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CapecitabineThis page contains recent news articles, when available, and an overview of Capecitabine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Capecitabine (when available) Capecitabine is a fluoropyrimidine carbamate with antineoplastic activity indicated for the treatment of patients with metastatic breast cancer. It is an orally administered systemic prodrug of 5'-deoxy-5-fluorouridine (5'-DFUR) which is converted to 5-fluorouracil. For the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen Mechanism Of Action: Capecitabine is a prodrug that is selectively tumour-activated to its cytotoxic moiety, fluorouracil, by thymidine phosphorylase. Fluorouracil is further metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP), within normal and tumour cells. FdUMP inhibits DNA synthesis by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate.3 The active moiety of capecitabine, fluorouracil, is cell cycle phase-specific (Sphase). Both normal and tumor cells metabolize 5-FU to 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). These metabolites cause cell injury by two different mechanisms. First, FdUMP and the folate cofactor, N5-10-methylenetetrahydrofolate, bind to thymidylate synthase (TS) to form a covalently bound ternary complex. This binding inhibits the formation of thymidylate from 2'-deaxyuridylate. Thymidylate is the necessary precursor of thymidine triphosphate, which is essential for the synthesis of DNA, so that a deficiency of this compound can inhibit cell division. Second nuclear transcriptional enzymes can mistakenly incorporate FUTP in place of uridine triphosphate (UTP) during the synthesis of RNA. This metabolic error can interfere with RNA processing and protein synthesis. News Articles on Capecitabine Docetaxel Plus Capecitabine Shows More Benefit as First-Line Therapy for ... - Dec 12, 2009 SAN ANTONIO, Tex -- December 12, 2009 -- The combination of docetaxel and capecitabine is associated with an increased nonprogression ... DG News Results from Phase 2 trial evaluating Nexavar with capecitabine and paclitaxel ... - Dec 13, 2009 The first of these studies evaluated Nexavar® (sorafenib) tablets in combination with chemotherapy agent capecitabine and the second study evaluated Nexavar ... News-Medical.net Fighting cancer in a bureaucratic Catch-22 - Dec 18, 2009 To control her disease, Ms. Warkus's oncologist recommended a combination of two drugs: capecitabine and lapatinib. About 100 breast-cancer patients across ... Globe and Mail Xeloda® in Combination with Oxaliplatin Filed in Europe for the Adjuvant ... - Jan 4, 2010 Roche announced today that it has submitted an application to the European Medicines Agency (EMEA) to extend the label of Xeloda (capecitabine) for use in ... Pharmaceutical Processing SABCS: Mixed Results for Targeted Agents in Breast CA - Dec 13, 2009 A second study paring sorafenib and capecitabine (Xeloda) showed an improvement in PFS compared with capecitabine alone. Sunitinib (Sutent) was inferior to ... MedPage Today Nexavar in Combination With Chemotherapy Demonstrates Activity in Patients ... - Dec 11, 2009 The first of these studies evaluated Nexavar® (sorafenib) tablets in combination with chemotherapy agent capecitabine and the second study evaluated Nexavar ... CNNMoney.com (press release) Neratinib Shows Promise in Treatment of HER2-positive Breast Cancer - Dec 18, 2009 ...[4] Neratinib was also evaluated in combination with Xeloda® (capecitabine) in patients with solid tumors.[5] However, there is a paucity of response data ... Cancer Consultants Committee For Medicinal Products For Human Use Post-Authorisation Summary Of ... - Dec 18, 2009 The Marketing Authorisation Holder for this medicinal product is Roche Registration Ltd. Herceptin in combination with capecitabine or 5-fluorouracil and ... PharmaLive.com (press release) EU Panel Backs DuoCover From Bristol-Myers Squibb Pharma - Dec 18, 2009 ...who have not received prior anti-cancer treatment for their metastatic disease in combination with capecitabine or 5-fluorouracil and cisplatin. ... Wall Street Journal Avastin for breast cancer shines in PFS but not overall survival - Dec 15, 2009 ...in which patients with, in the main, heavily pretreated metastatic breast cancer were given Avastin as an add-on to capecitabine (Xeloda, Roche), ... Pharma Times APRIL is a novel clinical chemo-resistance biomarker in colorectal ... - Dec 11, 2009 5-Fluorouracil(5-FU) and oral analogues, such as capecitabine, remain one of the most useful agents for the treatment of colorectal adenocarcinoma. ... 7thSpace Interactive (press release) Gut Reaction - Dec 23, 2009 Among the 22 percent of them whose tumors overproduced HER2, almost 600 patients received a chemotherapy regimen of Xeloda (capecitabine) or 5-fluorouracil, ... Curetoday.com (press release) Herceptin receives positive opinion in record time for the treatment of HER2 ... - Dec 19, 2009 Xeloda (capecitabine) is a highly effective targeted oral chemotherapy offering patients a survival advantage when taken on its own or in combination with ... PipelineReview.com (press release) Avastin Plus Commonly Used Chemotherapies Improved Progression-Free Survival ... - Dec 11, 2009 Gemcitabine Alone Avastin Plus Capecitabine vs. Capecitabine Alone Avastin Plus (304 patients) (160 patients) (144 patients) Vinorelbine vs. ... FOXBusiness Ghosts, masturbation and weird findings - Dec 15, 2009 The journal Annals of Oncology issued a travel warning for the drug capecitabine, which lists inflammation of the hands and peeling palms among its side ... Herald Sun 심í?‰ì›? 진료심사í?‰ê°€å§”, 7ê°œ 심ì?˜ì‚¬ë¡€ 공개 - Dec 30, 2009 ...결장암으로 XELOX(capecitabine+Oxaliplatin), FOLFIRI(5-FU+LV+Irinotecan), FOLFOX(5-FU/LV+Oxaliplatin) 치료 후 실패해 XELIRI(capecitabine+Irinotecan)요법ì?„ ... 데일리메디 ìœ ë°©ì•” 약물 병용효과 ë˜? 나와 - Dec 13, 2009 ...ë˜? 지난 2007ë…„, 허셉틴과 'ì ¤ë¡œë‹¤'(Xeloda, capecitabine) 병용시ì—?ë?„ 효과가 있다는 주장ë?„ 나온바 있어 ì‹ ì„ ë?„는 떨어지는 편ì?´ë‹¤. 헬스코리아뉴스 Kombinationen av kemoterapi och Nexavar effektivt vid behandling av spridd ... - Dec 18, 2009 Resultaten visade att de som fÃ¥tt kombinationen av Nexavar och capecitabine hade 74 procent längre liv utan sjukdomsförsämring (sk progressionsfri ... MyNewsdesk (pressmeddelande) “ConfÃo que pronto estaré con mi vida normalâ€? - Dec 12, 2009 Orvin recibe tres tipos de quimioterapia: la primera es la pastilla Nexavar, que interviene en el crecimiento de células malas, también ingiere Capecitabine ... Diario deportvo DIEZ CBG: positief advies voor DuoCover, negatief advies voor Cerepro - Dec 24, 2009 ...voor hun metastaserende ziekte nog geen eerdere antikankerbehandeling hebben gekregen, in combinatie met capecitabine of 5-fluorouracil en cisplatine. ... Medical facts 晚期乳癌新機化療藥物 æ ¸å‡†ä¸Šå¸‚ä½¿ç”¨ - 14 Nov 2009 ...以å?Šè”¥ç’°é¡žçš„化療藥物，ä»?復發或是轉移的患者。試驗共分為兩組，一組是使用目å‰?標準治療的capecitabine，å?¦ä¸€çµ„則是å†?åŠ ä¸ŠEpothilone類的藥物來å?šæ²»ç™‚。試驗çµ?果發ç?¾ï¼š 自立晚報 Landmark Study in The Lancet Oncology Shows Capecitabine (Xeloda(R ... - Nov 12, 2009 The pre-planned three-year interim analysis of a randomised, prospective trial (known as FinXX) compared adjuvant capecitabine in combination with docetaxel ... PR Newswire (press release) Addition of capecitabine to standard chemotherapy regimen increased recurrence ... - Nov 10, 2009 The addition of capecitabine to a chemotherapy regimen containing standard agents reduced the incidence of breast cancer recurrence but yielded a higher ... HemOncToday Drug "lowers cancer recurrence" - Nov 11, 2009 The trial compared adjuvant capecitabine in combination with docetaxel and cyclophophamide plus epirubicin for the treatment of early breast cancer with the ... Pharmacy Europe NICE Rejects Glaxo's Tyverb For Advanced Breast Cancer >GSK - Oct 21, 2009 ...said Wednesday it has rejected GlaxoSmithKline PLC's (GSK) oral Tyverb (lapatinib) in combination with capecitabine for the treatment of an aggressive ... Wall Street Journal Cost Of Care - Nov 5, 2009 ...gained by colorectal cancer patients using new treatment regimens, including irinotecan, capecitabine, oxaliplatin, cetuximab, bevacizumab, and panitumumab. American Journal of Hemotology and Oncology Report Highlights Cancer Advances - Nov 9, 2009 Acknowledging the better survival in the capecitabine arm, Gluck took issue with the trial's clinical significance. "This is not major research. ... MedPage Today Clinic Roundup - Nov 11, 2009 ...recurrence taking Xeloda (capecitabine) as part of their chemotherapy regimen had a 34 percent reduction in the risk of the cancer returning or death. ... Therapeutics Daily (press release) (registration) ASCO Releases Annual Progress Report on Top Cancer Research Advances - Nov 11, 2009 Standard three-drug chemotherapy is more effective and less toxic than single-drug treatment with capecitabine ( Xeloda ) in women age 65 and older ... Media Newswire (press release) ZIOPHARM Reports Third Quarter Financial Results and Updated Clinical Progress - Nov 11, 2009 Most recently, results of oral indibulin in combination with oral capecitabine (Xeloda ® ) were presented at this year's American Society of Clinical ... Business Wire (press release) Addition of Xeloda® to Gemzar® Improves Outcomes in Pancreatic Cancer - Nov 2, 2009 ...that the addition of Xeloda® (capecitabine) to Gemzar® (gemcitabine) improves outcomes of patients with advanced or metastatic pancreatic cancer. ... Cancer Consultants Array BioPharma Reports Financial Results for the First Quarter of Fiscal 2010 - Nov 2, 2009 ...with solid tumors and three Phase 1b trials in combination with Xeloda® (capecitabine), Taxotere® (docetaxel) and Gemzar® (gemcitabine), respectively. ... WELT ONLINE Clinical benefits and costs of new treatments for advanced colorectal cancer - Nov 4, 2009 However, recent advances in translational research have led to the introduction of 3 new chemotherapy agents (irinotecan, capecitabine, and oxaliplatin) and ... American Journal of Hemotology and Oncology Pancreatic Cancer Report Urges Changes in Clinical Trials - Nov 3, 2009 ...patients saw little or no benefit from the experimental treatment, in this case a combination of gemcitabine (Gemzar) and capecitabine (Xeloda), ... National Cancer Institute - NCI Cancer Bulletin Bristol-Myers Squibb Achieves Strong Sales, Earnings Performance in Third Quarter - Oct 22, 2009 Another Phase III study of ERBITUX plus chemotherapy (primarily capecitabine plus oxaliplatin) in first-line mCRC, known as COIN, was conducted in the UK by ... Reuters Court Report - Oct 25, 2009 1995) following a Paragraph IV certification as part of Teva's filing of an ANDA to manufacture a generic version of Roche's Xeloda® (capecitabine, ... Patent Docs (blog) ImmunoGen, Inc. Reports First Quarter Fiscal Year 2010 Financial Results - Oct 29, 2009 ...have received an anthracycline, a taxane, trastuzumab, lapatinib and capecitabine in the neoadjuvant, adjuvant, locally advanced or metastatic setting. ... Reuters Bristol-Myers Squibb Achieves Strong Sales, Earnings Performance in Third Quarter - Oct 22, 2009 Another Phase III study of ERBITUX plus chemotherapy (primarily capecitabine plus oxaliplatin) in first-line mCRC, known as COIN, was conducted in the UK by ... Business Wire (press release) 위암 ì¹˜ë£Œì œ 시장 10ë…„ë’¤ 2ë°° 성장 - Nov 12, 2009 ...특히 로슈ì?˜ 허셉틴, 아바스틴, 'ì ¤ë¡œë‹¤'(Xeloda, capecitabine)는 2018ë…„ 매출ì?˜ 1/3ì?„ ì ?ìœ í• ê²ƒìœ¼ë¡œ 기대ë?œë‹¤. 단, 2012ë…„ì—?는 허셉틴ì?˜ ë°”ì?´ì˜¤ì‹œë°€ëŸ¬ê°€, ... 디지틀보사 COMUNICADO: Estudio en The Lancet Oncology muestra que la capecitabina reduce ... - Nov 11, 2009 Significant improvement in recurrence-free survival (RFS) when capecitabine (X) is integrated into docetaxel (T) 5-FU + epirubicin + cyclophosphamide (CEF) ... Europa Press 로슈, 타미플루와 아바스틴 ë?•ì—? 3분기 매출 급ì¦? - Oct 18, 2009 ...ë˜?í•œ 허셉틴(trastuzumab)ì?´ 8% ìƒ?승한 13.3ì–µ 프랑, 타세바(erlotinib)ê°€ 11% ìƒ?승한 3.19ì–µ 프랑, ì œë¡œë‹¤(capecitabine)ì?´ 11% ìƒ?승한 3.26ì–µ 프랑으로 나타났다. ... 메디포뉴스 Cáncer de mama, la causa más común de cáncer - Nov 5, 2009 ...demostró que la combinación de ixabepilona más capecitabine “es la opción terapéutica más adecuada para este subgrupo de pacientesâ€?, concluyó. ... Asteriscos La Dra. Linda Vahdat presentó los últimos avances en Cancer Triple Negativo ... - Oct 22, 2009 La misma mostró ser más eficiente en comparación con capecitabine monodroga (37% menor posibilidad de progresión de enfermedad HR 0,63 (0.47 – 0.84)), ... Noticias Médicas (Comunicado de prensa) Phase II study of oral capecitabine in patients with hormone-refractor... - Mar 23, 2005 Correspondence: H Pandha, Division of Oncology, Department of Cellular & Molecular Medicine, St George's Hospital Medical School, Cranmer Terrace, London, ... Nature.com A phase II study of capecitabine plus 3-weekly oxaliplatin as first... - Mar 21, 2006 Correspondence: Dr BS Kim, Department of Internal Medicine, Division of Haematology and Oncology, Seoul Veterans Hospital, 6-2, Dunchon-Dong, Kangdong-Ku, ... Nature.com The clinical and economic benefits of capecitabine and tegafur with... - Apr 17, 2007 With reference to the study by Ward et al (2006), the article compares the cost effectiveness of oral fluoropyrimidine treatment for mCRC vs intravenously ... Nature.com Two drugs best for deadly cancer - Nov 2, 2005 Cancer Research UK scientists say adding capecitabine to standard ... The one-year survival rates for gemcitabine and capecitabine was 26% compared to only ... BBC News A case of cardiogenic shock caused by capecitabine treatment - Dec 6, 2008 Background A 52-year-old woman underwent successful resection of stage IIB primary mucinous adenocarcinoma of the appendix and was started on capecitabine ... Nature.com Trastuzumab, Docetaxel, and Capecitabine as First-Line Therapy for … - Dec 16, 2007 By Janet Fricker. SAN ANTONIO, TX -- December 16, 2007 -- Oral capecitabine, when added to the combination of trastuzumab and docetaxel, increases the ... DG News Are capecitabine and oxaliplatin as effective as fluorouracil and... - Feb 25, 2008 Cunningham D et al. (2008) Capecitabine and oxaliplatin for advanced esophagogastric cancer. N Engl J Med 358: 36–46 PubMed ... Nature.com GlaxoSmithKline halts Tykerb enrolment; plans US, Europe filing in … - Apr 3, 2006 Europe's biggest drug maker said it has halted phase III clinical trial combining Tykerb (previously called lapatinib) and capecitabine (Xeloda) versus ... Forbes Does addition of lapatinib to capecitabine improve outcome in women … - Feb 28, 2007 Geyer CE et al. (2006) Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 355: 2733–2743 PubMed ... Nature.com Capecitabine and mitomycin C as third-line therapy for patients with ... - Aug 9, 2005 Correspondence: Professor D Cunningham, Department of Medicine, The Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK. ... Nature.com Capecitabine: have we got the dose right? - Aug 21, 2008 In the past 5–10 years there has been a growing trend for substituting conventional 5-fluorouracil with the oral prodrug of 5-fluorouracil, capecitabine, ... Nature.com First-line treatment with oxaliplatin and capecitabine in patients... - Nov 20, 2006 This phase II study assessed the safety and efficacy of oxaliplatin and capecitabine in patients with advanced oesophageal cancer. ... Nature.com Capecitabine plus docetaxel every 3 weeks in first- and second-line … - Feb 28, 2005 Capecitabine and docetaxel have single-agent activity in upper gastrointestinal tumours, and have together demonstrated preclinical synergy and a survival ... Nature.com Study Compares Colon Cancer Drug Regimens - Jul 13, 2007 ...sequential treatment with capecitabine, irinotecan and oxaliplatin; ... of capecitabine plus irinotecan followed by capecitabine plus oxaliplatin. ... Washington Post Does the addition of oxaliplatin increase the risk of capecitabine... - Oct 26, 2005 Capecitabine is an oral fluoropyrimidine that is converted to 5-fluorouracil preferentially in tumor cells. It is licensed for the treatment of breast and ... Nature.com Capecitabine in combination with irinotecan (XELIRI), administered as... - Jan 25, 2008 Combination chemotherapy is standard treatment for metastatic colorectal cancer (MCRC). The aim of this study was to determine the efficacy and safety of ... Nature.com Lapatinib Plus Capecitabine Nearly Doubles Time to Progression in … - Jun 4, 2006 By Ed Susman. ATLANTA, GA -- June 4, 2006 -- Time to progression of metastatic or refractory breast cancer was nearly doubled when patients were ... DG News A phase II study of fixed-dose capecitabine and assessment of... - Dec 19, 2005 The purpose of this study was to evaluate the safety and activity of fixed-dose capecitabine in patients with advanced colorectal cancer and to correlate ... Nature.com FDA OKs Bristol-Myers' Ixempra - Oct 16, 2007 ...as a combination with capecitabine for patients resistant to anthracycline and taxane, or for those unable to take anthracycline anymore. ... TheStreet.com - TheStreet.com (subscription) Adding Lapatinib to Capecitabine Cuts Progression of Advanced Breast ... - Dec 27, 2006 By Anthony J. Brown, MD. NEW YORK DEC 27, 2006 (Reuters Health) - Adding lapatinib to chemotherapy with capecitabine reduces the risk of disease progression ... Cancerpage.com Study boosts Roche's Avastin in breast cancer - Nov 24, 2008 Avastin was tested in combination with either taxane-based, anthracycline-based or Xeloda (capecitabine) chemotherapies. The full results will be submitted ... Reuters Gastric cancer patients live longer on Roche pill - Sep 13, 2008 ..."Capecitabine (Xeloda) appears to offer a survival advantage in addition to the convenience of a tablet that can be taken at home," David Cunningham of ... Reuters Taking Cancer Drug With Food May Cut Costs - Jul 17, 2007 Additionally, concurrent medicines that patients may be taking, including capecitabine, must be considered. Each medicine has its own potential for drug and ... Washington Post The clinical and economic benefits of capecitabine and tegafur with... - Jun 15, 2005 Two oral fluoropyrimidine therapies have been introduced for metastatic colorectal cancer. One is a 5-fluorouracil pro-drug, capecitabine; the other is a ... Nature.com Options Expanding With First-line Capecitabine (Xeloda) Combinations... - Feb 22, 2006 By Chris Berrie. VIENNA, AUSTRIA -- February 22, 2006 -- Capecitabine (Xeloda(R)) is one of the essential components of first-line treatment for patients ... DG News Addition of Capecitabine Appears to Reduce Breast Cancer Relapse and ... - Dec 15, 2008 By Ed Susman. SAN ANTONIO, Tex -- December 15, 2008 -- Addition of capecitabine to an anthracycline-taxane regimen appears to reduce the risk of breast ... DG News Glaxo seeks Japan marketing OK for breast cancer pill Tykerb - Apr 2, 2007 The company is seeking approval as both monotherapy and combination treatment with chemotherapy agent capecitabine for patients with advanced or metastatic ... Forbes A phase II trial of S-1 monotherapy in metastatic colorectal cancer... - Nov 14, 2006 Capecitabine has recently been tried as salvage therapy, ... Capecitabine showed no objective response in 5-FU-resistant cancer in a phase II trial (Hoff et ... Nature.com Gemcitabine and Capecitabine Improved Overall Survival in Patients... - Nov 3, 2005 PARIS, FRANCE -- November 3, 2005 -- The prognosis of pancreatic cancer is poor but new therapies such as gemcitabine have contributed to improving the ... DG News Ixabepilone In Combination With Capecitabine Extends Progression-Free... - Sep 28, 2007 The results of a large Phase III clinical trial show that women with metastatic breast cancer that has rapidly progressed after prior treatment with ... Medical News Today - Medical News Today (press release) Oral Capecitabine vs Conventional Chemo - Jun 1, 2008 June 1, 2008 (Chicago, Illinois) — Single-agent oral capecitabine (Xeloda, Roche) was found to be inferior to conventional chemotherapy in older women with ... Medscape Solo Capecitabine Shows Good Results in Advanced Breast Cancer: … - Feb 6, 2007 By Jill Stein. PARIS, FRANCE -- February 6, 2007 -- Capecitabine is an appropriate first-line monochemotherapy for slowly progressing metastatic breast ... DG News … Respond to Treatment With Capecitabine and Vinorelbine: Presented... - Dec 18, 2006 The researchers treated these women with capecitabine 1000 mg/m 2 daily on ... Although the regimen contained a high dose of capecitabine, it appears to ... DG News Capecitabine Effective Alternative to Fluorouracil/Leucovorin for... - Jun 29, 2005 NEW YORK Jun 29, 2005 (Reuters Health) - Treatment of stage III colon cancer with adjuvant capecitabine is at least as effective as fluorouracil plus ... Cancerpage.com … as Effective as Vinorelbine Followed by Capecitabine in Metastatic... - Feb 8, 2008 By Shazia Qureshi. PARIS, FRANCE -- February 8, 2008 -- Whether capecitabine treatment is given before vinorelbine treatment or vice versa does not appear ... DG News GlaxoSmithKline starts Phase III trial on Tykerb for head, neck cancer - Feb 25, 2007 Lapatinib in combination with capecitabine has been submitted for marketing approval in the US, European Union and Switzerland for the treatment of advanced ... Forbes Capecitabine (Systemic). - Feb 1, 2006 Capecitabine (ka-pe-SITE-a-been ) belongs to the group of medicines called antimetabolites. It is used to treat breast cancer and colorectal cancer. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Capecitabine and Oxaliplatin Effective for Advanced Esophageal Cancer - Jan 4, 2008 NEW YORK JAN 04, 2008 (Reuters Health) - Capecitabine and oxaliplatin are effective alternatives to fluorouracil and cisplatin, respectively, for treating ... Cancerpage.com Gemcitabine and capecitabine improved overall survival in patients... - Nov 8, 2005 The prognosis of pancreatic cancer is poor but new therapies such as gemcitabine have contributed to improving the outcome for patients. ... Medical News Today - Medical News Today (press release) … lapatinib) in Combination With Xeloda(R) (capecitabine) for the... - Mar 13, 2007 Most commonly reported AEs in the TYKERB-capecitabine combination arm included diarrhea, hand-foot syndrome, nausea, rash, vomiting and fatigue. ... Free with registration - PR Newswire - AccessMyLibrary.com Capecitabine (Systemic).(Drug overview) - May 1, 2006 Capecitabine (ka-pe-SITE-a-been ) belongs to the group of medicines called antimetabolites. It is used to treat breast cancer and colorectal cancer. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Revolutionary drug that gives breast cancer sufferers precious months... - Jul 4, 2008 Women taking lapatinib plus capecitabine had a 50 per cent increase in the time before the disease worsened, compared with capecitabine alone, from 18 weeks ... Daily Mail Bristol-Myers Breast-Cancer Drug Gets Priority Review - Jun 19, 2007 A combination of ixabepilone and capecitabine prolonged progression-free survival by a median of 5.8 months, compared with 4.2 months for patients on ... Bloomberg XELIRI (Capecitabine and Irinotecan): A Novel Combination Under … - Apr 1, 2005 William B. Ershler, MD, INOVA Fairfax Hospital Cancer Center, Fairfax, VA; Director, Institute for Advanced Studies in Aging, Washington, DC, is Editor for ... Pay-Per-View - Clinical Oncology Report - Factiva, from Dow Jones Benefits of Oral Capecitabine (Xeloda) Over Continuous Intravenous … - Jan 7, 2008 BASEL, SWITZERLAND -- January 7, 2008 -- Data recently published in the New England Journal of Medicine confirm oral chemotherapy tablet capecitabine ... DG News … ) In Combination With Xeloda® (Capecitabine) For The Treatment Of … - Mar 19, 2007 Most commonly reported AEs in the TYKERB-capecitabine combination arm included diarrhea, hand-foot syndrome, nausea, rash, vomiting and fatigue. ... Medical News Today - Medical News Today (press release) Lapatinib Added to Capecitabine Improves Progression-Free Survival … - Dec 15, 2006 By Emma Hitt, PhD. SAN ANTONIO, TX -- December 15, 2006 -- Lapatinib added to capecitabine appears to improve progression-free survival (PFS) independent of ... DG News Capecitabine and vinorelbine in elderly patients (older than 65... - Jan 1, 2005 Synopsis: This regimen of capecitabine and vinorelbine is well tolerated and effective in elderly patients with metastatic breast cancer. ... Free with registration - Clinical Oncology Alert - AccessMyLibrary.com Nearly 60 New Studies of Oral Xeloda(R) (Capecitabine) Featured at... - May 22, 2008 NUTLEY, NJ, May 22 /PRNewswire/ -- Roche announced today that a total of 59 US and global abstracts involving its oral chemotherapy Xeloda(R) (capecitabine) ... RedOrbit GlaxoSmithKline Reports Positive New Data on Tykerb(R) (Lapatinib … - Jun 3, 2006 In this study, the combination of Tykerb and capecitabine (Xeloda(R)) ... AEs in the Tykerb-capecitabine arm included diarrhea, hand-foot syndrome and rash. ... RedOrbit Substituting Oral Capecitabine in Colorectal Cancer "Not Convincing" - Sep 3, 2007 September 3, 2007 -- Several trials have now shown that in the treatment of metastatic colorectal cancer, substituting oral capecitabine ( Xeloda, ... Medscape Capecitabine Found Equivalent to 5-Fluorouracil in Matched Pair … - Oct 24, 2005 By Ed Susman. DENVER, CO -- October 24, 2005 -- The oral anti-cancer drug capecitabine appears to have similar efficacy and toxicity as infusional ... DG News Breast Cancer; Studies add new findings to breast cancer body of … - Apr 12, 2006 Study 1: Mitomycin c (MMC) and capecitabine could be used to treat ... In preclinical studies, MMC and capecitabine showed a synergistic effect by ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones … Response Rates When Added to Capecitabine Therapy: Presented at … - Sep 8, 2008 In both studies, the ixabepilone/capecitabine combination produced a ... Median OS for the ixabepilone plus capecitabine arm versus capecitabine alone in ... DG News … Sequence-Specific Toxicity Seen With Capecitabine After 5-Fluoroura... - Jul 10, 2007 By Chris Berrie. LUGANO, SWITZERLAND -- July 10, 2007 -- Sequence-specific toxicity associated with use of capecitabine following 5-fluorouracil/ leucovorin ... DG News Xeloda (Capecitabine) Plus Xelox (Oxaliplatin) Dramatically Reduces … - Nov 3, 2005 PARIS, FRANCE -- November 3, 2005 -- New data confirm that Xelox, a combination of Xeloda® (capecitabine) and oxaliplatin, is as safe as the current ... DG News … Benefit From Lapatinib Plus Capecitabine Combination: Presented at... - Sep 27, 2007 The addition of lapatinib to capecitabine also appeared to thwart the risk of brain ... [Presentation title: Lapatinib (L) Plus Capecitabine (C) in HER2+ ... DG News Pharmac to fund bowel cancer drug - Jun 18, 2007 In its latest announcement, Pharmac will fund Capecitabine for an estimated ... He welcomes the funding of Capecitabine as he says it might take some of the ... TVNZ … ; Epirubicin, cisplatin, and capecitabine shows promise in biliary... - Mar 14, 2006 This combination chemotherapy with epirubicin, cisplatin, and capecitabine offered promising antitumor activity in patients with advanced BTC." ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones Article: When all else fails, consider capecitabine for SCC.(Cutaneous... - Jul 1, 2008 When all else fails, consider capecitabine for SCC.(Cutaneous Oncology) ... find Skin & Allergy News articles. VANCOUVER, BC -- Capecitabine, an oral ... Pay-Per-View - Skin & Allergy News - HighBeam Research Oral colon cancer drug effective - Oct 9, 2007 The study found 71 percent of colon cancer patients given Xeloda, or capecitabine, were alive after five years, compared to 68 percent of patients treated ... United Press International Tykerb (lapatinib) - new anti-cancer treatment approved - Mar 14, 2007 In the trial, half the patients received Tykerb with capecitabine and half ... Compared to patients receiving capecitabine alone, the group of patients ... News-Medical.net … -Analysis Shows Equivalence Between Capecitabine and 5-Fluorouracil:... - Jan 27, 2008 By Ed Susman. ORLANDO, FL -- January 27, 2008 -- A meta-analysis that compared treatment with oral capecitabine and its intravenous cousin 5-fluorouracil ... DG News Capecitabine Plus Irinotecan-Radiation Seen Safe, Effective for... - Mar 24, 2005 NEW YORK MAR 24, 2005 (Reuters Health) - A phase I trial shows that capecitabine, in combination with weekly irinotecan and radiotherapy, is at least as ... Cancerpage.com Phase II Trial of Capecitabine and rHu-interferon-α-2a in Patients... - Mar 27, 2007 BERKELEY, CA (UroToday.com) - Historically, interferon has been a mainstay of treatment for metastatic renal cell carcinoma (mRCC), although it is ... UroToday International Journal … Therapy With Nab-Paclitaxel/Capecitabine Seems Safe, Possibly … - Jun 11, 2007 By Earl R. Nichols. CHICAGO, IL -- June 11, 2007 -- Combination therapy with capecitabine (Xeloda®) and nanoparticle albumin-bound paclitaxel ... DG News Capecitabine as Single Agent Fails to Deliver Results in Older Women ... - Jun 4, 2008 By Cameron Johnston. CHICAGO -- June 4, 2008 -- Single-agent capecitabine does not provide any benefit for older women with early-stage breast cancer. ... DG News … Poliglumex (OPAXIO(TM))/Capecitabine Regimen Well Tolerated and … - Jun 3, 2008 CHICAGO, June 3 /PRNewswire-FirstCall/ -- At the 2008 Annual Meeting of the American Society of Clinical Oncology (ASCO), data were presented from a phase ... RedOrbit Gemcitabine Plus Capecitabine Extends Life in Advanced Pancreatic … - Jun 19, 2007 NEW YORK JUN 19, 2007 (Reuters Health) - In patients with advanced pancreatic cancer with a good Karnofsky performance score, adding capecitabine to ... Cancerpage.com A comparison of XELOX with FOLFOX-4 as first-line treatment for … - Aug 18, 2008 Oral capecitabine has been shown to be a convenient and well tolerated alternative to ... The question of whether capecitabine is an adequate and equally ... Nature.com European agency green-lights new breast cancer drug - Jun 13, 2008 The data showed that the median time to progression was 5.5 months (23.9 weeks) in the lapatinib plus capecitabine group compared to 4.2 months (18.3 weeks) ... Cancerfacts.com … To 'no Wait' Oral Bowel Cancer Treatment Xeloda (REG) (capecitabine... - Apr 27, 2006 Pharmacoeconomic analysis of capecitabine in the adjuvant setting. Results from the X-ACT trial comparing capecitabine with 5-FU/LV in patients with Dukes' ... Medical News Today - Medical News Today (press release) Capecitabine-Paclitaxel Combination Misses Primary Endpoint in Phase ... - Dec 16, 2007 By John Gever. SAN ANTONIO, TX -- December 16, 2007 -- Capecitabine plus paclitaxel for metastatic breast cancer is not inferior to epirubicin plus ... DG News Bortezomib (Velcade) and Capecitabine (Xeloda) in Combination … - Dec 9, 2005 By Cameron Johnston. SAN ANTONIO, TX -- December 9, 2005 -- A small phase 1 study has shown that bortezomib (Velcade) used in combination with capecitabine ... DG News First Line Capecitabine/Cisplatin Used to Treat Advanced … - Jun 2, 2008 By Cameron Johnston. CHICAGO -- June 2, 2008 -- The combination of capecitabine and cisplatin seems to offer an important advantage in terms of overall ... DG News Efficacy of lower dose capecitabine in patients with metastatic... - Jan 1, 2007 Objective: Capecitabine exerts considerable therapeutic efficacy in metastatic breast cancer (MBC) patients previously treated with anthracyclines and ... $4.95 - Southern Medical Journal - ECNext Cytokinetics and GlaxoSmithKline Amend Collaboration and License … - Nov 27, 2006 Dose limiting toxicities observed included Grade 2 rash that did not allow 75% of the capecitabine doses to be delivered and prolonged Grade 4 neutropenia. ... Free with registration - PR Newswire - AccessMyLibrary.com … Studies of IXEMPRA(TM) Plus Capecitabine Show Significant Increase... - Dec 15, 2008 In the pooled analysis of the subset of 443 patients with triple negative breast cancer, data show that IXEMPRA plus capecitabine (n = 191 patients) is the ... StreetInsider.com - StreetInsider.com (subscription) Study Shows Ixabepilone Demonstrated Clear Activity in Patients with ... - Jul 6, 2007 ...in patients with metastatic breast cancer whose tumors were resistant to three types of standard chemotherapy (anthracycline, taxane, and capecitabine). ... Free with registration - PR Newswire - AccessMyLibrary.com Adding Capecitabine to First-Line Breast Cancer Therapies Shows … - Oct 5, 2006 October 5, 2006 (Istanbul) –- Experts say adding a simple oral regimen to first-line therapy in HER2-positive metastatic breast cancer is beneficial. ... Medscape Neoadjuvant Docetaxel, Doxorubicin and Capecitabine Used in Women … - Dec 13, 2005 By Cameron Johnston. SAN ANTONIO, TX -- December 13, 2005 -- The neoadjuvant combination of docetaxel (T), doxorubicin (A), and capecitabine (X) has ... DG News How It Works - Oct 1, 2008 Capecitabine belongs to a class of drugs called antimetabolites. ... Capecitabine is available as tablets that are taken by mouth (oral). ... WebMD Article: Capecitabine for stage III colon ca.(CLINICAL CAPSULES)(colon... - Aug 15, 2005 Capecitabine for stage III colon ca.(CLINICAL CAPSULES)(colon cancer)(Brief Article) ... find Internal Medicine News articles. Pay-Per-View - Internal Medicine News - HighBeam Research Tykerb Tablets Activity In Brain Metastases Associated With Breast … - Jun 8, 2007 An exploratory analysis in a previous, Phase III study found that numerically fewer patients on Tykerb tablets plus capecitabine developed brain metastases ... Medical News Today - Medical News Today (press release) Capecitabine/Oxaliplatin Combination Therapy Effective in Treating … - Jan 22, 2007 By Ed Susman. ORLANDO, FL -- January 22, 2007 -- A treatment strategy that combines capecitabine (Xeloda) and oxaliplatin (Eloxatin) appears to be as ... DG News Options updated for adjuvant colon cancer Tx.(Clinical Rounds) - May 15, 2005 The capecitabine recommendation reflects the findings of the Xeloda in Adjuvant Colon ... Taken orally, capecitabine is converted by the body into 5-FU. ... Free with registration - Family Practice News - AccessMyLibrary.com Xeloda plus oxaliplatin (XELOX) dramatically reduces hospital visits... - Nov 2, 2005 New data confirm that XELOX, a combination of Xeloda® (capecitabine) and oxaliplatin, is as safe as the current standard treatment of intravenous ... eurekalert.org New Data From Several Satraplatin Clinical Trials In Solid Tumors … - Jun 3, 2008 The primary objective of this study was to determine the MTD and Phase 2 recommended dose for satraplatin administered sequentially with capecitabine ... Medical News Today - Medical News Today (press release) Health Canada Approves Xeloda (Capecitabine) for Adjuvant Therapy in ... - Mar 28, 2006 MISSISSAUGA, CANADA -- March 28, 2006 - Hoffmann-La Roche Ltd. announced today that Health Canada has approved Xeloda (capecitabine), an innovative oral ... DG News Concurrent Capecitabine With Preoperative Radiotherapy in Rectal … - Feb 4, 2005 By Chris Berrie. "The treatment of rectal adenocarcinoma nowadays is changing because before, radical surgery was advocated in locally advanced patients, ... DG News European breakthrough for lapatinib - May 29, 2007 Lapatinib (Tykerb®) has been approved in Switzerland, its first European market, in combination with capecitabine for treating patients with advanced breast ... Pharmacy Europe Bowel cancer pill for home treatment - Oct 14, 2008 He said: "Capecitabine is an excellent treatment option for patients, both in terms of ... Patients receiving capecitabine for bowel cancer experienced ... The Herald … of Heidelberg; Efficacy of irinotecan and capecitabine as second... - Mar 30, 2005 2005 MAR 30 - (NewsRx.com) -- The use of irinotecan and capecitabine as second-line ... Keywords: Mannheim, Germany, Capecitabine, Colorectal Cancer, ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones New Study Results Demonstrate Clinical Effectiveness of Gemzar(R)- … - May 16, 2005 Patients in the Gemzar/docetaxel arm were treated with 1000 mg/m2 of Gemzar combined with 75 mg/m2 of docetaxel, and patients in the capecitabine/docetaxel ... RedOrbit Capecitabine Plus Cisplatin Combination Effective in Patients With … - Jun 19, 2006 ATLANTA, GA -- June 19, 2006 -- In the first-ever phase 3 trial of oral Xeloda (capecitabine) as first-line treatment for gastric cancer, ... DG News Cancer Therapy; Efficacy of irinotecan and capecitabine as second... - Mar 28, 2005 2005 MAR 28 - (NewsRx.com) -- The use of irinotecan and capecitabine as second-line treatment in advanced colorectal cancer yielded tumor control in 61% of ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones … Data on TYKERB(R) (Lapatinib) Plus Capecitabine for the Treatment... - Dec 17, 2007 TYKERB, in combination with capecitabine, is approved in the United States for the ... In this study, the combination of TYKERB plus capecitabine showed a ... Pay-Per-View - PR Newswire - HighBeam Research ADVENTRX Presents CoFactor Data at the 2008 Annual Meeting of the … - Jun 3, 2008 Historically, capecitabine (Xeloda(R)), a widely-used treatment for advanced breast cancer, has demonstrated response rates between 14% and 26% when studied ... RedOrbit This breast cancer drug is first in new class of chemo agents. - Dec 10, 2007 If it is to be used as monotherapy, patients should be resistant to anthracyclines, taxanes, and capecitabine. As a combination treatment with capecitabine, ... $9.94 - Drug Topics - Alacra Store … -Capecitabine VersusDocetaxel-Doxorubicin-Cyclophosphamide: Results - Mar 13, 2008 The GeparTrio trial (NCT 00544765) started in August 2002 in 88 centers in Germany, with a total of 2090 patients who were confirmed to be eligible during ... Medscape Brand Names/Synonyms: Capecitabine is also known by the following brand names and/or synonymsCAPECITABINE; Capecitabine; Capecitabine [Usan]; Xeloda Drug Category: Capecitabine is categorized under the following by the FDA: Prodrugs; Antimetabolites; Antineoplastic Agents; ATC:L01BC06 Dosage Forms: TABLET Absorption: Not Available Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: pentyl[1-(3,4-dihydroxy-5-methyl-tetrahydrofuran-2-yl)-5-fluoro-2-oxo-1H-pyrimidin-4-yl]aminomethanoate |
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