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AbacavirThis page contains recent news articles, when available, and an overview of Abacavir but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Abacavir (when available) Abacavir is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Abacavir is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated. For the treatment of HIV-1 infection, in combination with other antiretroviral agents Mechanism Of Action: Abacavir is a carbocyclic synthetic nucleoside analogue. Intracellularly, Abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate, an analogue of deoxyguanosine-5'-triphosphate (dGTP). Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. News Articles on Abacavir Successes and challenges in personalized medicine - Dec 21, 2009 He used the example of the drug abacavir, FDA-approved in 1998 and used to treat HIV and AIDS. About 2-9 percent of patients can be hypersensitive to ... Farm and Dairy Study Identifies Viread And Emtriva As The Preferred Initial Treatment For HIV ... - Dec 10, 2009 ...effective nucleoside reverse transcriptase inhibitors (NRTIs) than Ziagen (abacavir) and Epivir (lamivudine) as an initial combination therapy for HIV. ... The AIDS Beacon (blog) The Genome Generation - Dec 15, 2009 Genetic tests are used to determine whether certain drugs are prescribed, and in what dose, for HIV-AIDS (the drug abacavir), psychosis (clozapine), ... Newsweek New Label For Anti-HIV Drug Lexiva Warns Of Heart Attack Risk - Dec 10, 2009 Ziagen (abacavir) has also been associated with increased risk of heart problems (see related AIDS Beacon news). HIV infection itself is also associated ... The AIDS Beacon (blog) What's New in HIV/AIDS: Treatment Immune reconstitution inflammatory syndrome ... - Dec 9, 2009 Her antiretrovirals were changed to abacavir, tenofovir, darunavir, and ritonavir. Following this change, her HIV viral load decreased from 10 million HIV ... Journal of the American Academy of Physician Assistants Exames de CD4 e carga viral no Rio Grande do Sul estão em fase de normalização ... - Dec 14, 2009 Na questão do Abacavir, a Secretaria informa que houve desabastecimento, informação que não foi confirmada pelo Ministério da Saúde. ... Agência de Notícias da Aids GlaxoSmithKline, Pfizer Launches Specialist HIV Company - Nov 4, 2009 ...-ViiV Healthcare has 10 medicines currently available including therapies such as Epzicom/Kivexa (abacavir sulfate+lamivudine) and Selzentry/Celsentri ... CNNMoney.com Pfizer/GSK HIV Spin-Off ViiV Healthcare Debuts With Personalized Drugs in ... - Nov 11, 2009 The other drug, Epizicom, combines abacavir and lamivudine. The US Food and Drug Administration last year updated the labeling for abacavir to include ... GenomeWeb Daily News Epzicom Associated With More Side Effects In HIV/AIDS Patients Than Truvada - Nov 9, 2009 Alternatively, Epzicom is a combination therapy that contains Ziagen (abacavir) and Epivir (lamivudine). Viread and Ziagen were originally introduced to ... The AIDS Beacon (blog) Generic Name: Tenofovir, emtricitabine - Nov 11, 2009 Do not take Truvada if you are already taking Atripla, Combivir (lamivudine/zidovudine), Emtriva, Epivir or Epivir-HBV (lamivudine), Epzicom (abacavir ... Pattaya Daily News GlaxoSmithKline and Pfizer launch HIV joint venture - Nov 5, 2009 ViiV Healthcare has 10 medicines currently available including therapies such as Epzicom/Kivexa (abacavir sulfate+lamivudine) and Selzentry/Celsentri ... Trading Markets (press release) Drug safety and your DNA - Oct 30, 2009 The HIV/AIDS drug abacavir (trade name Ziagen) is used to treat HIV by helping inhibit an enzyme that helps the virus reproduce. ... Common Ground.ca Pfizer And GSK Launch New Healthcare Company For HIV/AIDS Research - Nov 10, 2009 Currently, ViiV Healthcare's drug portfolio contains 17 different molecules, including Epzicom (abacavir/lamivudine) and Selzentry (maraviroc). ... The AIDS Beacon (blog) Glaxo-Pfizer tie-up opens new era in Aids battle - Oct 31, 2009 ...in which GSK acquired a 16pc stake in May, has a royalty-free licence to develop a cheaper, generic version of GSK's HIV treatment Abacavir. ... Telegraph.co.uk GSK y Pfizer presentan ViiV Healthcare, su nueva compañÃa especializada en VIH - Nov 3, 2009 ...y en su cartera de productos cuenta con diez fármacos ya aprobados actualmente --entre ellos el sulfato de abacavir y lamivudina, comercializados por ... Europa Press AIDS: NASCE VIIV, NUOVA AZIENDA CREATA DA CSK E PFIZER - Nov 4, 2009 ViiV Healthcare dispone attualmente di un portfolio di dieci farmaci compresi Epzicom/Kivexa (abacavir solfato+lamivudina) e Selzentry/Celsentri (maraviroc) ... AGI - Agenzia Giornalistica Italia Neues HIV-Unternehmen: ViiV Healthcare - Nov 3, 2009 Derzeit sind bei ViiV Healthcare 10 Medikamente verfügbar, einschließlich Therapien wie Kivexa(R) (Abacavir Sulfat+Lamivudin) und Celsentri(R) (Maraviroc). ... APA OTS (Pressemitteilung) Oprichting ViiV Healthcare - Nov 3, 2009 ViiV Healthcare brengt in Nederland 8 medicijnen op de markt, zoals Kivexa(R) (abacavir +lamivudine) en Celsentri(R) (maraviroc). ... Ezpress (persbericht) Megalakult a ViiV Healthcare - Nov 3, 2009 A ViiV Healthcare-nek jelenleg 10 gyógyszere elérhetÅ‘, beleértve olyan terápiás készÃtményeket is, mint például az Epzicom/Kivexa (abacavir sulfate + ... Weborvos ä¸å›½åŒ»è?¯äº§ä¸šç«žäº‰åŠ›æž„建与å?¯æŒ?ç»å?‘展 - Nov 2, 2009 ...å…¶ä¸ä¸å›½æ— è¿›å?£çš„有：甲磺酸阿拉曲ä¼?沙星（Alatrofloxacin Mesylate），2009å¹´11月美国专利到期；阿巴å?¡éŸ¦ï¼ˆAbacavir），2009å¹´6月美国专利到期；ä¾?å?‘韦 ... 中国生物技术信息网 Brand Names/Synonyms: Abacavir is also known by the following brand names and/or synonyms1592U89; ABC; Abacavir; Abacavir [Inn]; Ziagen Drug Category: Abacavir is categorized under the following by the FDA: Anti-HIV Agents; Nucleoside and Nucleotide Reverse Transcriptase Inhibitors; ATC:J05AF06 Dosage Forms: SOLUTION; TABLET Absorption: Rapid and extensive after oral administration (83% bioavailability) Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: [4-(2-amino-6-cyclopropylamino-9H-purin-9-yl)-1-cyclopent-2-enyl]methanol |
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