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BenazeprilThis page contains recent news articles, when available, and an overview of Benazepril but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Benazepril (when available) Benazepril, an angiotensin-converting enzyme (ACE) inhibitor, is a prodrug which, when hydrolyzed by estarases to its active Benazeprilat, is used to treat hypertension and heart failure, to reduce proteinuria and renal disease in patients with nephropathies, and to prevent stroke, myocardial infarction, and cardiac death in high-risk patients. Benazepril and Benazeprilat inhibit angiotensin-converting enzyme (ACE) in human subjects and animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. For the treatment of hypertension. It may be used alone or in combination with thiazide diuretics. Mechanism Of Action: Benazeprilat, the active metabolite of Benazepril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms, which leads to decreased vasopressor activity and to decreased aldosterone secretion. Benazeprilat may also act on kininase II, an enzyme identical to ACE that degrades the vasodilator bradykinin. News Articles on Benazepril Generic Name: Benazepril - Nov 11, 2009 Lotensin (generic name: Benazepril) belongs to a class of medications called angiotensin-converting enzyme (ACE) inhibitors. Lotesin is indicated for the ... Pattaya Daily News European Medicines Evaluation Agency (emea) - EMEA press release - Meeting ... - Nov 13, 2009 The Committee started a referral procedure for Fortekor vet and associated names (5 mg benazepril hydrochloride, film-coated tablets). ... DeHavilland (press release) (subscription) Teva sales leap again, eyeing acquisitions - Nov 4, 2009 Lotrel (almodipine/benazepril), Bayer's contraceptive Yasmin (drospirenone and ethinyl estradiol) and Wyeth's antiulcerant Protonix (pantoprazole). ... Pharma Times Fifty Years of Thiazide Diuretic Therapy for Hypertension - Nov 9, 2009 Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients. N Engl J Med. 2008;359(23):2417-2428. FREE FULL TEXT 36. ... Archives of Internal Medicine Novartis receives approval in the European Union for Exforge HCT(R), a new 3 ... - Oct 22, 2009 Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients. N Engl J Med 2008;359:2417-28. [9.] Exforge HCT(R) US Prescribing ... Trading Markets (press release) Brand Names/Synonyms: Benazepril is also known by the following brand names and/or synonymsBenazepril; Benazepril Hcl; Benazepril Hydrochloride; Benazeprilum [Latin]; Briem; Cibacen; Cibacene; Lotensin Drug Category: Benazepril is categorized under the following by the FDA: Antihypertensive Agents; Angiotensin-converting Enzyme Inhibitors; ATC:C09AA07 Dosage Forms: Tablets containing 5, 10, 20 and 40 mg of benazepril. Absorption: Peak in plasma within 0.5-1.0 hours. The extent of absorption is at least 37% as determined by urinary recovery and is not significantly influenced by the presence of food in the GI tract. Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: 2-[4-(1-ethoxycarbonyl-3-phenyl-propyl)amino-5-oxo-6-azabicyclo[5.4.0]undeca-7,9,11-trien-6-yl]ethanoicacid |
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