Alfentanil

This page contains recent news articles, when available, and an overview of Alfentanil but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Alfentanil (when available)

Pharmacology and use:
Thiamine is a vitamin that with antioxidant, erythropoietic, cognition-and mood-modulatory, antiatherosclerotic, putative ergogenic, and detoxification activities. Thiamine has been found to protect against lead-induced lipid peroxidation in rat liver and kidney. Thiamine deficiency results in selective neuronal death in animal models. The neuronal death is associated with increased free radical production, suggesting that oxidative stress may play an important early role in brain damage associated with thiamine deficiency. Thiamine plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Inhibition of endothelial cell proliferation may also promote atherosclerosis. Endothelial cells in culture have been found to have a decreased proliferative rate and delayed migration in response to hyperglycemic conditions. Thiamine has been shown to inhibit this effect of glucose on endothelial cells. For the treatment of thiamine and niacin deficiency states, Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome, delirium, and peripheral neuritis.

Mechanism Of Action:
It is thought that the mechanism of action of thiamine on endothelial cells is related to a reduction in intracellular protein glycation by redirecting the glycolytic flux.

News Articles on Vitamin B1 (Thiamine)

Brand Names/Synonyms:
Alfentanil is also known by the following brand names and/or synonymsAlfenta; Alfentanil; Alfentanilum [Inn-Latin]; Alfentanyl; Dea No. 9737; HSDB 6789

Drug Category:
Alfentanil is categorized under the following by the FDA: Anesthetics; Narcotics; Analgesics; Opiate Agonists; ATC:N01AH02

Dosage Forms:
SOLUTION, INJECTION

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
N-[1-[2-(4-ethyl-5-oxo-1,4-dihydrotetrazol-1-yl)ethyl]-4-(methoxymethyl)-4-piperidyl]-N-phenyl-propanamide

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