Alendronate

This page contains recent news articles, when available, and an overview of Alendronate but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Alendronate (when available)

Pharmacology and use:
Alendronate, a second-generation bisphosphonate is the first member of a group of drugs which strengthens bone. Alendronate is used to reduce hypercalcemia in tumor-induced bone disease, to treat corticosteroid-induced osteoporosis and Paget's disease, and to prevent osteoporosis in postmenopausal women. For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women

Mechanism Of Action:
The action of Alendronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Alendronate also targets farnesyl pyrophosphate (FPP) synthase. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting FPP synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.

News Articles on Alendronate

Options for Bone Loss, but No Magic Pill  -  04 Jan 2010
The first drug licensed to counter osteoporosis, Fosamax, is now available generically as alendronate, which can be taken once a day or, at a higher dose, ... New York Times

NASA ISS On-Orbit Status 3 January 2010  -  ‎Jan 3, 2010‎
The CDR & FE-5 Noguchi supported the weekly US “Bisphosphonates�? biomedical countermeasures experiment, ingesting an Alendronate pill before breakfast. ... Space Ref (press release)

Alendronate improves BMD in men on anti-androgen therapy  -  ‎Dec 29, 2009‎
NEW YORK (Reuters Health) - In men on androgen-deprivation therapy (ADT) who have severe osteopenia or osteoporosis, alendronate improves bone mineral ... news Stories

NASA ISS On-Orbit Status 27 December 2009  -  ‎Dec 27, 2009‎
The CDR & FE-5 Noguchi supported the weekly US “Bisphosphonates�? biomedical countermeasures experiment, ingesting an Alendronate pill before breakfast. ... Space Ref (press release)

Research says bone-building drugs can reduce breast cancer risk  -  ‎Dec 10, 2009‎
...(alendronate) - reported a 32 percent reduction in invasive breast cancer rates, vis-à-vis the women who were not using these bone-building drugs. ... TopNews United States

NICE guidelines limit options for low cost osteoporosis drugs  -  ‎Dec 13, 2009‎
Physicians following the guidelines treat postmenopausal women aged over 75 with low trauma fractures (known as fragility fractures) with alendronate. ... News-Medical.net

Early surgery advised for hip fracture  -  ‎Jan 3, 2010‎
Other osteoporosis treatments such as zoledronic acid, alendronate and risedronatehave also been shown to reduce rates of new fractures. ... 6minutes

NASA ISS On-Orbit Status 13 December 2009  -  ‎Dec 13, 2009‎
Jeff also supported the weekly US “Bisphosphonates�? biomedical countermeasures experiment, ingesting an Alendronate pill before breakfast. ... Space Ref (press release)

Patients denied alternative osteoporosis treatment on NHS  -  ‎Dec 15, 2009‎
People will still be entitled to receive alendronate - which costs around 11p per day - but will not have access to alternative treatments unless their ... Private Healthcare UK

Oral bisphosphonates linked to reduced incidence of invasive breast cancer  -  ‎Dec 18, 2009‎
A total of 2216 of 151592 postmenopausal women enrolled in the initiative were taking either alendronate (89.7%) or etidronate (10.1%) at their entry into ... Ortho SuperSite

The Male Face of Osteoporosis  -  ‎Dec 30, 2009‎
Alendronate (Fosamax), the oldest and best-studied drug in the bisphosphonate class, has been shown to be effective in men. An alternative for men receiving ... MSN Health & Fitness

Senate to review rules for prescription drug plan managers  -  ‎Dec 11, 2009‎
So this writer asked the company about her own medication, Alendronate, the generic version of the drug Fosamax, taken by thousands of women to restore and ... Alaskajournal.com

Bisphosphonates 'reduce breast cancer risk by a third'  -  ‎Dec 14, 2009‎
...there were 32% fewer cases of breast cancer in women who used bisphosphonates – mostly alendronate – compared to women who did not use the drugs. ... Pulse

Bone Drugs Linked to Fewer Cases of Breast Cancer  -  ‎Dec 15, 2009‎
The results translate into 32 percent fewer cases of invasive breast cancer among users of oral bisphosphonates—primarily alendronate (Fosamax)—compared ... NCI Cancer Bulletin

NICE Guidelines Ration Affordable Osteoporosis Drugs  -  ‎Dec 12, 2009‎
Physicians following the guidelines treat postmenopausal women aged over 75 with low trauma fractures (known as fragility fractures) with alendronate. ... Medical News Today (press release)

Fosamax Jaw Necrosis Lawsuits in MDL Scheduled for Trial in April and June  -  ‎Dec 15, 2009‎
Fosamax (alendronate sodium), is a member of a class of drugs known as bisphosphonates, and is prescribed for treatment of osteoporosis. ... AboutLawsuits.com

Legal fight fails as NICE stands firm on osteoporosis guidance  -  ‎Dec 10, 2009‎
Back in 2007, the National Institute for Health and Clinical Excellence recommended that doctors use Merck & Co's Fosamax (alendronate) as the first-line ... Pharma Times

Merck Appoints Dr. Michael Rosenblatt As Executive Vice President & Chief ...  -  ‎Dec 16, 2009‎
Laboratories where he co-led the worldwide development team for alendronate (FOSAMAX), Merck's bisphosphonate for osteoporosis and bone disorders. ... PharmiWeb.com (press release)

防骨質�?鬆藥也能�??制乳癌  -  ‎Dec 11, 2009‎
...這類藥包括�?牌藥�?善美(Fosamax)，其學�??藥為alendronate。 �?約時報報導，�?「婦女�?�康計畫�?�?集的資料進行分�?，以�?�以色列�?數�?��??更年期後婦女進行的觀察研究， ... 世界日報

골다공�? 치료제, 유방암 �?소 효과  -  ‎Dec 10, 2009‎
...'�?�사맥스'(Fosamax, alendronate), '조메타'(Zometa, zoledronic acid), '본비바'(Bonviva, ibandronate)와 같�?� 비스�?�스�?�네�?�트 골다공�? 치료제가 2개 연구 결과 ... 디지틀보사

Bisphosphonate könnten Brustkrebs vorbeugen  -  ‎Dec 11, 2009‎
San Antonio – Die Behandlung der Osteoporose mit Bisphosphonaten könnte bei postmenopausalen Frauen eine willkommene Nebenwirkung haben. ... Deutsches Ärzteblatt

骨鬆藥 �?�延長人工關節壽命  -  ‎Dec 9, 2009‎
...�?�?�研究人員發�?�，治療骨質�?鬆的�?��?雙磷酸鹽藥物（Alendronate，�?善美），�?�有效改善人工關節週�?的骨質，且藥效長�?�6年。研究人員讓人工髖關節置�?�者在術後接�?�1 ... 台視新聞

骨�?��?� �?�延长人工关节寿命  -  ‎Dec 9, 2009‎
...�?过研究人员�?�现，治疗骨质�?�?�的�?��?�?�磷酸�?�?�物（Alendronate，�?善美），�?�有效改善人工关节周围的骨质，且�?�效长达6年。研究人员让人工髋关节置�?�者在术�?�接�?�1 ... 大纪元

Chữa bệnh theo đặc tính gen  -  ‎Dec 12, 2009‎
Với đối tượng sau thì thuốc alendronate lại có hiệu quả hơn hẳn. Theo đánh giá của nhà di truy�?n h�?c Gilbert Lenoir - Giám đốc khoa h�?c Liên đoàn quốc gia ... Báo Khoa học

Teriparatide May Help Treat Steroid-Induced Osteoporosis Drug found better ...  -  ‎Nov 5, 2009‎
5 (HealthDay News) -- In patients with glucocorticoid-induced osteoporosis, treatment with teriparatide is more effective than alendronate in increasing ... ModernMedicine

Hormone Effective for Steroid-Induced Osteoporosis  -  ‎Oct 29, 2009‎
Note that teriparatide appears more effective than alendronate for treating glucocorticoid-induced osteoporosis. The synthetic parathyroid hormone ... MedPage Today

Teriparatide demonstrated greater increases in BMD, fewer vertebral fractures ...  -  ‎Nov 2, 2009‎
Teriparatide treatment led to a greater increase in bone mineral density and fewer vertebral fractures compared with alendronate treatment in patients with ... Endocrine Today

Sticks & Stones and osteoporosis  -  ‎Nov 7, 2009‎
Alendronate sodium works by inhibiting the activity of cells called osteoclasts that cause bone loss. Osteoclasts remove old bone cells that are then ... Jerusalem Post

NASA ISS On-Orbit Status 8 November 2009  -  ‎Nov 8, 2009‎
Williams also supported once again the weekly US “Bisphosphonates�? biomedical countermeasures experiment, ingesting an Alendronate pill before breakfast. ... Space Ref (press release)

Buy ALENDRONATE: Amazing prices!Great quality!Bonus pills added! Alendronate.  -  ‎Oct 31, 2009‎
Alendronate safe use of bisphosphonates. Do not take it on the morning. In the long-term effects occur jaw pain vision changes exercise and taking ... Newstalk ZB

Bilateral Low-Energy Simultaneous or Sequential Femoral Fractures in Patients ...  -  ‎Nov 2, 2009‎
Background: While alendronate therapy has been shown to decrease the risk of vertebral and femoral neck fractures in postmenopausal osteoporotic patients, ... Journal of Bone and Joint Surgery (subscription)

NASA ISS On-Orbit Status 2 November 2009  -  ‎Nov 3, 2009‎
FE-4 Thirsk supported once again the weekly US “Bisphosphonates�? biomedical countermeasures experiment, ingesting an Alendronate pill before breakfast. ... Space Ref (press release)

NASA ISS On-Orbit Status 9 November 2009  -  ‎Nov 9, 2009‎
FE-4 Thirsk supported once again the weekly US Bisphosphonates biomedical countermeasures experiment, ingesting an Alendronate pill before breakfast. ... Space Ref (press release)

Medicine charges to rise  -  ‎Nov 6, 2009‎
The other two groups, risedronate and alendronate, treat osteoporosis and Paget disease. The brand name for risedronate is Actonel. For alendronate, brand ... Courier Mail

Fracture risk gauges time on medicine  -  ‎Nov 9, 2009‎
Fosamax (alendronate) is an often-prescribed bisphosphonate. It stops the daily breakdown of bone, and thereby strengthens bone. How long is it necessary to ... Herald & Review

Teriparatide outperforms alendronate in treating steroid-induced osteoporosis  -  ‎Oct 31, 2009‎
Study participants were randomly assigned to receive injectable teriparatide (20 μg/day) plus oral placebo (150 subjects) or oral alendronate (10 mg/day) ... Webnewswire.com

What is Paget Disease?  -  ‎Nov 7, 2009‎
Biphosphonates include risedronate, alendronate, and pamidronate. Long-term treatment may be needed if the disease is severe, especially if the person has ... 24 Medica

Amgen: Prolia delay further dampens expectations of hyped drug  -  ‎Oct 20, 2009‎
Data released by Amgen have shown that denosumab is more effective than alendronate in increasing bone-mineral density, but is equivalent in terms of ... Trading Markets (press release)

Managing the adverse effects of bisphosphonate therapy on the jaw  -  ‎Nov 2, 2009‎
Thus, even when the drugs (such as alendronate sodium) are discontinued, the influence on osteoclastic activity can remain in effect for 10 years or longer. ... Journal of the American Academy of Physician Assistants

The Federal Court of Appeal Weighs in on the Scope of Section 8 Damages  -  ‎Oct 27, 2009‎
With respect to future losses, Apotex argued that during the period from February 2004 to May 2006, the market for alendronate became distorted because two ... Linex Legal (registration)

Merck & Co earnings climb as Januvia and Isentress impress  -  ‎Oct 23, 2009‎
Sales of the osteoporosis drug Fosamax (alendronate) also fell 22% to $276 million, the result of patent protection loss in the USA. ... Pharma Times

"맥스마빌, �??경여성 골밀�?� �?가 효과�?"  -  ‎Nov 13, 2009‎
...�??경 후 여성�?게 골밀�?�와 근력�?� �?가시키는�?� 알렌드로네�?�트(alendronate)와 칼시트리올(calcitriol)�?� 병합 제제�?� 맥스마빌(MAXMARVIL)�?� 효과�?�?��?�는 연구 ... 데일리메디

العوامل الدوائية المسببة لهشاشة العظام  -  ‎Oct 27, 2009‎
�?إذا كان عدد T 1.5- أو اقل �?معنى ذلك انه مصاب ببداية هشاشة �?ي العظام و يجب استخدام علاج Bisphosphonates مثل Alendronate الأسبوعي مع كالسيوم و �?يتامين د . الاقتصادية

스테로�?�드 유발 골다공�? '�?�르테오' 효과 최고  -  ‎Oct 30, 2009‎
...유발�?� 골다공�?�?� 치료하는�?� 있어서 '르테오(Forteo)로 잘 알려진 테리파�?�타�?�드(teriparatide)가 알렌드로네�?�트(alendronate)보다 효과�?�?� 것으로 나타났다. ... 메디컬투데이

건강한 중년, 아름다운 여성  -  ‎Nov 9, 2009‎
...골다공�?�?� �?�차�?�?� 치료제로 �?�히 사용하는 것�?� 주로 골�?�수를 억제하는 약물로 알렌드로네�?�트(alendronate), 리세드로네�?�트(risedronate), ... 쿠키뉴스

�?特定病患 �?�併兩種骨質�?鬆症藥物會比一種好  -  ‎Nov 5, 2009‎
...伯明罕阿拉巴馬大學醫學院Jane Knight Lowe教授Kenneth Saag醫師解釋，�?�去使用alendronate（一種用來�?防骨骼溶解，類似zoledronic acid，但效價較低） ... 臺灣新浪網

Un estudio de Novartis determina que Aclasta®, en combinación con teriparatida ...  -  ‎Oct 20, 2009‎
The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N Engl J Med 2003;349:1207-15. ... Noticias Médicas (Comunicado de prensa)

Brand Names/Synonyms:
Alendronate is also known by the following brand names and/or synonymsALENDRONIC ACID; Acide Alendronique [Inn-French]; Acido Alendronico [Inn-Spanish]; Acidum Alendronicum [Inn-Latin]; Adronat; Alendronate; Alendronate Sodium; Alendronic Acid; Alendronic Acid [Ban:Inn]; Alendros; Arendal; CHEMBANK1709; Fosamax; MK 217; Onclast

Drug Category:
Alendronate is categorized under the following by the FDA: Antiresorptives; Bisphosphonates; Antihypocalcemic Agents; ATC:M05BA04

Dosage Forms:
10 mg (Rx) Fosamax lactose 40 mg (Rx) Fosamax lactose

Absorption:
Relative to an intravenous (IV) reference dose, the mean oral bioavailability of alendronate in women was 0.7% for doses ranging from 5 to 40 mg when administered after an overnight fast and two hours before a standardized breakfast. Oral bioavailability of the 10 mg tablet in men (0.59%) was similar to that in women (0.78%) when administered after an overnight fast and 2 hours before breakfast.

Interactions:
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Chemical IUPAC Name:
(4-amino-1-hydroxy-1-phosphono-butyl)phosphonic acid

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