Brethine

This page contains recent news articles, when available, and an overview of Brethine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Brethine
(when available)

Pharmacology and use:
Terbutaline is a relatively selective beta2-adrenergic bronchodilator. Terbutaline is indicated for the relief of bronchospasm associated with chronic obstructive pulmonary disease. The pharmacologic effects of beta adrenergic agonist drugs, including Terbutaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells. For the prevention of and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema; For the management of preterm labor

Mechanism Of Action:
The pharmacologic effects of Terbutaline are at least in part attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.

News Articles on Terbutaline

Double duty  -  Oct 31, 2005
AstraZeneca manufactures it under the brand names Brethine and Bricanyl. Equally confusing to many people is the use of terms such as "off-label. ... Washington Times

usage of brethine during pregnancy  -  Jun 26, 2008
Are you an asthma suffer? Manage your asthma or COPD with great ideas from people like you.Start here. Brethine is a brand of Terbutaline Sulfate. ... HealthCentral.com

Brethine.(Drug overview)  -  Jan 22, 2007
Brethine is a bronchodilator (a medication that opens the bronchial tubes), prescribed for the prevention and relief of bronchial spasms in asthma. ... Free with registration - PDR Family Guide to Prescription Drugs - AccessMyLibrary.com

… - 72 FR 39629 Determination That Brethine (Terbutaline Sulfate)...  -  Jul 19, 2007
The petition requests that the agency determine whether Brethine ... AaiPharma ceased manufacture of Brethine injection and it was moved from the ... Pay-Per-View - Federal Register 2007 - Loislaw

Loislaw Federal District Court Opinions - VANDEVELDE v. POPPENS ( …  -  Mar 7, 2008
At some point while at the RCH Emergency Department during this second visit, Mrs. Vandevelde was given Brethine. Dr. Hill accepted the transfer and Mrs. ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Bankruptcy coming in days for aaiPharma.  -  May 10, 2005
The company will keep its Brethine drug. The decision to sell its pharmaceutical products brings aaiPharma back where it started 26 years ago with its core ... Free with registration - Star-News - AccessMyLibrary.com

Fexofenadine and Pseudoephedrine (Systemic ).  -  Feb 1, 2006
Desoxyn), norepinephrine (eg, Levophed), phenylephrine (eg, Neo-Synephrine), phenylpropanolamine (eg, Dexatrim), or terbutaline (eg, Brethine). ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

AaiPharma to restate earnings; stock to be delisted  -  Apr 15, 2005
...include an additional $15.3 million of impairment charges related to intangible assets associated with its Darvon/Darvocet and Brethine product lines. ... Triangle Business Journal

FDA approves Lannett respiratory drug  -  Mar 29, 2005
Terbutaline Sulfate is the generic equivalent of Brethine tablets, which are marketed by Novartis Pharmaceuticals and aaiPharma Inc. ... Philadelphia Business Journal

Combination therapy better for asthma exacerbations.(Tips from Other ...  -  Feb 1, 2007
Rabe and colleagues compared the effectiveness and safety of three reliever strategies: a short-acting [beta.sub.2] agonist (terbutaline [Brethine]), ... Free with registration - American Family Physician - AccessMyLibrary.com

menadione | Definition of menadione | HighBeam.com: Online Dictionary  -  Jul 12, 2006
Article: Drug safety group calls for replacement of Brethine ampuls. ... Brethine is used to treat pre-term labor, and Methergine is used primarily after ... Pay-Per-View - Oxford American College Dictionary - HighBeam Research

Article: Novartis Pharmaceuticals Corporation.(People)(Michelle...  -  Feb 27, 2006
Article: aaiPharma's Business Unit Acquires Brethine(R) From ... ... Brethine(R) product line from Novartis Pharmaceuticals Corporation. ... Pay-Per-View - Jet - HighBeam Research

Press Release: Novartis Pharmaceuticals Corporation to Appeal …  -  Jul 1, 2008
Article: aaiPharma's Business Unit Acquires Brethine(R) From ... ... Brethine(R) product line from Novartis Pharmaceuticals Corporation. ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: Leading NFL Quarterback Donovan McNabb Partners …  -  Oct 12, 2006
Article: aaiPharma's Business Unit Acquires Brethine(R) From ... ... Brethine(R) product line from Novartis Pharmaceuticals Corporation. ... Pay-Per-View - PR Newswire - HighBeam Research

Business News in Brief  -  Mar 30, 2005
Philadelphia generic-drugmaker Lannett Co. said the Food and Drug Administration had approved its application to sell a generic version of Brethine tablets ... $2.95 - Philadelphia Inquirer - NewsBank

Vandevelde v. Poppens, No. 1:06CV-40-R (WDKy. 03/11/2008)  -  Mar 11, 2008
At some point while at the RCH Emergency Department during this second visit, Mrs. Vandevelde was given Brethine. Dr. Hill accepted the transfer and Mrs. ... $2.95 - U.S. District Court, Western District... - VersusLaw

Are oral betamimetics effective maintenance therapies after threatened...  -  Mar 1, 2007
After the patient receives hydration and terbutaline (Brethine), the contractions stop. Should an oral betamimetic be used as maintenance therapy to prevent ... Free with registration - American Family Physician - AccessMyLibrary.com

Double duty; Medicines intended for one condition used to treat...  -  Nov 1, 2005
AstraZeneca manufactures it under the brand names Brethine and Bricanyl. Equally confusing to many people is the use of terms such as "off-label. ... Pay-Per-View - Washington Times - HighBeam Research

More In Features  -  Feb 1, 2008
His shop helped make mega-brands like Lopressor and Brethine. In 1981, he left C&G Advertising to join tiny, Miami-based Key Pharmaceuticals as SVP sales ... Medical Marketing & Media - Medical Marketing and Media

Relief in Children with Exercised-Induced Asthma  -  Oct 1, 2006
Hermansen and colleagues assessed the effect of formoterol versus terbutaline (Brethine) during exercise-induced bronchoconstriction in children with asthma ... AAFP News Now

Prevention and management of postpartum hemorrhage.(Disease/ …  -  Mar 15, 2007
If initial attempts to replace the uterus fail or a cervical contraction ring develops, administration of magnesium sulfate, terbutaline (Brethine), ... Free with registration - American Family Physician - AccessMyLibrary.com

Antihistamines and Decongestants (Systemic).(Drug overview)  -  Aug 1, 2006
Levophed), phenylephrine (e.g., Neo-Synephrine), pseudoephedrine (e.g., Sudafed), PPA (e.g., Dexatrim), or terbutaline (e.g., Brethine). Pregnancy -- ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

ACCP and ACAAI release guidelines on inhaled aerosol therapy for …  -  Sep 1, 2005
...short-acting beta2 agonists (eg, albuterol [Ventolin], metaproterenol [Alupent], terbutaline [Brethine]) in emergency department or inpatient settings. ... Free with registration - American Family Physician - AccessMyLibrary.com

Antihistamines, Decongestants, and Anticholinergics (Systemic ).  -  Feb 1, 2006
Desoxyn), norepinephrine (eg, Levophed), phenylephrine (eg, Neo-Synephrine), pseudoephedrine (eg, Sudafed), or terbutaline (eg, Brethine). ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Clinical quiz.  -  Mar 1, 2007
B. Terbutaline (Brethine) therapy for 24 to 48 hours and a steroid injection. [] D. Outpatient terbutaline therapy until the patient reaches 35 weeks' ... $4.95 - American Family Physician - ECNext

Loislaw Federal District Court Opinions - GRESS v. COSHOCTON …  -  Dec 24, 2008
Plaintiff also claims Defendant failed to appropriately use Brethine and Pitocin and failed to perform a culture and sensitivity. (Id.). ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Fexofenadine and Pseudoephedrine (Systemic ).(Drug overview)  -  May 1, 2006
Desoxyn), norepinephrine (eg, Levophed), phenylephrine (eg, Neo-Synephrine), phenylpropanolamine (eg, Dexatrim), or terbutaline (eg, Brethine). ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Federal Register 2008 - 73 FR 77723 Determination That RUBRAMIN PC …  -  Dec 19, 2008
Smyrna, GA Release Capsules, 30080 equivalent to (EQ) 15 mg and 30 mg base NDA 17-849 BRETHINE (terbutaline AAIPharma, LLC, 2320 sulfate) Tablets, ... Pay-Per-View - Federal Register 2008 - Loislaw

Prevention and management of postpartum hemorrhage.(Disease/ …  -  Mar 15, 2007
If initial attempts to replace the uterus fail or a cervical contraction ring develops, administration of magnesium sulfate, terbutaline (Brethine), ... $4.95 - American Family Physician - ECNext

Robert Baldini.  -  Feb 1, 2008
His shop helped make mega-brands like Lopressor and Brethine. In 1981, he left C&G Advertising to join tiny, Miami-based Key Pharmaceuticals as SVP sales ... $9.94 - Medical Marketing & Media - Alacra Store

Factiva Search  -  Mar 30, 2005
Lannett's generic Brethine gets FDA OK. 30 March, 2005 Datamonitor News and Comment. Pennsylvania-based generics firm Lannett Company has received approval ... Pay-Per-View - Datamonitor News and Comment - Factiva, from Dow Jones

AAIIQ, CXPI, HDVY, IFLB, MOBR, NIHK Have Also Been Added To Naked …  -  Jan 24, 2006
The company's critical care products include Brethine, which is approved in oral and injectable forms for the prevention and reversal of bronchospasm in ... $4.95 - M2 Presswire - ECNext

BCON, GEPT, ZIXI, AAIIQ, FMLY, SKPI Have Been On BUYINS.NET …  -  Dec 7, 2005
The company's critical care products include Brethine, which is approved in oral and injectable forms for the prevention and reversal of bronchospasm in ... $4.95 - M2 Presswire - ECNext

Daily Market Movers Digest Stock Alerts, Friday, August 18th, DNAG,...  -  Aug 18, 2006
...which include generic versions of brand name pharmaceuticals, such as Brethine, Florinef, Minocin, Claritin-D 12-hour, Claritin-D 24-hour, Wellbutrin SR ... $4.95 - M2 Presswire - ECNext

Press Release: ZIXI, AAIIQ, AANI, EKCS, HQSM, SKPI Have Also Been …  -  Nov 18, 2005
The company's critical care products include Brethine, which is approved in oral and injectable forms for the prevention and reversal of bronchospasm in ... Pay-Per-View - M2 Presswire - HighBeam Research

AAI PHARMA FOUNDER NOW SEEKS NEW QUESTS IN DRUGS  -  Jan 2, 2005
It also makes Brethine, an asthma drug. Sancilio tried to retire last year from AAI Pharma but was called back to help whip the company into shape after an ... Pay-Per-View - Palm Beach Post - NewsBank

Investor targets increase on Impax Laboratories Inc. stock (Pink...  -  Aug 24, 2006
...which include generic versions of brand name pharmaceuticals, such as Brethine, Florinef, Minocin, Claritin-D 12-hour, Claritin-D 24-hour, Wellbutrin SR ... $4.95 - M2 Presswire - ECNext

Lannett will collaborate with Wintac.(Lannett Co. signed contract …  -  Feb 27, 2006
PHILADELPHIA -- Lannett Co. has received Food and Drug Administration approval for a generic form of Brethine (Novartis Pharmaceuticals Corp.). ... Pay-Per-View - Chain Drug Review - HighBeam Research

Article: Lannett gets OK(RX/GENERIC DRUGS)(Brief Article) - Chain...  -  Apr 18, 2005
PHILADELPHIA -- Lannett Co. has received Food and Drug Administration approval for a generic form of Brethine (Novartis Pharmaceuticals Corp.). ... Pay-Per-View - Chain Drug Review - HighBeam Research

Nevada Administrative Code - NAC 467.850 Administration or use of …  -  Aug 11, 2005
...(i) Asthma products in aerosol form, such as Brethine, Metaproterenol (Alupent) or Salbutamol (Albuterol, Proventil or Ventolin). ... Pay-Per-View - Nevada Administrative Code - Loislaw

Lannett Co.(RX/GENERIC DRUGS--Profiles) | Article from Chain Drug …  -  Sep 25, 2006
PHILADELPHIA -- Lannett Co. has received Food and Drug Administration approval for a generic form of Brethine (Novartis Pharmaceuticals Corp.). ... Pay-Per-View - Chain Drug Review - HighBeam Research

Press Release: Large family study pinpoints genetic linkage in drug …  -  Apr 10, 2006
...treatment of opioid dependence in patients unable to take oral medication. The company's critical care products include Brethine, which is approved ... ... Pay-Per-View - M2 Presswire - HighBeam Research

Lannett gets OK  -  Apr 18, 2005
PHILADELPHIA -- Lannett Co. has received Food and Drug Administration approval for a generic form of Brethine (Novartis Pharmaceuticals Corp.). ... $9.94 - Chain Drug Review - Alacra Store

ZIXI, AAIIQ, AANI, EKCS, HQSM, SKPI Have Also Been Added To Naked …  -  Nov 18, 2005
The company's critical care products include Brethine, which is approved in oral and injectable forms for the prevention and reversal of bronchospasm in ... $4.95 - M2 Presswire - ECNext

Press Release: Investor targets increase on Impax Laboratories Inc....  -  Aug 24, 2006
...which include generic versions of brand name pharmaceuticals, such as Brethine, Florinef, Minocin, Claritin-D 12-hour, Claritin-D 24-hour, Wellbutrin SR ... Pay-Per-View - M2 Presswire - HighBeam Research

Naked Short Web Site announces PRKR, AAIIQ, ABRXQ, CDNR, MDLH, …  -  Jan 10, 2006
The company's critical care products include Brethine, which is approved in oral and injectable forms for the prevention and reversal of bronchospasm in ... $4.95 - M2 Presswire - ECNext

Washington Administrative Code - WAC 260-70-680 This section …  -  Mar 17, 2006
Tepoxalin Terazosin Hytrin Terbutaline Brethine, Bricanyl Testolactone Teslac Tetrahydrogestrinone Theophylline Aqualphyllin, etc. ... Pay-Per-View - Washington Administrative Code - Loislaw

New Jersey Administrative Code - 8:71-1.1 Precedence of lists  -  Aug 16, 2005
BLOCADREN Timolol maleate 5 mg, 10 mg, 20 mg Tablet Merck, Mylan, Watson BRETHINE Terbutaline sulfate 2.5 mg, 5 mg Tablet Impax BROMFED ... Pay-Per-View - New Jersey Administrative Code - Loislaw

Brand Names/Synonyms:
Brethine is also known by the following brand names and/or synonymsBrethaire; Brethine; Brican; Bricanyl; Bricar; Bricaril; Bricyn; CHEMBANK743; KWD 2019; T2528; Terbutalin; Terbutalina [Dcit]; Terbutaline; Terbutaline Sulfate; Terbutalino [Inn-Spanish]; Terbutalinum [Inn-Latin]

Drug Category:
Brethine is categorized under the following by the FDA: Adrenergic beta-Agonists; Tocolytic Agents; Bronchodilator Agents; Sympathomimetic; ATC:R03AC03; ATC:R03CC03

Dosage Forms:
METERED-DOSE (AEROSOL); POWDER; Tablets; IV Injection; Subcutaneous Injection

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
5-(1-hydroxy-2-tert-butylamino-ethyl)benzene-1,3-diol





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