Accupril

This page contains recent news articles, when available, and an overview of Accupril but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Accupril (when available)

Pharmacology and use:
Quinapril, an angiotensin-converting enzyme (ACE) inhibitor, is used to treat hypertension and heart failure. Like ramipril, quinapril is a prodrug that, upon deesterification, is converted to the active metabolite quinaprilat. The effect of quinapril in hypertension and in congestive heart failure (CHF) appears to result primarily from the inhibition of circulating and tissue ACE activity, thereby reducing angiotensin II formation. For the treatment of hypertension and chronic heart failure

Mechanism Of Action:
Quinaprilat competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms. Quinaprilat may also act on kininase II, an enzyme identical to ACE that degrades the vasodilator bradykinin.

News Articles on Quinapril

Hakim kabulkan gugatan Pfizer Pendaftaran merek Siagra atas nama pengusaha ...  -  04 Jan 2010
...yang terdepan dalam bidang usaha kesehatan dengan memperdagangkan berbagai macam obat-obatan dengan berbagai merek, al Accupril, Lipitor, dan Viagra. ... Bisnis Indonesia

Generic Name: quinapril, Accupro, Acuitel, Acupril, Asig, Filpril  -  ‎Nov 11, 2009‎
Accupril is used to lower high blood pressure (hypertension) and in the treatment of heart failure. Follow the directions for using this medicine provided ... Pattaya Daily News

Long-term pain requires diagnosis  -  ‎Oct 21, 2009‎
He is also taking Accupril once a day and hydrochlorothiazide for high blood pressure. DEAR READER: Your husband's physicians are correct in saying that ... Daily Gleaner

Brand Names/Synonyms:
Accupril is also known by the following brand names and/or synonymsAccupril; Accuprin; Accupro; Acequin; Acuitel; Korec; Quinapril; Quinapril Hcl; Quinapril Hydrochloride; Quinapril Hydrochloride: Accupril; Quinaprilum [Latin]; Quinazil

Drug Category:
Accupril is categorized under the following by the FDA: Antihypertensive Agents; Angiotensin-converting Enzyme Inhibitors; ATC:C09AA06

Dosage Forms:
Tablets

Absorption:
Following oral administration, peak plasma quinapril concentrations are observed within one hour. Based on recovery of quinapril and its metabolites in urine, the extent of absorption is at least 60%. The rate and extent of quinapril absorption are diminished moderately (approximately 25-30%) when ACCUPRIL tablets are administered during a high-fat meal.

Interactions:
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Chemical IUPAC Name:
2-[2-(1-ethoxycarbonyl-3-phenyl-propyl)aminopropanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

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