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ArthrotecThis page contains recent news articles, when available, and an overview of Arthrotec but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Arthrotec (when available) Misoprostol is a prostaglandin E1 (PGE1) analogue used for the treatment and prevention of stomach ulcers. When administered, misoprostol stimulates increased secretion of the protective mucus that lines the gastrointestinal tract and increases mucosal blood flow, thereby increasing mucosal integrity. It is sometimes co-prescribed with non-steroidal anti-inflammatory drugs (NSAIDs) to prevent the occurrence of gastric ulceration, a common adverse effect of the NSAIDs. Indicated for the treatment of ulceration (duodenal, gastric and NSAID induced) and prophylaxis for NSAID induced ulceration. Mechanism Of Action: Misoprostol seems to inhibit gastric acid secretion by a direct action on the parietal cells through binding to the prostaglandin receptor. The activity of this receptor is mediated by G proteins which normally activate adenylate cyclase. The indirect inhibition of adenylate cyclase by Misoprostol may be dependent on guanosine-5’-triphosphate (GTP). The significant cytoprotective actions of misoprostol are related to several mechanisms. These include: 1. Increased secretion of bicarbonate, 2. Considerable decrease in the volume and pepsin content of the gastric secretions, 3. It prevents harmful agents from disrupting the tight junctions between the epithelial cells which stops the subsequent back diffusion of H+ ions into the gastric mucosa, 4. Increased thickness of mucus layer, 5. Enhanced mucosal blood flow as a result of direct vasodilatation, 6. Stabilization of tissue lysozymes/vascular endothelium, and 7. Improvement of mucosal regeneration capacity. News Articles on Misoprostol REG-Pfizer Inc Pfizer Reports Third-Quarter 2009 Results - Oct 20, 2009 Examples of products in this business unit include, but are not limited to, Norvasc, Relpax, Medrol and Arthrotec. (7) The Emerging Markets business unit ... Reuters Brand Names/Synonyms: Arthrotec is also known by the following brand names and/or synonymsArthrotec; Cytotec; MISOPROSTOL 1 : 100 HPMC DISPERSION; Misoprostol; Misoprostol 1:100; Misoprostol [Usan:Ban:Inn:Jan]; Misoprostolum [Inn-Latin] Drug Category: Arthrotec is categorized under the following by the FDA: Oxytocics; Anti-ulcer Agents; Abortifacient Agents; Prostaglandins; ATC:A02BB01 Dosage Forms: TABLET Absorption: Misoprostol is extensively absorbed. Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: methyl7-[3-hydroxy-2-(4-hydroxy-4-methyl-oct-1-enyl)-5-oxo-cyclopentyl]heptanoate |
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