Article: Boxing: Sport SHORTS - Oyebola tribute.(Sport) - The Journal...  -  Jul 28, 2007
Pay-Per-View - The Journal - HighBeam ResearchThe researchers ... additional information, contact A.K. Lim, Charing Cross Hospital, Dept. of Imaging and Charing Cross Gestational Trophoblastic Disease ...

Article: BRITAIN: Shots death of ex-boxer.(News) - Daily Post...  -  Jul 28, 2007
Pay-Per-View - Daily Post - HighBeam ResearchThe researchers ... additional information, contact A.K. Lim, Charing Cross Hospital, Dept. of Imaging and Charing Cross Gestational Trophoblastic Disease ...

What are contraindications to IUDs?(CLINICAL INQUIRIES)  -  Aug 1, 2006
Pay-Per-View - Journal of Family Practice - Factiva, from Dow Jones...by patients with recent postpartum endometritis, gynecologic malignancy, genital bleeding of unknown cause, and gestational trophoblastic disease. ...

Article: Gang kill schoolboy.(News) - Birmingham Mail (England) | …  -  Mar 16, 2007
Pay-Per-View - Birmingham Mail - HighBeam ResearchThe researchers ... additional information, contact A.K. Lim, Charing Cross Hospital, Dept. of Imaging and Charing Cross Gestational Trophoblastic Disease ...

Article: PerkinElmer grows prenatal screening business.(Executive …  -  Jul 31, 2006
Pay-Per-View - Instrument Business Outlook - HighBeam ResearchIntroduction Human chorionic gonadotropin (HCG) tests are the mainstay in the diagnosis of gestational trophoblastic disease (GTD) and very high levels of ...

Loislaw Federal District Court Opinions - SEPULVEDA v. STIFF (EDVa. …  -  Nov 13, 2006
Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw...for proper and timely treatment, which negligence led to the development of gestational trophoblastic disease, which became metastatic choriocarcinoma. ...

Abnormal Uterine Bleeding: A Primary Care Primer.  -  Feb 1, 2006
$4.95 - Consultant - ECNextThese complications include threatened, missed, or incomplete abortion; ectopic pregnancy; and gestational trophoblastic disease. ...

Utusan Malaysia Online - kesihatan  -  Feb 18, 2007
utusan.com.mySebelum kita pergi lebih jauh lagi, ada baiknya jika saya menyentuh sedikit mengenai Gestational Trophoblastic Disease (Penyakit Trofoblastik kehamilan/GTD) ...



Background information on Gestational Trophoblastic Disease [When available]

Gestational trophoblastic disease — usually referred to as a mole — is a very rare abnormality of pregnancy in the reproductive female that involves abnormal trophoblast proliferation. It is the result of a (purely chance) genetic error during the fertilization process that in turn causes the growth of abnormal tissue (which is not an embryo) within the uterus. The growth of this material is disproportionately rapid when compared to normal fetal growth.

The two types of hydatidiform molar pregnancy are complete and partial.

Complete moles are the most common type of moles, and are when the mass of tissue is completely made up of abnormal cells that would have become the placenta in a normal pregnancy. There is no fetus and nothing can be found at the time of the first scan. Complete moles often have a diploid karyotype 46,XX due to fertilization of an empty ovum by a single sperm followed by replication of the haploid chromosome. On ultrasound, a complete mole has a "snow storm pattern", and the uterus is large for dates. Microscopically, there is edema of most villi, which gives the appearance of a large and random collection of grape-like cell clusters.

In a partial mole, the mass may contain both these abnormal cells and often a fetus that has severe defects. In this case, the fetus will be consumed by the growing abnormal mass very quickly. Partial moles have a triploid karyotype (69,XXX or 69,XXY) due to the fertilization of a single egg with two sperm. They also have a lower volume of tissue, and smaller hydropic villi (grape-like), as well as normal villi mixed in with the abnormal. Rarely, partial moles can progress to gestational choriocarcinoma.

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