Brimonidine

This page contains recent news articles, when available, and an overview of Brimonidine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Brimonidine
(when available)

Pharmacology and use:
Brimonidine significantly lowers intraocular pressure with minimal effects on cardiovascular and pulmonary parameters. It lowers intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow. For the lowering of intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

Mechanism Of Action:
Brimonidine is an alpha adrenergic receptor agonist. It has a peak ocular hypotensive effect occurring at two hours post-dosing. Fluorophotometric studies in animals and humans suggest that Brimonidine has a dual mechanism of action by reducing aqueous humor production and increasing uveoscleral outflow.

News Articles on Brimonidine

Allergan wins brimonidine patent infringement case  -  ‎Nov 4, 2009‎
The court ruled that Apotex's proposed two generic brimonidine formations infringed on each of the five Allergan patents and that Exela's proposed generic ... ModernMedicine

Allergan wins patent infringement suit over generic versions of brimonidine  -  ‎Oct 30, 2009‎
Allergan filed the suit claiming the defendants infringed on the patent for Alphagan (brimonidine tartrate ophthalmic solution 0.1% and 0.15%) when seeking ... OSN SuperSite

Allergan wins brimonidine patent infringement case against Exela PharmSci & Apotex  -  ‎Oct 27, 2009‎
...the 'Defendants') for seeking to market purported generic versions of Allergan's drugs Alphagan P (brimonidine tartrate ophthalmic solution) 0.1% and ... pharmabiz.com

Allergan wins ruling in patent case against 2 drugmakers  -  ‎Oct 25, 2009‎
With the ruling, the US Food and Drug Administration must delay clearance of the defendants' proposed generic versions of Alphagan, generically brimonidine, ... MarketWatch

Allergan Reports Third Quarter 2009 Operating Results  -  ‎Oct 29, 2009‎
...proposed generic versions of Allergan`s ALPHAGAN P (brimonidine tartrate ophthalmic solution) 0.1% and 0.15% products infringe Allergan`s patents. ... Reuters

Allergan Claims Victory in Patent Suit Over Generics  -  ‎Nov 7, 2009‎
...versions of Alphagan P. Alphagan P is a variant of Allergan's original Alphagan glaucoma drug with a lower dosage of active ingredient brimonidine. ... Orange County Business Journal

Alcon Posts 5.9 Percent Sales Growth for Third Quarter  -  ‎Oct 27, 2009‎
On October 2, 2009, the company launched brimonidine 0.15% in the United States which is the only non-branded version of Alphagan® P 0.15% on the market. ... Reuters

Lumigan X EU Committee Recomendation  -  ‎Oct 28, 2009‎
Allergan's ill-advised manipulation of concentrations with their Alphagan (brimonidine) product by bringing out Alphagan-P did not take market share from ... Gerson Lehrman Group

Alcon Posts 5.9 Percent Sales Growth for Third Quarter  -  ‎Oct 27, 2009‎
On October 2, 2009, the company launched brimonidine 0.15% in the United States which is the only non-branded version of Alphagan® P 0.15% on the market. ... istockAnalyst.com (press release)

Twenty-four-hour efficacy of the brimonidine/timolol fixed combination...  -  Jun 15, 2007
Correspondence: WC Stewart, PRN Pharmaceutical Research Network, LLC, 1 Southpark Circle, Suite 110, Charleston, SC 29407, USA. Tel: +1 843 762 6500; ... Nature.com

… of fixed-combination glaucoma drug: brimonidine/timolol dual...  -  Feb 1, 2005
In addition, significantly fewer patients using brimonidine/timolol ... Mean reductions in the brimonidine and timolol groups ranged from 2.7 to 5.5 mm Hg ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Changes in visual function after intraocular pressure reduction using...  -  Aug 1, 2008
2, 13 Evans et al 2 evaluated 16 POAG patients using brimonidine or timolol ... On the other hand, in this study, patients using brimonidine showed a lower ... Nature.com

FDA approves combo eye drop for glaucoma  -  Oct 31, 2007
The company said Combigan would combine "two strong agents in one bottle" -- brimonidine and timolol -- to control pressure within the eye that can harm the ... Reuters

… and Alcon Reach Agreement on Brimonidine 0.15% Patent Litigation.  -  Mar 9, 2006
IRVINE, Calif. -- Allergan, Inc. (NYSE:AGN) announced today that Allergan and Alcon, Inc. (NYSE:ACL) have settled Allergan's patent infringement lawsuit in ... Free with registration - Business Wire - AccessMyLibrary.com

… Letter for COMBIGAN(TM) (brimonidine tartrate/timolol maleate …  -  Dec 21, 2006
Allergan Inc. (NYSE:AGN) today announced that the US Food and Drug Administration (FDA) issued an approvable letter for COMBIGAN(TM) (brimonidine ... Genetic Engineering News - Genetic Engineering News (press release)

Adjunctive brimonidine results in greater IOP lowering: study finds...  -  Sep 1, 2007
Fort Lauderdale, FL -- Results of a prospective, randomized, investigator-masked trial comparing brimonidine 0.15% containing an oxidative preservative ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Comparison study: brimonidine fares well as add-on therapy: addition...  -  Jan 15, 2008
New Orleans -- The addition of brimonidine tartrate 0.15 % (Alphagan P, Allergan) to a prostaglandin analog resulted in significantly greater reductions in ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Brimonidine (Ophthalmic).  -  Feb 1, 2006
Brimonidine (bri-MOE-ni-deen ) is used to treat glaucoma or another condition in which pressure in the eye is too high (ocular hypertension). ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Brimonidine (Ophthalmic).(Drug overview)  -  May 1, 2006
Brimonidine (bri-MOE-ni-deen ) is used to treat glaucoma or another condition in which pressure in the eye is too high (ocular hypertension). ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Study: Brimonidine tartrate shows short-term efficacy for reducing...  -  Jun 10, 2008
Brimonidine tartrate can successfully reduce halo size and pupil size in patients with night-vision symptoms after LASIK, a small 24-hour study by ... OSN SuperSite

University of Mainz; Brimonidine and dapiprazole have similar effects...  -  Oct 12, 2005
2005 OCT 12 - (NewsRx.com) -- Brimonidine and dapiprazole have comparable effects on pupil size in patients undergoing refractive surgery. ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones

Brimonidine reduced intra- and postoperative bleeding in adult …  -  Oct 17, 2007
Administering topical brimonidine before strabismus surgery may reduce intraoperative bleeding and postoperative subconjunctival hemorrhaging in adult ... OSN SuperSite

… 1% Found More Effective Than Brimonidine 0.15% When Added to …  -  May 1, 2006
By Michael Casasnovas. FT. LAUDERDALE, FL -- May 1, 2006 -- The addition of brinzolamide 1% (Azopt) to a prostaglandin analog appears to be more effective ... DG News

Refractive Surgery; Brimonidine and dapiprazole have similar effects...  -  Oct 14, 2005
2005 OCT 14 - (NewsRx.com) -- Brimonidine and dapiprazole have comparable effects on pupil size in patients undergoing refractive surgery. ... Pay-Per-View - Drug Week - Factiva, from Dow Jones

A new 0.1% formulation of brimonidine ophthalmic solution (Alphagan...  -  Sep 1, 2005
A new 0.1% formulation of brimonidine ophthalmic solution (Alphagan P, Allergan) was approved for the lowering of intraocular pressure (IOP) in patients ... Free with registration - Formulary - AccessMyLibrary.com

Watch for toxic brimonidine exposure in children.(Clinical Rounds)(Bri...  -  Sep 1, 2006
SAN FRANCISCO -- Toxic exposures to brimonidine tartrate affected 43-55 patients per year between 2000 and 2005, and more than half of them were children 5 ... Free with registration - Family Practice News - AccessMyLibrary.com

Allergan reports 23% rise in first-quarter total product net sales  -  May 8, 2008
Alphagan P (brimonidine tartrate 0.15%), Alphagan (brimonidine tartrate) and Combigan (0.2% brimonidine tartrate, 0.5% timolol maleate) sales totaled $99.5 ... OSN SuperSite

… & Alcon Reach Agreement on Brimonidine 0.15% Patent Litigation  -  Nov 3, 2006
IRVINE, CA - Allergan, Inc. announced on Saturday that Allergan and Alcon Inc. have settled Allergan's patent infringement lawsuit in the United States ... ag-IP-news Agency

… Court Opinions - IN RE BRIMONIDINE PATENT LITIGATION (JPML 2007 …  -  Aug 20, 2007
IN RE BRIMONIDINE PATENT LITIGATION (JPML 2007) 507 F. Supp.2d 1381 IN RE Brimonidine Patent Litigation Allergan, Inc. v. Exela Pharmsci, Inc., et al., ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Brimonidine Helps Soldiers With Poor Night Vision Following Refractive...  -  May 8, 2006
By Earl R. Nichols. FT. LAUDERDALE, FL -- May 8, 2006 -- A study done for the United States Army has found that soldiers who have had visual problems ... DG News

Allergan Receives Positive Opinions for COMBIGAN(TM) From 21 …  -  Sep 28, 2005
Allergan's ALPHAGAN(R)/timolol combination product for glaucoma (brimonidine tartrate/timolol ophthalmic solution), from all twenty-one Concerned Member ... RedOrbit

… said the FDA approved Combigan (brimonidine tartrate/timolol...  -  Dec 1, 2007
Allergan said the FDA approved Combigan (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5%.(Pipeline) ... find Medical Marketing & Media ... Pay-Per-View - Medical Marketing & Media - HighBeam Research

Watch for toxic brimonidine exposure in children.(Clinical Rounds)(Bri...  -  Sep 1, 2006
Watch for toxic brimonidine exposure in children.(Clinical Rounds)(Brief article) ... find Family Practice News articles. SAN FRANCISCO -- Toxic exposures ... Pay-Per-View - Family Practice News - HighBeam Research

timolol + brimonidine Allergan receives approvable letter from US FDA.  -  Jan 8, 2007
...reduction of elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension who require adjunctive or replacement therapy because of ... Pay-Per-View - R & D Focus Drug News - Factiva, from Dow Jones

Most brimonidine poisonings occur in child aged 5 or less.(Clinical …  -  Sep 1, 2006
Most brimonidine poisonings occur in child aged 5 or less.(Clinical Rounds) ... find Pediatric News articles. SAN FRANCISCO -- Toxic exposures to ... Pay-Per-View - Pediatric News - HighBeam Research

Akorn, Inc. Reports First Quarter 2006 Revenues of $30 million, 40% …  -  May 1, 2006
Two new drug product approvals were received from the FDA for Brimonidine and Inapsine(R). -- Six ANDA's have been submitted. Three of these ANDA's are from ... Genetic Engineering News - Genetic Engineering News (press release)

Akorn wins FDA approval for glaucoma treatment  -  Mar 20, 2006
The approval covers a solution of brimonidine tartrate, the active ingredient in Allergan Inc.'s Alphagan P. The solution works by decreasing the pressure ... Crain's Chicago Business

Loislaw Federal District Court Opinions - ALLERGAN, INC. v. ALCON INC...  -  Dec 8, 2005
B. Brimonidine Tartrate, Its Uses, and Allergan's Market Exclusivity The patents ... According to Allergan, the 0.2% brimonidine was effective at treating ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Loislaw Federal District Court Opinions - ALLERGAN v. ALCON (Del. …  -  Dec 4, 2005
B. Brimonidine Tartrate, Its Uses, and Allergan's Market Exclusivity The patents ... According to Allergan, the 0.2% brimonidine was effective at treating ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Adrenergic agonists for glaucoma  -  May 23, 2008
A commonly used adrenergic agonist (brimonidine tartrate) eyedrop has a purple ... Apraclonidine and brimonidine are used to treat high pressure in the eyes ... WebMD

Adjunctive Medications to Lower Intraocular Pressure Go Head-to-Head:...  -  Nov 13, 2007
Overall, 87% of patients receiving brimonidine Purite had a final IOP of less than 18 mmHg ... Most patients using brimonidine Purite experienced additional ... DG News

Panel weighs pros and cons of fixed combination therapy for glaucoma  -  Oct 17, 2005
The panel noted that the fixed combination product containing brimonidine tartrate 0.2% and timolol 0.5% (Combigan, Allergan) is a rationale choice since it ... Ophthalmology Times

Allergan receives FDA nod for glaucoma drug Combigan  -  Nov 3, 2007
Allergan, Inc. announced that the US Food and Drug Administration has approved Combigan (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2 per ... pharmabiz.com

Allergan reports 20.1% rise in second-quarter product sales  -  Aug 1, 2008
Alphagan P (brimonidine tartrate 0.15%), Alphagan (brimonidine tartrate) and Combigan (0.2% brimonidine tartrate, 0.5% timolol maleate) sales totaled ... OSN SuperSite

Education Affiliates Inc acquires RETS Technical Center - Deal...  -  Jan 2, 2006
...(brimonidine). Falcon is an affiliate of Alcon, Inc. the world…he results of this multi-center, randomized, double-blind, placebo-controll… ... Pay-Per-View - deals - Alacra Store

Fixed combination glaucoma medications await US approvals  -  Nov 1, 2005
The timolol-brimonidine fixed combo only recently became available in parts of Europe, he said. The drug, marketed as Combigan by Allergan, was approved by ... OSN SuperSite

A prospective ultrasound biomicroscopy evaluation of changes in...  -  Jun 16, 2008
After the intervention, patients were given one drop of brimonidine and prednisolone eye drops (qid) for 7 days. All patients gave written informed consent ... Nature.com

The pregnant glaucoma patient: here, we demystify the safety of …  -  Sep 15, 2006
Most topical glaucoma medications are class C, except for brimonidine and ... However, brimonidine may cross the placental barrier, and we do not know if it ... Free with registration - Review of Optometry - AccessMyLibrary.com

ASK AN EXPERT  -  Jul 17, 2008
Examples include apraclonidine (Iopidine) and brimonidine (Alphagan). Possible side effects include fatigue; dizziness; red, itchy or swollen eyes; ... CNN International

Tartrato de brimonidina: su eficacia para reducir halos después de...  -  Sep 10, 2008
Brimonidine tartrate 0.2% twice daily vs timolol 0.5% twice daily: 1-year ... The efficacy of brimonidine in decreasing elevations in intraocular pressure ... Intramed.net - Intramed.net (Suscripción)

Glaucoma In-Depth Report  -  Sep 13, 2006
Brimonidine is proving to be particularly effective for long-term therapy. ... The most common side effects of brimonidine and apraclonidine are dry mouth ... New York Times

FDA Approvals: Aceon, 0.1% Alphagan P, Namenda Oral Solution  -  Aug 25, 2005
19, the FDA approved a 0.1% formulation of brimonidine tartrate ophthalmic solution (Alphagan P, made by Allergan, Inc.) for lowering intraocular pressure ... Medscape

Costs Rising to Make Intraocular Pressure Fall  -  Dec 28, 2007
Generic brimonidine tartrate 0.2% was less expensive, but again the 15.0 mL bottle was actually more expensive than the 10.0 mL bottle at $383.82 and ... MedPage Today

Indication of Alphagan Eye Drops:  -  Aug 2, 2008
Alphagan contains a drug called brimonidine. Brimonidine reduces the fluid produced in the eye and increases the flow of fluid out of the eye, thus lowering ... Virtual Medical Centre - The Virtual Medical Centre

Article: Dementia from glaucoma eye drops?(MEDICAL MAILBOX)(Brief …  -  Sep 1, 2006
My wife has been using Cosopt, Xalatan, and brimonidine to treat glaucoma. ... A link between the use of Xalatan or brimonidine and dementia has not been ... Pay-Per-View - Saturday Evening Post - HighBeam Research

Contact lens measures drug concentration in the anterior eye  -  Dec 1, 2005
This reference scan was then subtracted from signal scans taken in recorded intervals after application of fluorescein or brimonidine, two ocular solutions ... Laser Focus World Magazine

Press Release: Lotus Pharmaceuticals, Inc. Announces First Quarter …  -  May 21, 2008
We focused our sales efforts on our top selling products, Brimonidine Tartrate Eyes Drops and VALSARTAN Capsules, and continued to distribute higher-margin, ... Pay-Per-View - PR Newswire - HighBeam Research

Allergan gains FDA appro for Combigan.  -  Nov 12, 2007
The US Food and Drug Administration has approved Allergan's Combigan (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5%, ... $4.95 - Pharma Marketletter - ECNext

New formulation of Allergan's Alphagan P receives US FDA approval.  -  Aug 19, 2005
The new product is an optimised formulation of Alphagan (brimonidine tartrate ophthalmic solution) 0.2% and was developed to further minimise drug exposure ... Pay-Per-View - Company Reports - Factiva, from Dow Jones

Allergan Reports First Quarter Operating Results; Pharmaceutical...  -  Mar 31, 2006
...for the District of Delaware contending that Alcon's proposed brimonidine 0.15% product infringed two brimonidine-related patents owned by Allergan. ... businesswire.com

Factiva Search  -  Oct 15, 2005
Refractive Surgery; Brimonidine and dapiprazole have similar effects on pupil size. 15 October, 2005 Obesity, Fitness & Wellness Week ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

Woman referred for pressure in left eye  -  Sep 15, 2006
...eye found narrow angles and IOP of 36 mm Hg. She was subsequently given brimonidine-P 0.15%, dorzolamide hydrochloride-timolol maleate and latanoprost. ... OSN SuperSite

Efficacy, once-daily convenience make drug good choice: formulation …  -  Jan 15, 2006
Brimonidine had the second greatest IOP-lowering effect at peak (-25%), but was much less efficacious at trough (-18%). Data from placebo-treated patients ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Early diagnosis, diurnal IOP control among hot topics in glaucoma  -  Sep 15, 2006
Because timolol is a once-a-day drug and brimonidine is a twice-a-day drug, this creates some systemic issues. But the efficacy results were impressive. ... OSN SuperSite

Contact lens measures drug concentration  -  Jan 1, 2006
This reference scan was then subtracted from signal scans taken in recorded intervals after application of fluorescein or brimonidine, two ocular solutions ... Laser Focus World Magazine

Factiva Search  -  Oct 11, 2005
Refractive Surgery; Brimonidine and dapiprazole have similar effects on pupil size. 11 October, 2005 Science Letter. 2005 OCT 11 - (NewsRx.com) ... Pay-Per-View - Science Letter - Factiva, from Dow Jones

Allergan Reports First Quarter Operating Results and Increases Full...  -  Apr 27, 2005
...--The FDA issued an approvable letter for Alphagan(R) Z (brimonidine tartrate ophthalmic solution), for the lowering of intraocular pressure in patients ... $4.95 - Business Wire - ECNext

고안압ì¦?·녹내장ì—? 보조·대치 치료제  -  Nov 1, 2007
...엘러간(Allergan)� 안압강하제 '콤비간'(Combigan, brimonidine/ timolol)� 미국 ... 콤비간� �미 승�� 녹내장 치료제 '알파간'(Alphagan, brimonidine)� 티모 ... 디지틀보사

Allergan Reports First Quarter Operating Results; Pharmaceutical...  -  May 3, 2006
...for the District of Delaware contending that Alcon's proposed brimonidine 0.15% product infringed two brimonidine-related patents owned by Allergan. ... $4.95 - Business Wire - ECNext

Grand Rounds: could occupational exposure to n-Hexane and other …  -  Jan 1, 2007
A therapy with idebenone (270 mg/day) and brimonidine (2 drops, 3times/day) was initiated (Mashima et al. 2000; Newman et al. 2005). ... $4.95 - Environmental Health Perspectives - ECNext

Laser trabeculoplasty for glaucoma  -  May 23, 2008
This complication can be prevented by using apraclonidine or brimonidine before or after laser surgery, especially in people with high intraocular pressure ... WebMD

Northwest, Merck, HJ Heinz  -  Aug 20, 2005
The new formulation is a 0.1% brimonidine tartrate ophthalmic solution as opposed to the original 0.2% formulation. A shareholder derivative complaint has ... MarketWatch

Glaucoma and vision 2020  -  Oct 15, 2008
Alpha agonists, like Cannabis sativa derivatives (Canasol - a product unique to Jamaica, and prepared from ganja), and brimonidine (Alphagan) are examples. ... Jamaica Gleaner

Article: Pacific Communications has been named agency of record for …  -  Jan 1, 2007
Allergan said the FDA approved Combigan (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5%, for the reduction of elevated intraocular ... Pay-Per-View - Medical Marketing & Media - HighBeam Research

Beta-blockers for glaucoma  -  May 23, 2008
Beta-blockers are often used in combination with a cholinergic, a carbonic anhydrase inhibitor, newer adrenergic agents such as brimonidine (Alphagan), ... WebMD

ZP120 causes relaxation by pre-junctional inhibition of noradrenergic...  -  Nov 1, 2007
The 2 -adrenoceptor antagonist, rauwolscine, antagonized the effect of clonidine and brimonidine, but ZP120 and N/OFQ inhibition of EFS-evoked contraction ... Nature.com

24-h blood pressure monitoring in normal tension glaucoma: night-time...  -  Apr 5, 2005
In all, 21 patients were on local IOP-lowering medications (-blockers, adrenaline, carbonic anhydrase inhibitors, brimonidine, prostaglandins or ... Nature.com

Cost of glaucoma medications may impact treatment  -  Dec 30, 2007
The generic selective a2-agonist brimonidine tartrate 0.2% costs approximately $352.89 and $529.34 per year for the respective two and three drops daily per ... The Hindu

Corneal topographic response to intraocular pressure reduction in …  -  Nov 4, 2005
...were given acetazolamide for 3 days and simultaneously started on topical antiglaucoma treatment -0.2% brimonidine, 0.5% timolol, or 0.005% latanoprost. ... Nature.com

Loislaw Federal District Court Opinions - McELHINNEY v. ASTRUE (Ariz....  -  Aug 12, 2008
Alprazolam to help with sleep and anxiety, Brimonidine Tartrate and Travoprost for ... Amoxicillin/Clavulanate for infection, Brimonidine for glaucoma, ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Fusion Power - 대중경제문화지 '헤럴드경제'  -  Jul 11, 2007
...콤비간� 브리모니딘(Brimonidine)과 티몰롤(Timolol)� 복합제제로 약물복용순�� 와 안압저하를 �시� 만족시켜 준다. 브리모니딘� 녹내장 환�� 시신경 보호작용 ... 헤럴드경제

Lotus Pharmaceuticals Announces Third Quarter 2008 Results  -  Nov 18, 2008
This increase was attributable to strong sales for the Company's Brimonidine Tartrate Eye Drops, used in the treatment of glaucoma, and strong sales of a ... Genetic Engineering News - Genetic Engineering News (press release)

Allergan Reports Fourth Quarter Operating Results.(Financial report)  -  Jan 31, 2007
On December 21, 2006, Allergan announced that the FDA issued an approvable letter for COMBIGAN[TM] (brimonidine tartrate/timolol maleate ophthalmic ... Free with registration - Business Wire - AccessMyLibrary.com

Senior Health Report: Eye Disease  -  Jan 3, 2007
Lantanoprost Reported More Effective in Treating Glaucoma: Lantanoprost is more effective than brimonidine in reducing diurnal intraocular pressure in ... Senior Health Report

TheSUBWAY.coms Early Stock Market Alerts for Wednesday, July 25, …  -  Jul 25, 2007
Brimonidine tartrate eye drops for the treatment of glaucoma and ocular hypertension, with annual sales estimated at $4 million. ... Free with registration - M2 Presswire - AccessMyLibrary.com

SLT comparable with medical therapy for open-angle glaucoma: added …  -  Jan 15, 2007
In the third step, brimonidine tartrate (Alphagan, Allergan) was added or substituted, and in the fourth step, dorzolamide (Trusopt, Merck), ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

OCULAR SURGERY NEWS US EDITION September 15, 2005  -  Sep 15, 2005
US regulators have granted marketing approval to Allergan's Alphagan P (brimonidine tartrate) 0.1% for the lowering of IOP in patients with open-angle ... OSN SuperSite

Genesis and Beijing Pharmaceuticals Partner Announce Four New Drugs …  -  May 11, 2006
Exclusive new drug curing open-angle glaucoma, alpha-2 Receptor Excitant-brimonidine tartrate material and eye drops (Muxin) was approved by the State SFDA ... primezone.com

Apraclonidine Eyedrops May Cause Severe Lethargy in Infants  -  Jul 5, 2007
The authors note that excessive sleepiness and lethargy were recently reported in 76% of children given brimonidine, a similar drug, and that some of these ... Medscape

SLT an evolutionary approach to glaucoma: selective laser, argon...  -  Aug 1, 2005
Step 3: If target IOP is not met but the second medication is deemed effective: brimonidine. Step 4: If the target IOP is not met, but the third medication ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Event Brief of Q2 2005 Allergan Earnings Conference Call - Final.  -  Jul 27, 2005
In glaucoma, AGN is currently marginally losing market share due to the gradual incursion of brimonidine generics, and the decline of older products such as ... Free with registration - Fair Disclosure Wire - AccessMyLibrary.com

Patient presents with blurred, decreased vision  -  Nov 15, 2007
The patient had her IOP controlled with topical brimonidine, dorzolamide and timolol, while her inflammation was treated with topical prednisolone acetate ... OSN SuperSite

AAO 2007 New Orleans exhibitor's guide.(Special Section: AAO Exhibitor...  -  Nov 1, 2007
Allergan's commitment to eye care includes bimatoprost ophthalmic solution 0.03% (Lumigan); brimonidine tartrate ophthalmic solution 0.1% and 0.15% ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Event Brief of Q3 2007 Allergan Earnings Conference Call - Final.  -  Nov 6, 2007
COMBIGAN is an important part of AGN's strategy for long-term mgt. of overall brimonidine franchise. 6. With COMBIGAN, co. has strong method of use patent ... Free with registration - Fair Disclosure Wire - AccessMyLibrary.com

New pharmaceutical products for glaucoma in the pipeline  -  Nov 10, 2007
Three prostaglandin combinations have been approved in some major markets, while a brimonidine/timolol combination is approved in much of the world, ... Ophthalmology Times

Woman referred for progressing unilateral glaucoma  -  May 15, 2007
Ocular medications included timolol twice daily in the right eye, brimonidine twice daily in the right eye and dorzolamide every night in the right eye. ... OSN SuperSite

Piggyback IOL may resolve poor postop acuity, halos  -  Oct 1, 2005
After ruling out IOL exchange and Alphagan (brimonidine tartrate, Allergan) and pilocarpine drops as treatment options, Dr. Ernest drew on his experience ... OSN SuperSite

Lotus Pharmaceuticals Announces Second Quarter 2008 Results  -  Aug 18, 2008
This increase was because of increased sales of third- party pharmaceuticals and increased sales of the Company's Brimonidine Tartrate Eyes Drops (sold ... Genetic Engineering News - Genetic Engineering News (press release)

Ophthalmologists face reimbursement cuts despite some gains in eye …  -  Dec 1, 2007
Combigan consists of two already-approved therapies, brimonidine tartrate 0.2% and timolol maleate 0.5%. It is expected to enter the US market by the end of ... OSN SuperSite

RCI Reclassifies Steroids as Class 3  -  Aug 23, 2008
6--Brimonidine is an alpha adrenergic receptor agonist that has recently been approved by the US FDA for use in people. The Board voted to include this in ... BloodHorse

Meticulous attention to detail can help prevent or manage surgical …  -  Sep 1, 2007
Alphagan (brimonidine tartrate, Allergan) can help reduce some pupils with different lighting conditions and will not constrict, he said. ... OSN SuperSite

Allergan Reports Second Quarter Operating Results and Increases Full ...  -  Jun 24, 2005
The FDA issued an approvable letter for Alphagan(R) Z (brimonidine tartrate ophthalmic solution) for the lowering of intraocular pressure in patients with ... businesswire.com

Combigan.(Approvable designations)(Drug overview)(Brief article)  -  Feb 1, 2007
Brimonidine/timolol ophthalmic solution, 0.2%/0.5% (Combigan, Allergan) for the reduction of elevated intraocular pressure (IOP) in patients with glaucoma ... Free with registration - Formulary - AccessMyLibrary.com

Getting started in therapeutics (C7947)  -  Nov 30, 2007
Brimonidine (Alphagan) can be used long-term as monotherapy where beta blockers are contraindicated or as adjunctive therapy in primary open angle glaucoma ... Optician Online

Generic Ophthalmic Medications: As Good as a Xerox?  -  Nov 26, 2008
An exception to the general rule of erosion by generic products into a branded market in ophthalmology is generic brimonidine and formulations of the ... Medscape

Divesting APIs  -  Feb 15, 2008
...used in Betagan, and Brimonidine, used in Alphagan and Alphagan-R. In October 2005, NPIL collaborated with AstraZeneca (Sweden) to develop processes for ... Express Pharma

Allergan Reports Second Quarter Operating Results and Increases Full ...  -  Jul 27, 2005
...--The FDA issued an approvable letter for Alphagan(R) Z (brimonidine tartrate ophthalmic solution) for the lowering of intraocular pressure in patients with ... $4.95 - Business Wire - ECNext

Last-minute 2006 US FDA decisions end with mostly "approvable"...  -  Jan 8, 2007
California, USA-based pharmaceutical firm Allergan's drug Combigan (brimonidine tartrate/timolol maleate opthalmic solution) 0.2%/0.5%, under development as ... $9.94 - Pharma Marketletter - Alacra Store

Last-minute 2006 US FDA decisions end with mostly "approvable" letters  -  Jan 4, 2007
California, USA-based pharmaceutical firm Allergan's drug Combigan (brimonidine tartrate/timolol maleate opthalmic solution) 0.2%/0.5%, under development as ... Pay-Per-View - Pharma Marketletter - Factiva, from Dow Jones

Brand Names/Synonyms:
Brimonidine is also known by the following brand names and/or synonymsAlphagan; Alphagan P; Brimonidine; Brimonidine Tartrate; Bromoxidine; CHEMBANK1623

Drug Category:
Brimonidine is categorized under the following by the FDA: Antihypertensive Agents; EENT Drugs; ATC:S01EA05

Dosage Forms:
0.2% solution

Absorption:
Minimal systemic absorption occurs after ocular insertion.

Interactions:
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Chemical IUPAC Name:
5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine





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