This page contains recent news articles, when available, and an overview of Rhabdomyosarcoma but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

News: Rhabdomyosarcoma

Cytheris Announces Initiation of NCI/NIH-Sponsored Phase I/IIa Clinical Study ...  -  23 Nov 2009
Earthtimes (press release)Patients treated with cytotoxic chemotherapy for ESFT, alveolar rhabdomyosarcoma and neuroblastoma universally sustain T cell depletion. ...

Concert adds to appeal total  -  ‎Nov 19, 2009‎
Newark AdvertiserHe was diagnosed with alveolar rhabdomyosarcoma — a rare form of leukaemia — a year ago. The NHS contributed towards the treatment but his parents, ...

Walking for Miles in New York City  -  ‎Nov 6, 2009‎
New York TimesEven during a year of treatment for rhabdomyosarcoma, a rare cancer, Ms. Nesciur walked. “I'm afraid of not being able to walk one day,�? she says. ...

Record Turnout for Lindsay's Legacy 5K  -  ‎Nov 14, 2009‎
WKBW-TVLindsay's Legacy is named after Lindsay MacIver, who in 2004 at age 21 lost her battle with Alveolar Rhabdomyosarcoma. Funds raised through the race are ...

Next stop Florida in Ruddi Waterworth-Jones 's cancer fight  -  ‎Nov 20, 2009‎
Huddersfield ExaminerRuddi was diagnosed with rhabdomyosarcoma – a rare form of cancer of the soft tissue on the prostate – when he was just six months old. ...

Jordan Paganelli : An Angel Gets His Wings  -  ‎Nov 11, 2009‎
Bay Net11, 2008 when he was diagnosed with Alveolar Rhabdomyosarcoma stage IV. Rhabdomyosarcoma - Alveolar subtype is a very aggressive, highly malignant ...

Checkers Fight For Ellie  -  ‎Nov 6, 2009‎
OurSports Central (press release)Ellie Shoal Potvin is a seven-year-old girl who, last July, was diagnosed with Stage 4 Rhabdomyosarcoma, a rare childhood cancer. Last season, the Checkers ...

Checkers Fight For Ellie A Success  -  ‎Nov 9, 2009‎
OurSports Central (press release)Ellie Shoal Potvin is a seven-year-old girl battling Stage 4 Rhabdomyosarcoma, a rare childhood cancer. Her cancer went into remission over the summer but ...

With amazing grace  -  ‎Nov 11, 2009‎
So Md News11, 2008, Jordan Paganelli was diagnosed with alveolar rhabdomyosarcoma, an aggressive soft-tissue cancer that most often affects children. ...

Snooker marathon raises more than £1000 for Ruddi  -  ‎Nov 13, 2009‎
Huddersfield ExaminerHe is the youngest person on record to have been diagnosed with rhabdomyosarcoma, a cancer of the soft tissue on the prostate. His family is now waiting to ...

Health Matters : What is Sarcoma ?  -  ‎Nov 20, 2009‎
PR-inside.com (press release)For instance, rhabdomyosarcoma is more common in children than in adults. Synovial sarcomas are more common in adolescents. though an exact cause for the ...

Southern Maryland joins the big dance  -  ‎Nov 4, 2009‎
Washington PostTeam JP, which was set up to honor 17-year-old Leonardtown High student Jordan Paganelli, who is battling rhabdomyosarcoma, a rare soft-tissue cancer, ...

Big Sur Half Marathon: Monterey family runs to beat cancer  -  ‎Nov 14, 2009‎
The Salinas CalifornianShe signed up for the 2005 Big Sur Half Marathon just as Nathan was beginning six months of chemotherapy for rhabdomyosarcoma, a relatively rare cancer that ...

Beads bring hope to Holly  -  ‎Nov 17, 2009‎
Macon TelegraphEleven months ago, Holly was diagnosed with rhabdomyosarcoma, a rare form of childhood cancer. Doctors found a tumor behind her right eye. ...

Couple hear from Hall on health care  -  ‎Nov 11, 2009‎
Poughkeepsie JournalThe Ollives' 12-year-old son, Liam, a Rombout Middle School student, has twice had rhabdomyosarcoma, a form of cancer that occurs in soft tissue. ...

Swim team to participate in Hour of Power fundraiser  -  ‎Nov 8, 2009‎
CMU The Tartan OnlineSkapek is currently focusing on rhabdomyosarcoma, a type of sarcoma that is particularly common in children and young adults. “I think it's important for ...

Dance of the undead  -  ‎Oct 30, 2009‎
So Md News...a neighbor of Campbell's who is dealing with Stage IV Rhabdomyosarcoma, a rare soft-tissue cancer that predominantly affects children, and the Liddy ...

First Home Game This Sunday  -  ‎Oct 28, 2009‎
OurSports Central (press release)Ellie Shoal Potvin is a beautiful seven year old girl who was diagnosed with a rare childhood cancer called Rhabdomyosarcoma in July of 2008. ...

Gustavito, está en el cielo  -  ‎Nov 3, 2009‎
El Sol de Cordoba...nucleoeléctrica lo que le provocó el cáncer en la vista que se le denomina Rhabdomyosarcoma alveolar embrionario de tercer nivel (cáncer en el ojo). ...

Art on the Square Silent Auction to donate to local man with cancer  -  ‎Aug 5, 2009‎
News CourierFriends planned a day-long benefit for Haney, who was diagnosed with the cancer rhabdomyosarcoma, at the Limestone County Sheriff's Rodeo Arena on Alabama

Similar cancer, equal struggle shared by Athens man and girl  -  ‎Aug 5, 2009‎
The Huntsville Times - al.comRhabdomyosarcoma. It's a word few people may understand, but for two families in Athens it's a household name.

Testicular germ cell tumors with sarcomatous components: An ...  -  ‎Aug 3, 2009‎
UroTodayThe most common histologic type of SC was rhabdomyosarcoma (n=24), followed by high-grade unclassified sarcoma (n=5), rhabdomyosarcoma admixed with

Relay for Life to be July 24 at high school  -  ‎Jul 22, 2009‎
Liberty TribuneAmong the participants will be Karlee Jo McQueen of Liberty, a four-year old who underwent extensive treatment for Embryonal Rhabdomyosarcoma.

Homecoming brings Will power  -  ‎Jul 28, 2009‎
News CourierWill was diagnosed with rhabdomyosarcoma and will return to Houston for the next round of therapy on Aug. 3. On Friday, before flying home, Will and Emily

'Our little girl's cancer is back'  -  ‎Jul 30, 2009‎
Stoke & StaffordshireThe three-year-old, who touched the hearts of Sentinel readers when she was diagnosed with a rare form of childhood cancer, called rhabdomyosarcoma,

Life against  -  ‎Jul 29, 2009‎
Berwick NewsHe was diagnosed with rhabdomyosarcoma. He had growths in the right side of his neck, and a mother tumour in his nose, which left him with a disfigured face

Brat fry will raise funds for Fond du Lac toddler  -  ‎Jul 19, 2009‎
The ReporterThe 2-year-old has rhabdomyosarcoma, a rare childhood cancer. He is undergoing chemotherapy treatment at Children's Hospital in Milwaukee.

Golf outing to benefit young cancer patient  -  ‎Jul 15, 2009‎
Carroll County CometChance, a second grader at Delphi Community Elementary School, has been diagnosed with an aggressive type of cancer, Rhabdomyosarcoma.

Family stays positive in battle with cancer  -  ‎Jul 13, 2009‎
The Huntsville Times - al.comNewton, who lives in Athens with her parents and 8-year-old brother, was diagnosed with Rhabdomyosarcoma in May. After Sydney complained of vision problems,

NHS pays for cancer child's treatment in Swizerland  -  ‎Jul 21, 2009‎
This is NottinghamToby Clough, of Bingham, was diagnosed with a rare form of cancer called Rhabdomyosarcoma in his eye muscles when he was 21 months' old.

Cancer just another mountain to climb  -  ‎Jul 21, 2009‎
Herald SunWhile he doesn't have the strength to reach the peaks he scaled before he was diagnosed with rhabdomyosarcoma, Jerome still spends every moment he can

Our Heroes: Olivia is still smiling despite cancer battle  -  ‎Jul 13, 2009‎
Stoke & StaffordshireShe was diagnosed with a rare form of muscle cancer called Rhabdomyosarcoma in February. Since then Olivia has spent many nights in hospital and has

Teen girl faces a third life struggle  -  ‎Aug 2, 2009‎
Akron Beacon JournalMegan — a two-time cancer survivor (alveolar rhabdomyosarcoma when she was 11 months old and again when she was 2) — is now battling interstitial pulmonary

Kristen Hoenshell is Pan-Massachusetts Challenge 'Pedal Partner'  -  ‎Jul 29, 2009‎
Littleton IndependentKristen was diagnosed with Rhabdomyosarcoma in May 2008 and is being treated at Dana-Farber Cancer Institute's pediatric oncology center, the Jimmy Fund

Wyatt's Ride for 'the House'  -  ‎Aug 1, 2009‎
Valley Bugler NewspaperWyatt was 9 yrs. old when he was diagnosed with rhabdomyosarcoma. He had treatment and fought for 6 years. He was so positive and had a good attitude

St. Jude runners motivated to raise money for cancer research  -  ‎Jul 28, 2009‎
Peoria Journal StarBy PAT OLDENDORF Ten months after Joshua Malavolti finished treatment for rhabdomyosarcoma at St. Jude Children's Research Hospital, he started training for

When he needed it, his 'family' of firefighters cared  -  ‎Aug 1, 2009‎
Florida Times-UnionWhat started out seeming like a cold or sinus infection turned out to be rhabdomyosarcoma, a rare form of cancer, in the head of a little boy with an

Neighborhood unite for co-ed softball fundraiser  -  ‎Jul 31, 2009‎
Frankfort StationMeekma is in remission from the rare form of cancer Alveolar Rhabdomyosarcoma, and has recently been diagnosed with acute myeloid leukemia, as well.

Prenatal Detection of an Extra-Adrenal Neuroblastoma With Hepatic ...  -  ‎Jul 30, 2009‎
Journal of Ultrasound in Medicine (subscription) (subscription)27 – 29 These include neuroblastoma, malignant teratoma, atypical mesoblastic nephroma, embryonal rhabdomyosarcoma, congenital fibrosarcoma, melanoma,

The American Red Cross  -  ‎Jul 22, 2009‎
Carroll County CometChance has been diagnosed with an aggressive type of cancer, Rhabdomyosarcoma. The 18-hole, four-man best ball scramble will begin at 12 noon.

Greenville 8-year-old faces crucial surgery for cancer  -  ‎Jul 28, 2009‎
Greenville NewsAt 2, the Greenville boy was diagnosed with rhabdomyosarcoma, a rare cancer that strikes about 250 children a year. And while he's been in remission for a

Reasons to relay  -  ‎Jul 11, 2009‎
Fort Dodge MessengerThat mass turned out to be rhabdomyosarcoma, a fast-growing, highly malignant tumor. "We were told to go straight to Iowa City that night," said Jodi Telfer

Karlee's Angels bring smiles, toys to sick kids  -  ‎Jul 13, 2009‎
KATUMiller had to have her leg amputated while battling a muscle cancer, called Rhabdomyosarcoma. She remembered how good it felt to receive a toy when she was

Keryx Biopharmaceuticals, Inc. Commences Phase 1 Study of KRX-0401 ...  -  ‎Jul 14, 2009‎
PR Newswire (press release)...glioblastoma, rhabdomyosarcoma, and medulloblastoma. Perifosine's inhibition of this and other pathways, as well as its ability to cross the blood-brain

Good Samaritan taxi driver waives fee for rushing grandparents to ...  -  ‎Jul 20, 2009‎
This is Local LondonLittle Lilia Grace had rhabdomyosarcoma – a fast-growing and highly-malignant form of cancer which frequently leaves lumps on the body or head – diagnosed

Background information on Rhabdomyosarcoma [When available]

A rhabdmyosarcoma is a form of cancer of the sarcoma subtype that shows differentiation or determination towards resembling skeletal muscle.

In general, as a result of oncogenesis, the cells comprising a cancer will have a different genotype to the constitutional genotype of the host. The genotypic changes may induce a perceptible change in the phenotype. Both of these changes may be used to classify the neoplasm. Medically useful systems of classification offer the means for diagnosis and prognosis, and may assist the physician in the choice of optimal treatment.

The cells in a particular cancer might show no overt differentiation or they might show varying degrees of differentiation that parody the appearances of some normal tissue. In a histogenetic classification, the cancer is named for the normal tissue whose phenotype is most closely mimicked. A cancer whose cells show no resemblance to any particular tissue is said to be undifferentiated. The differentiation may be perceived at the level of tissue architecture (that is, how the individual cells group together and organise themselves compared with normal tissues). An assessment of architectural relationships is the most important part of histopathology. It provides an important means to predict the biological behaviour of a neoplasm, that is, to form an opinion whether it will behave in a benign or malignant fashion. Assessment of individual cells is the main subject of cytopathology. Cytopathological assessment of cellular phenotype is best undertaken on suitably prepared whole cells that have been spread onto a glass slide. However, with some limitations, it may also be undertaken on those individual cells that form part of a neoplasm that are present in a thin section of a biopsied specimen.

Light microscopy may be used to assess the architecture of sampled tissues and the phenotype of its cells. A biopsied specimen is typically hardened and preserved in some suitable fixative. It is dehydrated and embedded in paraffin wax to allow thin sections to be taken onto glass slides. Routine assessment of these sections involves rehydration and staining with haematoxylin (which stains acidic molecules, such as nucleic acids, blue) and eosin (which stains basic molecules, such as proteins, red).

The cellular phenotype may also be assessed at the higher magnifications afforded by electron microscopy. The biopsied specimen is processed in a similar way, except that the fixatives, embedding media and stains are chosen to allow the generation of thinner sections and differential opacity to transmitted electrons rather than photons.

A change in the phenotype of a cell is effected by changes in the proteins within its cytoplasm. When this is visible using light microscopy, it may be possible to use this cellular phenotype to classify the cancer. In a rhabdomyosarcoma, the accumulation in a variable proportion of the malignant cells of large amounts of the particular isomers of the proteins that are responsible for the contractile properties of skeletal muscle typically result in large cells with cytoplasm that stains deeply red with eosin. In a small number of the malignant cells these proteins might be assembled in a structured way that imparts the "striated" appearance, characterised by alternating bands of dark and pale red, that is typical of normal skeletal muscle.

In poorly differentiated cells, the proteins that accumulate may not be present in sufficient quantities to produce a perceptible change in the appearance of the cell as judged by light microscopy. It is possible to probe for the presence of these proteins using other techniques such as immunohistochemistry. In the absence of a perceptible change in the cellular phenotype, this provides an opportunity to identify an "immunophenotype". Using this technique, the presence of proteins such as desmin, myoglobin, muscle specific actin, and others would provide strong evidence for the diagnosis of rhabdomyosarcoma.

Some cancers do not contain cells that are sufficiently differentiated to allow histogenetic classification by assessment of the cellular phenotype or immunophenotype. In some of these cells, it may be possible to identify other proteins whose presence indicates "determination" toward some particular tissue type. A cell that is "determined" has undergone modification of its genome so that the pathways of differentiation that remain open to it are restricted to those that are associated with the cells of some specific tissue. During the early stages of development of skeletal muscle cells, a protein called "myo D1" binds itself to genetic material in the cell nuclei. This is an indicator of determination towards skeletal muscle differentiation. Once skeletal muscle cells become innervated by nerve cells, the concentration of this protein falls dramatically. The same protein (myo D1) may be found in the nuclei of the cells in a rhabdomyosarcoma. As the malignant cells do not become innervated by nerve cells, this protein remains in a high concentration. This may be exploited as a means to identify malignant neoplasms that contain cells that show determination towards rhabdomyosarcoma, even when there is insufficient differentiation to allow phenotypic assessment to be used for the diagnosis. As this protein may also be present in the cytoplasm of cells of other neoplasms whose other characteristics show that they are not rhabdomyosarcomas, demonstration of the presence of myo D1 should be considered supportive for rhabdomyosarcoma only if the protein is present in the cell nuclei.

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