Astemizole

This page contains recent news articles, when available, and an overview of Astemizole but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Astemizole (when available)

Pharmacology and use:
Astemizole, an H₁-receptor antagonist, is similar in structure to terfenadine and haloperidol, a butyrophenone antipsychotic. It has anticholinergic (atropine-like) and antipruritic effects. For the relief of symptoms associated with seasonal allergic rhinitis and chronic idiopathic urticaria

Mechanism Of Action:
Astemizole competes with histamine for binding at H₁-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. This reversible binding of astemizole to H₁-receptors suppresses the formation of edema, flare, and pruritus resulting from histaminic activity. As the drug does not readily cross the blood-brain barrier and preferentially binds at H1 receptors in the peripehery rather than within the brain, CNS depression is minimal. Astemizole may also act on H₃-receptors, producing adverse effects.

News Articles on Astemizole

Brand Names/Synonyms:
Astemizole is also known by the following brand names and/or synonymsAlermizol; Astemisan; Astemisol; Astemison; Astemizole; Hismanal; Histamen; Histaminos; Histazol; Kelp; Laridal; Metodik; Nono-Nastizol A; Paralergin; Retolen; Waruzol

Drug Category:
Astemizole is categorized under the following by the FDA: Anti-allergic Agents; Antihistamines; ATC:R06AX11

Dosage Forms:
SUSPENSION; TABLET

Absorption:
rapidly absorbed from the gastrointestinal tract

Interactions:
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Chemical IUPAC Name:
1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidyl]-benzoimidazol-2-amine

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