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AvinzaThis page contains recent news articles, when available, and an overview of Avinza but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Avinza (when available) Morphine is a narcotic pain management agent indicated for the relief of pain in patients who require opioid analgesics for more than a few days. Morphine interacts predominantly with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, with high densities in the posterior amygdala, hypothalamus, thalamus, nucleus caudatus, putamen, and certain cortical areas. They are also found on the terminal axons of primary afferents within laminae I and II (substantia gelatinosa) of the spinal cord and in the spinal nucleus of the trigeminal nerve. In clinical settings, Morphine exerts its principal pharmacological effect on the central nervous system and gastrointestinal tract. Its primary actions of therapeutic value are analgesia and sedation. Morphine appears to increase the patient's tolerance for pain and to decrease discomfort, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Opioids also produce respiratory depression by direct action on brain stem respiratory centers. For the relief and treatment of severe pain Mechanism Of Action: The precise mechanism of the analgesic action is unknown. However, specific CNS opiate receptors have been identified and likely play a role in the expression of analgesic effects. The mechanism of respiratory depression involves a reduction in the responsiveness of the brain stem respiratory centers to increases in carbon dioxide tension and to electrical stimulation. News Articles on Morphine Ligand Pharmaceuticals Announces Third Quarter Results - Nov 5, 2009 For example, we may not receive expected royalties on AVINZA from King Pharmaceuticals, PROMACTA from GSK or any other partnered products or from research ... WELT ONLINE Ligand to Buy Metabasis - Oct 27, 2009 The deal gives Ligand, developer of the painkiller Avinza and Promacta for low platelet levels, access to Metabasis' HepDirect platform technology for drug ... San Diego Business Journal Penwest Pharmaceuticals Co. Q3 2009 Earnings Call Transcript - Nov 5, 2009 Market share for Opana ER has also continued to increase steadily, with market share recently exceeding that of Avinza as well as Kadian. ... Seeking Alpha (blog) King Beats, but Earnings Down - Nov 5, 2009 Avinza sales also declined 13.9% to $31 million. Flector Patch, obtained through King's acquisition of Alpharma, recorded $40 million in sales in the ... Zacks.com Community leaders sign letter opposing addiction clinic - Nov 5, 2009 ...in treating addiction to opiates, such as the popular prescription pain medications Oxycontin, Lortab and Avinza, a time-released morphine drug. ... News Enterprise News In Brief - Nov 2, 2009 The deal gives Ligand, developer of the painkiller Avinza and Promacta for low platelet levels, access to Metabasis' HepDirect platform technology for drug ... San Diego Business Journal FDA Has New Web Page for Select Medicine Disposal Instructions - Oct 20, 2009 The medicines listed as recommended for disposal by flushing include Actiq, Avinza, Daytrana, Demerol, Diastat/Diastat AcuDial, Dilaudid, ... DOTmed.com (press release) King Pharmaceuticals, Inc. - Pharmaceuticals & Healthcare - Deals and ... - Nov 9, 2009 The company's product line includes Avinza, CII Skelaxin, Thrombin-JMI, Altace, Levoxyl, Cytomel, Sonata, CIV Meridian and Auto injector Products/EpiPen. ... PR-Inside.com (Pressemitteilung) Brand Names/Synonyms: Avinza is also known by the following brand names and/or synonymsAVINZA; Apokyn; Astramorph Pf; Avinza; Depodur; Diacetylmorphine Hydrochloride; Diamorphine Hydrochloride; Dulcontin; Duramorph; Duramorph Pf; Duromorph; Epimorph; Heroin Hydrochloride; Heroine Hydrochloride; Kadian; L-Morphine; M S Contin; M-Eslon; M.O.S; M.O.S.-S.R; MS IR; MS.IR; MS/L; MS/S; MSIR; Meconium; Morfina; Morphia; Morphin; Morphina; Morphine; Morphine Extra-Forte; Morphine Forte; Morphine H.P; Morphine Sulfate; Morphinism; Morphinum; Morphitec; Morphium; Moscontin; Ms Contin; Ms/L Concentrate; Nepenthe; O,O'-Diacetylmorphine Hydrochloride; Oms Concentrate; Oramorph Sr; Ospalivina; Rescudose; Rms Uniserts; Roxanol; Roxanol 100; Roxanol Ud; Statex; Statex Drops Drug Category: Avinza is categorized under the following by the FDA: Narcotics; Analgesics; Opiate Agonists; ATC:G04BE07; ATC:N02AA01; ATC:N02AA04; ATC:N02AA09; ATC:N04BC07; ATC:R05DA01; ATC:R05DA05; ATC:S01XA06 Dosage Forms: CAPSULE (SUSTAINED-RELEASE); DROPS; LIQUID; SOLUTION; SUPPOSITORY; SUPPOSITORY (SUSTAINED-RELEASE); SYRUP; TABLET; TABLET (EXTENDED-RELEASE); TINCTURE Absorption: Bioavailability is ~30% Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: (5α,6α)-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol |
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