Capozide

This page contains recent news articles, when available, and an overview of Capozide but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Capozide
(when available)

Pharmacology and use:
Thiazides promote water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. For the treatment of high blood pressure and management of edema

Mechanism Of Action:
As a diuretic, Hydrochlorothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like Hydrochlorothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of Hydrochlorothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.

News Articles on Hydrochlorothiazide

صناعة الأدوية Ù?ÙŠ لبنان رهينة مصالح "التجّار"  -  ‎Oct 23, 2009‎
Ù?على سبيل المثال لا الحصر، يقول رئيس مجلس إدارة شركة «باسيÙ?يك Ù?ارم»، مروان حكيم، إن سعر دواء «Capozide» الذي يستورده أغلى بنسبة 20 Ù?ÙŠ المئة من الدواء ذي ... النشرة

Glaxo expands in Egypt with $210 mln acquisition  -  Oct 15, 2008
...including Duricef (antibiotic); Capozide and Capoten (ACE inhibitors); Theragran-H (iron supplement) and Kenacomb (topical steroid). ... Reuters

Capozide.(Drug overview)  -  Jan 22, 2007
Capozide is used in the treatment of high blood pressure. It combines an ACE inhibitor with a thiazide diuretic. Captopril, the ACE inhibitor, ... Free with registration - PDR Family Guide to Prescription Drugs - AccessMyLibrary.com

Diabetes Drug Also Preventive; Avandia Reduces Risk of Developing …  -  Sep 16, 2006
The Washington Post; March 14, 1992 ; 573 words ... ... in the upgraded warnings are Capoten, Capozide and Monopril made by Bristol-Myers Squibb; ... Pay-Per-View - Washington Post - HighBeam Research

Daily News Egypt - Full Article  -  Dec 23, 2008
...including Duricef (antibiotic); Capozide and Capoten (ACE inhibitors); Theragran-H (iron supplement) and Kenacomb (topical steroid). ... Daily News Egypt

Eplerenone (Systemic).  -  Oct 27, 2005
Angiotensin-converting enzyme (ACE) inhibitors (Benazepril [eg, Lotensin], captopril [eg, Capoten, Capozide], enalapril [eg, Lexxel, Teczem, Vaseretic, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Article: FDA panel backs Avalide as first-line HT therapy.(Cardiovascu...  -  Jun 1, 2007
The combination antihypertensives that have previously been approved as first-line treatments are Capozide (captopril and hydrochlorothiazide, or HCTZ), ... Pay-Per-View - Internal Medicine News - HighBeam Research

Article: Calif. Targets 39 Companies in Drug Suit - AP Online |...  -  Aug 26, 2005
...according to a company spokeswoman ... 25 mg./25 mg. and 50 mg./25 mg. (Bristol-Myers Squibb Co.'s Capozide); nitrofurantoin 50 mg. and 100 mg ... ... Pay-Per-View - AP Online - HighBeam Research

Egypt pharma: GSK to buy BMS unit for US$210m  -  Oct 20, 2008
...including: the antibiotic Duricef (cefadroxil); the ACE-inhibitors Capozide (captopril and hydrochlorothiazide) and Capoten (captopril); Theragran-H, ... $34.00 - EIU Country Analysis - Alacra Store

Combo antihypertensive backed for initial therapy.(NEWS FROM THE …  -  May 15, 2007
The combination antihypertensives that have previously been approved as first-line treatments are Capozide (captopri] and HCTZ), Ziac (bisoprolol/HCTZ), ... Pay-Per-View - Family Practice News - HighBeam Research

New Jersey Administrative Code - 8:71-1.1 Precedence of lists  -  Aug 16, 2005
Dupont Pharma, Egis, Geneva, Mova, Mylan, Novopharm, Par, Stason, TEVA, TorPharm, Watson, West-ward CAPOZIDE Captopril/hydrochlorothiazide 25 mg/15 mg, ... Pay-Per-View - New Jersey Administrative Code - Loislaw

Competitors by Product Report  -  Mar 29, 2008
Enalapril Maleate/Hydrochlorothiazide; Quinapril Hydrochloride/Hydrochlorothiazide; Strativa Capozide (Captopril/Hydrochlorothiazide) ... $75.00 - Revere Reports - Revere

Minnesota - Official Notices - Department of Human Services  -  Jan 3, 2006
Capozide Uniretic Lotensin HCT Vaseretic Monopril HCT Zestoretic Dihydropyridine calcium channel blockers Adalat Adalat CC Procardia Procardia XL Cardene ... Pay-Per-View - RegAlert - Factiva, from Dow Jones

GSK, BMS ì?´ì§‘트 사업부 ì?¸ìˆ˜  -  Oct 16, 2008
...�번 �수로 GSK는 항�제 '듀리세프'(Duricef, cefadroxil), 항고혈압제 '카� �'(Capoten, captopril)·'카�지드'(Capozide, captopril/ hydrochlorothiazide), ... 디지틀보사

GlaxoSmithKline приобретает египетÑ?кое подразделение у Bristol- …  -  Oct 15, 2008
Ð’ их чиÑ?ле антибиотик Duricef, ингибиторы Ð?ПФ Capozide и Capoten, топикальный Ñ?тероид Kenacomb и др. Ð’ 2007 г. общий объем продаж Ñ?тих лекарÑ?твенных Ñ?редÑ?тв ... ФармацевтичеÑ?кий веÑ?тник

Brand Names/Synonyms:
Capozide is also known by the following brand names and/or synonymsAcuretic; Aldactazide; Aldoril; Apresazide; Aquarills; Aquarius; Bremil; Caplaril; Capozide; Chlorosulthiadil; Chlorothiazide; Chlorsulfonamidodihydrobenzothiadiazine Dioxide; Chlorzide; Cidrex; Dichlorosal; Dichlorotride; Dichlotiazid; Dichlotride; Diclotride; Dicyclotride; Dihydrochlorothiazid; Dihydrochlorothiazide; Dihydrochlorothiazidum; Dihydrochlorurit; Dihydrochlorurite; Dihydroxychlorothiazidum; Direma; Disalunil; Diu-Melusin; Diuril; Drenol; Dyazide; Esidrex; Esidrix; Esimil; Fluvin; H.H. 25/25; H.H. 50/50; HCTZ; HCZ; Hidril; Hidrochlortiazid; Hidroronol; Hidrotiazida; Hydril; Hydro-Aquil; Hydro-D; Hydro-Diuril; Hydrochlorothiazid; Hydrochlorothiazide; Hydrochlorothiazide Intensol; Hydrochlorthiazide; Hydrodiuretic; Hydrodiuril; Hydropres; Hydrosaluric; Hydrothide; Hydrozide; Hypothiazid; Hypothiazide; Hyzaar; Idrotiazide; Inderide; Ivaugan; Jen-Diril; Lopressor Hct; Lotensin Hct; Maschitt; Maxzide; Megadiuril; Microzide; Moduretic; Nefrix; Neo-Codema; Neoflumen; Newtolide; Oretic; Palonyl; Panurin; Perovex; Primogyn; Prinzide; Ro-Hydrazide; Servithiazid; Su 5879; Thiaretic; Thiazide, Hydrochloro-; Thiuretic; Thlaretic; Timolide; Unipres; Urodiazin; Vaseretic; Vetidrex; Ziac; Zide

Drug Category:
Capozide is categorized under the following by the FDA: Diuretics; Antihypertensive Agents; ATC:C03AA03

Dosage Forms:
Oral tablets, various strength

Absorption:
50-60%

Interactions:
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Chemical IUPAC Name:
9-chloro-5,5-dioxo-5$l^{6}-thia-2,4-diazabicyclo[4.4.0]deca-6,8,10-triene-8-sulfonamide





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