Aldesleukin

This page contains recent news articles, when available, and an overview of Aldesleukin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Aldesleukin (when available)

Pharmacology and use:
Used to treat renal cell carcinoma, proleukin induces the enhancement of lymphocyte mitogenesis and stimulation of long-term growth of human interleukin-2 dependent cell lines, the enhancement of lymphocyte cytotoxicity, the induction of killer cell (lymphokine-activated (LAK) and natural (NK)) activity; and the induction of interferon-gamma production. IL-2 is normally produced by the body, secreted by T cells, and stimulates growth and differentiation of T cell response. It can be used in immunotherapy to treat cancer. It enhances the ability of the immune system to kill tumor cells and may interfere with blood flow to the tumor. For treatment of adults with metastatic renal cell carcinoma

Mechanism Of Action:
Proleukin binds to the IL-2 receptor which leads to heterodimerization of the cytoplasmic domains of the IL-2R beta and gamma(c) chains, activation of the tyrosine kinase Jak3, and phosphorylation of tyrosine residues on the IL-2R beta chain. These events led to the creation of an activated receptor complex, to which various cytoplasmic signaling molecules are recruited and become substrates for regulatory enzymes (especially tyrosine kinases) that are associated with the receptor. These events stimulate growth and differentiation of T cells.

News Articles on Aldesleukin

Brand Names/Synonyms:
Aldesleukin is also known by the following brand names and/or synonymsInterleukin-2 precursor;IL-2;T-cell growth factor;TCGF; Proleukin (Chiron Corp)

Drug Category:
Aldesleukin is categorized under the following by the FDA: Antineoplastic Agents

Dosage Forms:
POWDER FOR SOLUTION

Absorption:
Not Available

Interactions:
Not Available

Chemical IUPAC Name:
Human interleukin 2 (modified)

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