Chlorpropamide

This page contains recent news articles, when available, and an overview of Chlorpropamide but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Chlorpropamide (when available)

Pharmacology and use:
Chlorpropamide, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Chlorpropamide is twice as potent as the related second-generation agent glipizide. For managing hyperglycemia in Non-insulin-dependent diabetes mellitus (NIDDM).

Mechanism Of Action:
Sulfonylureas such as Chlorpropamide likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.

News Articles on Chlorpropamide

常用的糖尿病藥物與心衰竭有關  -  ‎Dec 10, 2009‎
...研究中探討的第1代磺醯尿素類藥物包括：acetohexamide (商�?�??Dymelor)�?chlorpropamide (商�?�??Diabinese)�?tolbutamide以�?�tolazamide (商�?�??Tolinase)。 ... 臺灣新浪網

… Administrative Code - 77 Ill. Adm. Code 790.2510 CHLORPROPAMIDE ( …  -  Aug 10, 2005
77 Ill. Adm. Code 790.2510 CHLORPROPAMIDE (Repealed) Repealed. (Source: Repealed at 17 Ill. Reg. 15916, effective September 20, 1993) ... Pay-Per-View - Illinois Administrative Code - Loislaw

Mortality risk increases with exposure to sulfonylurea  -  Jan 18, 2006
Subjects were then divided according to the drug they were prescribed metformin, glyburide, or first-generation sulfonylureas (chlorpropamide or ... Medscape

Learn about Chlorpropamide from Consumer Reports Health.  -  Jan 5, 2007
Chlorpropamide is used to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar ... consumerreports.org

Risks of sulfonylurea drugs in the treatment of diabetes mellitus...  -  Aug 28, 2006
Patients who were prescribed a sulfonylurea drug (chlorpropamide, tolbutamide or glyburide) experienced higher mortality rates than those who received ... Natural News.com

Antidiabetic Agents, Sulfonylurea (Systemic).  -  Aug 1, 2006
Antidiabetic Acetohexamide Chlorpropamide Gliclazide Glimepiride Glipizide Glyburide Tolazamide Tolbutamide Antidiuretic Chlorpropamide Description ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Antidiabetic Agents, Sulfonylurea (Systemic).(Disease/Disorder...  -  May 1, 2006
Antidiabetic Acetohexamide Chlorpropamide Gliclazide Glimepiride Glipizide Glyburide Tolazamide Tolbutamide Antidiuretic Chlorpropamide Description ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Pancreatic Islets; Prolonged exposure to sulfonylureas disrupts...  -  Apr 25, 2005
..."Quantitative RT-PCR studies showed that, compared with the control islets, cells preincubated with glibenclamide or chlorpropamide had an increased ... Pay-Per-View - Diabetes Week - Factiva, from Dow Jones

Le contrôle intensif de la glycémie diminue les complications du...  -  Nov 25, 2006
à un traitement intensif visant à atteindre un niveau de glycémie < 6 mmol/l (association d'un régime aux antidiabétiques oraux [chlorpropamide, ... EBM Journal (Abonnement)

Kinetics-Effect Relations of Insulin-Releasing Drugs in Patients With...  -  Jan 23, 2005
Chlorpropamide, for example, seems unique in promoting secretion of antidiuretic hormone and hence water retention (7). Some sulfonylureas might activate ... RedOrbit

Diabetes mellitus drugs in India  -  Nov 21, 2007
...a) First generation drugs like chlorpropamide and tolbutamide, which are not in use or preferred currently. b) Second generation drugs like Glibenclamide, ... pharmabiz.com

Strategies for insulin therapy in type 2 diabetes.(Review Article)  -  Mar 1, 2005
No significant difference in microvascular risk reduction was observed among the chlorpropamide, glibenclamide, and glipizide treatment modalities. ... $4.95 - Southern Medical Journal - ECNext

Do sulfonylurea drugs increase the risk of cardiac events?( …  -  Jan 17, 2006
...(10) The effects of chlorpropamide or glipizide have not been documented in people, but animal studies suggest that the effects of glipizide are similar to ... Free with registration - CMAJ: Canadian Medical Association... - AccessMyLibrary.com

Drug dosing adjustments in patients with chronic kidney disease.(Drug...  -  May 15, 2007
Sulfonylureas (e.g., chlorpropamide [Diabinese], glyburide [Micronase]) should ... (18) The half-life of chlorpropamide is significantly increased in these ... $4.95 - American Family Physician - ECNext

Side Effects. Side effects include:  -  Jul 15, 2006
A number of brands are available, including chlorpropamide (Diabinese), tolazamide (Tolinase), acetohexamide (Dymelor), glipizide (Glucotrol), ... HealthCentral.com

糖尿病的傳統藥物(1)  -  Aug 8, 2007
...腎功能�?全時，應儘�?�?��?使用經由腎臟排泄的磺醯尿素，如chlorpropamide，改用95% ... 低血糖�?�能�?續數天，長效型製劑如chlorpropamide�?�glibenclamide，�?比短效 ... udn.com

'설�?�요소제' 혈당강하 초기치료 �?�한 처방  -  Oct 20, 2005
Chlorpropamide는 반�?기가 35 시간으로 길어 역시 저혈당�?� 위험�?� 높다. 반�?기가 짧�?� gliclazide와 tolbutamide는 저혈당�?� 위험�?� 낮다고 알려져 있으나 비슷한 ... 디지틀보사

A case of fluoxetine-induced syndrome of inappropriate antidiuretic …  -  Oct 12, 2007
...of the etiologies of SIADH, but various drugs, including chlorpropamide, clofibrate and carbamazepine, have also been reported to cause the condition. ... Nature.com

Medicines and alcohol  -  Sep 28, 2005
Flushing may occur in susceptible patients when alcohol is taken with chlorpropamide. Anti-epileptics – Alcohol increases the sedative effect when taken ... Malaysia Star

Advances In The Management Of Patients With Diabetes Mellitus  -  Sep 2, 2008
Two major drug classes that have been in use for some decades are biguanides (metformin) and sulphonylureas (eg:- chlorpropamide, gliclazide and glyburide). ... Medical News Today - Medical News Today (press release)

How to take Desmopressin Nasal from Consumer Reports Health.  -  Jan 1, 2008
...carbamazepine (Tegretol); chlorpromazine (Thorazine, Sonazine); chlorpropamide (Diabinese); clofibrate; demeclocycline (Declomycin); fludrocortisone; ... consumerreports.org

NPPA raises bulk drugs, formulations prices  -  Feb 2, 2006
...information with it, has decided that the existing notified price of bulk drug Chlorpropamide, which is used in the treatment of diabetes, be continued. ... Hindu Business Line

How to take Chloramphenicol Injection from Consumer Reports Health.  -  Jan 2, 2008
...cyanocobalamin (vitamin B12); folic acid; iron supplements; certain oral medications for diabetes such as chlorpropamide (Diabinese) and tolbutamide; ... consumerreports.org

H is for Hypo  -  May 31, 2007
The first-generation sulfonylureas include Dymelor (acetohexamide), Diabinese (chlorpropamide), Orinase (tolbutamide), Tolinase (tolazamide). ... HealthCentral.com

DRUG CAPSULE WHAT YOU SHOULD KNOW  -  Jul 17, 2006
Interactions: Tell your doctor if you drink alcohol or are taking any other medications, particularly carbamazepine, chlorpropamide, demeclocycline, ... $2.95 - Milwaukee Journal Sentinel - NewsBank

Top 5 skin diagnoses vary by ethnicity in study.(Skin Disorders) |...  -  Jan 1, 2008
Family Practice News; February 15, 2001 ; 700+ words ... ... sulfonylurea drugs such as tolbutamide and chlorpropamide, said researchers Dr. Oded Langer of ... Pay-Per-View - Family Practice News - HighBeam Research

DRUG CAPSULE WHAT YOU SHOULD KNOW | Article from The …  -  Jul 17, 2006
Interactions: Tell your doctor if you drink alcohol or are taking any other medications, particularly carbamazepine, chlorpropamide, demeclocycline, ... Pay-Per-View - Milwaukee Journal Sentinel - HighBeam Research

Independent Nurse: Clinical - Prescribing - Oral therapy options for...  -  Sep 30, 2005
The risk of hypoglycaemia appears to be greatest with the long-acting sulphonylureas chlorpropamide and glibenclamide, and these should be avoided in favour ... Free with registration - GP - AccessMyLibrary.com

How to take Nortriptyline from Consumer Reports Health.  -  Jan 8, 2007
Be sure to mention any of the following: anticoagulants (blood thinners) such as warfarin (Coumadin); antihistamines; chlorpropamide (Diabinese); ... consumerreports.org

Bitter Melon.(Drug overview)  -  Feb 1, 2007
Aslam M & Stockley IH: Interaction between curry ingredient (karela) and drug (chlorpropamide) (letter). Lancet 1979; 1:607. ... Free with registration - AltCareDex Alternative Medicines - AccessMyLibrary.com

New diabetic drug class shows promise  -  Mar 24, 2005
...short acting agent, Tolbutamide, intermediate acting agents, Gilpizide and Glicazide, and long acting agents, Chlorpropamide, Glyburide and Climepiride. ... DrugResearcher.com

메디팜뉴스 - �?�약전문 1등 �?�터넷 신문 (주소창�? 한글로 '메디팜뉴스'를...  -  Jan 18, 2008
...단 설�?��?우레아계 약물(성분 : glimepiride, glibenclamide, gliclazide, glipizide, gliquidone, chlorpropamide) 단�?�요법 �?는 biguanide계 약물(metformin) 단�?� ... 메디팜뉴스

Clinical quiz.  -  May 15, 2007
D. Chlorpropamide (Diabinese). Uterine Fibroid Tumors: Diagnosis and Treatment (p. 1503) Q8. A 42-year-old parous woman is contemplating hysterectomy ... Free with registration - American Family Physician - AccessMyLibrary.com

Chloramphenicol (Otic).  -  Jul 28, 2005
Chloramphenicol may increase the blood levels of these medications: alfentanil, chlorpropamide, phenobarbital, phenytoin, tolbutamide, and warfarin. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

FLUOROQUINOLONE (Oral route, Injection route, Intravenous route).( …  -  May 1, 2007
Chlorpropamide * Clarithromycin * Clomipramine * Desipramine * Dibenzepin * Disopyramide * Dofetilide * Dolasetron * Dothiepin * Doxepin * Droperidol ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Seniors Given Harmful Drugs .  -  Mar 2, 2005
...for elderly people has not decreased. 'llie medications cited as ways avoid" include: Barbiturates, Belladonna alkaloids, Chlorpropamide and Dicyclomine . Tuscaloosa News - Google News Archive

Widely Prescribed Diabetes Drug Falls Short Of Promise, Says New …  -  Oct 21, 2006
...drugs called "sulfonylureas," which are marketed in the United States under the generic names glipizide, glyburide, glimepiride and chlorpropamide. ... Medical News Today - Medical News Today (press release)

Effects of Exenatide (Exendin-4) on Glycemic Control Over 30 Weeks in...  -  May 8, 2005
1.25 mg/ day glibenclamide, 0.75 mg/day micronized glibenclamide, 100 mg/ day chlorpropamide, 100 mg/day tolazamide, or 250 mg/day tolbutamide). ... RedOrbit

Sun Herald : Photosensitive medicines listed  -  Aug 23, 2007
Anti-diabetic agents: acetohexamide (Dymelor); chlorpropamide (Diabinese); glimepiride (Amaryl); glipizide (Glucotrol); glyburide (DiaBeta, Micronase); ... $2.95 - Sun Herald - NewsBank

Sulfonylureas :: Diabetes Self-Management  -  Jun 16, 2006
The first-generation sulfonylureas, which have been around for many years, are tolbutamide, tolazamide (brand name Tolinase), and chlorpropamide (Diabinese) ... Diabetes Self Management

Widely Prescribed Diabetes Drug Falls Short of Promise, Says New …  -  Oct 18, 2006
...drugs called "sulfonylureas," which are marketed in the United States under the generic names glipizide, glyburide, glimepiride and chlorpropamide. ... DG News

Diabetes Therapy; Kinetics-effect relations of insulin-releasing...  -  Feb 21, 2005
..."Moreover, there was no difference in patient outcome between the first-generation sulfonylurea chlorpropamide and the second-generation glyburide in the UK ... Pay-Per-View - Diabetes Week - Factiva, from Dow Jones

Clinical quiz.  -  May 15, 2007
D. Chlorpropamide (Diabinese). Uterine Fibroid Tumors: Diagnosis and Treatment (p. 1503) Q8. A 42-year-old parous woman is contemplating hysterectomy ... $4.95 - American Family Physician - ECNext

Independent Nurse: Support for reduction of sulphonylurea use.(Brief ...  -  Jan 27, 2006
The researchers looked at data from 4138 patients on sulphonylurea monotherapy, 120 patients on a first-generation drug (either chlorpropamide or ... Free with registration - GP - AccessMyLibrary.com

Diabetes Therapy; Kinetics-effect relations of insulin-releasing...  -  Feb 26, 2005
..."Moreover, there was no difference in patient outcome between the first-generation sulfonylurea chlorpropamide and the second-generation glyburide in the UK ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

Press of Atlantic City, The : Question & Answer from the pharmacy:...  -  Aug 27, 2007
Antidiabetic agents: acetohexamide (Dymelor); chlorpropamide (Diabinese); glimepiride (Amaryl); glipizide (Glu-cotrol); glyburide (DiaBeta, Micronase); ... $2.95 - Press of Atlantic City, The - NewsBank

Look before you gulp  -  Nov 21, 2006
There are some drugs like Metronidazole, Chlorpropamide, which are not compatible with alcohol consumption. So during the course of the medication and some ... Merinews

Antiadrenal Ketoconazole Antifungal, systemic Fluconazole Itraconazole...  -  Aug 1, 2006
...these medicines should be taken at least 2 hours after itraconazole or ketoconazole Antidiabetic agents, oral (chlorpropamide [eg, Diabinese], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Widely Prescribed Diabetes Drug Falls Short of Promise, Says New …  -  Oct 11, 2006
...drugs called "sulfonylureas," which are marketed in the United States under the generic names glipizide, glyburide, glimepiride and chlorpropamide. ... newswise.com

Oral Medicines for Type 2 Diabetes  -  Jul 18, 2006
Glynase, Micronase), glimepiride (Amaryl), and the less commonly used chlorpropamide (Diabinese), tolazamide (Tolinase), and tolbutamide (Orinase)—works ... Diabetes Self Management

Antifungals, Azole (Systemic).(Drug overview)  -  May 1, 2006
...these medicines should be taken at least 2 hours after itraconazole or ketoconazole Antidiabetic agents, oral (chlorpropamide [eg, Diabinese], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Missouri Regulations - 13 CSR 70-20.040 Five Prescription Limit Per …  -  Aug 16, 2005
Carbachol Ophthalmic Solution Carbamazepine Carbidopa and Levodopa Chlorothiazide Chlorpropamide Tablets Chlorthalidone and Clonidine HCl Chlorthalidone ... Pay-Per-View - Missouri Regulations - Loislaw

Georgia Code - 16-13-71. (a) A "dangerous drug" means any drug other ...  -  Aug 4, 2005
...(179) Chlorphenesin; (180) Chlorpheniramine — See exceptions; (181) Chlorphenoxamine; (182) Chlorpromazine; (183) Chlorpropamide; (184) Chlorprothixene; ... Pay-Per-View - Georgia Code - Loislaw

Salipran - Précautions, Posologie, Grossesse, Comment ça marche  -  Jan 4, 2007
Associations faisant l'objet de précautions d'emploi : antidiabétiques (insuline, chlorpropamide) ; glucocorticoïdes par voie générale ; diurétiques avec ... Santé AZ

Alcohol: the good, the bad, and the ugly.(Editorial) | Article from...  -  Jan 1, 2005
Southern Medical Journal; January 1, 2002 ; 700+ words ... ... taking chlorpropamide may experience a disulfiram-like reaction (usually facial flushing ... Pay-Per-View - Southern Medical Journal - HighBeam Research

California Code of Regulations - § 16:1744. Drug Warnings.  -  Aug 16, 2005
...(1) Disulfiram and other drugs (eg chlorpropamide, metronidazole) which may cause a disulfiram-like reaction. (2) Mono amine oxidase inhibitors. ... Pay-Per-View - California Code of Regulations - Loislaw

India drug maker Albert David ties up with Japan's Ajinomoto.  -  Jan 7, 2005
Albert David has filed drug master files for two of its bulk drugs -- tolbutamide and chlorpropamide -- with the US Food and Drugs Administration (USFDA). ... $9.94 - Knight Ridder/Tribune Business News - Alacra Store

Medication safety issue brief: look-alike, sound-alike drugs: 5 of 6...  -  Oct 1, 2005
One patient died, for example, after receiving 750 mg of chlorpropamide (used to treat type II diabetes) instead of 75 mg of chlorpromazine daily (used to ... $9.94 - H&HN - Alacra Store

INAPPROPRIATE MEDICATION PRESCRIBED TO THE ELDERLY  -  Mar 2, 2005
The medications cited as "Always avoid" are: Barbiturates, Belladonna alkaloids, Chlorpropamide, Dicyclomine, Flurazepam, Hyoscyamine, Meperidine, ... Pay-Per-View - Palm Beach Post - NewsBank

Secondary headaches more common in elderly.(Geriatrics) | Article...  -  Apr 15, 2005
...the prevention of microvascular complications ... the sulfonylureas are preferred for the elderly. The exceptions to this rule are chlorpropamide ... ... Pay-Per-View - Internal Medicine News - HighBeam Research

Individualize diabetes care in the elderly for good glucose control....  -  Jun 1, 2005
The exceptions to this rule are chlorpropamide and glyburide, because both have prolonged half-lives and a tendency to cause hypoglycemia. ... Pay-Per-View - Internal Medicine News - HighBeam Research

Inappropriate medication prescribed to elderly  -  Mar 8, 2005
The medications cited as "Always avoid" are: barbiturates, belladonna alkaloids, chlorpropamide, dicyclomine, flurazepam, hyoscyamine, meperidine, ... Helena Independent Record

췌장 베타세�?��?서 �?��?린 분비 �?강작용  -  May 1, 2006
...▷Chlorpropamide : 1957년부터 사용�?�기 시작한 1세대 설�?�요소제�?�며, 대사 후 모�? 신장�?� 통해 배설�?�므로 신장기능�?� �?��?�?� 있거나 �?습관�?� �?�정치 않�?� 노�?��?� ... 디지틀보사

Revue : la metformine n'augmente pas le risque d'acidose lactique ni...  -  Mar 27, 2006
...glibenclamide, glimepiride, chlorpropamide, tolbutamide, acarbose, nateglinide, repaglinide, miglitol, troglitazone, rosiglitazone et gomme arabique. ... EBM Journal (Abonnement)

�?��?린분비촉진제�?� 새로운 고찰  -  Nov 3, 2005
...기존 약물�?� tolbutamide, chlorpropamide, gliclazide 등�?� sulfornylurea moiety만 존재하기때문�? 베타세�?� 선�?성�?� 갖고 있다. �?한 KATP 채�?�?� 차단하지만 심근 ... 메디칼트리뷴

Broncorinol Toux Seche Adulte - Indications, Contre indications,...  -  Oct 6, 2005
...les médicaments destinés au traitement du diabète (chlorpropamide, glibenclamide, glipizide, insuline, metformine, sulfamides hypoglycémiants). Santé AZ

Cephalgan - Précautions, Posologie, Grossesse, Conduite, Comment ça …  -  Jan 4, 2006
Associations nécessitant des précautions d'emploi : antidiabétiques (insuline, chlorpropamide) ; glucocorticoïdes (voie générale) ; diurétiques, ... Santé AZ

La metformine n'augmente pas le risque d'acidose lactique mortelle ou...  -  Jan 3, 2006
Les comparateurs étaient les suivants : placebo, régime, insuline, glyburide, gliclazide, glipizide, glibenclamide, glimépiride, chlorpropamide, tolbutamide ... EBM Journal (Abonnement)

Article - Bulletin d'information toxicologique - Centre de toxicologie...  -  Jun 19, 2006
Les sulfonylurées, dont les plus répandus sont le chlorpropamide, le glibenclamide (Diamicron®), le glyburide (Diabeta®, Euglucon®) et le tolbutamide, ... INSPQ

A clinical review of antibody-mediated pure red cell aplasia.(Continui...  -  Jan 1, 2005
Cardiovascular Procainamide Chemotherapeutic Rifampicin Erythropoietic Recombinant erythropoietins Other agents Azathioprine Chlorpropamide Allopurinol ... $4.95 - Nephrology Nursing Journal - ECNext

New Jersey Administrative Code - 8:71-1.1 Precedence of lists  -  Aug 16, 2005
Shire Richwood DIABETA Glyburide 1.25 mg, 2.5 mg, 5 mg Tablet Hoechst-Roussel/Coventry, Novopharm DIABINESE Chlorpropamide 100 mg, 250 mg Tablet Mylan, ... Pay-Per-View - New Jersey Administrative Code - Loislaw

Brand Names/Synonyms:
Chlorpropamide is also known by the following brand names and/or synonymsAdiaben; Apo-Chlorpropamide; Asucrol; Catanil; Chlorodiabina; Chloronase; Chloropropamide; Chlorpropamid; Chlorpropamide; Chlorpropamide Bp/ Usp; Clorpropamide; Diabaril; Diabechlor; Diabenal; Diabenese; Diabeneza; Diabet-Pages; Diabetoral; Diabinese; Diamel Ex; Dynalase; Glisema; Glucamide; Hexathane; Insulase; Meldian; Melitase; Mellinese; Millinese; Novo-Propamide; Oradian; P 607; P-607; Stabinol; U-9818

Drug Category:
Chlorpropamide is categorized under the following by the FDA: Hypoglycemic Agents; Sulfonylureas; ATC:A10BB02

Dosage Forms:
TABLET

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
N-(4-chlorophenyl)sulfonylmethanamide

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