|
 |
ArgatrobanThis page contains recent news articles, when available, and an overview of Argatroban but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Argatroban (when available) Argatroban is a synthetic direct thrombin inhibitor derived from L-arginine indicated as an anticoagulant for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia. Argatroban is a direct thrombin inhibitor that reversibly binds to the thrombin active site. Argatroban does not require the co-factor antithrombin III for antithrombotic activity. Argatroban exerts its anticoagulant effects by inhibiting thrombin-catalyzed or -induced reactions, including fibrin formation; activation of coagulation factors V, VIII, and XIII; protein C; and platelet aggregation. Argatroban is highly selective for thrombin with an inhibitory constant (Ki) of 0.04 µM. At therapeutic concentrations, Argatroban has little or no effect on related serine proteases (trypsin, factor Xa, plasmin, and kallikrein). Argatroban is capable of inhibiting the action of both free and clot-associated thrombin. For prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia Mechanism Of Action: Argatroban exerts its anticoagulant effects by inhibiting thrombin-catalyzed or -induced reactions, including fibrin formation; activation of coagulation factors V, VIII, and XIII; protein C; and platelet aggregation. News Articles on Argatroban Medicines Company Reports Operating Results (10-Q) - Nov 9, 2009 ...ready-to-use formulation of Argatroban which was recorded in research and development expense in the third quarter of 2009 and increased expenditures in ... GuruFocus.com The Medicines Company Reports Third Quarter 2009 Financial Results - Nov 1, 2009 Inc. under which The Medicines Company will have rights in the United States and Canada to an innovative, ready-to-use formulation of Argatroban, ... PR-CANADA.net (press release) Brand Names/Synonyms: Argatroban is also known by the following brand names and/or synonymsArgatroban Drug Category: Argatroban is categorized under the following by the FDA: Anticoagulants; Anticoagulants; ATC:B01AE03 Dosage Forms: SOLUTION Absorption: Not Available Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: 1-[5-guanidino-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methyl-piperidine-2-carboxylicacid |
|
Health Home | Conditions | Cancer | Medications | Surgery | Vaccines The Cancer News Network
COPYRIGHT 2009 CANCERNEWSNETWORK | Privacy |