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AlamastThis page contains recent news articles, when available, and an overview of Alamast but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Alamast (when available) Pemirolast is used for the prophylactic treatment of itching of the eye associated with allergic conjunctivitis. Pemirolast potassium is a mast cell stabilizer that inhibits the in vivo Type I immediate hypersensitivity reaction. Pemirolast inhibits the antigen-induced release of inflammatory mediators (e.g., histamine, leukotriene C4, D4, E4) from human mast cells. Allergic reactions lead to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, Pemirolast is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of blood vessels. It provides effective, temporary relief of watery and itchy eyes. For the prevention of itching of the eyes caused by allergies such as hay fever, and allergic conjunctivitis Mechanism Of Action: Pemirolast binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Pemirolast has also been observed to block antigen-stimulated calcium ion influx into mast cells. Pemirolast inhibits the chemotaxis of eosinophils into ocular tissue, and prevents inflammatory mediator release from human eosinophils. News Articles on Pemirolast Santen Inc. announces plan to open staff development office in ... - Aug 11, 2009 ...and Alamast (pemirolast potassium ophthalmic solution 0.1%). Santen manufactures and oversees research and regulatory activities related to those drugs. OSN SuperSite Japanese Eye Drug Maker Opens Office Near Airport - Aug 23, 2009 ...drop that treats bacterial infections; Betimol, a beta blocker for treating glaucoma and pressure in the eye; and Alamast, which treats eye allergies. Orange County Business Journal Brand Names/Synonyms: Alamast is also known by the following brand names and/or synonyms: Alamast; Pemirolast; Pemirolast Potassium; Pemirolastum [Inn-Latin]; Pemiroplast Potassium Drug Category: Alamast is categorized under the following by the FDA: Anti-allergic Agents; Ophthalmics; Antipruritics; Histamine Antagonists Dosage Forms: Ophthalmic Solution Absorption: Not Available Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: 10-methyl-4-(2H-tetrazol-5-yl)-2,6-diazabicyclo[4.4.0]deca-1,3,7,9-tetraen-5-one |
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