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AgeneraseThis page contains recent news articles, when available, and an overview of Agenerase but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Agenerase (when available) Amprenavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Amprenavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs. For the treatment of HIV-1 infection in combination with other antiretroviral agents Mechanism Of Action: Amprenavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. News Articles on Amprenavir MHT All-Star Roger Tung: Life saver - Nov 3, 2009 Tung co-invented two key HIV protease inhibitors, marketed as Agenerase and Lexiva, which he calls two of his most important achievements. ... Mass High Tech Vertex Pharmaceuticals Reports Third Quarter 2009 Financial Results and ... - Oct 26, 2009 Note 6: In the first quarter of 2008, the Company recognized royalty revenues based on actual and estimated net sales of Lexiva/Telzir and Agenerase by ... Reuters Brand Names/Synonyms: Agenerase is also known by the following brand names and/or synonyms141w94, Kvx-478, Agenerase, Prozei,; Agenerase; Amprenavir; Lexiva; VX-478 Drug Category: Agenerase is categorized under the following by the FDA: Anti-HIV Agents; Antibiotics; Anti-HIV Agents; ATC:J05AE05; ATC:J05AE07 Dosage Forms: CAPSULE Absorption: Not Available Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: tetrahydrofuran-3-yl[3-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-1-benzyl-2-hydroxy-propyl]aminomethanoate |
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