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CalcijexThis page contains recent news articles, when available, and an overview of Calcijex but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Calcijex (when available) Calcitriol, a pharmaceutical form of vitamin D, has anti-osteoporotic, immunomodulatory, anticarcinogenic, antipsoriatic, antioxidant, and mood-modulatory activities. Calcitriol has been found to be effective in the treatment of psoriasis when applied topically. Calcitriol has been found to induce differentiation and/or inhibit cell proliferation in a number of malignant cell lines including human prostate cancer cells. Vitamin D deficiency has long been suspected to increase the susceptibility to tuberculosis. The active form of Calcitriol, 1,25 (OH)2 D, has been found to enhance the ability of mononuclear phagocytes to suppress the intracellular growth of Mycobacterium tuberculosis. 1,25(OH)2D has demonstrated beneficial effects in animal models of such autoimmune diseases as rheumatoid arthritis. It has also been found to induce monocyte differentiation and to inhibit lymphocyte proliferation and production of cytokines, including interleukin IL-1 and IL-2, as well as to suppress immunoglobulin secretion by B lymphocytes. Vitamin D appears to demonstrate both immune-enhancing and immunosuppressive effects. Used to treat vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis. Mechanism Of Action: The mechanism of action of Calcitriol in the treatment of psoriasis is accounted for by their antiproliferative activity for keratinocytes and their stimulation of epidermal cell differentiation. The anticarcinogenic activity of the active form of Calcitriol appears to be correlated with cellular vitamin D receptor (VDR) levels. Vitamin D receptors belong to the superfamily of steroid-hormone zinc-finger receptors. VDRs selectively bind 1,25(OH)2D and retinoic acid X receptor (RXR) to form a heterodimeric complex that interacts with specific DNA sequences known as vitamin D-responsive elements. VDRs are ligand-activated transcription factors. The receptors activate or repress the transcription of target genes upon binding their respective ligands. It is thought that the anticarcinogenic effect of Calcitriol is mediated via VDRs in cancer cells. The immunomodulatory activity of Calcitriol is thought to be mediated by vitamin D receptors (VDRs) which are expressed constitutively in monocytes but induced upon activation of T and B lymphocytes. 1,25(OH)2D has also been found to enhance the activity of some vitamin D-receptor positive immune cells and to enhance the sensitivity of certain target cells to various cytokines secreted by immune cells. News Articles on Calcitriol PMPRB Issues Notice Of Hearing: Abbott Laboratories, Limited And The ... - Aug 21, 2007 Furthermore, it recommended the product CALCIJEX as the most appropriate, and only, comparator medicine for purposes of a therapeutic class comparison (TCC) ... Free with registration - Mondaq Business Briefing - AccessMyLibrary.com HEART DISEASE In middle-aged ... | Article from The Washington Post |... - Mar 15, 2005 About 73 percent got vitamin D injections (mostly Calcijex or Zemplar). Injections were given for varying lengths of time; the average number of doses was ... Pay-Per-View - Washington Post - HighBeam Research IV versus PO Vitamin D: the road already traveled.(Controversies in … - May 1, 2006 IL) or injectable form--Hectorol, (Genzyme Corporation, Cambridge, MA), Calcijex[R], and Zemplar[TM] (Abbott Laboratories, Abbott Park, IL). ... Free with registration - Nephrology Nursing Journal - AccessMyLibrary.com VITAMIN D AND RELATED COMPOUNDS (Oral route, Parenteral route).( … - May 1, 2007 Calcijex * Delta D3 * DHT * DHT Intensol * Dovonex * Drisdol * Hectorol * Rocaltrol * Vitamin D * Zemplar Brand names in the Canada -- * D-Vi-Sol ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com IV versus PO Vitamin D: the road already traveled.(Controversies in … - May 1, 2006 IL) or injectable form--Hectorol, (Genzyme Corporation, Cambridge, MA), Calcijex[R], and Zemplar[TM] (Abbott Laboratories, Abbott Park, IL). ... Pay-Per-View - Nephrology Nursing Journal - HighBeam Research ABBOTT LABORATORIES - Mar 1, 2008 ...such as Zemplar®, Calcijex®, Simdax®, and Survanta®. Through a network of distributors, the. division distributes its products to government agencies, ... $3,450.00 - GLOBAL INDUSTRY ANALYSTS KEY PLAYERS - Alacra Store Arkansas Regulations - 272.451 Injections Conditionally Covered - Apr 2, 2008 90737 Hemophilus Influenza B, 2 months through 5 years of age J0170 Adrenalin Epinephrine, up to 1 ml ampule J0635 Injection, Calcitrol, 1mcg AMP, Calcijex, ... Pay-Per-View - Arkansas Regulations - Loislaw Press Release: Barr Challenging Patents Protecting Prozac(R) Weekly( … - May 11, 2006 These forward-looking statements represent the ... these forward-looking statements. Calcijex ... trademark of Eli Lilly and Company ... ... Pay-Per-View - PR Newswire - HighBeam Research Loislaw Federal District Court Opinions - IN RE PHARMACEUTICAL … - Aug 16, 2005 995.84 $ 125.00 $ 870.84 697% Calcitriol (Calcijex) $1390.66 $1079.00 $ 311.66 29% Cimetidine $ 214.34 $ 35.00 $ 179.34 512% Hydrochloride Clindamycin ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw Press Release: New Study Shows BOTOX(R) Injections for Treatment of … - Oct 4, 2006 Calcijex). An additional 6725 patients did not receive any Vitamin D treatment. Patients receiving paricalcitol averaged 9 ... ... Pay-Per-View - PR Newswire - HighBeam Research Brand Names/Synonyms: Calcijex is also known by the following brand names and/or synonymsCalcijex; Calcitriol; Rocaltrol Drug Category: Calcijex is categorized under the following by the FDA: ATC:A11CC04; ATC:D05AX03; Antihypocalcemic Agents; Antihypoparathyroid Agents; Essential Vitamin; Vitamins (Vitamin D) Dosage Forms: Capsule, solution Absorption: Rapidly absorbed from the intestine. Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: 5-[2-[1-(6-hydroxy-6-methyl-heptan-2-yl)-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol |
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