Aggrenox

This page contains recent news articles, when available, and an overview of Aggrenox but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Aggrenox
(when available)

Pharmacology and use:
Dipyridamole, a non-nitrate coronary vasodilator that also inhibits platelet aggregation, is combined with other anticoagulant drugs, such as warfarin, to prevent thrombosis in patients with valvular or vascular disorders. Dipyridamole is also used in myocardial perfusion imaging, as an antiplatelet agent, and in combination with aspirin for stroke prophylaxis. For as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and also used in prevention of angina

Mechanism Of Action:
Dipyridamole likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Dipyridamole also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation.

News Articles on Dipyridamole

Blood thinners  -  ‎Dec 28, 2009‎
What to watch out for: You should stop taking Aggrenox and go to your doctor or to an emergency room if you find black or tarry-appearing stools, ... Augusta Free Press

Generic Name: Aspirin/Dipyridamole, Asasantin Retard  -  ‎Nov 11, 2009‎
Each Aggrenox capsule contains 200 mg dipyridamole in an extended-release form and 25 mg aspirin, as an immediate-release sugar-coated tablet. ... Pattaya Daily News

US Court of Appeals Enforces Subpoenas in FTC's Androgel Investigation; In ...  -  ‎Oct 28, 2009‎
...settlements and related agreements between Boehringer and Barr Pharmaceuticals, Inc. involving generic versions of the drugs Mirapex and Aggrenox. ... 7thSpace Interactive (press release)

Brand Names/Synonyms:
Aggrenox is also known by the following brand names and/or synonymsAggrenox; Agilease; Anginal; Apo-Dipyridamole Fc; Apo-Dipyridamole Sc; Apricor; Cardioflux; Cardoxil; Cardoxin; Chilcolan; Cleridium; Cleridium 150; Coribon; Coridil; Coronarine; Corosan; Coroxin; Curantyl; Dipiridamol; Dipyridamine; Dipyridamol; Dipyridamole; Dipyridamole, Pharma; Dipyridan; Dipyudamine; Dypyridamol; Gulliostin; Iv Persantine; Justpertin; Kurantil; Natyl; Novo-Dipiradol; Peridamol; Permiltin; Persantin; Persantine; Piroan; Prandiol; Prandiol 75; Protangix; RA 8; RA-8; Stenocardil; Stenocardiol; Stimolcardio; Usaf Ge-12

Drug Category:
Aggrenox is categorized under the following by the FDA: Vasodilator Agents; Vasodilator Agents; ATC:B01AC07

Dosage Forms:
tablets

Absorption:
70%

Interactions:
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Chemical IUPAC Name:
2-[[3-[bis(2-hydroxyethyl)amino]-5,10-bis(1-piperidyl)-2,4,7,9-tetrazabicyclo[4.4.0]deca-2,4,7,9,11-pentaen-8-yl]-(2-hydroxyethyl)amino]ethanol





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