ARALEN

This page contains recent news articles, when available, and an overview of ARALEN but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

ARALEN (when available)

Pharmacology and use:
Chloroquine is the prototype anti malarial drug, most widely used to treat all types of malaria except for disease caused by chloroquine resistant Plasmodium falciparum. It is highly effective against erythrocytic forms of Plasmodium vivax, Plasmodium ovale and Plasmodium malariae, sensitive strains of Plasmodium falciparum and gametocytes of Plasmodium vivax. Being alkaline, the drug reaches high concentration within the food vacuoles of the parasite and raises its pH. It is found to induce rapid clumping of the pigment. Chloroquine inhibits the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. It may also interfere with the biosynthesis of nucleic acids. For the suppressive treatment and for acute attacks of malaria due to P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum, Second-line agent in treatment of Rheumatoid Arthritis

Mechanism Of Action:
The mechanism of plasmodicidal action of chloroquine is not completely certain. Like other quinoline derivatives, it is thought to inhibit heme polymerase activity. This results in accumulation of free heme, which is toxic to the parasites.

News Articles on Chloroquine

Brand Names/Synonyms:
ARALEN is also known by the following brand names and/or synonyms3377 RP; 3377 RP opalate; Amokin; Aralen; Aralen HCl; Arechin; Arthrochin; Artrichin; Avlochlor; Avloclor; Bemaco; Bemaphate; Bemasulph; Benaquin; Bipiquin; Capquin; Chemochin; Chingamin; Chloraquine; Chlorochin; Chlorochine; Chloroquina; Chloroquine; Chloroquine Phosphate; Chloroquinium; Chlorquin; Cidanchin; Clorochina; Cocartrit; Delagil; Dichinalex; Elestol; Gontochin; Heliopar; Hydroxychloroquine Sulfate; Imagon; Iroquine; Klorokin; Lapaquin; Malaquin; Malaren; Malarex; Mesylith; Neochin; Nivachine; Nivaquine; Nivaquine B; Nivaquine [as sulfate]; Pfizerquine; Plaquenil; Quinachlor; Quinagamin; Quinagamine; Quinercyl; Quingamine; Quinilon; Quinoscan; RP 3377; Resochen; Resochin; Resoquina; Resoquine; Reumachlor; Reumaquin; Roquine; SN 6718; SN 7618; Sanoquin; Silbesan; Siragan; Solprina; Sopaquin; Tanakan; Tresochin; Trochin; W 7618; WIN 244; Chloroquine (VAN)

Drug Category:
ARALEN is categorized under the following by the FDA: Antirheumatic Agents; Antimalarials; Amebicides; ATC:P01BA01; ATC:P01BA02

Dosage Forms:
TABLET

Absorption:
Completely absorbed from gastrointestinal tract

Interactions:
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Chemical IUPAC Name:
N'-(7-chloroquinolin-4-yl)-N,N-diethyl-pentane-1,4-diamine

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