Brimonidine tartrate

This page contains recent news articles, when available, and an overview of Brimonidine tartrate but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Brimonidine tartrate
(when available)

Pharmacology and use:
Brimonidine significantly lowers intraocular pressure with minimal effects on cardiovascular and pulmonary parameters. It lowers intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow. For the lowering of intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

Mechanism Of Action:
Brimonidine is an alpha adrenergic receptor agonist. It has a peak ocular hypotensive effect occurring at two hours post-dosing. Fluorophotometric studies in animals and humans suggest that Brimonidine has a dual mechanism of action by reducing aqueous humor production and increasing uveoscleral outflow.

News Articles on Brimonidine

Allergan wins brimonidine patent infringement case  -  ‎Nov 4, 2009‎
...purported generic versions of the company's formulations of brimonidine tartrate 0.1% and 0.15% (Alphagan P) for ocular hypertension and glaucoma. ... ModernMedicine

Allergan wins patent infringement suit over generic versions of brimonidine  -  ‎Oct 30, 2009‎
Allergan filed the suit claiming the defendants infringed on the patent for Alphagan (brimonidine tartrate ophthalmic solution 0.1% and 0.15%) when seeking ... OSN SuperSite

Allergan Reports Third Quarter 2009 Operating Results  -  ‎Oct 29, 2009‎
...proposed generic versions of Allergan`s ALPHAGAN P (brimonidine tartrate ophthalmic solution) 0.1% and 0.15% products infringe Allergan`s patents. ... Reuters

Allergan wins brimonidine patent infringement case against Exela PharmSci & Apotex  -  ‎Oct 27, 2009‎
...the 'Defendants') for seeking to market purported generic versions of Allergan's drugs Alphagan P (brimonidine tartrate ophthalmic solution) 0.1% and ... pharmabiz.com

… for COMBIGAN(TM) (brimonidine tartrate/timolol maleate ophthalmic  -  Dec 21, 2006
COMBIGAN(TM) includes two agents known to reduce IOP - ALPHAGAN(R) (brimonidine tartrate ophthalmic solution 0.2%) and timolol ophthalmic solution 0.5%, ... Genetic Engineering News - Genetic Engineering News (press release)

Study: Brimonidine tartrate shows short-term efficacy for reducing...  -  Jun 10, 2008
Brimonidine tartrate can successfully reduce halo size and pupil size in patients with night-vision symptoms after LASIK, a small 24-hour study by ... OSN SuperSite

… for COMBIGAN(TM) (brimonidine tartrate/timolol maleate ophthalmic ...  -  Oct 31, 2007
Allergan, Inc. (NYSE:AGN) today announced that the US Food and Drug Administration has approved COMBIGAN([TM]) (brimonidine tartrate/timolol maleate ... $4.95 - Business Wire - ECNext

Article: Allergan said the FDA approved Combigan (brimonidine...  -  Dec 1, 2007
Allergan said the FDA approved Combigan (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5%.(Pipeline) ... find Medical Marketing & Media ... Pay-Per-View - Medical Marketing & Media - HighBeam Research

Loislaw Federal District Court Opinions - ALLERGAN, INC. v. ALCON INC...  -  Dec 8, 2005
B. Brimonidine Tartrate, Its Uses, and Allergan's Market Exclusivity The ... Alpha-2-adrenergic agonists, including brimonidine tartrate, are used to treat ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Changes in visual function after intraocular pressure reduction using...  -  Aug 1, 2008
Not all patients were receiving antiglaucoma treatment when included in the study, and they randomly received timolol maleate 0.5%, brimonidine tartrate ... Nature.com

Loislaw Federal District Court Opinions - ALLERGAN v. ALCON (Del. …  -  Dec 4, 2005
B. Brimonidine Tartrate, Its Uses, and Allergan's Market Exclusivity The ... Alpha-2-adrenergic agonists, including brimonidine tartrate, are used to treat ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Allergan reports 23% rise in first-quarter total product net sales  -  May 8, 2008
Alphagan P (brimonidine tartrate 0.15%), Alphagan (brimonidine tartrate) and Combigan (0.2% brimonidine tartrate, 0.5% timolol maleate) sales totaled $99.5 ... OSN SuperSite

Allergan receives FDA nod for glaucoma drug Combigan  -  Nov 3, 2007
Allergan, Inc. announced that the US Food and Drug Administration has approved Combigan (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2 per ... pharmabiz.com

Alcon and Allergan Reach Agreement on Brimonidine 0.15% Patent …  -  Mar 9, 2006
The first lawsuit was filed by Allergan in the US District Court for the District of Delaware claiming that Alcon's proposed brimonidine tartrate 0.15% ... Free with registration - Business Wire - AccessMyLibrary.com

Allergan reports 20.1% rise in second-quarter product sales  -  Aug 1, 2008
Alphagan P (brimonidine tartrate 0.15%), Alphagan (brimonidine tartrate) and Combigan (0.2% brimonidine tartrate, 0.5% timolol maleate) sales totaled ... OSN SuperSite

FDA Approvals: Aceon, 0.1% Alphagan P, Namenda Oral Solution  -  Aug 25, 2005
19, the FDA approved a 0.1% formulation of brimonidine tartrate ophthalmic solution (Alphagan P, made by Allergan, Inc.) for lowering intraocular pressure ... Medscape

Watch for toxic brimonidine exposure in children.(Clinical Rounds)(Bri...  -  Sep 1, 2006
SAN FRANCISCO -- Toxic exposures to brimonidine tartrate affected 43-55 patients per year between 2000 and 2005, and more than half of them were children 5 ... Free with registration - Family Practice News - AccessMyLibrary.com

New formulation of Allergan's Alphagan P receives US FDA approval.  -  Aug 19, 2005
The new product is an optimised formulation of Alphagan (brimonidine tartrate ophthalmic solution) 0.2% and was developed to further minimise drug exposure ... Pay-Per-View - Company Reports - Factiva, from Dow Jones

Allergan gains FDA appro for Combigan.  -  Nov 12, 2007
The US Food and Drug Administration has approved Allergan's Combigan (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5%, ... $4.95 - Pharma Marketletter - ECNext

Watch for toxic brimonidine exposure in children.(Clinical Rounds)(Bri...  -  Sep 1, 2006
SAN FRANCISCO -- Toxic exposures to brimonidine tartrate affected 43-55 patients per year between 2000 and 20... Pay-Per-View - Family Practice News - HighBeam Research

Press Release: Lotus Pharmaceuticals, Inc. Announces First Quarter …  -  May 21, 2008
We focused our sales efforts on our top selling products, Brimonidine Tartrate Eyes Drops and VALSARTAN Capsules, and continued to distribute higher-margin, ... Pay-Per-View - PR Newswire - HighBeam Research

Allergan Reports First Quarter Operating Results and Increases Full...  -  Apr 27, 2005
...--The FDA issued an approvable letter for Alphagan(R) Z (brimonidine tartrate ophthalmic solution), for the lowering of intraocular pressure in patients ... $4.95 - Business Wire - ECNext

Most brimonidine poisonings occur in child aged 5 or less.(Clinical …  -  Sep 1, 2006
Rounds) ... find Pediatric News articles. SAN FRANCISCO -- Toxic exposures to brimonidine tartrate affected 43-55 patients per year between 2000 and 20... Pay-Per-View - Pediatric News - HighBeam Research

Northwest, Merck, HJ Heinz  -  Aug 20, 2005
The new formulation is a 0.1% brimonidine tartrate ophthalmic solution as opposed to the original 0.2% formulation. A shareholder derivative complaint has ... MarketWatch

Cost of glaucoma medications may impact treatment  -  Dec 30, 2007
The generic selective a2-agonist brimonidine tartrate 0.2% costs approximately $352.89 and $529.34 per year for the respective two and three drops daily per ... The Hindu

Adrenergic agonists for glaucoma  -  May 23, 2008
A commonly used adrenergic agonist (brimonidine tartrate) eyedrop has a purple bottle cap. If you need to use more than one type of eyedrop, you may need to ... WebMD

Comparison study: brimonidine fares well as add-on therapy: addition...  -  Jan 15, 2008
New Orleans -- The addition of brimonidine tartrate 0.15 % (Alphagan P, Allergan) to a prostaglandin analog resulted in significantly greater reductions in ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Allergan Reports Fourth Quarter Operating Results.(Financial report)  -  Jan 31, 2007
On December 21, 2006, Allergan announced that the FDA issued an approvable letter for COMBIGAN[TM] (brimonidine tartrate/timolol maleate ophthalmic ... Free with registration - Business Wire - AccessMyLibrary.com

Akorn wins FDA approval for glaucoma treatment  -  Mar 20, 2006
The approval covers a solution of brimonidine tartrate, the active ingredient in Allergan Inc.'s Alphagan P. The solution works by decreasing the pressure ... Crain's Chicago Business

Costs Rising to Make Intraocular Pressure Fall  -  Dec 28, 2007
Generic brimonidine tartrate 0.2% was less expensive, but again the 15.0 mL bottle was actually more expensive than the 10.0 mL bottle at $383.82 and ... MedPage Today

Allergan Receives Positive Opinions for COMBIGAN(TM) From 21 …  -  Sep 28, 2005
Allergan's ALPHAGAN(R)/timolol combination product for glaucoma (brimonidine tartrate/timolol ophthalmic solution), from all twenty-one Concerned Member ... RedOrbit

Genesis and Beijing Pharmaceuticals Partner Announce Four New Drugs …  -  May 11, 2006
Exclusive new drug curing open-angle glaucoma, alpha-2 Receptor Excitant-brimonidine tartrate material and eye drops (Muxin) was approved by the State SFDA ... primezone.com

Lotus Pharmaceuticals Announces Third Quarter 2008 Results  -  Nov 18, 2008
This increase was attributable to strong sales for the Company's Brimonidine Tartrate Eye Drops, used in the treatment of glaucoma, and strong sales of a ... Genetic Engineering News - Genetic Engineering News (press release)

SLT comparable with medical therapy for open-angle glaucoma: added …  -  Jan 15, 2007
In the third step, brimonidine tartrate (Alphagan, Allergan) was added or substituted, and in the fourth step, dorzolamide (Trusopt, Merck), ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

OCULAR SURGERY NEWS US EDITION September 15, 2005  -  Sep 15, 2005
US regulators have granted marketing approval to Allergan's Alphagan P (brimonidine tartrate) 0.1% for the lowering of IOP in patients with open-angle ... OSN SuperSite

TheSUBWAY.coms Early Stock Market Alerts for Wednesday, July 25, …  -  Jul 25, 2007
Brimonidine tartrate eye drops for the treatment of glaucoma and ocular hypertension, with annual sales estimated at $4 million. ... Free with registration - M2 Presswire - AccessMyLibrary.com

Panel weighs pros and cons of fixed combination therapy for glaucoma  -  Oct 17, 2005
The panel noted that the fixed combination product containing brimonidine tartrate 0.2% and timolol 0.5% (Combigan, Allergan) is a rationale choice since it ... Ophthalmology Times

Lotus Pharmaceuticals Announces Second Quarter 2008 Results  -  Aug 18, 2008
This increase was because of increased sales of third- party pharmaceuticals and increased sales of the Company's Brimonidine Tartrate Eyes Drops (sold ... Genetic Engineering News - Genetic Engineering News (press release)

Article: Allergan patents self tanning method. - Household & Personal...  -  Aug 1, 2006
Ophthalmology Times; April 15, 2006 ; 692 words ... ... s proposed brimonidine tartrate 0.15% solution made with polyquaternium-1 (Polyquad) preservative ... Pay-Per-View - Household & Personal Products Industry - HighBeam Research

Fixed combination glaucoma medications await US approvals  -  Nov 1, 2005
Combigan (timolol maleate 0.5%, brimonidine tartrate 0.2%, Allergan) and an as-yet unbranded combination of bimatoprost and timolol, also from Allergan. ... OSN SuperSite

Meticulous attention to detail can help prevent or manage surgical …  -  Sep 1, 2007
Alphagan (brimonidine tartrate, Allergan) can help reduce some pupils with different lighting conditions and will not constrict, he said. ... OSN SuperSite

Prasco Laboratories Pictures from October 28, 2008 | HighBeam …  -  Oct 28, 2008
R]) (bimatoprost ophthalmic solution) 0.03% and ALPHAGAN ... P (brimonidine tartrate ophthalmic solution) 0.1% and 0.15 ... ... Pay-Per-View - AP Images - HighBeam Research

Allergan Reports Second Quarter Operating Results and Increases Full ...  -  Jun 24, 2005
The FDA issued an approvable letter for Alphagan(R) Z (brimonidine tartrate ophthalmic solution) for the lowering of intraocular pressure in patients with ... businesswire.com

Ophthalmologists face reimbursement cuts despite some gains in eye …  -  Dec 1, 2007
Combigan consists of two already-approved therapies, brimonidine tartrate 0.2% and timolol maleate 0.5%. It is expected to enter the US market by the end of ... OSN SuperSite

AAO 2007 New Orleans exhibitor's guide.(Special Section: AAO Exhibitor...  -  Nov 1, 2007
Allergan's commitment to eye care includes bimatoprost ophthalmic solution 0.03% (Lumigan); brimonidine tartrate ophthalmic solution 0.1% and 0.15% ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Piggyback IOL may resolve poor postop acuity, halos  -  Oct 1, 2005
After ruling out IOL exchange and Alphagan (brimonidine tartrate, Allergan) and pilocarpine drops as treatment options, Dr. Ernest drew on his experience ... OSN SuperSite

Article: The effect of natural sunlight on ciprofloxacin ophthalmic...  -  Oct 1, 2005
R]) (bimatoprost ophthalmic solution) 0.03% and ALPHAGAN ... P (brimonidine tartrate ophthalmic solution) 0.1% and 0.15 ... ... Pay-Per-View - Journal of the Mississippi Academy of... - HighBeam Research

Article: Local Focus.(Business) - Daily Herald (Arlington Heights,...  -  Jul 28, 2007
R]) (bimatoprost ophthalmic solution) 0.03% and ALPHAGAN ... P (brimonidine tartrate ophthalmic solution) 0.1% and 0.15 ... ... Pay-Per-View - Daily Herald - HighBeam Research

Article: PediaMed has entered into a US co-promotion agreement for …  -  Apr 1, 2005
R]) (bimatoprost ophthalmic solution) 0.03% and ALPHAGAN ... P (brimonidine tartrate ophthalmic solution) 0.1% and 0.15 ... ... Pay-Per-View - Medical Marketing & Media - HighBeam Research

Combigen gets FDA approvable letter.  -  Jan 8, 2007
California, USA-based pharmaceutical firm Allergan says that Combigan (brimonidine tartrate/timolol maleate opthalmic solution) 0.2%/0.5%, under development ... $9.94 - Pharma Marketletter - Alacra Store

Allergan Reports Second Quarter Operating Results and Increases Full ...  -  Jul 27, 2005
...--The FDA issued an approvable letter for Alphagan(R) Z (brimonidine tartrate ophthalmic solution) for the lowering of intraocular pressure in patients with ... $4.95 - Business Wire - ECNext

Last-minute 2006 US FDA decisions end with mostly "approvable" letters  -  Jan 4, 2007
California, USA-based pharmaceutical firm Allergan's drug Combigan (brimonidine tartrate/timolol maleate opthalmic solution) 0.2%/0.5%, under development as ... Pay-Per-View - Pharma Marketletter - Factiva, from Dow Jones

Combigan.  -  Dec 10, 2007
Allergan Inc., Irvine, Calif., (714) 246-4500, has FDA approval for Combigan (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5%. ... $9.94 - Drug Topics - Alacra Store

Press Release: International Survey Shows People Over Forty Ignore …  -  Oct 2, 2007
R)/timolol combination product for glaucoma (brimonidine tartrate/timolol ophthalmic ... in patients with chronic open-angle glaucoma or ocular hypertension ... Pay-Per-View - PR Newswire Europe - HighBeam Research

Press Release: Allergan Receives Positive Opinions for COMBIGAN(TM) …  -  Sep 29, 2005
Allergan's ALPHAGAN(R)/timolol combination product for glaucoma (brimonidine tartrate/timolol ophthalmic solution), from all twenty-one Concerned Member ... Pay-Per-View - PR Newswire Europe - HighBeam Research

FDA clears new formulation of Allergan's Alphagan P.(Food and Drug …  -  Aug 29, 2005
...the Food and Drug Administration to market a new formulation of its ocular hypertension drug Alphagan P (brimonidine tartrate ophthalmic solution) 0.1%. ... $4.95 - Pharma Marketletter - ECNext

Factiva Search  -  Jan 3, 2007
California, USA-based pharmaceutical firm Allergan says that Combigan (brimonidine tartrate/timolol maleate opthalmic ... Copyright 2007. ... Pay-Per-View - Pharma Marketletter - Factiva, from Dow Jones

FDA APPROVES LESS POTENT FORMULA OF ALPHAGAN GLAUCOMA …  -  Aug 23, 2005
The new formulation of Alphagan contains 0.1 percent of the active ingredient, brimonidine tartrate ophthalmic solution, while the original Alphagan ... Pay-Per-View - FDAnews Drug Pipeline Alert - Factiva, from Dow Jones

Florida Administrative Code - 64B13-18.002 Formulary of Topical...  -  Jul 5, 2005
Brimonidine tartrate — 0.15%, 0.2%; and 2. Apraclonidine HCI — 0.5%. (e) Carbonic Anhydrase Inhibitors (CAI's) 1. Brinzolamide — 1.0%; and 2. ... Pay-Per-View - Florida Administrative Code - Loislaw

OVER THE COUNTER: New prescription product - Combigan.(Brief …  -  Jun 4, 2005
Eye drops containing brimonidine tartrate 2mg and timolol 5mg per 5ml Usual dose: one drop into the affected eye twice daily Cautions: should not be used in ... $4.95 - Chemist & Druggist - ECNext

Article: Pacific Communications has been named agency of record for …  -  Jan 1, 2007
Allergan said the FDA approved Combigan (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5%, for the reduction of elevated intraocular ... Pay-Per-View - Medical Marketing & Media - HighBeam Research

Combigan for glaucoma.(Brief Article)  -  Jun 21, 2005
Allergan has launched Combigan eye drops (brimonidine tartrate 2mg, timolol 5mg) for reducing intraocular pressure in patients with chronic open-angle ... $4.95 - Community Pharmacy - ECNext

OVER THE COUNTER: New prescription product - Combigan.  -  Jun 4, 2005
Eye drops containing brimonidine tartrate 2mg and timolol 5mg per 5ml For reducing pressure in the eye in patients with chronic open-angle glaucoma or ... $9.94 - Chemist & Druggist - Alacra Store

Combigan for glaucoma.  -  Jun 21, 2005
Allergan has launched Combigan eye drops (brimonidine tartrate 2mg, timolol 5mg) for reducing intraocular pressure in patients with chronic open-angle ... $9.94 - Community Pharmacy - Alacra Store

Tartrato de brimonidina: su eficacia para reducir halos después de...  -  Sep 10, 2008
Brimonidine tartrate 0.2% twice daily vs timolol 0.5% twice daily: 1-year results in glaucoma patients; the Brimonidine Study Group. Am J Ophthalmol 1999; ... Intramed.net - Intramed.net (Suscripción)

Loislaw Federal District Court Opinions - McELHINNEY v. ASTRUE (Ariz....  -  Aug 12, 2008
Flunisolide nasal spray, Omeprazole "for stomach (should help asthma)", Alprazolam to help with sleep and anxiety, Brimonidine Tartrate and Travoprost ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Brand Names/Synonyms:
Brimonidine tartrate is also known by the following brand names and/or synonymsAlphagan; Alphagan P; Brimonidine; Brimonidine Tartrate; Bromoxidine; CHEMBANK1623

Drug Category:
Brimonidine tartrate is categorized under the following by the FDA: Antihypertensive Agents; EENT Drugs; ATC:S01EA05

Dosage Forms:
0.2% solution

Absorption:
Minimal systemic absorption occurs after ocular insertion.

Interactions:
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Chemical IUPAC Name:
5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine





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