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ActiqThis page contains recent news articles, when available, and an overview of Actiq but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Actiq (when available) Fentanyl is an opioid analgesic. Fentanyl interacts predominately with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, spinal cord, and other tissues. In clinical settings, Fentanyl exerts its principal pharmacologic effects on the central nervous system. Its primary actions of therapeutic value are analgesia and sedation. Fentanyl may increase the patient's tolerance for pain and decrease the perception of suffering, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Fentanyl depresses the respiratory centers, depresses the cough reflex, and constricts the pupils. For the treatment of cancer patients with severe pain that breaks through their regular narcotic therapy. Mechanism Of Action: Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Fentanyl's analgesic activity is, most likely, due to its conversion to morphine. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability. News Articles on Fentanyl OK για συγχώνευση Alapis - ΓεÏ?ολυμάτος - 04 Jan 2010 Το χαÏ?τοφυλάκιο της εν λόγω εταιÏ?είας αποτελείται από φαÏ?μακευτικά και ΟΤCÏ€Ï?οϊόντα (Sinomarin, Basiscream, Pulvo, Septrin, Actiq, Rinopanteina, Predictor, ... AgroNews (Εγγραφή) Alapis: Announcement. - Dec 31, 2009 GENESIS ILAC product portfolio comprises of pharmaceutical and OTC products (Sinomarin, Basiscream, Pulvo, Septrin, Actiq, Rinopanteina, Predictor, ... Capital.gr (press release) Η Alapis εξαγόÏ?ασε τουÏ?κική εταιÏ?ία φαÏ?μάκων - Dec 31, 2009 ΔιαθÎτει μεγάλο χαÏ?τοφυλάκιο φαÏ?μακευτικών και ΟΤC Ï€Ï?οιόντων (Sinomarin, Basiscream, Pulvo, Septrin, Actiq, Rinopanteina, Predictor, Mentopin, Calcimed D3, ... Sofokleousin.gr Alapis: «ΠÏ?άσινο» για συγχώνευση με την Î Î?Γ ΓεÏ?ολυμάτος - Dec 31, 2009 Το χαÏ?τοφυλάκιο της εν λόγω εταιÏ?είας αποτελείται από φαÏ?μακευτικά και ΟΤC Ï€Ï?οιόντα (Sinomarin, Basiscream, Pulvo, Septrin, Actiq, Rinopanteina, Predictor, ... Nαυτεμπορικη Covidien gets approval for generic pain drug Actiq - Oct 30, 2009 AP , 10.30.09, 04:45 PM EDT NEW YORK -- Covidien PLC said Friday it expects to start selling a generic version of the painkiller Actiq in early 2010. ... Forbes Mallinckrodt painkiller gets FDA OK - Nov 2, 2009 It is a generic alternative to the branded ACTIQ. Covidien said Friday that it expects to launch the drug in the US in early 2010. ... St. Louis Business Journal Stock Review: Cephalon - Nov 6, 2009 Other significant drugs in the portfolio are Fentora and Actiq (the former a replacement for the latter), which account for nearly 25% of sales. ... Motley Fool Cephalon Net Sales Increase 9% and Net Cash from Operations Surpasses $200 ... - Oct 27, 2009 ...trioxide) injection, GABITRIL® (tiagabine hydrochloride), NUVIGIL® (armodafinil) Tablets [C-IV] and ACTIQ® (oral transmucosal fentanyl citrate) [C-II]. ... Reuters Pivotal Data Published in the Journal Cancer Demonstrate that TREANDA Induced ... - Nov 5, 2009 PROVIGIL® (modafinil) Tablets [C-IV] and ACTIQ® (oral transmucosal fentanyl citrate) [C-II]. The company also markets numerous products internationally. ... Reuters Cephalon, Inc. to Webcast R&D Day - Nov 4, 2009 GABITRIL® (tiagabine hydrochloride) and ACTIQ® (oral transmucosal fentanyl citrate) [C-II]. The company also markets numerous products internationally. ... Reuters Chevron: Analysts' Upgrades, Downgrades - Nov 2, 2009 Estimates also increased, to reflect generic Actiq sales and better currency trends. Overweight rating. Chevron (CVX Quote) estimates raised at UBS through ... TheStreet.com Mayo Clinic Proceedings Publishes Study of NUVIGIL in Patients with Shift Work ... - Nov 2, 2009 GABITRIL(R) (tiagabine hydrochloride), PROVIGIL(R) (modafinil) Tablets [C-IV], and ACTIQ(R) (oral transmucosal fentanyl citrate) (C-II). ... Reuters Monday's biggest gaining and declining stocks - Nov 2, 2009 The drug is a generic version of Actiq, which is produced by Cephalon Inc., CEPH the Frazer, Pa., biopharmaceutical company. The drug helps manage pain in ... Middle East North Africa Financial Network FDA Has New Web Page for Select Medicine Disposal Instructions - Oct 20, 2009 The medicines listed as recommended for disposal by flushing include Actiq, Avinza, Daytrana, Demerol, Diastat/Diastat AcuDial, Dilaudid, ... DOTmed.com (press release) Cephalon Net Sales Increase 9% and Net Cash from Operations Surpasses $200 ... - Oct 28, 2009 ...trioxide) injection, GABITRIL® (tiagabine hydrochloride), NUVIGIL® (armodafinil) Tablets [C-IV] and ACTIQ® (oral transmucosal fentanyl citrate) [C-II]. ... PharmaLive.com (press release) Cephalon Appoints Bob Repella as Senior Vice President of US Pharmaceutical ... - Oct 27, 2009 GABITRIL(R) (tiagabine hydrochloride), PROVIGIL(R) (modafinil) Tablets [C-IV], and ACTIQ(R) (oral transmucosal fentanyl citrate) (C-II). ... Trading Markets (press release) Brand Names/Synonyms: Actiq is also known by the following brand names and/or synonymsActiq; CHEMBANK1683; Dea No. 9801; Duragesic; Duragesic-100; Durogesic; F5886; Fentanest; Fentanil; Fentanil [Dcit]; Fentanila; Fentanila [Inn-Spanish]; Fentanyl; Fentanyl Citrate; Fentanyl Citrate Preservative Free; Fentanylum; Fentanylum [Inn-Latin]; HSDB 3329; Pentanyl; Phentanyl; R 4263; Sentonil; Sublimaze; Sublimaze Preservative Free Drug Category: Actiq is categorized under the following by the FDA: Anesthetics; Narcotics; Adjuvants; Analgesics; Opiate Agonists; ATC:N01AH01; ATC:N02AB03 Dosage Forms: DISC (SUSTAINED-RELEASE); LIQUID; SOLUTION Absorption: Not Available Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: N-(1-phenethyl-4-piperidyl)-N-phenyl-propanamide |
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