Celecoxib

This page contains recent news articles, when available, and an overview of Celecoxib but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Celecoxib
(when available)

Pharmacology and use:
Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is classified as a nonsteroidal anti-inflammatory drug (NSAID). Celecoxib is used to treat rheumatoid arthritis, osteoarthritis, and familial adenomatous polyposis (FAP). It is not known if there are any effects of Celecoxib on platelets. For relief and management of osteoarthritis (OA), rheumatoid arthritis (RA), ankylosing spondylitis, acute pain, primary dysmenorrhea and oral adjunct to usual care for patients with familial adenomatous polyposis

Mechanism Of Action:
The mechanism of action of Celecoxib is believed to be due to inhibition of prostaglandin synthesis. Unlike most NSAIDs, which inhibit both types of cyclooxygenases (COX-1 and COX-2), Celecoxib is a noncompetitive inhibitor of cyclooxygenase-2 (COX-2) enzyme. It binds with its polar sulfonamide side chain to a hydrophilic side pocket region close to the active COX-2 binding site. Both COX-1 and COX-2 catalyze the conversion of arachidonic acid to prostaglandin (PG) H2, the precursor of PGs and thromboxane.

News Articles on Celecoxib

Celebrex combats skin cancer in vulnerable group  -  05 Jan 2010
The inflammation-fighting drug celecoxib prevents some outbreaks of skin cancer in people genetically predisposed to developing the ... Science News

Turmeric (Curcumin) for Inflammatory Conditions  -  05 Jan 2010
Down-regulation of COX-2, which is the enzyme targeted by celecoxib (Celebrex); 2. Inhibition of the production of TNF-alpha, which is the cytokine targeted ... EmpowHer (blog)

Common anti-inflammatory drug could help prevent skin cancers, Stanford ...  -  05 Jan 2010
Although oral administration of the drug, celecoxib, is associated with an increased risk of heart attack and stroke in some people, it's possible that ... ScienceBlog.com (blog)

Celebrex inhibited the burden of skin cancer in high-risk patients  -  05 Jan 2010
According to results of a placebo-controlled, randomized, double-blind, Phase II study, the use of celecoxib was effective in inhibiting the development of ... Bioscience Technology

COX-2-Hemmer könnte Hautkrebs vorbeugen  -  05 Jan 2010
Oakland – Der COX-2-Hemmer Celecoxib kann möglicherweise der Entwicklung von Basaliomen vorbeugen. In einer randomisierten klinischen Studie in Cancer ... Deutsches Ärzteblatt

Gyulladásellenes szer a bÅ‘rrák ellen  -  05 Jan 2010
Egy gyakran alkalmazott nem-szteroid gyulladásgátló gyógyszer, a celecoxib csökkentheti a bazális sejtes karcinóma kockázatát. Bár a celecoxib szájon át ... medicalonline.hu/

Celecoxib could impede effects of low-dose aspirin  -  ‎Dec 17, 2009‎
Celecoxib is the only COX-2 inhibitor to have remained on the market in the US, and doctors who recommend this painkiller often coprescribe a daily low dose ... TheHeart.Org

Aspirin Plus Celebrex May Reduce Heart Benefits  -  ‎Dec 15, 2009‎
Millions of people who have arthritis or other types of pain also take Celebrex (celecoxib), a type of drug known as a coxib or COX-2 inhibitor. ... eMaxHealth

Cox-2 Inhibitor Blunts Aspirin's Cardioprotection  -  ‎Dec 16, 2009‎
The pain killer celecoxib (Celebrex) may interfere with the cardioprotective benefit of low-dose ... MedPage Today

Taking Celebrex May Interfere With Aspirin's Anti-Clotting Effects, New Study Says  -  ‎Dec 18, 2009‎
A new US study suggests taking celecoxib, the arthritis pain drug sold under the brand name Celebrex, may prevent low-dose aspirin from preventing ... Attorney at Law

Latest Tylenol Recall Adds to Arthritis Patients Woes  -  ‎Dec 29, 2009‎
One of the most commonly used prescription drugs, Celebrex (celecoxib), has remained on the market even though its two cousins, Vioxx and Bextra, ... eMaxHealth

Recommendations for Prescribing NSAIDs in the Primary Care Setting  -  ‎Dec 28, 2009‎
The risk for myocardial infarction is increased with COX-2 inhibitors, although celecoxib, which is the only COX-2 inhibitor still available in the United ... Medscape

Chronic Kidney Disease — More Common Than You Think  -  ‎Jan 2, 2010‎
Another culprit is long-term use, on a regular basis, of medications including anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil) or celecoxib ... Ethiopian Review

The American Journal of Geriatric Psychiatry December 2008 Table of Contents  -  ‎Dec 10, 2009‎
FRANZCP, Ph.D. Cognitive and Cerebral Metabolic Effects of Celecoxib Versus Placebo in People With Age-RelatedMemory Loss: Randomized Controlled Study, ... Newswise (press release)

Gov't urged to fund BioChem Informatics Center for drug manufacture  -  ‎Dec 25, 2009‎
...“We came up with a score of new candidates predicted to be more potent than existing compounds in the market like celebrex and celecoxib,� said Billones in ... Manila Bulletin

In re: Vioxx Class Cases  -  ‎Dec 16, 2009‎
The first such COX-2 inhibitor was celecoxib, marketed by Pfizer under the trade name Celebrex. The second COX-2 inhibitor was rofecoxib, which was marketed ... Leagle, Inc.

FDA Grants Cequent IND - Clears Way for First-Ever Clinical Trial of Orally ...  -  ‎Dec 10, 2009‎
Dr. Steinbach is associate professor of medicine at the University of Washington, and served as the PI of a previous celecoxib FAP Phase II trial that ... PR Newswire (press release)

Pain Meds Can Cause Serious Side Effects  -  ‎Dec 18, 2009‎
Celecoxib (Celebrex), a COX-2 specific NSAID, may also be considered an option for some patients. "The good news is that for people who take NSAIDs, ... Greenwood Today

La buena guerra  -  ‎Dec 19, 2009‎
Comenzaron “casi de casualidad� (sic) usando una droga llamada Celecoxib para contrarrestar la pérdida de peso en pacientes con cáncer de pulmón, ... Noticias y Protagonistas

Wechselwirkung: Rheuma-Medikament stört Gerinnungshemmer  -  ‎Dec 17, 2009‎
Dabei zeigte sich, dass Celecoxib nicht nur wie gewünscht das Enzym Cox 2 bindet, das bei Rheuma eine Rolle spielt, sondern auch ASS vom verwandten Enzym ... NetDoktor.de

An Giang: Ä?ình chỉ lưu hành, rút số đăng ký và thu hồi các lô thuốc không đạt ...  -  ‎Jan 1, 2010‎
TP HCM sản xuất; thuốc viên nang Ceex-100 (Celecoxib 100mg), do Công ty Syncon Formulations (India) Ltd sản xuất; thuốc hoàn cứng MAKOTA l� 40g, ... cand.com

Is Short-term Celecoxib Intervention A Effective Method For Preventing Gastric ...  -  ‎Oct 28, 2009‎
According to the findings of this study, Celecoxib may have effects including anti-oncogenic effect, inhibition of angiogenesis and metastasis, ... Science Daily (press release)

Cyclin-mediated G1 arrest by celecoxib differs in low-versus high-grade ...  -  ‎Nov 5, 2009‎
Celecoxib and other non-steroidal anti-inflammatory drugs (NSAIDs) are being evaluated in the prevention of bladder and other cancers. ... UroToday

Cost-cutting helps Pfizer's bottom line  -  ‎Oct 22, 2009‎
Other big sellers under the cosh included anti-inflammatory drug Celebrex (celecoxib), which fell 4% to $602 million, the antihypertensive Norvasc ... Pharmafocus

Online Pharmacy - celebrex  -  ‎Oct 31, 2009‎
I took Celebrex should have linked celecoxib at doses without a doctor's prescription. In practice. Patients with this form where you can order Celebrex in ... Newstalk ZB

COX-2 cure for paralytic ileus?  -  ‎Oct 25, 2009‎
Perioperative low dose celecoxib markedly reduces the development of paralytic ileus following major abdominal surgery, South Australian ... 6minutes

Pharmacological Inhibition of 5-Lipoxygenase Accelerates and Enhances Fracture ...  -  ‎Nov 2, 2009‎
At day 10 after fracture, AA-861 and celecoxib treatment increased Type-II collagen mRNA levels (16.0-fold and 6.1-fold, respectively; p < 0.001 for both), ... Journal of Bone and Joint Surgery (subscription)

What is the appropriate use of chronic medications in the perioperative setting?  -  ‎Nov 5, 2009‎
The patient's home medications include aspirin, carbidopa/levodopa, celecoxib, clonidine, estradiol, ginkgo, lisinopril, NPH insulin, sulfasalazine, ... The Hospitalist Online

Beyond the Abstract - Fibrin clot inhibitor medication and efficacy of ...  -  ‎Oct 29, 2009‎
Celecoxib Inhibits N-Butyl-N-(4-Hydroxybutyl)-Nitrosamine-Induced Urinary Bladder Cancers in Male B6D2F1 Mice and Female Fischer-344 Rats. ... UroToday

Cephalon Signs Option Agreement to Acquire BioAssets Development Corporation  -  ‎Oct 26, 2009‎
The Cephalon pipeline of pain products includes intravenous celecoxib and two tamper-deterrent opioid medications. Earlier this year, Cephalon completed the ... Reuters

ACR: Tanezumab Keeps OA Knee Pain Under Control  -  ‎Oct 23, 2009‎
For example, the COX-2 inhibitor celecoxib (Celebrex) retails for about $1500 per year at the most common dosage. Joanne Jordan, MD, MPH, director of the ... MedPage Today

Effect of Periarticular Corticosteroid Injections During Total Knee Arthroplasty  -  ‎Nov 2, 2009‎
All patients were treated with similar preoperative medications, including a 200-mg oral dose of celecoxib. Patients who were seventy years of age or ... Journal of Bone and Joint Surgery (subscription)

Cephalon Gains Option to Take Over BioAssets for $30M  -  ‎Oct 26, 2009‎
The Cephalon pipeline of pain products includes intravenous celecoxib for postoperative pain (Phase I) and two tamper-deterrent opioid medications (Phase I ... Genetic Engineering News (press release)

Is ibuprofen a killer?  -  ‎Oct 26, 2009‎
A line in this column questioning why vaccine-related side-effects receive so much media coverage while thousands of deaths caused by the ibuprofen family ... Times Online

The Pharmaceutical Industrial Complex: A Deadly Fairy Tale  -  ‎Oct 23, 2009‎
For example, a group of Swiss investigators filed an FOI to procure trial data about the musculoskeletal pain drug Celecoxib and received back only 16 of ... Auburn Journal

Thêm 8 loại thuốc bị đình chỉ lưu hành  -  ‎Nov 3, 2009‎
Thuốc viên nang Ceex-100 (Celecoxib): LSX 8001E, HD 12.2010 do công ty Syncon Fomulations, Ấn Ä?á»™ sản xuất; 3. Thuốc viên nang Omlife (Omeprazol 20mg): LSX ... Dân Trí

í™”ì?´ìž? 3/4분기 리피토 등 거대 품목 매출 ê°?소  -  ‎Oct 22, 2009‎
...금연 치료약 *참픽스(varenicline)는 안전성 문제로 15% ê°?소한 1ì–µ 5500ë§Œ 달러, COX-2 차단 진통소염제 *세레브렉스(celecoxib)는 4%ê°?소한 6ì–µ 200ë§Œ 달러, ... 메디포뉴스

Рациональное применение Ð?ПВП: оÑ?ознанный выбор  -  ‎Oct 21, 2009‎
ИÑ?Ñ?ледованиÑ? CLASS (Celecoxib Long-term Arthritis Safety Study) проходило в 386 центрах СШÐ? и Канады Ñ? учаÑ?тием более 8000 пациентов Ñ? ревматоидным артритом ... Аптека online

NSAR schädigen auch die Darmmukosa  -  ‎Oct 20, 2009‎
Es handelt sich dabei um einen randomisierten, doppelblinden Parallelgruppenvergleich bei 4402 Patienten unter 200 mg Celecoxib oder 75 mg Diclofenac plus ... DAZ.online - Das Internetportal der Deutschen Apotheker Zeitung

Study finds no benefit in arthritis compounds  -  Feb 23, 2006
Others, serving as comparison subjects, took a placebo or celecoxib, sold as Celebrex, a prescription drug that is approved for osteoarthritis. ... New York Times

Celecoxib CV risk  -  Feb 2, 2005
Washington, DC - For a long time, celecoxib (Celebrex, Pfizer) managed to maintain a distance from the furor that unfurled over the increased cardiovascular ... Medscape

Celecoxib and the drug research roller coaster  -  Oct 20, 2008
In clinical trials, the arthritis drug showed promise in preventing cancer, but then it fell into the Vioxx controversy's wake. The drug celecoxib (also ... Los Angeles Times

Celecoxib—fewer gastrointestinal adverse events in patients with …  -  Apr 24, 2006
Singh G et al. (2006) Celecoxib versus naproxen and diclofenac in osteoarthritis patients: SUCCESS-I Study. Am J Med 119: 255–266 PubMed ... Nature.com

Inhibition of COX-2 by celecoxib enhances glucocorticoid receptor …  -  Feb 8, 2005
Correspondence: Dr AH Miller, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000, ... Nature.com

Celecoxib and a novel COX-2 inhibitor ON09310 upregulate death …  -  Oct 29, 2007
Correspondence: Professor MS Sheikh, Department of Pharmacology, State University of New York, Upstate Medical University, 750 E Adams Street Syracuse, ... Nature.com

Painkillers don't prevent Alzheimer's: study  -  Apr 30, 2007
The subjects were randomized to receive naproxen (220 mg), celecoxib (200 mg), ... Compared with placebo takers, subjects taking celecoxib and naproxen were ... Reuters UK

Naproxen and Celecoxib Do Not Improve Cognitive Function in the …  -  May 13, 2008
May 13, 2008 — In elderly patients, use of naproxen and celecoxib did not improve cognitive function, according to the results of the Alzheimer's Disease ... Medscape

Celecoxib modulates adhesion of HT29 colon cancer cells to vascular …  -  Jul 24, 2007
Correspondence: Dr M Collino, Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Via Pietro Giuria, 9, Torino 10125, Italy. ... Nature.com

Patients Exposed to Rofecoxib and Celecoxib Have Different Odds of …  -  Feb 1, 2005
Stephen E. Kimmel, MD, MSCE; Jesse A. Berlin, ScD; Muredach Reilly, MB; Jane Jaskowiak, BSN, RN; Lori Kishel, MS; Jesse Chittams, MS; and Brian L. Strom, ... ACP Observer

The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in...  -  Feb 21, 2006
Aspects of the paper have been pre-published at the 43rd annual meeting of the 'American College of Neuropsychopharmacology', 12–16 December, 2004, ... Nature.com

Prostate hope in green tea mixture  -  Mar 2, 2007
American researchers have previously shown both celecoxib, sold as Celebrex, ... Celecoxib, one of a group of drugs called Cox-2 inhibitors, is usually used ... Telegraph.co.uk

Celecoxib, naproxen, ibuprofen in heart disease  -  Dec 14, 2005
Cleveland, OH - A huge trial comparing three anti-inflammatories in patients with both heart disease and arthritis should answer once and for all questions ... Medscape

Polyp stopper: controversial drug may prevent colon growths.(Celebrex)  -  Apr 8, 2006
However, regulatory clearance of the drug, called celecoxib, for cancer prevention is ... Since 2005, the company has been required to sell celecoxib with a ... Free with registration - Science News - AccessMyLibrary.com

The quest for cancer-preventing drugs  -  Oct 20, 2008
...the arthritis drug celecoxib (also known as Celebrex) -- might reduce the odds of developing lung cancer in a smoker or ex-smoker. ... Los Angeles Times

… docetaxel in combination with estramustine and celecoxib in...  -  Oct 23, 2007
Celecoxib with weekly docetaxel and estramustine is an effective and safe treatment for ... Celecoxib belongs to a family of drugs called nonsteroidal ... Nature.com

Studies confirm celecoxib may help prevent colorectal cancer in high...  -  Apr 3, 2006
WASHINGTON, DC – During the past year, the study of the potential use of COX-2 (cyclooxygenase-2) inhibitors to prevent colorectal and breast cancer has ... eurekalert.org

Celebrex shows promise in lung cancer prevention  -  Jun 1, 2008
The Pfizer Inc drug, also known as celecoxib, works by blocking the COX-2 enzyme that causes inflammation, which has been linked with cancer. ... Reuters India

Celecoxib Prophylaxis Reduces Risk for Adenomatous Colorectal Polyps  -  May 22, 2008
May 22, 2008 (San Diego) — Results of the Prevention of Colorectal Sporadic Adenomatous Polyps (PreSAP) trial show that taking a daily dose of 400 mg ... Medscape

Celecoxib backed for juvenile rheumatoid arthritis.(News)  -  Dec 15, 2006
GAITHERSBURG, MD. -- The need for a child-friendly formulation and more treatment options contributed to a federal advisory panel's nearly unanimous support ... Free with registration - Family Practice News - AccessMyLibrary.com

Patients Exposed to Rofecoxib and Celecoxib Have Different Odds of …  -  Feb 4, 2005
Background: Studies have postulated that cyclooxygenase-2 (COX- 2) selective inhibitors affect cardiovascular risk through various mechanisms. ... RedOrbit

New study to test arthritis drugs  -  Dec 17, 2007
The Universities of Glasgow, Edinburgh and Aberdeen will also be partners in the SCOT trial (Standard Care versus Celecoxib Outcome Trial). ... BBC News

Celecoxib May Help Prevent Colorectal Cancer In High Risk Patients, …  -  Apr 4, 2006
During the past year, the study of the potential use of COX-2 (cyclooxygenase-2) inhibitors to prevent colorectal and breast cancer has come under intense ... Medical News Today - Medical News Today (press release)

Arthritis drug celecoxib can adversely affect heart rhythm  -  Jan 14, 2008
COX-2 inhibitors like Celecoxib have come under scrutiny lately due to adverse cardiovascular side-effects stemming from COX-2 reduction. ... Health Newstrack

Combination of Lipitor® and Celecoxib at lower doses is most effective...  -  Apr 21, 2005
Combination of Lipitor® and Celecoxib at lower doses is most effective at limiting colon cancer developmentAnaheim, Calif. -- Combinations of Lipitor® and ... i-newswire.com

Naproxen, Celecoxib Do Not Prevent Alzheimer's Disease  -  Apr 27, 2007
April 27, 2007 — Primary-end-point results from the controversial AD Anti-inflammatory Prevention Trial (ADAPT) show no protection from Alzheimer's disease ... Medscape

Online painkillers could kill more than pain  -  Dec 5, 2008
Available drugs included opioids such as tramadol and non-steroidal anti-inflammatories, such as naproxen and celecoxib, which are usually prescribed for ... Inquirer

Study: Celebrex Heart Attack Risk Twice That of Other Drugs  -  Mar 1, 2006
..."Given the popularity of celecoxib (Celebrex) in the treatment of arthritis ... drug regulatory authorities need to urgently re-examine the assessment of ... FOXNews

Celebrex risks cardiovascular problems - Otago  -  Apr 15, 2005
Patients taking the arthritis drug celecoxib (Celebrex) have a similar risk of heart attacks ... This raised concerns as to whether celecoxib (Celebrex), ... scoop.co.nz

Direct non-cyclooxygenase-2 targets of celecoxib and their potential ...  -  Jul 9, 2007
Celecoxib (Celebrex ® ) was developed as a selective cyclooxygenase-2 (COX-2) inhibitor for the treatment of chronic pain. However, it now appears that this ... Nature.com

… Risk of Cardiovascular Events With High-Dose Celecoxib in Patients...  -  Apr 4, 2008
..."Similarly, we should be cautious in prescribing celecoxib to patients who have ... The lowest dose tested in the trials was celecoxib 400 mg once a day, ... DG News

Celecoxib Reduces Colorectal Adenomas, but CV Risk Remains High  -  Aug 31, 2006
August 31, 2006 — The primary results of the Adenoma Prevention with Celecoxib (APC) and the Prevention of Colorectal Sporadic Adenomatous Polyps (PreSAP) ... Medscape

Combination of Lipitorо and Celecoxib  -  Apr 7, 2005
Combination of Lipitorо and Celecoxib at lower doses is most effective at limiting colon cancer developmentAnaheim, Calif. -- Combinations of Lipitorо and ... PsychCentral.com

Effect of Celecoxib in Preventing Colorectal Adenomas Maintained at 5...  -  Apr 16, 2008
By Sophie Bainbridge. SAN DIEGO -- April 16, 2008 -- Patients at high risk for developing colorectal adenomas who took cyclooxigenase 2 inhibitor celecoxib ... DG News

NSAIDs Appear to Increase Blood Pressure More Than Celecoxib  -  May 22, 2006
May 22, 2006 (New York) — The cyclooxygenase 2 (COX-2) inhibitor celecoxib (Celebrex) appears to slightly raise blood pressure, but the effect is not as ... Medscape

What next for pain relief?  -  Oct 2, 2005
Indeed, cox-2s like rofecoxib, valdecoxib and celecoxib were regarded as ... The APC (Adenoma Prevention with Celecoxib) trial, a colorectal cancer ... Malaysia Star

Celecoxib No Help Against Barrett"s Esophagus Progression  -  Apr 9, 2007
By David Douglas. NEW YORK APR 09, 2007 (Reuters Health) - In patients with Barrett"s esophagus, celecoxib treatment is not associated with a reduced risk ... Cancerpage.com

Increased MI in new celecoxib meta-analysis  -  Mar 2, 2006
Wellington, New Zealand - Celecoxib (Celebrex, Pfizer) is associated with an increased risk of myocardial infarction consistent with a class effect of COX-2 ... Medscape

… Of Superficial Bladder Tumors: Celecoxib For The Treatment Of Non-...  -  Apr 6, 2008
UroToday.com - Cyclooxygenase-2 (Cox-2) expression increases with bladder cancer tumor grade and stage. Dr. Pagliarulo presented preliminary results from a ... Medical News Today - Medical News Today (press release)

Celecoxib lung-cancer trial resumes  -  Jul 19, 2005
Los Angeles, CA - A trial looking at the role of celecoxib (Celebrex, Pfizer) in the prevention of lung cancer in smokers has been restarted by researchers ... Medscape

Celecoxib Noninferior to Diclofenac for Short-Term Pain Relief in...  -  Jul 16, 2007
July 16, 2007 — In patients with ankylosing spondylitis, celecoxib at a dose of 200 mg either once or twice daily appears to be comparable to 75 mg of ... Medscape

Popular painkiller may pose heart danger: study  -  Nov 16, 2006
The trial showed no increased or decreased heart risk for Celebrex, known generically as celecoxib, compared to placebo. But it did show an increased risk ... Reuters

Celecoxib can adversely affect heart rhythm  -  Jan 17, 2008
New technique could eliminate inherited mitochondrial disease — [26 Aug 2009] — Researchers have developed an experimental technique with the potential to ... Science Centric

Celebrex's new role in killing cancer?  -  May 17, 2007
They found the Cox-2 inhibitor pain drug celecoxib (Celebrex) worked the best, ... The team tested the effects of celecoxib (Celebrex), sulindac sulfide ... United Press International

Some pain drugs help prevent cancer - studies  -  Apr 18, 2005
Glebov's team found that Celebrex, known generically as celecoxib, ... "We found that treatment of patients with celecoxib led to changes in more than 1400 ... Reuters AlertNet

Chemopreventive Role for Celecoxib  -  Jun 5, 2008
June 5, 2008 (Chicago, Illinois) — Celecoxib (Celebrex) could potentially play a role as a chemopreventive agent for lung cancer; it was able to reduce the ... Medscape

Cox-2 drugs shrink pre-malignant tumors: studies - Apr. 3, 2006  -  Apr 3, 2006
A randomized study, conducted by researchers with Adenoma Prevention with Celecoxib Study, of 2035 patients showed that Celebrex reduced the formation of ... CNNMoney.com

Celecoxib (Celebrex) Reduced Restenosis after Stenting  -  Aug 17, 2007
By Judith Groch, Senior Writer, MedPage Today. SEOUL, South Korea, Aug. 17 -- The Cox-2 inhibitor celecoxib (Celebrex) used for six months after ... MedPage Today

Celebrex (celecoxib) Associated with Increased Cardiovascular Death  -  Feb 15, 2005
By Angelo DePalma,. Consider switching appropriate patients to lower doses of Celebrex (celecoxib) or to other NSAIDs, acetaminophen, or aspirin. ... MedPage Today

No Benefit Seen When Celecoxib Added to FOLFIRI or Modified …  -  Jun 8, 2006
By Cameron Johnston. ATLANTA, GA -- June 8, 2006 -- There is no benefit to adding celecoxib to other chemotherapy regimens in patients being treated for ... DG News

Arthritis Medicines and Cardiovascular Events—"House of Coxibs"  -  Jan 19, 2005
While celecoxib is the least COX-2 selective in the class of 5 agents that ... Some studies therefore concluded that celecoxib did not carry any risk for MI ... Journal of American Medical Association - Journal of American Medical Association...

AACR: Colon Cancer Prevention Continues after Stopping Celecoxib ( …  -  Apr 18, 2008
Patients in the trial who took celecoxib had 25% to 41% reduction in the ... Explain that celecoxib has cardiovascular side effects and should be used for ... MedPage Today

Celecoxib Capsules 200mg  -  Aug 3, 2007
...(chemical) taken to cure, prevent or reduce Celecoxib Capsules 200mg of an illness or medical condition. Medications are generally divided Celecoxib ... Sokwanele

Massive meta analysis clarifies cardiovascular safety of celecoxib ( …  -  Nov 23, 2005
The COX-2 specific inhibitor celecoxib (Celebrex) is not associated with an ... The meta-analysis showed that patients taking celecoxib had no more risk for ... Medical News Today - Medical News Today (press release)

Glucosamine and chondroitin sulfate in knee osteoarthritis: where now?  -  Apr 7, 2006
This was a randomized, double-blind, placebo-controlled, celecoxib-controlled, multicenter trial. Patients who were diagnosed with knee OA, defined as pain ... Nature.com

Celecoxib protects against colorectal adenoma 2 years out.(News) | …  -  Jun 15, 2008
Celecoxib protects against colorectal adenoma 2 years out.(News) ... find Internal Medicine News articles. SAN DIEGO -- Celecoxib reduced the incidence of ... Pay-Per-View - Internal Medicine News - HighBeam Research

Effects of Selective vs. Nonselective Cyclooxygenase Inhibition on …  -  Dec 6, 2007
The celecoxib and ibuprofen randomization groups were similar in age, proportion of ... Both celecoxib and ibuprofen produced statistically significant ... Nature.com

Risk of Cardiovascular Events and Celecoxib: a Systematic Review and ...  -  Mar 31, 2006
Objectives: To examine whether the increased risk of cardiovascular events with rofecoxib represents a class effect of cyclooxygenase-2 (COX-2) specific ... RedOrbit

Celecoxib demonstrates benefit in preventing premalignant colorectal ...  -  Nov 1, 2006
Celecoxib demonstrates benefit in preventing premalignant colorectal adenomas, but cardiovascular risk raises concerns. Although use of the cyclooxygenase ... $9.94 - Formulary - Alacra Store

The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in...  -  Feb 21, 2006
Aspects of the paper have been pre-published at the 43rd annual meeting of the 'American College of Neuropsychopharmacology', 12–16 December, 2004, ... Nature.com

Celecoxib shows potential to prevent colon cancer.(News)(Clinical...  -  May 15, 2006
WASHINGTON -- Results from two double-blind, randomized, controlled trials support the potential of celecoxib (Celebrex) to prevent colon cancer in people ... Free with registration - Internal Medicine News - AccessMyLibrary.com

Celecoxib (Systemic).  -  Jul 28, 2005
Celecoxib ( sell -- a -- COKS -- ib) is used to relieve some symptoms caused by arthritis, such as inflammation, swelling, stiffness, and joint pain. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Celecoxib Safe and Effective for Sore Throat Pain at 50 and 100 mg …  -  Sep 20, 2008
By Maggie Schwarz. PHILADELPHIA -- September 20, 2008 -- Celecoxib is safe and effective for treatment of pain due to pharyngitis in doses of 50 and 100 mg, ... DG News

Celebrex (Celecoxib) Approved to Treat Juvenile Rheumatoid Arthritis  -  Dec 18, 2006
BETHESDA, MD -- December 18, 2006 -- The US Food and Drug Administration (FDA) today approved Celebrex (celecoxib) for a new use - the relief of the signs ... DG News

Inhaled Celecoxib shows new promise for lung cancer treatment  -  Mar 6, 2007
In recent years, Cycloxygenase (COX)-2 has emerged as a therapeutic target for the prevention and treatment of various types of cancers. However, celecoxib ... News-Medical.net

Celecoxib (Systemic).  -  Feb 1, 2006
Celecoxib ( sell -- a -- COKS -- ib) is used to relieve some symptoms caused by arthritis, such as inflammation, swelling, stiffness, and joint pain. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Celecoxib (Systemic).(Drug overview)  -  May 1, 2006
Celecoxib ( sell -- a -- COKS -- ib) is used to relieve some symptoms caused by arthritis, such as inflammation, swelling, stiffness, and joint pain. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Efficacy and Safety of Rofecoxib 12.5 Mg and Celecoxib 200 Mg in Two ...  -  Feb 9, 2006
Objective: To compare the lower osteoarthritis (OA) dose of rofecoxib to the recommended dose of celecoxib in two identically designed studies. ... RedOrbit

Celecoxib for Prevention of Colorectal Polyps  -  Nov 10, 2006
Although risk for recurrent adenomas was lowered, this benefit might be outweighed by adverse cardiovascular effects. Because cyclooxygenase 2 (COX-2) is ... Medscape

Celecoxib As Effective As Diclofenac for Treatment of Low Back Pain, ...  -  Jun 27, 2006
By Chris Berrie. AMSTERDAM, THE NETHERLANDS -- June 27, 2006 -- The cyclooxygenase-2 (COX-2) inhibitor celecoxib is not only well tolerated and as active as ... DG News

Are there differences in the renal effects of selective cyclo...  -  Jul 18, 2005
In salt-sensitive hypertensive rats, celecoxib ameliorates endothelial dysfunction (a ... 5 These observations indicate that celecoxib might have beneficial ... Nature.com

IN BRIEF / PHARMACEUTICALS; Abraxis to Buy Pfizer Facility in Puerto ...  -  Apr 26, 2006
Under the deal, Abraxis would lease a portion of the site back to the seller to continue the manufacturing of Pfizer's celecoxib, the active ingredient of ... Pay-Per-View - Los Angeles Times - ProQuest Archiver

Celecoxib backed for juvenile rheumatoid arthritis.(News) | Article...  -  Dec 15, 2006
Celecoxib backed for juvenile rheumatoid arthritis.(News) ... find Family Practice News articles. GAITHERSBURG, MD. -- The need for a child-friendly ... Pay-Per-View - Family Practice News - HighBeam Research

Celecoxib and NSAIDs for OA  -  Feb 23, 2006
Palo Alto, CA - The coxib wars heated up again this week, with publication in the March 2006 issue of the American Journal of Medicine of data from a large ... Medscape

Celecoxib for JRA under surveillance.(News)(drug approvals for...  -  Jan 15, 2007
Long-term surveillance for safety is part of the Food and Drug Administration's recent approval of celecoxib for treatment of juvenile rheumatoid arthritis. ... Free with registration - Family Practice News - AccessMyLibrary.com

… exhibits anti-cancer effects in PCa: celecoxib decreases tumor...  -  Sep 1, 2006
Celecoxib, a nonsteroidal anti-inflammatory drug in the cyclooxygenase-2 ... "In this first randomized controlled trial of celecoxib in patients prior to ... Free with registration - Urology Times - AccessMyLibrary.com

Celecoxib Reduces Incidence and Recurrence of Colorectal Adenoma: …  -  May 20, 2008
By Bruce Sylvester. SAN DIEGO -- May 20, 2008 -- Celecoxib therapy appears to reduce the incidence and recurrence of colorectal adenoma, ... DG News

Halted trials: celecoxib tied to rise in CV risk.(News)  -  Jul 15, 2006
LOS ANGELES -- Celecoxib cannot be recommended to reduce colorectal cancer risk--despite its proven efficacy for that indication--until more is known about ... Free with registration - Internal Medicine News - AccessMyLibrary.com

Celecoxib Helps Prevent Restenosis and Appears Safe  -  Aug 16, 2007
LONDON, UK -- August 16, 2007 -- Adjunctive use of the COX-2 inhibitor celecoxib after stent implantation in patients with coronary artery disease is safe ... DG News

Colon Adenoma Prevention With Certain Non-steroidal Anti-inflammatory...  -  Apr 14, 2008
..."There has been a significant amount of negative press about Cox-2 inhibitors including celecoxib, and clearly these drugs are risky for some patients. ... sciencedaily.com

Article: Celecoxib nearly doubled CV risk in halted trials.(Cardiovasc...  -  Jul 15, 2006
Celecoxib nearly doubled CV risk in halted trials.(Cardiovascular disease)(Disease/Disorder overview) ... find Family Practice News articles. Pay-Per-View - Family Practice News - HighBeam Research

Celecoxib Helps Prevent Restenosis And Appears Safe  -  Aug 20, 2007
Adjunctive use of the COX-2 inhibitor celcoxib after stent implantation in patients with coronary artery disease is safe and can reduce the need for ... Medical News Today - Medical News Today (press release)

Pain reliever stops multiple myeloma cancer  -  Aug 30, 2005
The study showed that the drug dimethyl-celecoxib (DMC) halts tumor growth even ... Recent attention on celecoxib has focused on the withdrawal of two COX-2 ... Cancerfacts.com

Celecoxib nearly doubled CV risk in halted trials.(Clinical Rounds) |...  -  Jul 15, 2006
Celecoxib nearly doubled CV risk in halted trials.(Clinical Rounds) ... find OB GYN News articles. LOS ANGELES -- Celecoxib cannot be recommended to reduce ... Pay-Per-View - OB GYN News - HighBeam Research

Article: Celecoxib approved for AS despite cardiovascular risk.(Clinic...  -  Oct 1, 2005
Celecoxib approved for AS despite cardiovascular risk.(Clinical Rounds) ... find Skin & Allergy News articles. Celecoxib, the only cyclooxygenase-2 ... Pay-Per-View - Skin & Allergy News - HighBeam Research

Celecoxib safe for short-term use in patients with cirrhosis  -  Feb 22, 2005
Short-term use of selective COX-2 inhibitors may be safe for patients with cirrhosis of the liver, according to a recent study that compared the effects of ... eurekalert.org

Article: Celecoxib for JRA under surveillance.(News)(drug approvals...  -  Jan 15, 2007
Celecoxib for JRA under surveillance.(News)(drug approvals for juvenile rheumatoid arthritis) ... find Family Practice News articles. Pay-Per-View - Family Practice News - HighBeam Research

Meta-Analysis Shows Celecoxib Increases Risk of Myocardial Infarction...  -  Mar 28, 2007
By Danny Kucharsky. NEW ORLEANS, LA -- March 28, 2007 -- Celecoxib increases the risk of myocardial infarction but not of death or stroke, according to a ... DG News

Celecoxib Increases Risk Of Heart Attack, New Study Finds  -  Mar 3, 2006
A study published in the March issue of the Journal of the Royal Society of Medicine, has found celecoxib increases the risk of a heart attack by over ... Medical News Today - Medical News Today (press release)

Learn about Celecoxib from Consumer Reports Health.  -  Jan 1, 2006
People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as celecoxib ... Full Alert. Celecoxib is used to relieve pain, ... consumerreports.org

Celecoxib safe for short-term use in patients with cirrhosis, says...  -  Feb 25, 2005
Short-term use of selective COX-2 inhibitors may be safe for patients with cirrhosis of the liver, according to a recent study that compared the effects of ... i-newswire.com

Celecoxib deemed safer than NSAIDs in osteoarthritis patients.( …  -  Sep 1, 2006
Celecoxib is just as effective as naproxen and diclofenac for treating osteoarthritis, and it causes significantly fewer serious upper GI events than the ... Free with registration - Internal Medicine News - AccessMyLibrary.com

Celecoxib no safer than naproxen for peptic ulcer.(POEMs)(Drug …  -  Apr 15, 2006
Clinical Question: In patients with previous peptic ulcer, is celecoxib (Celebrex) ... Patients receiving celecoxib were more likely to report dyspepsia ... Free with registration - American Family Physician - AccessMyLibrary.com

Celecoxib Plus Esomeprazole Reduced Risk of Recurrent GI Bleeds  -  May 14, 2007
By Peggy Peck, Managing Editor, MedPage Today. HONG KONG, May 14 -- For arthritis patients with a history of upper-GI bleeds, adding the proton pump ... MedPage Today

Celecoxib No Safer Than Naproxen for Peptic Ulcer  -  Apr 15, 2006
Clinical Question: In patients with previous peptic ulcer, is celecoxib (Celebrex) safer than naproxen (Naprosyn) taken with a proton pump inhibitor? ... AAFP News Now

… ; Study shows INGN 241 and celecoxib combination kills breast...  -  Dec 13, 2005
2005 DEC 13 - (NewsRx.com) -- Introgen Therapeutics, Inc. (INGN) reported the publication of preclinical data demonstrating that INGN 241 works ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Article: Celecoxib gets new indication, new warning: drug is now …  -  Oct 1, 2005
Celecoxib gets new indication, new warning: drug is now approved for ankylosing spondylitis, but black box highlights risk of MI and stroke. Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Celecoxib Increases Risk of Cardiovascular Complications  -  Jul 1, 2005
Synopsis: This study was an attempt to broaden the indication of celecoxib by determining whether it can prevent recurrent colon polyps. ... AAFP News Now

Pfizer Inc. v. Teva Pharmaceuticals USA, Inc., No. 04-754 (DNJ 10/13/...  -  Oct 13, 2006
The patents-in-suit are directed toward celecoxib, the active ingredient in Celebrex, and a broad genus of compounds that includes celecoxib, pharmaceutical ... $2.95 - U.S. District Court, District of New... - VersusLaw

Halted trials: celecoxib tied to rise in CV risk.(News) | Article...  -  Jul 15, 2006
Halted trials: celecoxib tied to rise in CV risk.(News) ... find Internal Medicine News articles. LOS ANGELES -- Celecoxib cannot be recommended to reduce ... Pay-Per-View - Internal Medicine News - HighBeam Research

Brand Names/Synonyms:
Celecoxib is also known by the following brand names and/or synonymsCelebra; Celebrex; Celecoxib; Celocoxib; HSDB 7038; YM 177

Drug Category:
Celecoxib is categorized under the following by the FDA: Cyclooxygenase Inhibitors; Anti-inflammatory Agents; Nonsteroidal Antiinflammatory Agents (NSAIDs); ATC:L01XX33; ATC:M01AH01

Dosage Forms:
CELEBREX oral capsules contain 100 mg and 200 mg of celecoxib.

Absorption:
When CELEBREX capsules were taken with a high fat meal, peak plasma levels were delayed for about 1 to 2 hours with an increase in total absorption (AUC) of 10% to 20%. Coadministration of CELEBREX with an aluminum-and magnesium-containing antacid resulted in a reduction in plasma celecoxib concentrations with a decrease of 37% in Cmax and 10% in A.C. CELEBREX capsules can be administered without regard to the timing of meals.

Interactions:
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Chemical IUPAC Name:
4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide





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