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AbacavirThis page contains recent news articles, when available, and an overview of Abacavir but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Abacavir (when available) Abacavir is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Abacavir is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated. For the treatment of HIV-1 infection, in combination with other antiretroviral agents Mechanism Of Action: Abacavir is a carbocyclic synthetic nucleoside analogue. Intracellularly, Abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate, an analogue of deoxyguanosine-5'-triphosphate (dGTP). Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. News Articles on Abacavir GlaxoSmithKline, Pfizer Launches Specialist HIV Company - Nov 4, 2009 ...-ViiV Healthcare has 10 medicines currently available including therapies such as Epzicom/Kivexa (abacavir sulfate+lamivudine) and Selzentry/Celsentri ... CNNMoney.com Pfizer/GSK HIV Spin-Off ViiV Healthcare Debuts With Personalized Drugs in ... - Nov 11, 2009 The other drug, Epizicom, combines abacavir and lamivudine. The US Food and Drug Administration last year updated the labeling for abacavir to include ... GenomeWeb Daily News Epzicom Associated With More Side Effects In HIV/AIDS Patients Than Truvada - Nov 9, 2009 Alternatively, Epzicom is a combination therapy that contains Ziagen (abacavir) and Epivir (lamivudine). Viread and Ziagen were originally introduced to ... The AIDS Beacon (blog) Generic Name: Tenofovir, emtricitabine - Nov 11, 2009 Do not take Truvada if you are already taking Atripla, Combivir (lamivudine/zidovudine), Emtriva, Epivir or Epivir-HBV (lamivudine), Epzicom (abacavir ... Pattaya Daily News GlaxoSmithKline and Pfizer launch HIV joint venture - Nov 5, 2009 ViiV Healthcare has 10 medicines currently available including therapies such as Epzicom/Kivexa (abacavir sulfate+lamivudine) and Selzentry/Celsentri ... Trading Markets (press release) Drug safety and your DNA - Oct 30, 2009 The HIV/AIDS drug abacavir (trade name Ziagen) is used to treat HIV by helping inhibit an enzyme that helps the virus reproduce. ... Common Ground.ca Pfizer And GSK Launch New Healthcare Company For HIV/AIDS Research - Nov 10, 2009 Currently, ViiV Healthcare's drug portfolio contains 17 different molecules, including Epzicom (abacavir/lamivudine) and Selzentry (maraviroc). ... The AIDS Beacon (blog) Glaxo-Pfizer tie-up opens new era in Aids battle - Oct 31, 2009 ...in which GSK acquired a 16pc stake in May, has a royalty-free licence to develop a cheaper, generic version of GSK's HIV treatment Abacavir. ... Telegraph.co.uk GSK y Pfizer presentan ViiV Healthcare, su nueva compañÃa especializada en VIH - Nov 3, 2009 ...y en su cartera de productos cuenta con diez fármacos ya aprobados actualmente --entre ellos el sulfato de abacavir y lamivudina, comercializados por ... Europa Press AIDS: NASCE VIIV, NUOVA AZIENDA CREATA DA CSK E PFIZER - Nov 4, 2009 ViiV Healthcare dispone attualmente di un portfolio di dieci farmaci compresi Epzicom/Kivexa (abacavir solfato+lamivudina) e Selzentry/Celsentri (maraviroc) ... AGI - Agenzia Giornalistica Italia Neues HIV-Unternehmen: ViiV Healthcare - Nov 3, 2009 Derzeit sind bei ViiV Healthcare 10 Medikamente verfügbar, einschließlich Therapien wie Kivexa(R) (Abacavir Sulfat+Lamivudin) und Celsentri(R) (Maraviroc). ... APA OTS (Pressemitteilung) Oprichting ViiV Healthcare - Nov 3, 2009 ViiV Healthcare brengt in Nederland 8 medicijnen op de markt, zoals Kivexa(R) (abacavir +lamivudine) en Celsentri(R) (maraviroc). ... Ezpress (persbericht) Megalakult a ViiV Healthcare - Nov 3, 2009 A ViiV Healthcare-nek jelenleg 10 gyógyszere elérhetÅ‘, beleértve olyan terápiás készÃtményeket is, mint például az Epzicom/Kivexa (abacavir sulfate + ... Weborvos ä¸å›½åŒ»è?¯äº§ä¸šç«žäº‰åŠ›æž„建与å?¯æŒ?ç»å?‘展 - Nov 2, 2009 ...å…¶ä¸ä¸å›½æ— è¿›å?£çš„有：甲磺酸阿拉曲ä¼?沙星（Alatrofloxacin Mesylate），2009å¹´11月美国专利到期；阿巴å?¡éŸ¦ï¼ˆAbacavir），2009å¹´6月美国专利到期；ä¾?å?‘韦 ... 中国生物技术信息网 Tenofovir Not Necessarily Hard on the Kidneys - Aug 28, 2009 Tenofovir (found in Viread, Truvada and Atripla) as part of a first HIV regimen isn't necessarily harder on the kidneys than drugs such as Ziagen (abacavir) AIDSmeds.com HIV/AIDS Treatment News New HIV Guidelines Push 'Adherence to Care' - Aug 14, 2009 Patients positive for the haplotype should not be treated with abacavir. Baseline urinalysis and calculated creatinine clearance should be considered, MedPage Today Abacavir as potent as tenofovir for patients starting HIV ... - Aug 6, 2009 Regardless of baseline viral load, an HIV treatment combination that includes abacavir (Ziagen, also in the combination pill Kivexa) is just as effective at Aidsmap High Viral Load Patients Equally Fine on Epzicom or Truvada - Aug 7, 2009 People who start antiretroviral treatment for the first time with a viral load over 100000 do equally well on a regimen containing abacavir (found in Ziagen AIDSmeds.com HIV/AIDS Treatment News Treatments news from the IAS Conference - Aug 19, 2009 All participants in the study were started on a boosted dose of atazanavir plus abacavir/lamivudine (Kivexa) then half of them dropped the ritonavir at 36 NAPWA Updated HIV Guidelines Emphasise Primary Care Need of Patients - Aug 17, 2009 HLA-B*5701 testing should be performed prior to initiating abacavir therapy to reduce the risk of a hypersensitivity reaction. Patients who are positive for DG News Cardio fears allayed in HIV drug - Aug 20, 2009 He said the pipeline of new drugs had slowed down with many now in the trial phase and pointed to recent drug company research which indicates Abacavir, Sydney Star Observer Updated HIV care guidelines issued in USA - Aug 4, 2009 HLA-B*5701 testing should be performed on all patients before treatment with abacavir is initiated. Patients whose tests are positive should not take Aidsmap Risk of kidney problems similar for tenofovir and alternative drugs - Aug 26, 2009 A total of 201 individuals were treated with tenofovir and 231 with an alternative drug (57% AZT; 37% abacavir; 37% d4T; and 6% ddI). Aidsmap Row over seizure of low-cost drugs - Aug 9, 2009 In February 2009, the AIDS medicine abacavir which was bound for Nigeria was seized in Amsterdam and was released after a complaint by the UN, which was the Malaysia Star Novartis Denies it Will Resubmit Application to Market Painkiller ... - Aug 7, 2009 ...that pinpoint which patients will develop serious side effects associated with a drug — such as the HIV drug abacavir and the anticoagulant warfarin. GenomeWeb Daily News Mashelkar report draws health groups' ire again - Aug 16, 2009 Roche's pegylated interferon alfa-2a (both for hepatitis C) and GlaxoSmithKline's abacavir oral solutions for HIV, which, say legal activists, Daily News & Analysis HEALTH: Activists Press for 'People's Property Rights' to Medications - Aug 12, 2009 In July, the drug firm GlaxoSmithKline (GSK) granted a free voluntary licensing agreement to a South African company to produce abacavir, a second-line IPS Psychiatric Aspects of HIV Spectrum Disease - Aug 28, 2009 ...yet to date results to support specific agents are limited to the use of zidovudine and, to a lesser extent, abacavir, nevirapine, and indinavir. Focus (subscription) Alerta VIH - Aug 17, 2009 ...tienen el potencial de producir resistencia cruzada (tenofovir con lamivudina y abacavir serÃan un ejemplo de ese tipo de combinación). El Universal (Venezuela) Terapia antiretrovirale precoce riduce mortalità in lattanti HIV ... - Aug 26, 2009 La terapia antiretrovirale di II linea prevedeva didanosina, abacavir e nevirapina (o efavirenz se il bambino era >3 anni). I partecipanti allo studio Pillole.org SIDA: Activistas arremeten contra patentes - Aug 12, 2009 ...el laboratorio GlaxoSmithKline concedió una licencia gratuita y voluntaria a una empresa sudafricana para producir la versión genérica del abacavir, Costa Rica Hoy Medicamentos de bajo costo - Aug 13, 2009 ...dÃas antes de que retornara a India. l En febrero de 2009 fue incautado en Ã?msterdam un medicamento contra el sida, el abacavir, destinado a Nigeria. La Primera Estudo associa antirretrovirais de segunda linha a risco ... - Aug 12, 2009 Em 2008, a Agência de NotÃcias da Aids repercutiu a informação de que as drogas abacavir ea didadosina, das companhias GlaxoSmithKline e Bristol-Myers Agência de Notícias da Aids Una investigación del hospital Carlos III, mejor trabajo de ... - 13 Jul 2009 El mismo tipo de trabajo se realizó también con el abacavir y "en estos momentos estamos investigando las posibles complicaciones del tenofovir, elmundo.es Buy cheap Epzicom information , side effects, online pills - Jun 30, 2009 Once you have had an allergic reaction to abacavir and lamivudine, you must never use it again. You may need a blood test before you start taking Epzicom На плувка и дъно Aurobindo gets nod for 5 new registrations from MCC - South Africa - Jun 23, 2009 According to a company press release, the MCC has approved two ARV category drugs of Auro-Abacavir 300mg tablets (Abacavir), Auro-Abacavir 20mg/ml pharmabiz.com Aurobindo gets five new approvals from MCC, South Africa - Jun 23, 2009 The drugs include Auro-Abacavir (300 mg) in the tablet form, Auro-Abacavir (200 mg/ml) in oral form. It also comprises of Auroprozil (250 mg & 500 mg) in Myiris.com Aurobindo Pharma receives MCC approval for five more products - Jun 23, 2009 The company has got the approval for Auro-Abacavir tablets in 300mg strength and Auro-Abacavir oral solutions in 20mg/ml strength in the ARV ( Aids Indopia Gradual Efavirenz Dosing Shows Promise - Jul 7, 2009 The 114 patients enrolled received efavirenz plus either Truvada (tenofovir and emtricitabine), Epzicom (abacavir and lamivudine) or a combination of two AIDSmeds.com HIV/AIDS Treatment News A highly annotated whole-genome sequence of a Korean individual - Jul 8, 2009 ...rosiglitazone, warfarin, citalopram, abacavir, debrisoquine, bleomycin, fluorouracil and aramycin-C (Fig. 3b). CNVs have shown associations with common, Nature.com (subscription) Monogram Acquisition Bolsters LabCorp's PGx Test Portfolio ... - Jun 24, 2009 ...to LabCorp's assay for screening HIV patients for the HLA-B*5701 allele before initiating treatment with the drug abacavir (GlaxoSmithKline's Ziagen). GenomeWeb Daily News Qiagen Transfers Distribution Rights for Transplantation Testing ... - Jun 17, 2009 ...of the HLA-B*5701 allele – a test to assess the risk of AIDS patients for severe adverse reactions to the widely prescribed HIV drug component Abacavir. PharmaLive.com (press release) El mejor estudio de 2008 en farmacogenética es español - Jul 6, 2009 Actualmente sólo se emplean test de este tipo para un fármaco, abacavir —incluido en la cartera de servicios del Carlos III— mediante la determinación del Gaceta Médica La farmacogenética identifica diagnóstico y terapia concretas - Jul 1, 2009 Apoyo a la Investigación Biomédica en Red (Caiber), formado por 39 centros, se refiere a un haplotipo HLA relacionado con el antirretroviral abacavir. Diario Médico (Suscripción) Gilead Initiates Phase II Clinical Trial Of Integrase-Based ... - 20 Apr 2009 Epzicomâ„¢ (abacavir sulfate/lamivudine) or Trizivir® (abacavir sulfate/lamivudine/zidovudine). Atripla should not be taken with Hismanal® (astemizole), Medical News Today (press release) GSK and Pfizer HIV divisions to form new company - Apr 17, 2009 Research suggesting that abacavir can increase the risk of heart attack (disputed by GSK) and work less well in patients with a high viral load, Aidsmap HIV/AIDS Update - Tentative approval of abacavir sulfate and ... - Mar 31, 2009 ROCKVILLE, Md., March 30, 2009--On March 30, 2009, FDA granted tentative approval for abacavir sulfate and lamivudine tablets, 600 mg / 300 mg, PharmaLive.com (press release) Drug shortages roll back the clock on beating AIDS in Africa - Apr 9, 2009 Yet one of the drugs, Abacavir, was unavailable at public clinics in Free State because of the budget problems. Without a supply of Abacavir, Globe and Mail Gilead Initiates Phase II Clinical Trial of Integrase-Based ... - Apr 17, 2009 Epivir ® or Epivir-HBV ® (lamivudine), Epzicomâ„¢ (abacavir sulfate/lamivudine) or Trizivir ® (abacavir sulfate/lamivudine/zidovudine). Business Wire (press release) Common Genetic Variation and Human Traits - Apr 15, 2009 For example, when exposed to the anti-HIV drug abacavir, a hypersensitivity reaction develops in more than half the carriers of the HLA-B*5701 allele, New England Journal of Medicine (subscription) Personalized Medicine Is Growing, but Health Plans Need Policies ... - Apr 3, 2009 A genetic screening can help prevent potentially fatal hypersensitivity reactions from the use of the HIV drug abacavir and epilepsy drug carbamazepine in Atlantic Information Services, Inc. My Word: UC must insist that drug companies lower HIV prices - Apr 3, 2009 Yudof's history with HIV is poor — when he led the University of Minnesota, Yudof refused calls to drop royalty rights on abacavir, an HIV therapy, Inside Bay Area Gilead initie un essai clinique de Phase II avec un régime ... - Apr 19, 2009 ...l'Epivir ® ou l' Epivir-HBV ® (lamivudine), l'Epzicomâ„¢ (abacavir sulfate/lamivudine) ou le Trizivir ® (abacavir sulfate/lamivudine/zidovudine). Euroinvestor GSK-í™”ì?´ìž?, HIV 합작회사 ì°¨ë ¤ - Apr 16, 2009 ...합작회사는 GSKì?˜ ‘컴비비어'(Combivir, lamivudine/ zidovudine), ‘엡지컴'(Epzicom, abacavir/ lamivudine)ê³¼ í™”ì?´ìž?ì?˜ ‘셀센트리'(Selzentry, maraviroc) 등 11ê°œ 디지틀보사 全世界引用率最高的医å¦è®ºæ–‡ - Apr 2, 2009 49 S. Mallal, et al., "HLA-B*5701 screening for hypersensitivity to abacavir," New Engl. J. Med., 358(6): 568-79, 7 February 2008. 49 NS Beckett, et al., 科讯网 Brand Names/Synonyms: Abacavir is also known by the following brand names and/or synonyms: 1592U89; ABC; Abacavir; Abacavir [Inn]; Ziagen Drug Category: Abacavir is categorized under the following by the FDA: Anti-HIV Agents; Nucleoside and Nucleotide Reverse Transcriptase Inhibitors; ATC:J05AF06 Dosage Forms: SOLUTION; TABLET Absorption: Rapid and extensive after oral administration (83% bioavailability) Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: [4-(2-amino-6-cyclopropylamino-9H-purin-9-yl)-1-cyclopent-2-enyl]methanol |
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