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BendroflumethiazideThis page contains recent news articles, when available, and an overview of Bendroflumethiazide but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Bendroflumethiazide (when available) Bendroflumethiazide, a thiazide diuretic, removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. For the treatment of high blood pressure and management of edema Mechanism Of Action: As a diuretic, bendroflumethiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like bendroflumethiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of bendroflumethiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. News Articles on Bendroflumethiazide How to control high blood pressure - Dec 17, 2009 Bendroflumethiazide also works well in older patients, but some are unwilling to put up with the increased urinary frequency that is a side-effect of water ... WalesOnline Cross-breeding leading to native livestock decline in Orissa - Dec 13, 2009 Company supplies generics to the European and UK markets like Amlodipine Maleate, Bendroflumethiazide, Benzhexol (Trihexyphenidyl), Bisacodyl 5mg Tablets, ... TopNews Baseline Heart Rate, Antihypertensive Treatment, and Prevention of ... - Nov 5, 2009 ...a randomized trial of atenolol ± bendroflumethiazide (atenolol-based) versus amlodipine ± perindopril (amlodipine-based) regimen for treatment of ... Cardiosource FDA approves Twynsta® (telmisartan plus amlodipine) a new single pill ... - Oct 19, 2009 Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide ... Insciences Organisation Novartis receives approval in the European Union for Exforge HCT(R), a new 3 ... - Oct 22, 2009 Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide ... Trading Markets (press release) Brand Names/Synonyms: Bendroflumethiazide is also known by the following brand names and/or synonymsAprinox; BHFT; BL H368; Bendrofluazide; Bendroflumethazide; Bendroflumethiazide; Bendroflumethiazide [Inn]; Bendroflumethiazidum [Inn-Latin]; Bendroflumetiazida [Inn-Spanish]; Bendroflumetiazide [Dcit]; Bendrofumethiazide; Bentride; Benuron; Benzhydroflumethiazide; Benzy-Rodiuran; Benzydroflumethiazide; Benzylhydroflumethiazide; Benzylrodiuran; Berkozide; Bhft; Bristuric; Bristuron; CHEMBANK917; Centyl; Corzide; FT 8; FT 81; Flumersil; Flumesil; HSDB 3293; Intolex; Livesan; Naigaril; Nateretin; Naturetin; Naturetin-2.5; Naturine; Neo-Naclex; Neo-Rontyl; Niagaril; Nikion; Orsile; Pluryl; Pluryle; Plusuril; Poliuron; Rautrax N; Rauzide; Relan Beta; Repicin; Salural; Salures; Sinesalin; Sodiuretic; Thiazidico; Urlea Drug Category: Bendroflumethiazide is categorized under the following by the FDA: Diuretics, Thiazide; Antihypertensive Agents; ATC:C03AA01 Dosage Forms: TABLET Absorption: Absorbed relatively rapidly after oral administration Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: 3-benzyl-5,5-dioxo-9-(trifluoromethyl)-5$l^{6}-thia-2,4-diazabicyclo[4.4.0]deca-7,9,11-triene-8-sulfonamide |
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