Anzemet

This page contains recent news articles, when available, and an overview of Anzemet but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Anzemet (when available)

Pharmacology and use:
Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT₃ receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors. For the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy, including initial and repeat courses and prevention of postoperative nausea and vomiting

Mechanism Of Action:
Dolasetron is a selective serotonin 5-HT₃ receptor antagonist. The serotonin 5-HT₃ receptors are located on the nerve terminals of the vagus in the periphery and centrally in the chemoreceptor trigger zone of the area postrema. It is thought that chemotherapeutic agents produce nausea and vomiting by releasing serotonin from the enterochromaffin cells of the small intestine, and that the released serotonin then activates 5-HT₃ receptors located on vagal efferents to initiate the vomiting reflex. Therefore Dolasetron works by blocking the reception of serotonin at these 5-HT₃ receptors.

News Articles on Dolasetron

Iowa will recover $1.2 million in pharma funds - 14 Nov 2009
ANZEMET: Sanofi-Aventis Group reported an average wholesale price of $166.50 for Anzemet Injectable, while the US Department of Justice determined the ... DesMoinesRegister.com

Brand Names/Synonyms:
Anzemet is also known by the following brand names and/or synonymsAnzemet; CHEMBANK1627; Dolasetron; Dolasetronum [Inn-Latin]; Dolasteron

Drug Category:
Anzemet is categorized under the following by the FDA: Antiemetics; Serotonin Antagonists; ATC:A04AA04

Dosage Forms:
Intravenous injection; Tablet

Absorption:
Orally-administered dolasetron is well absorbed

Interactions:
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Chemical IUPAC Name:
Not Available

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