Aricept

This page contains recent news articles, when available, and an overview of Aricept but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Aricept
(when available)

Pharmacology and use:
Donepezil is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. Donepezil is indicated for the treatment of mild to moderate dementia of the Alzheimer's type. Donepezil is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, Donepezil's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. There is no evidence that Donepezil alters the course of the underlying dementing process. For management of symptoms associated with Alzheimer's Disease

Mechanism Of Action:
Donepezil's proposed mechanism of action involves the increase of the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase.

News Articles on Donepezil

Norfolk people helping scientists in dementia research  -  04 Jan 2010
The new international study will look at the effects of Dimebon on people who are already taking the Alzheimer's drug Aricept. ... Beccles and Bungay Journal

Eden man reported missing  -  04 Jan 2010
SALISBURY — State police are searching for a 64-year-old Eden man with Alzheimer's after he was reported missing Monday morning. Ellwood Henry Morris Sr. ... Delmarva Daily Times

Generic Aricept Approved for Alzheimer's Dementia  -  ‎Dec 15, 2009‎
15 (HealthDay News) --Generic versions of the drug Aricept (donepezil hydrochloride) that will dissolve instantly on the tongue have been approved by the US ... BusinessWeek

Some Brand-Name Patents: Going, Going, Gone in 2010  -  ‎Dec 29, 2009‎
Eisai and Pfizer's Alzheimer's drug Aricept will lose patent protection in November, but it shouldn't be a major loss for Pfizer. Despite the rather large ... Motley Fool

Generic Aricept Approved to Treat Alzheimers-Related Dementia  -  ‎Dec 22, 2009‎
The US Food and Drug Administration approved the first generic version of Aricept (donepezil hydrochloride) orally disintegrating tablets on Dec. 11. ... Citizens Report

FDA Approves Generic Aricept to Treat Dementia Related to Alzheimer's Disease  -  ‎Dec 21, 2009‎
The US Food and Drug Administration approved the first generic versions of Aricept (donepezil hydrochloride) orally disintegrating tablet s on Dec. 11. ... PR-CANADA.net (press release)

Hub in mind, Japanese pharma firm enters  -  ‎Dec 23, 2009‎
Its two blockbuster drugs -- Aricept for Alzheimer's disease and Pariet for gastro enterology ailments -- are worth over $5.2 billion together. ... Daily News & Analysis

FDA Approves First Generic Donepezil Orally Disintegrating Tablets for ...  -  ‎Dec 18, 2009‎
Aricept ODT, Eisai, Inc) for the treatment of dementia related to Alzheimer's disease. In contrast with previously approved generic donepezil tablets, ... Medscape

Eisai announces acquisition of AkaRx  -  ‎Dec 22, 2009‎
In other Eisai news, the organisation introduced a new product to the pharmaceutical market earlier this month - Aricept in oral jelly form. ... Zenopa

Brain procedure gives life back to McKean Township man  -  ‎Jan 2, 2010‎
A neurologist diagnosed him with dementia in 2003, Helene Patsy said, and put him on Aricept, a drug used for treating Alzheimer's disease. ... GoErie.com

A lifelong love affair: The old soldier and his wife  -  ‎Jan 1, 2010‎
She takes the medication Aricept, which Pete hopes will stymie the progression of the disease. So far, he said, the drug appears to be effective. ... FayObserver.com

Early Alzheimer's diagnosis 'is vital'  -  ‎Dec 10, 2009‎
However, the 73-year-old is successfully countering the most common cause of dementia and has called for drug treatment — Aricept — to be made readily ... Belfast Newsletter

Ginkgo Biloba Extract Effective in Treating Dementia  -  ‎Dec 31, 2009‎
One trial showed that compared to donepezil, a centrally acting reversible acetylcholinesterase inhibitor marketed under the trade name Aricept by its ... Food Consumer

Nanotherapeutics Acquires Two Late Stage Clinical Programs for Alzheimer's ...  -  ‎Dec 19, 2009‎
In this study, PRX-3140 appeared to be well tolerated alone and in combination with Aricept with no serious drug-related adverse events reported. ... Nanotechwire.com

Anti-smoking drugs in health basket  -  ‎Dec 23, 2009‎
Xarelto, Pradaxa and Soliris for hematology; Multaq, Inspra and Rqasilez for cardiovascular disease; Eraxis for infections; Avonex, Aricept, Exelon, ... Jerusalem Post

Boehringer in supply talks with India's Cipla; Merck taps Tufts dean as ...  -  ‎Dec 16, 2009‎
Report > FDA approved the first generic, orally disintegrating versions of the Alzheimer's drug Aricept, to be made by Mutual Pharmaceutical of Philadelphia ... FiercePharma

More meds in the state-subsidized basket  -  ‎Dec 23, 2009‎
...of daytime sleepiness among people with multiple sclerosis and a number of drugs to treat Alzheimer's disease (Exelon, Aricept, Memorit and Asenta). ... Ha'aretz

WTHRWTHR/Wishard Health Fair focuses on brain health  -  ‎Dec 10, 2009‎
..."They had her on Aricept ever since the closed head injury nine years ago and she had been taking that ever since and he took her right off. ... WTHR

Tokyo's Eisai injects Rs 250 cr for pharma plant in Vizag  -  ‎Dec 11, 2009‎
Some of the products to be manufactured in this facility include Aricept, a drug for the treatment of Alzheimer's disease and Aciphex/Parit, a proton pump ... Financial Express

Outsourcing steroid for Indian pharma firms  -  ‎Dec 20, 2009‎
...an innovator company) for products such as Valtrex, Aricept, Lipitor, Caduet, Nexium and Flomax in five years, estimated analysts with Morgan Stanley. ... Rediff

Eisai Opens New Manufacturing and Process Research Base in India  -  ‎Dec 17, 2009‎
In addition to the manufacturing of APIs and formulations of its major products such as the Alzheimer's disease treatment Aricept®, Eisai plans to conduct ... PharmaLive.com (press release)

ì—?ìž?ì?´ ì?¸ë?„ì—? ìƒ?산연구거ì ? 설립  -  ‎Dec 21, 2009‎
2010ë…„ì—?는 본격 ê°€ë?™ì?„ 시작할 예정ì?´ë©°, 알츠하ì?´ë¨¸í˜• 치매치료제 '아리셉트'(Aricept, donepezil) , 근육ì?´ì™„ì œ '미오날'(Myonal, eperisone) 등 기존제품ì?˜ ì›?료약 ... 디지틀보사

Eisai vai exercer opção de compra da AkaRx  -  ‎Dec 21, 2009‎
...irão ajudar a empresa a compensar a perda da patente do Aricept®, um fármaco indicado para o tratamento da doença de Alzheimer, em Novembro de 2010. RCM Pharma

Hoy, hace 94 años, murió el doctor Alzheimer  -  ‎Dec 18, 2009‎
...la progresión de la enfermedad, pero mientras tanto sólo disponemos en nuestro arsenal terapéutico de tratamientos sintomáticos, como el Aricept. ... El Correo Digital (Vizcaya) (Comunicado de prensa) (blog)

Brand Name: Aricept  -  ‎Nov 11, 2009‎
Aricept is indicated for the treatment of mild, moderate and severe Alzheimer's disease, also called dementia of the Alzheimer's type. ... Pattaya Daily News

The forgetten epidemic: Alzheimer's an often overlooked killer  -  ‎Nov 9, 2009‎
Along with Aricept, a prescription medication that has shown promise in slowing the progression of Alzheimer's, patients can take over-the-counter ... DeRidder Beauregard Daily News

Ask Dr. H: If you think a copper bracelet can help arthritis, go for it  -  ‎Nov 2, 2009‎
FDA-approved medications like Aricept and Exelon can only temporarily slow the progressive memory loss of Alzheimer's disease. ... Philadelphia Inquirer

Breakthrough in Alzheimer's disease may lie with new research drug  -  ‎Nov 2, 2009‎
Current Alzheimer's medications, including Aricept, Exelon and Razadyne — the three most popular cholinesterase inhibitors used to treat patients — act as ... UAB News

Strong Yen Slows Japanese Drug Firms' Recovery  -  ‎Oct 30, 2009‎
Eisai's revenue from its best-selling drug Aricept drug for Alzheimer's disease grew only 2% in the fiscal first half as the drug's US sales slipped 1%. ... Wall Street Journal

Dear Annie: Suppress the urge to move  -  ‎Nov 12, 2009‎
She has been on Aricept ever since, and it has helped slow the progression of the disease enough to enable her to continue daily tasks. ... Pasadena Star-News

Medivation Reports Third Quarter 2009 Financial Results and Provides Corporate ...  -  ‎Nov 4, 2009‎
...dimebon to ongoing treatment with Aricept®, the leading Alzheimer's medication worldwide, on neuropsychiatric symptoms and activities of daily living. ... Reuters

The thorny politics of NHS drug approval  -  ‎Oct 21, 2009‎
In 2001, Nice said that Aricept and others like it could be used for patients with mild to moderate disease, but in 2005 it changed its mind. ... guardian.co.uk

Demographic time bomb  -  ‎Nov 2, 2009‎
In its original decision, NICE decided not to recommend the reimbursement of Aricept, Novartis' Exelon (rivastigmine) and Shire's Reminyl (galantamine), ... Pharmaceutical Technology Magazine

Axona, A Medical Food for Alzheimer's Disease  -  ‎Nov 12, 2009‎
There were no significant interactions noted with commonly used Alzheimer's drugs, including donepezil (Aricept) or memantine (Namenda). ... eMaxHealth

Eisai Co., Ltd. - SWOT Analysis - research report released  -  ‎Oct 26, 2009‎
The revenue increase in FY2008 was mainly due to the growth in the sales of Aricept and AcipHex/Pariet. The operating profit of the company was JPY17,749 ... PR-Inside.com (Pressemitteilung)

Smart Pills: More Focus or Hocus Pocus?  -  ‎Oct 29, 2009‎
...and to learn new skills, and cholinesterase inhibitors like Aricept (donepezil), the Alzheimer's medication, to treat normal age-related memory changes. ... HealthNewsDigest.com

Medco Health 3Q profit jumps 13.5 percent  -  ‎Nov 3, 2009‎
Medco expects to earn 25 cents per share for the year from sales of generic drugs, as top sellers like Effexor XR, Flomax, and Aricept lose patent ... The Associated Press

REG-Pfizer Inc Pfizer Reports Third-Quarter 2009 Results  -  ‎Oct 20, 2009‎
2020 1871 8 1094 1064 3 926 807 15 GEODON / ZELDOX 713 731 (3 ) 597 594 - 116 137 (15 ) ZOLOFT 368 408 (10 ) 62 95 (35 ) 306 313 (2 ) ARICEPT** 311 356 ... Reuters

Pfizer earnings up 26% despite lower sales of many drugs  -  ‎Oct 21, 2009‎
Alliance revenues, notably from Eisai's Alzheimer's disease treatment Aricept (donepezil) and Boehringer Ingelheim's Spiriva (tiotropium) for chronic ... Pharma Times

NC event honors those with dementia  -  ‎Nov 5, 2009‎
The Wilsons try to eat right and exercise, practices that could slow the progression of the disease, as could Ron's doses of the medication Aricept. ... News & Observer

Scientists rally for Pfizer battle against Alzheimer's  -  ‎Nov 3, 2009‎
Currently, one of the best Alzheimer's therapies is the Pfizer drug Aricept, which generally helps patients in the first six to nine months after diagnosis, ... Trading Markets (press release)

Reader: Soap relieves RLS  -  ‎Nov 11, 2009‎
...extract (Journal of Molecular Neuroscience, June 2006) acted in a similar manner to donepezil (Aricept), a prescription drug used to treat Alzheimer's. ... Youngstown Vindicator

Sugar Heals Wounds; Menthol Helps Engorgement  -  ‎Nov 7, 2009‎
...extract (Journal of Molecular Neuroscience, June 2006) acted in a similar manner to donepezil (Aricept), a prescription drug used to treat Alzheimer's. Hartford Courant

Bổ ngá»­a vì... thuốc bổ óc  -  ‎Oct 20, 2009‎
Má»™t số thuốc như donepezil (biệt dược Aricept trị bệnh Alzheimer), piracefam (biệt dược Nootropil), citicholin, glyceryl phostphorylcholin, ginkgo biloba ... Thanh Niên

Thuốc bổ... ngá»­a  -  ‎Oct 25, 2009‎
Em có ghi đây: Dexerine, Ritalin, Aricept, Nootropil… và má»™t má»› nữa, nêu cần em sẽ ghi thêm cho bác. - Chú á»?c làm… trình dược viên khi nào mà rành rẽ tên ... An ninh thủ đô

Lite norsk hjernedoping  -  ‎Nov 2, 2009‎
...men amfetamin, betablokkere, koffein, kokain, benzopreparater, Piracetam, adrenalinforbindelser, Aricept, ecstacy og efedrin er også nevnt. ... forskning.no

Eisai verzeichnet solides Finanzergebnis im ersten Geschäftshalbjahr 2009 ...  -  ‎Nov 5, 2009‎
Die beiden umsatzstärksten Präparate sind nach wie vor das Alzheimer-Medikament Aricept® sowie der Protonenpumpen-Inhibitor Pariet®. ... news aktuell (Pressemitteilung)

EPIX Pharmaceuticals gibt die FDA-Zulassung des ärztlich gesponserten IND ...  -  ‎Oct 19, 2009‎
...in deren Rahmen sie täglich 100 mg PRX-03140 zusätzlich zu ihrer üblichen Tagesdosis von Aricept(R) (10 mg) verabreicht erhielt. ... PR-Inside.com (Pressemitteilung)

EPIX Pharmaceuticals annonce que le PRX-03140, un nouveau médicament de ...  -  ‎Oct 19, 2009‎
...phase 2a de deux semaines en août 2007, recevait chaque jour 100 mg de PRX-03140 en association avec sa dose quotidienne normale d'Aricept(R) (10 mg). ... Euroinvestor

Brand Names/Synonyms:
Aricept is also known by the following brand names and/or synonymsAricept; Aricept Odt; CHEMBANK1629; Donepezil; Eranz

Drug Category:
Aricept is categorized under the following by the FDA: Nootropic Agents; Parasympathomimetics; ATC:N06DA02

Dosage Forms:
oral tablets

Absorption:
Donepezil is well absorbed with a relative oral bioavailability of 100% and reaches peak plasma concentrations in 3 to 4 hours.

Interactions:
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Chemical IUPAC Name:
2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one





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