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AnakinraThis page contains recent news articles, when available, and an overview of Anakinra but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Anakinra (when available) Used to treat rheumatoid arthritis, Kineret blocks the biologic activity of IL-1 by competitively inhibiting IL-1 binding to the interleukin-1 type I receptor (IL-1RI), which is expressed in a wide variety of tissues and organs.1 IL-1 production is induced in response to inflammatory stimuli and mediates various physiologic responses including inflammatory and immunological responses. Patients with rheumatoid arthritis have elevated levels of IL-1. The levels of the naturally occurring IL-1Ra in synovium and synovial fluid from rheumatoid arthritis (RA) patients are not sufficient to compete with the elevated amount of locally produced IL-1. Increasing the levels of IL-1Ra by artificial means reduces the negative effects (cartilage degradation, bone resorption) of IL-1. For treatment of adult rheumatoid arthritis Mechanism Of Action: Kineret binds to the Interleukin-1 type I receptor (IL-1RI), thereby inhibiting the action of elevated levels IL-1 leading to cartilage degradation and bone resorption. News Articles on Anakinra Sjogren's Syndrome Update - Dec 31, 2009 Other drugs being tested are rituximab, mycophenolate, hydroxychloroquine, rebamipide, pilocarpine, anakinra, dexamethasone, azathioprine, and thalidomide ... EmpowHer (blog) New and Upcoming Biologic Agents for Rheumatoid Arthritis - Dec 29, 2009 Centocor), etanercept (Enbrel, Amgen), and adalimumab (Humira, Abbott) and the interleukin-1 receptor antagonist anakinra (Kineret, Biovitrum). ... Ortho SuperSite Leading Eye-Plastic Surgeon Returns to Australian Shores - Dec 12, 2009 ...treatment of Thyroid eye disease with Rituxan and Anakinra and other novel antibody fragment interventions; genetic markers for ocular and periocular ... PR-USA.net (press release) UCB announces initial clinical trial results involving patients taking ... - Dec 21, 2009 An increased risk of serious infections has been seen in clinical trials of other TNF blocking agents used in combination with anakinra or abatacept. ... PipelineReview.com (press release) Two studies show that treatment with Cimzia (certolizumab pegol) for moderate ... - Dec 9, 2009 An increased risk of serious infections has been seen in clinical trials of other TNF blocking agents used in combination with anakinra or abatacept. ... PharmaLive.com (press release) Kineret: modesta efficacia nel trattamento dell'artrite reumatoide - Dec 18, 2009 Sabato 19 Dicembre 2009 - Anakinra ( Kineret ) è un antagonista del recettore dell'interleuchina approvato nel trattamento dell'artrite reumatoide, ... XagenaSalute XOMA Expands Development Strategy for XOMA 052 to Include Cardiovascular Diseases - Nov 6, 2009 Two ongoing clinical trials of anakinra, another agent targeting IL-1, in acute coronary syndromes provide further support for a new anti-inflammatory ... CNNMoney.com (press release) Bristol-Myers Squibb Releases Study Results that Support Orencia - Oct 22, 2009 Orencia is not recommended for use concomitantly with other biologic rheumatoid arthritis therapy, such as anakinra. The US Food and Drug Administration ... Trading Markets (press release) ORENCIA® (abatacept) Demonstrated Sustained Clinical Response in a Study of ... - Oct 19, 2009 ORENCIA is not recommended for use concomitantly with other biologic rheumatoid arthritis therapy, such as anakinra. The US Food and Drug Administration ... Reuters Biovitrum Will Pay up to $533M for Swedish Orphan - Nov 10, 2009 They include recombinant Factor VIII (Refacto and albumin-free successor Xyntha), for hemophilia A; anakinra (Kineret) for treating pain and swelling in ... BioWorld Online New Data Describe Safety of Subcutaneous Administration of ORENCIA® (abatacept ... - Oct 20, 2009 ORENCIA should not be used with TNF antagonists and is not recommended for use with other biologic RA therapy, such as anakinra. ... Reuters New Data Show CIMZIA(R) (certolizumab pegol) Provides Sustained and ... - Oct 26, 2009 Drug Interactions An increased risk of serious infections has been seen in clinical trials of other TNF blocking agents used in combination with anakinra or ... Reuters New SIMPONI(TM) Data Show Inhibition of Joint Damage in Patients With ... - Oct 19, 2009 ORENCIA (abatacept), KINERET (anakinra), RITUXAN (rituximab) or another TNF blocker, or if you are scheduled to or recently received a vaccine. ... Reuters ORENCIA® (abatacept) Demonstrated Sustained Clinical Response in a Study of ... - Oct 19, 2009 ORENCIA is not recommended for use concomitantly with other biologic rheumatoid arthritis therapy, such as anakinra. The US Food and Drug Administration ... PipelineReview.com (press release) Artritis psoriásica, Artritis reumatoide en combinación con metotrexato ... - Oct 18, 2009 En estudios clínicos se han observado infecciones graves con el uso concurrente de anakinra y otro antagonista del TNF, etanercept, sin beneficio clínico ... Las Provincias Brand Names/Synonyms: Anakinra is also known by the following brand names and/or synonymsInterleukin-1 receptor antagonist protein precursor;IL-1ra;IRAP;IL1 inhibitor;IL-1RN;ICIL-1RA; Kineret (Amgen Inc) Drug Category: Anakinra is categorized under the following by the FDA: Immunomodulatory Agents; Antirheumatic Agents; unclassified therapeutic agents (92:00.00) Dosage Forms: SOLUTION Absorption: Not Available Interactions: Not Available Chemical IUPAC Name: Human interleukin-1 receptor antagonist protein |
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