Chlorpromazine

This page contains recent news articles, when available, and an overview of Chlorpromazine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Chlorpromazine
(when available)

Pharmacology and use:
Chlorpromazine is a psychotropic agent indicated for the treatment of schizophrenia. It also exerts sedative and antiemetic activity. Chlorpromazine has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on multiple organ systems. Chlorpromazine has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It also possesses slight antihistaminic and antiserotonin activity. For the treatment of schizophrenia, control nausea and vomiting, For relief of restlessness and apprehension before surgery, adjunct in the treatment of tetanus, control the manifestations of the manic type of manic-depressive illness.

Mechanism Of Action:
Chlorpromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects). Additionally, Chlorpromazine is a weak presynaptic inhibitor of Dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use).

News Articles on Chlorpromazine

Improving Quality of Life for Patients with Terminal Respiratory Disease  -  ‎Dec 29, 2009‎
A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients. Am. J. Psychiatry 153231–237 ... Medscape

Pharmacotherapy for borderline personality disorder: Cochrane systematic ...  -  ‎Dec 31, 2009‎
Two FGAs, loxapine and chlorpromazine, were compared in one study with 80 participants. 26 Tolerability did not differ significantly. ... British Journal of Psychiatry

WALK TO RAISE AWARENESS OF MENTAL HEALTH ISSUES  -  ‎Dec 15, 2009‎
The Largactyl Shuffle is named after the oldest anti-psychotic drug chlorpromazine, which was sold as Largactil in Europe, and has severe side effects. ... Community Newswire

Cross-breeding leading to native livestock decline in Orissa  -  ‎Dec 13, 2009‎
Bendroflumethiazide, Benzhexol (Trihexyphenidyl), Bisacodyl 5mg Tablets, Cetirizine Hydrochloride, Chlordiazeproxide, Chlorpromazine, Ciprofloxacin, ... TopNews

Hiccups for 60 years?  -  14 Nov 2009
Medications that have been shown to reduce hiccups are chlorpromazine, metoclopramide, and baclofen. Medications that can cause hiccups include midazolam (a ... MSN Health & Fitness

UK study warns against anti-psychotics for dementia  -  ‎Nov 12, 2009‎
...[ID:nN20262573] Anti-psychotic drugs include generic treatments like thioridazine, chlorpromazine, haloperidol, trifluorperazine and Johnson & Johnson's ... Reuters

UK study warns against anti-psychotics for dementia  -  ‎Nov 12, 2009‎
...[ID:nN20262573] Anti-psychotic drugs include generic treatments like thioridazine, chlorpromazine, haloperidol, trifluorperazine and Johnson & Johnson's ... 路透中国

Historical perspective on antipsychotic long-acting injections  -  ‎Oct 31, 2009‎
The history of antipsychotics began when the sedative effects of chlorpromazine were first reported by Delay & Deniker in 1952, 1 and entered into clinical ... British Journal of Psychiatry

BBC NEWS | Health | Chlorpromazine  -  Jan 5, 2007
Prior to its introduction, people with severe mental illnesses were given a range of treatments including electro-convulsive therapy (ECT) and sedatives ... BBC News

… floppy-iris syndrome associated with chronic use of chlorpromazine  -  Jun 29, 2007
His medical history revealed that he has been using chlorpromazine 50–200 mg ... Long-term blockade of these receptors by chlorpromazine may prevent ... Nature.com

… floppy-iris syndrome associated with chronic use of chlorpromazine  -  Feb 15, 2008
Discontinuation of chlorpromazine before cataract surgery to avoid the ... In conclusion, this report suggests that chlorpromazine may be added to the list ... Nature.com

… floppy-iris syndrome associated with chronic use of chlorpromazine  -  Feb 29, 2008
1 The authors conclude that 'discontinuation of chlorpromazine might be a wise ... Chlorpromazine is not an uncommon drug and has been in use for many years ... Nature.com

Frank Ayd, 87, Who Advanced Thorazine Use, Is Dead  -  Mar 21, 2008
In May 1955, he reported at the annual meeting of the American Psychiatric Association on his use of two antipsychotic drugs, chlorpromazine, best known by ... New York Times

Treatment For Mental Illness Falls Short  -  Oct 3, 2005
Drugs like chlorpromazine can also cause akithesia, a profound restlessness that makes it hard for people to sit still. They feel as if they are about to ... HealthCentral.com

Chlorpromazine.(Drug overview)  -  Jan 22, 2007
Chlorpromazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment ... Free with registration - PDR Family Guide to Prescription Drugs - AccessMyLibrary.com

Learn about Chlorpromazine from Consumer Reports Health.  -  Jan 11, 2008
Studies have shown that older adults with dementia (a brain disorder that affects the ability to ... Full Alert. Chlorpromazine is used to treat the ... consumerreports.org

Dr. Frank Ayd Jr., 87; advanced use of antipsychotics  -  Mar 22, 2008
In May 1955, he reported at the annual meeting of the American Psychiatric Association on his use of two antipsychotic drugs, chlorpromazine, best known by ... Boston Globe

… -Induced Growth Hormone Stimulation by Pyridoxine and Chlorpromazine...  -  Aug 1, 2006
Chlorpromazine also inhibited L-dopa-induced GH stimulation. Glucose concentrations were unaffected by L-dopa, chlorpromazine, and pyridoxine administration ... Journal of Clinical Endocrinology and...

How to take Chlorpromazine from Consumer Reports Health.  -  Jan 11, 2008
Studies have shown that older adults with dementia (a brain disorder that affects the ability to ... Full Alert. tell your doctor and pharmacist if you are ... consumerreports.org

Trials of lithium, chlorpromazine and amitriptyline in schizoaffective...  -  Jul 1, 2007
Two drug trials in schizoaffective patients are reported. Nineteen "schizomanic" patients were treated for one month, on a double blind basis, ... British Journal of Psychiatry (subscript...

chlorpromazine | Definition of chlorpromazine | HighBeam.com: Online ...  -  Jul 12, 2006
Find out what chlorpromazine means: The Oxford American College Dictionary has the definition of chlorpromazine. Research related newspaper, magazine, ... Pay-Per-View - Oxford American College Dictionary - HighBeam Research

Psychiatric Times. Through the Times With Max Fink, MD  -  Sep 1, 2005
He conducted a random assignment study of chlorpromazine (Thorazine), for example, ... Published in JAMA in 1958, that study showed chlorpromazine to be as ... Psychiatric Times

Psychiatric pills can pack on pounds  -  Mar 31, 2008
...or clozapine; Zyprexa, Seroquel or quetiapine; Risperdal, or risperidone; Modecate or chlorpromazine; fluphenazine and Haldol or haloperidol. ... United Press International

… Administrative Code - 77 Ill. Adm. Code 790.2500 CHLORPROMAZINE …  -  Aug 10, 2005
77 Ill. Adm. Code 790.2500 CHLORPROMAZINE HYDROCHLORIDE (Repealed) Repealed. (Source: Repealed at 17 Ill. Reg. 15916, effective September 20, 1993) ... Pay-Per-View - Illinois Administrative Code - Loislaw

Introduction to Mental Health Medications  -  Aug 30, 2006
Medications for mental illnesses were first introduced in the early 1950s with the antipsychotic chlorpromazine. Other medications have followed. ... PsychCentral.com

chlorpromazine (drug) -- Britannica Online Encyclopedia  -  Jun 16, 2008
Enter the e-mail address you used when enrolling for Britannica Premium Service and we will e-mail your password to you. Upload your own images and video ... Subscription - Encyclopedia Britannica

Hi I'M DONOHUE .  -  Jul 20, 2005
Chlorpromazine,. often successfully used. In cases that are resistant to medicine treatment and that are disrupting a person's life, doctors can interrupt, ... Sun Journal - Google News Archive

Phenothiazines (Systemic).  -  May 1, 2006
Analgesic Methotrimeprazine Anesthetic adjunct Chlorpromazine ... Chlorpromazine is used also in the treatment of certain types of porphyria, and with other ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Chlorpromazine modulates the morphological macro- and microstructure ...  -  Mar 1, 2008
Chlorpromazine (CP), an amphipathic, antipsychotic agent, causes concave membrane bending in red blood cells with formation of stomatocytic shapes by ... AJP - Cell Physiology (subscription)

Medication 'will not make you slur like Kerry'  -  Nov 6, 2008
..."Chlorpromazine is an anti-psychotic drug, it's a strong form of medication. "If her body wasn't able for the dose she was on, it could have caused slurred ... Herald.ie

Kerry Katona reduces bipolar medication to stop slurring  -  Dec 20, 2008
...'If you look up chlorpromazine you'll realise the side-effects – I wasn't drunk on This Morning,' she says. 'I'll never go back on the show. ... Now Magazine Online

Focus on Levomepromazine  -  Feb 25, 2005
Levomepromazine, therefore, belongs to the phenothiazine group of drugs, like chlorpromazine. Phenothiazines have a three-ring structure in which two ... RedOrbit

The rational use of medications in acute psychotic presentations--the...  -  May 1, 2006
The psychiatrist on call ordered a small dose of chlorpromazine, 100 mg, for the purpose of sedation. The patient's behaviour became more appropriate, ... Free with registration - Journal of Psychiatry and Neuroscience - AccessMyLibrary.com

PHARMACY UPDATE: Drug metabolism.  -  May 14, 2005
And yet essentially none of a normal dose of chlorpromazine will be found in the body ... Chlorpromazine is very lipid soluble and so, if there were no drug ... $4.95 - Chemist & Druggist - ECNext

Revue : la chlorpromazine diminue les récidives de la schizophrénie...  -  May 12, 2006
Thornley B, Adams CE, Awad G. Chlorpromazine versus placebo for those with schizophrenia. Cochrane Review, 1 Dec 1997. In: The Cochrane Library. ... EBM Journal (Abonnement)

Treating schizophrenia  -  Nov 24, 2007
A bubbly psychiatrist told us of a recently started study on the effect of chlorpromazine on schizophrenia, the major disease of the patients there. ... New Scientist

Steroid-induced psychosis complicating orthognathic surgery: A case …  -  Nov 26, 2005
Initial treatment with chlorpromazine, a Group 1 phenothiazine, ... Her chlorpromazine prescription was altered. Over the next two days she finally ... Nature.com

Olanzapine may reduce anorectic ruminations.(What's New In Research)  -  Jun 1, 2005
Chlorpromazine was started at 25 mg a day, and increased by 25 to 50 mg increments a week to a maximum dose of 200 mg per day. ... Free with registration - Brown University Psychopharmacology... - AccessMyLibrary.com

The Biology of Psychosis: An Expert Interview With Philip Seeman, MD,...  -  Nov 15, 2006
Dr. Seeman: At first there was some disbelief that a single receptor target could accommodate drugs as disparate as haloperidol, chlorpromazine, pimozide, ... Medscape

Acupuncture therapy rapidly terminates intractable hiccups complicatin...  -  Mar 1, 2005
Antipsychotic agents such as chlorpromazine and haloperidol have been widely used, ... Chlorpromazine (Thorazine) in the treatment of intractable hiccups. ... $4.95 - Southern Medical Journal - ECNext

BDNF Levels and Genotype are Associated with Antipsychotic-Induced …  -  Nov 7, 2007
Mean antipsychotic dose (as chlorpromazine equivalents) was 425342 mg/day. The average duration of the current antipsychotic treatment was 62 years at the ... Nature.com

Ex-Atomic Kitten geeft opgemerkt tv-interview  -  Oct 23, 2008
...die haar moesten helpen in slaap te geraken. De voormalige ster van Atomic Kitten vertelde ook dat ze Chlorpromazine nam, pillen die psychoses onderdrukken. Showbizzsite.be

Loislaw Federal District Court Opinions - JANSSEN PHARMACEUTICA v. …  -  Oct 13, 2006
The discovery that chlorpromazine could treat some symptoms of schizophrenia ... Physicians were testing chlorpromazine as a sedative when they noticed that ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Depression, anxiety, and delirium  -  Jan 1, 2005
Chlorpromazine is a potent antipsychotic that is more sedating than ... Typically, chlorpromazine is given at a dose of 25-50 mg PO/IVPB every 6 to 12 hours ... Psychiatric Times

Sanitation Beats Antibiotics, Vaccines on Greatest Medical Advances...  -  Jan 22, 2007
Discovered in 1952, chlorpromazine (Thorazine) was the first antipsychotic medication. It was used to treat psychotic disorders and their symptoms, ... FOXNews

Ziprasidone may control unresponsive schizophrenia  -  Oct 30, 2007
Sixty-two patients had participated in an earlier 12-week study in which 32 patients received ziprasidone and 30 received chlorpromazine. ... Reuters

Loislaw Federal District Court Opinions - WOODS v. WILLS (EDMo. 2005)  -  Nov 18, 2005
Plaintiffs assert that they were administered the prescription medications chlorpromazine (trade name Thorazine), carbamazepine (trade name Tegretol), ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Antipsychotics; Muscarinic receptor blockade underlies antipsychotic-...  -  Apr 1, 2005
..."The reduced in vivo potencies of thioridazine and chlorpromazine are consistent with their significantly weaker functional antagonist activity at human ... Pay-Per-View - Drug Week - Factiva, from Dow Jones

Pfizer Global Research & Development; Muscarinic receptor blockade …  -  Mar 30, 2005
..."The reduced in vivo potencies of thioridazine and chlorpromazine are consistent with their significantly weaker functional antagonist activity at human ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones

Metabolism; Researchers from Biomolecular Research Institute discuss ...  -  Dec 19, 2006
N-Oxygenation of chlorpromazine was significantly less catalytically efficient for His360-FMO3 compared with wild-type FMO3. ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Greatest Medical Advance: Sanitation  -  Jan 19, 2007
Discovered in 1952, chlorpromazine (Thorazine) was the first antipsychotic medication. It was used to treat psychotic disorders and their symptoms, ... CBS News

Antipsychotics; Muscarinic receptor blockade underlies antipsychotic-...  -  Mar 29, 2005
..."The reduced in vivo potencies of thioridazine and chlorpromazine are consistent with their significantly weaker functional antagonist activity at human ... Pay-Per-View - Science Letter - Factiva, from Dow Jones

Cancer risk among users of neuroleptic medication: a population-based...  -  Mar 10, 2006
Neuroleptic medications, in the form of chlorpromazine and other phenothiazine compounds, were introduced into clinical psychiatry in the 1940s and 1950s, ... Nature.com

Antipsychotics; Muscarinic receptor blockade underlies antipsychotic-...  -  Mar 28, 2005
..."The reduced in vivo potencies of thioridazine and chlorpromazine are consistent with their significantly weaker functional antagonist activity at human ... Pay-Per-View - Biotech Business Week - Factiva, from Dow Jones

Schizophrenia is a life of ups and downs  -  Mar 19, 2005
Although my medications generally work well with my body and mind, there are times I need extra medication such as chlorpromazine. When I hear voices or see ... Pay-Per-View - The Spectator - ProQuest Archiver

Antipsychotics; Muscarinic receptor blockade underlies antipsychotic-...  -  Mar 28, 2005
..."The reduced in vivo potencies of thioridazine and chlorpromazine are consistent with their significantly weaker functional antagonist activity at human ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones

Antipsychotics; Muscarinic receptor blockade underlies antipsychotic-...  -  Mar 29, 2005
..."The reduced in vivo potencies of thioridazine and chlorpromazine are consistent with their significantly weaker functional antagonist activity at human ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Polypharmacy and excessive dosing: psychiatrists' perceptions of …  -  Jun 1, 2008
All dosages of antipsychotic drugs were converted into chlorpromazine equivalents to facilitate comparisons (Bezchlibnyk-Butler & Jeffries, 1998; ... British Journal of Psychiatry (subscript...

La Psychopharmacologie et le Gouvernement de Soi  -  Jun 15, 2005
Seulement 16 ans après la découverte de la chlorpromazine, qui a libéré les malades ... La grande assurance des avocats et partisans de la chlorpromazine ... Psythère

What's the Greatest Medical Advance?  -  Jan 4, 2007
Chlorpromazine: Discovered in 1952, chlorpromazine (Thorazine) was the first antipsychotic medication. It was used to treat psychotic disorders and their ... CBS News

Spontaneous cellular uptake of exogenous messenger RNA in vivo is …  -  May 3, 2007
Neurotoxicity of chlorpromazine and modulation by amantadine as a function of mouse strain. Neurotoxicology 1991; 12: 571–581. | PubMed | ChemPort | ... Nature.com

A new drug to fight schizophrenia This breakthrough aims at different...  -  Mar 2, 2008
Chlorpromazine, sold under the brand name Thorazine, blocks the brain's dopamine receptors. That led the way in the 1960s for drug companies to introduce ... San Francisco Chronicle

Specialist psychiatrist who established effective drug-free treatment...  -  Jun 25, 2005
Before long the insulin treatment was dropped and chlorpromazine given more selectively. Dally had decided that the effective component of this treatment ... Times Online

Assessment of Terminal Restlessness  -  Feb 1, 2005
If haloperidol is ineffective, chlorpromazine (Thorazine[R]) is an alternative that is more ... Both chlorpromazine and haloperidol have a low incidence of ... Free with registration - MedSurg Nursing - AccessMyLibrary.com

Neuroleptics and mortality: a 50-year cycle Invited commentary on.. ....  -  May 10, 2005
However, chlorpromazine was different. Although previous treatments had provided ... Chlorpromazine ignited a wave of enthusiasm in psychiatry sufficient to ... British Journal of Psychiatry (subscript...

All antipsychotic drugs are risky, study says  -  Feb 28, 2007
...medication in this patient population, drugs like chlorpromazine (Largactil, Thorazine), haloperidol (Haldol) and loxapine (Loxapac, Loxitane). ... Pay-Per-View - The Record - ProQuest Archiver

Schizophrenia drug says goodbye to dopamine  -  Mar 6, 2008
...that a new antihistamine called chlorpromazine had unusual tranquilizing effects which, he proposed, could treat psychosis without major sedation. ... Nature.com

Article: Managing the risk of tardive dyskinesia: based on an...  -  Dec 1, 2005
Tardive dyskinesia (TD) is a set of symptoms caused ... medicines that are known to cause tardive dyskinesia include: * chlorpromazine . ... Pay-Per-View - Nursing Homes - HighBeam Research

NEED TO KNOW: SCHIZOPHRENIA  -  Nov 5, 2005
Certainly the addition of older drugs such as chlorpromazine is not advisable. Short-term increases in the dose of the atypical, while remaining within the ... Pay-Per-View - Pulse - Factiva, from Dow Jones

Article: Schizophrenia or tardive dyskinesia?(LETTERS)(Letter to the ...  -  Aug 1, 2005
Tardive dyskinesia (TD) is a set of symptoms caused ... medicines that are known to cause tardive dyskinesia include: * chlorpromazine . ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Loislaw Federal District Court Opinions - WOODS v. WILLS (EDMo. 2005)  -  Oct 27, 2005
Specifically, Mr. Corpus opined that laboratory analysis of hair samples taken from Ms. Lueken and Ms. Teasley showed the presence of chlorpromazine and ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Modern antipsychotic drugs: a critical overview.(Synthese)  -  Jun 21, 2005
S] Representative conventional antipsychotics Chlorpromazine (1953) T, L, [IM.sub.S] Flupenthixol (1983) T, L Flupenthixol decanoate (1983) [IM.sub. ... Free with registration - CMAJ: Canadian Medical Association... - AccessMyLibrary.com

33 stricken by tainted grouper  -  May 13, 2005
The insomnia pills contain two major ingredients, diazepam and chlorpromazine, both prescription drugs. Diazepam is a tranquilizer that can cause drowsiness ... The Standard

Estrogen link in mental illness  -  Aug 2, 2008
As clinicians such as Berk and Kulkarni note, chlorpromazine and daughter drugs manage the psychotic symptoms of schizophrenia, hence the push for ways to ... The Australian

Adverse Drug Reactions for the Emergency Physician: Part II  -  Jun 26, 2006
Chlorpromazine (25 mg IM) is a neuroleptic with 5-HT1A and 5-HT2 receptor antagonism that also has anticholinergic effects. One case of partial improvement ... Free with registration - Emergency Medicine Reports - AccessMyLibrary.com

Conflicting testimonies; Seshiah stands his ground  -  Oct 28, 2007
She said tests had also revealed traces of a sedative known as chlorpromazine in Woolmer's stomach, but ruled out any foul play as officials had blundered. ... Jamaica Observer

Medicine in pictures Adverse drug reactions Part 1: rashes.  -  Jul 1, 2006
It most commonly occurs in association with tetracycline, diuretics, chlorpromazine, sulphonamides, promethazine and amiodarone. ... Free with registration - Update - AccessMyLibrary.com

Schizophrenia treatment lags, US study finds new drugs dont help much...  -  Sep 20, 2005
The first antipsychotic medicines arrived 50 years ago, when a French surgeon observed that an antihistamine called chlorpromazine calmed patients without ... Pay-Per-View - Newsday - ProQuest Archiver

DR. FRANK J. AYD JR., INFLUENTIAL PSYCHIATRIST  -  Mar 29, 2008
In May 1955, he reported at the annual meeting of the American Psychiatric Association on his use of two antipsychotic drugs, chlorpromazine, best known by ... Pay-Per-View - South Florida Sun - Sentinel - ProQuest Archiver

Greyhound chiefs publish list of offending trainers  -  Dec 5, 2006
Dr Jim Healy explained the nature of Chlorpromazine as having a calming effect. He also advised the Committee that the substance can also have the effect of ... unison.ie

Librium and Valium - anxious times  -  Sep 28, 2005
The advent of the synthetic drug chlorpromazine 2 in 1952 provided the first effective treatment for schizophrenia, and led pharmaceutical companies to ... Chemistry World

Alternativ virkningsmekanisme for antipsykotiske medikamenter  -  Aug 28, 2007
Chlorpromazine, olanzapine and articaine interacting with saturated and unsaturated phosphatidylserines and saturated phosphatidylcholines " ... På Høyden

변비·위경련 등 효과…외과ì ? ì?‘급질환ì?€ 제외  -  Apr 25, 2005
Pistor� 방법� 첫째 방문시 Lidocaine 1% 2cc + Chlorpromazine 1cc를 혼합하여 ... Le Coz� Procaine 2% 1.5cc + Magnesium 1.5cc + Chlorpromazine 1.5cc 배합� ... 디지틀보사

Le hasard, ferment des psychotropes  -  Apr 1, 2007
Ayant remarqué que l'une de ses molécules, la chlorpromazine, provoquait un « désintérêt du malade pour ce qui se passe autour de lui », Henri Laborit ... La Recherche

Pharmacologic agents associated with QT interval prolongation.  -  Jun 1, 2005
High medication doses (chlorpromazine 1001 to 2000 mg or an equivalent dose of another medication) were associated with an odds ratio (OR) of 5.4 (P = .03) ... Pay-Per-View - Journal of Family Practice - Factiva, from Dow Jones

Pharmacologic agents associated with QT interval prolongation.  -  Jun 1, 2005
High medication doses (chlorpromazine 1001 to 2000 mg or an equivalent dose of another medication) were associated with an odds ratio (OR) of 5.4 (P = .03) ... $4.95 - Journal of Family Practice - ECNext

Antipsychotic Drugs in Dementia What Should Be Made of the Risks?  -  Oct 19, 2005
The introduction of the first antipsychotic drug, chlorpromazine, into clinical practice more than 50 years ago revolutionalized psychiatry and neurology. ... Journal of American Medical Association - Journal of American Medical Association...

FLUOROQUINOLONE (Oral route, Injection route, Intravenous route).( …  -  May 1, 2007
Chlorpromazine * Cisapride * Clomipramine * Desipramine * Disopyramide * Dofetilide ... Chlorpromazine * Chlorpropamide * Clarithromycin * Clomipramine ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Managing persistent hiccups in advanced cancer 2: treatment  -  Aug 29, 2008
Chlorpromazine has been widely used in the management of hiccups for over 50 ... The dopamine-antagonistic effect of chlorpromazine is thought to block the ... Nursing Times

Management of clozapine-resistant schizophrenia  -  Jul 1, 2008
In addition, arbitrary defining criteria include failure to respond to at least two neuroleptic drugs equivalent to 600mg chlorpromazine per day for more ... Adv Psychiatric Treat (subscription)

Second-generation antipsychotics offer mixed results; finding the...  -  Jun 1, 2007
They include Haldol (haloperidol), Thorazine (chlorpromazine), Mellaril (thioridazine), Prolixin (fluphenazine), Navane (thiothixene), and Trilafon ... Free with registration - Managed Healthcare Executive - AccessMyLibrary.com

Caution issued on Chinese medicine  -  May 12, 2005
Diazepam is a tranquiliser which can cause drowsiness and dizziness, while chlorpromazine is used for psychiatric conditions and may cause liver damage. ... news.gov.hk

Thorazine | Definition of Thorazine | HighBeam.com: Online Dictionary  -  Jul 12, 2006
He was ... projects to test chlorpromazine, also known by the trademark Thorazine. ... Compazine (prochlorperazine), (Thorazine (chlorpromazine), ... Pay-Per-View - Oxford American College Dictionary - HighBeam Research

What are effective medical treatments for adults with acute migraine?(...  -  Jun 1, 2006
When compared with other antiemetics (chlorpromazine [Thorazine] and ... No differences were seen between DHE alone and chlorpromazine or lidocaine. ... $4.95 - Journal of Family Practice - ECNext

Nitric oxide inhibits metamorphosis in larvae of Crepidula fornicata,...  -  Oct 1, 2007
However, chlorpromazine can do more than inhibit NOS. It can, for example, act as a histamine [H.sub.1] antagonist or inhibit calmodulin-stimulated cyclic ... Pay-Per-View - Biological Bulletin - HighBeam Research

Effect of Gender Differences on the Cardiovascular System in Patients...  -  Jan 1, 2005
Haloperidol (Haldol), chlorpromazine (Thorazine), trifluoperazine (Stelazine), pericycline, prochlorperazine (Compazine), fluphenazine (Prolixin) are all at ... Pay-Per-View - Psychiatric Times - Factiva, from Dow Jones

Treatment mental illness falls short .  -  Oct 6, 2005
Drugs like chlorpromazine can also cause a profound restlessness that makes It hard for people to still. They feel as If they are about to jump out of their ... Bryan Times - Google News Archive

Issues that May Determine the Outcome of Antipsychotic Trials:...  -  Jul 4, 2007
Clozapine for the treatment-resistant schizophrenic: a double-blind comparison with chlorpromazine. The Clozaril Collaborative Study Group. ... Nature.com

'Woolmer toxicology tests inconclusive'  -  Oct 27, 2007
Dunbar, who is a 26-year-old veteran at Jamaica's Government Forensic Science Laboratory, said there were traces of the tranquiliser chlorpromazine in ... Expressindia.com

Medication 'worsens Alzheimer's'  -  Apr 1, 2008
The neuroleptics which came under analysis in the study were thioridazine (Melleril), chlorpromazine (Largactil), haloperidol (Serenace), ... BBC News

Common drugs linked to sudden deaths  -  May 11, 2005
...which are used to treat gastro-intestinal conditions, and the anti-psychotic medications chlorpromazine, haloperidol and pimozide. ... 新�网

Antipsychotic Drugs Raise Death Rates in Elderly  -  Jun 5, 2007
..."conventional" drugs -- haloperidol (Haldol), loxapine (Loxitane), thioridazine (Mellaril), chlorpromazine (Thorazine) and perphenazine (Trilafon). ... Washington Post

Sedatives linked to pneumonia, strokes  -  Mar 30, 2007
Those being taken by patients in the research were chlorpromazine (Largactil), haloperidol (Serenace), trifluoperazine (Stelazine), risperidone (Risperdal) ... Telegraph.co.uk

Schofield denies Katona 'ambush'  -  Oct 23, 2008
Katona had been taking Chlorpromazine, an anti-psychotic drug. She has previously battled drug addiction and depression, spending time in rehab for both. ... BBC News

Management of common opioid-induced adverse effects.(dosage and …  -  Oct 15, 2006
...(33) Haloperidol and chlorpromazine (Thorazine) were found to be effective in ... A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the ... Free with registration - American Family Physician - AccessMyLibrary.com

One Pill Makes You Happy, and One Pill Makes You Mad  -  Aug 14, 2008
...for fear of waking us, they'd whisper words like 'meprobamate,' 'diazepan,' 'chlorpromazine,' as if they were speaking a secret language of love.� ... New York Times

Antibiotic resistance countered  -  Jul 9, 2007
NHS Foundation Trust, said other drugs had also been tested for their anti-conjugation properties, including the schizophrenia drug chlorpromazine. ... BBC News

Veelbelovend wapen tegen schizofrenie  -  Sep 3, 2007
De huidige geneesmiddelen tegen schizofrenie zijn allemaal afgeleid van het vijftig jaar geleden ontdekte middel chlorpromazine en ze doen eigenlijk ... DePers.nl

Brand Names/Synonyms:
Chlorpromazine is also known by the following brand names and/or synonymsLargactil; Contomin; Chlorpromados; Chlorderazin; Ampliactil; Aminazine; Aminazin; Fenactil; Fenaktyl; Chlorpromanyl-20; Chlorpromanyl-40; Chlorpromazine Hydrochloride Intensol; Largactil Liquid; Largactil Oral Drops; Novo-Chlorpromazine; Thorazine; Thorazine Spansule

Drug Category:
Chlorpromazine is categorized under the following by the FDA: Antipsychotics; Antiemetics; Dopamine Antagonists; Phenothiazines; ATC:N05AA01

Dosage Forms:
DROPS; LIQUID; SOLUTION; SYRUP; TABLET

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-propan-1-amine





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