Acyclovir

This page contains recent news articles, when available, and an overview of Acyclovir but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Acyclovir
(when available)

Pharmacology and use:
Acyclovir is a synthetic deoxyguanosine analog and it is the prototype antiviral agent that is activated by viral thymidine kinase. The selective activity of acyclovir is due to its affinity for the thymidine kinase enzyme encoded by HSV and VZV. For the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox

Mechanism Of Action:
Viral (HSV-1, HSV-2 and VZV) thymidine kinase converts acyclovir to the acyclovir monophosphate, which is then converted to the diphosphate by cellular guanylate kinase, and finally to the triphosphate by phosphoglycerate kinase, phosphoenolpyruvate carboxykinase, and pyruvate kinase. Acyclovir triphosphate competitively inhibits viral DNA polymerase and competes with the natural deoxyguanosine triphosphate, for incorporation into viral DNA. Once incorporated, acyclovir triphosphate inhibits DNA synthesis by acting as a chain terminator.

News Articles on Acyclovir

Medivir to introduce cold sores drug in Sweden H1 '10  -  ‎Dec 21, 2009‎
The product, a combination of acyclovir (antiviral) and hydrocortisone (anti-inflammatory) ingredients, was approved for the treatment of early signs and ... Trading Markets (press release)

BioAlliance Pharma: Breakthrough Positive Phase III Results With Acyclovir ...  -  ‎Dec 13, 2009‎
This international multicenter randomized, double-blind, placebo-controlled study compared the efficacy and safety of a single dose of acyclovir Lauriad® ... Medical News Today (press release)

What could strike you after chicken pox  -  ‎Dec 21, 2009‎
Drugs that fight viruses (antivirals), such as acyclovir (Zovirax), valacyclovir (Valtrex), or famciclovir (Famvir), can reduce the severity and duration of ... Express Buzz

Niacin may be effective in lowering cholesterol  -  ‎Dec 18, 2009‎
There are three prescription medications used to fight the herpes virus: Famvir (famciclovir), Valtrex (valacyclovir) and Zovirax (acyclovir). ... Los Angeles Times

Genital herpes common, does not preclude a full, happy love life  -  ‎Dec 23, 2009‎
There are three medications used to fight the herpes virus: Famvir (famciclovir), Valtrex (valacyclovir) and Zovirax (acyclovir). For occasional outbreaks ... Palm Beach Post

BioAlliance Pharma : Entry Into Clinical Phase: Clonidine Lauriad(R) Into ...  -  ‎Dec 16, 2009‎
Clonidine Lauriad® uses the innovative muco-adhesive technology validated with Loramyc® and more recently with acyclovir Lauriad®. ... Medical News Today (press release)

Mit Acyclovir kann bei Krebserkrankungen Infektionen mit Herpes simplex-Viren ...  -  ‎Dec 30, 2009‎
Als effektiv erwiesen sich der antivirale Wirkstoff Acyclovir und seine Vorstufe, das so genannte Valacyclovir, das im Körper in Acyclovir umgewandelt wird. ... DKG Krebsgesellschaft

BIOALLIANCE: résultats positifs de l' essai de phase III du Lauriad  -  ‎Dec 11, 2009‎
Cette étude a comparé l'efficacité et la tolérance d'une dose unique d'acyclovir Lauriad? 50 mg comprimé gingival muco-adhésif à celles d'un placebo chez ... TF1

Les valeurs à suivre à la Bourse de Paris  -  ‎Dec 10, 2009‎
BIOALLIANCE PHARMA a annoncé jeudi le succès de l'essai de phase III de l'Acyclovir Lauriad contre l'herpès labial récurrent chez les patients ... nouvelobs.com

Bourse en ligne, actualité des cours et bourse en ligne  -  ‎Dec 15, 2009‎
Clonidine Lauriad ® utilise la technologie mucoadhésive innovante validée par Loramyc ® , et plus récemment par acyclovir Lauriad ® . ... TF1

Bệnh thá»§y đậu  -  ‎Dec 10, 2009‎
...kháng sinh chống bá»™i nhiá»…m và thuốc chống siêu vi trùng (Acyclovir là thuốc được xem có hiệu quả chống siêu vi gây nên bệnh thá»§y đậu. ... Nông Nghiệp

Les valeurs suivies à la clôture de la Bourse de Paris  -  ‎Dec 11, 2009‎
La société a annoncé le succès de l'essai de phase III de l'Acyclovir Lauriad contre l'herpès labial récurrent chez les patients immunocompétents. nouvelobs.com

Generic Name: Acyclovir, Aciclovir, Cyclovir, Herpex, Acivir, Zovirax, Zovir  -  ‎Nov 11, 2009‎
Zovirax (generic name: Acyclovir; brand names: Cyclovir / Herpex / Acivir / Zovirax / Zovir) is an antiviral agent indicated for the treatment of cold sores ... Pattaya Daily News

Postherpetic Neuralgia in Herpes Zoster—Reply  -  ‎Nov 3, 2009‎
The sentence in question should have read, "A Cochrane review of antiviral treatment for preventing PHN reported no benefit of acyclovir for reducing the ... Journal of American Medical Association (subscription)

Ministry withdraws two more drugs  -  ‎Oct 26, 2009‎
The two drugs withdrawn were Anti Snake Venom Serum given to snake bite victims and the injection Acyclovir given to chicken pox victims. ... Daily Mirror

Optimal guidelines needed for preventing neonatal herpes simplex virus  -  ‎Nov 5, 2009‎
Proposed regimens include a 400-mg dose of oral acyclovir (Zovirax, GlaxoSmithKline) three times daily or 500 mg of oral valacyclovir (Valtrex, ... Pediatric SuperSite

BioAlliance Pharma SA: Q3 2009: Strong Sales Growth and Significant Progress ...  -  ‎Oct 21, 2009‎
...clinical progress in its other muco-adhesive tablet programs: * Strongly positive interim results in the acyclovir Lauriad® Phase III clinical trial, ... Reuters

Viral infections and the eye  -  ‎Oct 28, 2009‎
Herpes Simplex Virus – treatment includes anti-viral drops or pills such as Acyclovir (Zovirax), Famcyclovir (Famvir), and Valcyclovir (Valtrex), ... Examiner.com

From the infectious diseases meeting: What's with the vaccine-o-phobia?  -  ‎Oct 31, 2009‎
Development of resistance to acyclovir during chronic infection with the Oka vaccine strain of varicella-zoster virus, in an immunosuppressed child. ... Science News

MPs debate Fabio Alves-Nunes  -  ‎Oct 28, 2009‎
It was this examination, unrecorded in the medical notes, that led to the decision to discharge and also not to treat Fabio with Acyclovir. ... DeHavilland (press release) (subscription)

BioAlliance Pharma : chiffre d'affaires de 1,6 ME au T3  -  ‎Oct 21, 2009‎
Des résultats préliminaires positifs importants dans l'étude de Phase III avec acyclovir Lauriad, constituant une base solide de discussion avec les agences ... Challenges

Hút thuốc lá làm tăng nhiá»…m trùng và rụng tóc  -  ‎Nov 5, 2009‎
...những ngưá»?i hút thuốc lá phải tiêm vắc-xin ngăn ngừa cúm hằng năm, tiêm vắc-xin ngừa sưng phổi, và nếu lỡ bị bệnh bá»?ng rạ thì phải uống thuốc acyclovir. ... Thanh Niên

Brand Names/Synonyms:
Acyclovir is also known by the following brand names and/or synonymsAC2; Aciclovier; Aciclovir; Acycloguanosine; Acyclovir; Acyclovir Sodium; Alti-Acyclovir; Avirax; BW-248U; Valtrex; Vipral; Virorax; Wellcome-248u; Zovirax; Zovirax Wellstat Pac; Zovirax Zostab Pac

Drug Category:
Acyclovir is categorized under the following by the FDA: Antivirals; Nucleosides and Nucleotides (08:18.32); ATC:J05AB

Dosage Forms:
Intravenous Infusion; Capsules; Tablets; Suspension; Topical Cream; Topical Ointment

Absorption:
Oral _ Bioavailability 10 to 20%

Interactions:
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Chemical IUPAC Name:
2-amino-9-(2-hydroxyethoxymethyl)-3H-purin-6-one





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