Chloroprocaine

This page contains recent news articles, when available, and an overview of Chloroprocaine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Chloroprocaine (when available)

Pharmacology and use:
Chloroprocaine is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery. Chloroprocaine (like cocaine) has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine. Chloroprocaine is an ester anesthetic. For the production of local anesthesia by infiltration and peripheral nerve block. They are not to be used for lumbar or caudal epidural anesthesia.

Mechanism Of Action:
Chloroprocaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Chloroprocaine has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.

News Articles on Chloroprocaine

Abraxis completes purchase of AstraZeneca brands.(acquisitions)(Brief...  -  Jul 3, 2006
Polocaine (mepivacaine), Nesacaine (chloroprocaine HCl Injection, USP), Sensorcaine (bupivacaine) and Astramorph (morphine sulfate injection, USP). ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

Part One: Dental Carpules Single Use  -  Mar 24, 2008
A comparative in vivo study of local neurotoxicity of lidocaine, bupivacaine, 2–chloroprocaine, and a mixture of 2–chloroprocaine and bupivacaine. ... RDH

Abraxis BioScience Announces Co-Promotion Agreement with …  -  Apr 27, 2006
Nesacaine(R) (chloroprocaine HCl Injection, USP), Sensorcaine(R) (bupivacaine), and Astramorph(R) (morphine sulfate injection, USP). ... Genetic Engineering News - Genetic Engineering News (press release)

Pediatrics- regional anesthesia  -  Apr 3, 2005
Esters include cocaine, procaine, tetracaine, and chloroprocaine. 4. How are ester and amide local anesthetics metabolized? ... AnaesthesiaUK

News and Press release service TransWorldNews  -  Jul 26, 2007
...after disinfecting the skin with an iodine solution, 10 cc of the local anesthetic procaine HCL 2% or analogs (chloroprocaine, bupivacaine) is used, ... TransWorldNews - TransWorldNews (press release)

Anesthetic, local, ophthalmic Proparacaine Tetracaine Description  -  Jul 28, 2005
...local anesthetics, such as benzocaine, butacaine, butamben, chloroprocaine, procaine, or propoxycaine, when given by injection or applied to the skin. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Abraxis BioScience Completes Acquisition of the AstraZeneca US …  -  Jun 28, 2006
Nesacaine(R) (chloroprocaine HCl Injection, USP), Sensorcaine(R) (bupivacaine), and Astramorph(R) (morphine sulfate injection, USP). On April 26, 2006, ... Genetic Engineering News - Genetic Engineering News (press release)

Article: Hands Up's performance - The Nelson Mail | HighBeam Research...  -  Jul 2, 2008
...a system failure that could cause patient injury, namely the reappearance of a formulation of 3% chloroprocaine with low pH and added sodium bisulfite. ... Pay-Per-View - Nelson Mail - HighBeam Research

Article: Two new faces to join health board - The Nelson Mail |...  -  Oct 15, 2007
...a system failure that could cause patient injury, namely the reappearance of a formulation of 3% chloroprocaine with low pH and added sodium bisulfite. ... Pay-Per-View - Nelson Mail - HighBeam Research

Georgia Code - 16-13-71. (a) A "dangerous drug" means any drug other ...  -  Aug 4, 2005
...(173) Chloroguanide; (174) Chloroprocaine; (175) Chloroquine; (176) Chlorothiazide; (177) Chlorotrianisene; (178) Chloroxine; (179) Chlorphenesin; ... Pay-Per-View - Georgia Code - Loislaw

Competitors by Product Report  -  Aug 11, 2007
Naropin (Ropivacaine Hydrochloride); Nesacaine (Chloroprocaine); Polocaine (Mepivacaine); Sensorcaine (Bupivacaine); Xylocaine (Lidocaine) ... $75.00 - Revere Reports - Revere

Washington Administrative Code - WAC 260-70-680 This section …  -  Mar 17, 2006
Chloraldehyde (chloral) Chlordiazepoxide Librium Chlormezanone Trancopal Chloroform Chlorhexidol Chloroprocaine Nesacaine Chlorproethazine Newiplege ... Pay-Per-View - Washington Administrative Code - Loislaw

Article: WA: Rose's mansion to be bulldozed for a possible $36...  -  Feb 25, 2005
...a system failure that could cause patient injury, namely the reappearance of a formulation of 3% chloroprocaine with low pH and added sodium bisulfite. ... Pay-Per-View - AAP General News - HighBeam Research

Oregon Regulations - 850-060-0226 Naturopathic Formulary by …  -  Feb 1, 2006
...(e) Chloroprocaine*; (f) Dyclonine*; (g) Ethyl Chloride; (h) Etidocaine*; (i) Hydroxypolyetho-xydodecane*; (j) Lidocaine (non-injectable dosage form); ... Pay-Per-View - Oregon Regulations - Loislaw

Oregon Regulations - 850-060-0225 Naturopathic Formulary …  -  Feb 1, 2006
...(390) Yohimbine; (391) Zalcitabine; (392) Zidovudine; (393) Zolpidem; (394) Local Anesthetics: (a) Benzocaine*; (b) Bupivacaine*; (c) Chloroprocaine*; ... Pay-Per-View - Oregon Regulations - Loislaw

New Jersey Administrative Code - 10:58A-4.3 HCPCS procedure codes …  -  Aug 16, 2005
3.08 (Neo-Synephrine), up to 1 ml J2400 Injection, chloroprocaine HCI, (Nesacaine 18.84 and Nesacaine MPF), per 30 ml J2405 Injection, ondansetron HCI, ... Pay-Per-View - New Jersey Administrative Code - Loislaw

Hospira Inc intends a stock buyback - Deal Snapshot - AlacraStore.com  -  Feb 28, 2006
Supplement M Chloroprocaine hydrochlor ide HOSPIRA Anesthesia M Desmopressin acetate HOSPIRA Diabetes Insipidus M Digoxin HOSPIRA Congestive Heart Failure M ... Pay-Per-View - deals - Alacra Store

Article: A note on nonparametric estimation of the effective dose in ...  -  Jun 1, 2005
Article: Spinal 2-Chloroprocaine: Minimum Effective Dose Regional Anesthesia and Pain Medicine; January 1, 2005 ; 700+ words ... ... not been performed. ... Pay-Per-View - Journal of the American Statistical... - HighBeam Research

Brand Names/Synonyms:
Chloroprocaine is also known by the following brand names and/or synonymsAstracaine 4%; Astracaine 4% Forte; CHLOROPROCAINE; Carbocaine; Carbocaine with Neo-Cobefrin; Chirocaine; Chlor-Procaine; Chloroprocain; Chloroprocaine; Chloroprocaine Hcl; Chloroprocainum [Inn-Latin]; Chlorprocaine; Chlorprocainum; Citanest Forte; Citanest Plain; Cloroprocaina [Inn-Spanish]; Dalcaine; Dilocaine; Duranest; Duranest-Mpf; HSDB 3301; Halestyn; Isocaine; Isocaine 2%; Isocaine 3%; L-Caine; Lidoject-1; Lidoject-2; Marcaine; Marcaine Spinal; Nesacaine; Nesacaine-Ce; Nesacaine-Mpf; Novocain; Octocaine; Octocaine-100; Octocaine-50; Piocaine; Polocaine; Polocaine-Mpf; Pontocaine; Sensorcaine; Sensorcaine Forte; Sensorcaine-Mpf; Sensorcaine-Mpf Spinal; Septocaine; Ultracaine D-S; Ultracaine D-S Forte; Xylocaine; Xylocaine 5% Spinal; Xylocaine Test Dose; Xylocaine-Mpf; Xylocaine-Mpf with Glucose

Drug Category:
Chloroprocaine is categorized under the following by the FDA: Anesthetics; Local Anesthetics; ATC:N01BA04

Dosage Forms:
LIQUID

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
2-diethylaminoethyl4-amino-2-chloro-benzoate

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