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AlfentanilThis page contains recent news articles, when available, and an overview of Alfentanil but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Alfentanil (when available) Thiamine is a vitamin that with antioxidant, erythropoietic, cognition-and mood-modulatory, antiatherosclerotic, putative ergogenic, and detoxification activities. Thiamine has been found to protect against lead-induced lipid peroxidation in rat liver and kidney. Thiamine deficiency results in selective neuronal death in animal models. The neuronal death is associated with increased free radical production, suggesting that oxidative stress may play an important early role in brain damage associated with thiamine deficiency. Thiamine plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Inhibition of endothelial cell proliferation may also promote atherosclerosis. Endothelial cells in culture have been found to have a decreased proliferative rate and delayed migration in response to hyperglycemic conditions. Thiamine has been shown to inhibit this effect of glucose on endothelial cells. For the treatment of thiamine and niacin deficiency states, Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome, delirium, and peripheral neuritis. Mechanism Of Action: It is thought that the mechanism of action of thiamine on endothelial cells is related to a reduction in intracellular protein glycation by redirecting the glycolytic flux. News Articles on Vitamin B1 (Thiamine) Training Course for Propofol Administration Available Nationally - Jun 30, 2009 Hypnotic and anaesthetic interactions between midazolam, propofol and alfentanil. Br J Anaesth 1992;69: 162-7. 4) Cohen LB, Wecsler JS, Gaetano JN, et al. dBusinessNews New Orleans (press release) New Progress on Treatment to Keep You Safe Following Surgery - Apr 7, 2009 ...demonstrating that CX717 could prevent the reduction in basal breathing rate induced by the opioid analgesic, alfentanil, as compared to placebo. Best Syndication Pain times two: Stanford researchers recruit twin pairs for pain study - Mar 3, 2009 Then they'll repeat the experiment while getting an infusion of alfentanil, a drug commonly used to control pain during and after surgery. San Jose Mercury News Cortex Reports Third Quarter Operating Results - Nov 7, 2008 The analgesic properties of alfentanil were maintained in an acute pain model in the presence of CX717, whereas alfentanil's pain relieving properties were MarketWatch New Progress on Treatment to Keep You Safe Following Surgery - Nov 13, 2008 ...demonstrating that CX717 could prevent the reduction in basal breathing rate induced by the opioid analgesic, alfentanil, as compared to placebo. MarketWatch Stanford Study Recruits Twins for Pharmacogenetic Study of Opiates - Nov 10, 2008 ...sensitivity measured by using a mild heat probe and by immersing a hand in ice-cold water, both before and during an infusion of the opiate alfentanil. MarketWatch Cortex's AMPAKINE(R) Research in Opioid-induced Respiratory ... - Oct 9, 2008 In this study, a single oral 1500 mg dose of CX717 was administered two hours before the infusion of the potent opioid, alfentanil. WELT ONLINE, Cortex's second Phase IIa respiratory depression study meets end point - Oct 7, 2008 CX717 prevented the reduction in basal breathing rate induced by alfentanil, in comparison to placebo (p = 0.005). The degree of the reversal of the basal Trading Markets (press release), AMPAKINE Compound, CX717, Achieves Primary Endpoints In Second ... - Oct 7, 2008 CX717 prevented the reduction in basal breathing rate induced by alfentanil, in comparison to placebo (p = 0.005). The degree of the reversal of the basal Medical News Today (press release), Cortex’s AMPAKINE Molecule CX717 Has Positive Effects in Opiate ... - 06 Aug 2008 This study uses a single dose of 1500mg of CX717 and focuses on both the respiratory depression and the analgesic effects associated with alfentanil. Business Wire (press release), Cortex Study Reveals Ampakine as Having Positive Effects in Opiate ... - 06 Aug 2008 ...placebo that was orally administered two hours before each subject received an intravenous infusion of the opiate agonist, alfentanil. by RTT Staff Writer. RTT News, Synthetic Narcotics-Safe or Addictive? - Jul 19, 2008 Thereafter, two other fentanyl analogues were introduced: alfentanil (Alfenta®), an ultra-short (5-10 minutes) acting analgesic, and sufentanil (Sufenta®), TransWorldNews (press release), The Calmative Before the Storm - Jul 14, 2008 According to Davison, “the requirement for rapid immobilization apparently led to consideration of fentanyl analogues, in particular alfentanil. Dissident Voice, Gli effetti del fentanil - Jul 25, 2008 Ciò dovrebbe costituire un campanello d'allarme per i medici e le autorità competenti: la somministrazione di fentanil o dei suoi derivati (alfentanil, ECPlanet, Cortex Reports First Quarter Operating Results - May 8, 2008 One study is evaluating whether CX717 may prevent the respiratory depression induced by alfentanil, while preserving that opiate’s desired pain relieving Business Wire (press release), Cortex Reports First Quarter Operating Results - May 8, 2008 One study is evaluating whether CX717 may prevent the respiratory depression induced by alfentanil, while preserving that opiate's desired pain relieving Genetic Engineering News (press release), Market Report -- In Play (WIRES) - Mar 31, 2008 ...the German regulatory agency which approves the use of narcotic drugs that it can proceed with the trial which will use alfentanil, an opiate analgesic. MSN Money Cortex Initiates Enrollment in Opiate Induced Respiratory ... - Mar 31, 2008 ...was notified by the German regulatory agency which approves the use of narcotic drugs that it can proceed with the trial which will use alfentanil, PharmaLive.com (press release), Cortex Pharma Receives German Regulatory Approval To Initiate ... - Mar 7, 2008 The primary study objective is to determine if CX717 could prevent RD while preserving the underlying desired analgesic effect of alfentanil. RTT News, Alfentanil Combined With Morphine Gives Quicker Pain Relief in ... - Feb 19, 2008 By Ed Susman KISSIMMEE, FL -- February 19, 2008 -- The combination of the fentanyl analogue alfentanil (Alfenta) with morphine provides faster pain relief DG News Brand Names/Synonyms: Alfentanil is also known by the following brand names and/or synonyms: Alfenta; Alfentanil; Alfentanilum [Inn-Latin]; Alfentanyl; Dea No. 9737; HSDB 6789 Drug Category: Alfentanil is categorized under the following by the FDA: Anesthetics; Narcotics; Analgesics; Opiate Agonists; ATC:N01AH02 Dosage Forms: SOLUTION, INJECTION Absorption: Not Available Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: N-[1-[2-(4-ethyl-5-oxo-1,4-dihydrotetrazol-1-yl)ethyl]-4-(methoxymethyl)-4-piperidyl]-N-phenyl-propanamide |
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