Chlorzoxazone

This page contains recent news articles, when available, and an overview of Chlorzoxazone but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Chlorzoxazone
(when available)

Pharmacology and use:
Chlorzoxazone, a synthetic compound, inhibits antigen-induced bronchospasms and, hence, is used to treat asthma and allergic rhinitis. Chlorzoxazone is used as an ophthalmic solution to treat conjunctivitis and is taken orally to treat systemic mastocytosis and ulcerative colitis. Chlorzoxazone is also a centrally-acting agent for painful musculoskeletal conditions. Data available from animal experiments as well as human study indicate that chlorzoxazone acts primarily at the level of the spinal cord and subcortical areas of the brain where it inhibits multisynaptic reflex a.c. involved in producing and maintaining skeletal muscle spasm of varied etiology. The clinical result is a reduction of the skeletal muscle spasm with relief of pain and increased mobility of the involved muscles. For the relief of discomfort associated with acute painful musculoskeletal conditions.

Mechanism Of Action:
Chlorzoxazone inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. Chlorzoxazone also may reduce the release of inflammatory leukotrienes. Chlorzoxazone may act by inhibiting calcium influx.

News Articles on Chlorzoxazone

Validation of incorporating flurbiprofen into the Pittsburgh cocktail...  -  Jan 26, 2006
The ability to hydroxylate chlorzoxazone (CYP2E1) was estimated by the ... Use of chlorzoxazone as an in vivo probe of cytochrome P450 2E1: choice of dose ... Nature.com

… Administrative Code - 77 Ill. Adm. Code 790.2580 CHLORZOXAZONE ( …  -  Aug 10, 2005
77 Ill. Adm. Code 790.2580 CHLORZOXAZONE (Repealed) Repealed. (Source: Repealed at 17 Ill. Reg. 15916, effective September 20, 1993) ... Pay-Per-View - Illinois Administrative Code - Loislaw

桂行丸ç¦?藥悄悄賣  -  Dec 11, 2007
...衛生局藥物食�管�處長姜�美指出,歸�街一家食�行所販售的桂行丸,檢驗出 �有Ethoxybenzamide(解熱鎮痛)�Chlorzoxazone(骨骼肌鬆弛劑)�Caffeine(�中樞神經 ... ��新�網

Skeletal Muscle Relaxants (Systemic).  -  Feb 1, 2006
It is not known whether chlorphenesin, chlorzoxazone, metaxalone, or methocarbamol ... However, carisoprodol and chlorzoxazone have been used in children. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Occupational toluene exposure induces cytochrome P450 2E1 mRNA …  -  Apr 1, 2006
Key words: chlorzoxazone, CYP2E1 mRNA induction, lymphocytes, ... Chlorzoxazone (CHZ) is a centrally acting muscle relaxant drug that has been used ... $4.95 - Environmental Health Perspectives - ECNext

[U] Garner v. Workers' Compensation Appeal Board, No. 1559 CD 2007 ( …  -  Feb 25, 2008
Upon review, although the pharmaceutical literature (particularly that discussing Celebrex, Chlorzoxazone and Hydrocodone) refers to liver disease or liver ... $2.95 - Pennsylvania Commonwealth Court - VersusLaw

Federal Register 2008 - 73 FR 79486 Teva Pharmaceutical Industries...  -  Dec 29, 2008
...manufacture and market generic: (1) chlorzoxazone tablets; (2) deferoxamine injection; ... (2) chlorzoxazone tablets; (3) desmopressin acetate tablets; ... Pay-Per-View - Federal Register 2008 - Loislaw

Federal Register 2007 - 72 FR 8184 Withdrawal of Approval of 128 …  -  Feb 23, 2007
Drug Petitioner --------------------------------------------------------------- --------- 82N-0032/ Chlorzoxazone 500 milligrams (mg) Mikart, ... Pay-Per-View - Federal Register 2007 - Loislaw

Drug prices costlier by 25-30% as rupee wilts  -  Nov 3, 2008
Pentaprazole costs Rs 7400 for five kg, a rise of 64.4 per cent while the price of Chlorzoxazone USP has increased by 53.8 per cent to Rs 600 per 25 kg. ... सिफी - सिफी

Garlic.(Drug overview)  -  Feb 1, 2007
Chlorzoxazone (Paraflex(R)) * Indomethacin (Indocin(R)) * Medicine for human immunodeficiency virus (HIV) (examples: saquinavir (Fortovase(R), ... Free with registration - AltCareDex Alternative Medicines - AccessMyLibrary.com

Showa University; Effects of anti-TB drugs on cytochrome P450...  -  Feb 23, 2005
7-hydroxylation, while a preincubation step in the presence of NADPH was needed to inhibit chlorzoxazone 6-hydroxylation," according to the report. ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones

St. John's Wort.(Drug overview)  -  Feb 1, 2007
Chlorzoxazone (Paraflex(R)) * Clozapine (Clozaril(R)) * Hormonal contraceptives (birth control) may interact with St. John's Wort, resulting in unplanned ... Free with registration - AltCareDex Alternative Medicines - AccessMyLibrary.com

St. John's Wort.(Health Aspects)  -  May 1, 2006
Chlorzoxazone (Paraflex(R)) * Clozapine (Clozaril(R)) * Hormonal contraceptives (birth control) may interact with St. John's Wort, resulting in unplanned ... Free with registration - AltCareDex Alternative Medicines - AccessMyLibrary.com

Pharmacology; Reports add new data to pharmacology research  -  Sep 2, 2005
7-hydroxylation, while a preincubation step in the presence of NADPH was needed to inhibit chlorzoxazone 6-hydroxylation," according to the report. ... Pay-Per-View - Drug Week - Factiva, from Dow Jones

Digitek Maker Warned on Quality Control Issues in 2006  -  May 21, 2008
Carisoprodol and Aspirin tablets, USP, 200mg/325mg; Carisoprodol tablets, USP, 350mg; Chlorzoxazone tablets, USP, 250mg and 500mg; Digoxin tablets, USP, ... US Recall News - US Recall News (press release)

BENZODIAZEPINE (Oral route, Parenteral route, Rectal route).(Drug …  -  May 1, 2007
Chlorzoxazone * Codeine * Dantrolene * Digoxin * Ethchlorvynol * Fentanyl * Fluconazole * Hydrocodone * Hydromorphone * Itraconazole * Ketoconazole ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Erie Times-News : Front Page<br>  -  Oct 27, 2006
Parafon Chlorzoxazone 500mg tab. Tagamet Cimetidine 800mg tab. Celexa Citalopram 20mg tab. Klonopin Clonazepam 1mg tab. Catapress Clonidine 0.1mg tab ... $2.95 - Erie Times-News - NewsBank

Georgia Code - 16-13-71. (a) A "dangerous drug" means any drug other ...  -  Aug 4, 2005
...(185) Chlorquinaldol; (186) Chlortetracycline; (187) Chlorthalidone; (188) Chlorzoxazone; (189) Cholera vaccine; (190) Cholestyramine resin; ... Pay-Per-View - Georgia Code - Loislaw

Antipsychotics; Sulpiride does not inhibit cytochrome P450 activity  -  Mar 28, 2005
CYP2D6-mediated debrisoquine 4-hydroxylation, CYP2E1-mediated chlorzoxazone 6-hydroxylation, CYP3A4-mediated nifedipine oxidation, or CYP3A4-mediated ... Pay-Per-View - Hepatitis Weekly - Factiva, from Dow Jones

Life can be incredibly lonely and difficult for people suffering from...  -  Apr 30, 2008
Like Magnuson, Sanderson takes numerous medications - Neurontin, Chlorzoxazone for muscle spasms, Tramadol for pain, help for difficulty with sleeping, ... $2.95 - Chinook Observer - NewsBank

Pharmacy update: How food affects drugs.(Food and drinks are packed …  -  Sep 16, 2006
Watercress (50g) increased the bioavailability of the muscle relaxant chlorzoxazone by 50 per cent compared with the control and increased the half-life ... $4.95 - Chemist & Druggist - ECNext

Toxicology; Research from Germany, India and Canada in the area of …  -  Jan 9, 2007
...coumarin (CYP2A6), tolbutamide (CYP2C9), S-(+)-mephenytoin (CYP2C19), dextromethorphane (CYP2D6), chlorzoxazone (CYP2E1) and testosterone (CYP3A4). ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Antipsychotics; Sulpiride does not inhibit cytochrome P450 activity  -  Apr 1, 2005
CYP2D6-mediated debrisoquine 4-hydroxylation, CYP2E1-mediated chlorzoxazone 6-hydroxylation, CYP3A4-mediated nifedipine oxidation, or CYP3A4-mediated ... Pay-Per-View - Drug Week - Factiva, from Dow Jones

VGS Acquisition Corp acquires Fortes Financial Inc (pending) - Deal …  -  May 16, 2008
Muscle Relaxing Agents Products: Parafon Forte DSC (Chlorzoxazone) Flexeril (Cyclobenzaprine HCL…Scientific ChoICE Standard Boston Scientific Forte Boston ... Pay-Per-View - deals - Alacra Store

Options for osteoarthritis pain: despite concerns about certain pain ...  -  Jul 1, 2006
Muscle relaxants (carisoprodol, chlorzoxazone, cyclobenzaprine, methocarbamol, metaxalone, oxybutynin) * Nifedipine, short-acting * Nitrofurantoin * NSAIDs, ... Pay-Per-View - Men's Health Advisor - HighBeam Research

Antipsychotics; Sulpiride does not inhibit cytochrome P450 activity  -  Mar 29, 2005
CYP2D6-mediated debrisoquine 4-hydroxylation, CYP2E1-mediated chlorzoxazone 6-hydroxylation, CYP3A4-mediated nifedipine oxidation, or CYP3A4-mediated ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Actavis Totowa, Little Falls, NJ, Feb. 1 (Parsippany, NJ).(HUMAN...  -  Mar 1, 2007
Carisoprodol and Aspirin Tablets, USP, 200mg/325mg; Carisoprodol Tablets, USP, 350mg; Chlorzoxazone Tablets, USP, 250mg and 500mg; Digoxin Tablets, USP, ... $4.95 - Warning Letter Bulletin - ECNext

Congressman charges that FDA fails in protecting the public.(News)(Bri...  -  Mar 17, 2008
Chain Drug Review; August 28, 1989 ; 671 words ... ... approval to market chlorzoxazone on June 5, and ATI received its approval June 23. ... Pay-Per-View - Chain Drug Review - HighBeam Research

Antipsychotics; Sulpiride does not inhibit cytochrome P450 activity  -  Mar 28, 2005
CYP2D6-mediated debrisoquine 4-hydroxylation, CYP2E1-mediated chlorzoxazone 6-hydroxylation, CYP3A4-mediated nifedipine oxidation, or CYP3A4-mediated ... Pay-Per-View - Pharma Business Week - Factiva, from Dow Jones

FTC is considering Teva's acquisition of Barr.  -  Sep 29, 2008
For example, they say, chlorzoxazone is one product where Barr and Teva have nearly all of the worldwide market share. The companies' combined strengths in ... $9.94 - Chain Drug Review - Alacra Store

Antipsychotics; Sulpiride does not inhibit cytochrome P450 activity  -  Mar 28, 2005
CYP2D6-mediated debrisoquine 4-hydroxylation, CYP2E1-mediated chlorzoxazone 6-hydroxylation, CYP3A4-mediated nifedipine oxidation, or CYP3A4-mediated ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones

å°?心ï¼? 21%中藥檢出西藥æˆ?份ï¼?  -  Oct 15, 2007
...苯塞(Hydrochlorothiazide)�最常被檢出;其次為「解熱鎮痛劑─乙醯氨 酚(Acetaminophne)�;「止痛劑(如Indomethacin�Piroxicam�Chlorzoxazone�Mefanamic ... udn.com

Loislaw Federal District Court Opinions - EDWARDS v. GU (NJ 2005)  -  Aug 30, 2005
Dr. Godinsky also explained to plaintiff that an MRI and neurological surgery was not indicated, and instead prescribed Prednisone, Chlorzoxazone, ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Loislaw Federal District Court Opinions - BROWN v. RUNNELS (EDCal. 6 …  -  Jun 18, 2008
During the period from 2002 to 2003, Dr. Rohlfing prescribed several medications for Mr. Brown, including: Motrin, Tylenol, Chlorzoxazone (a muscle ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Antipsychotics; Sulpiride does not inhibit cytochrome P450 activity  -  Mar 29, 2005
CYP2D6-mediated debrisoquine 4-hydroxylation, CYP2E1-mediated chlorzoxazone 6-hydroxylation, CYP3A4-mediated nifedipine oxidation, or CYP3A4-mediated ... Pay-Per-View - Science Letter - Factiva, from Dow Jones

Pharmacology; Reports add new data to pharmacology research  -  Aug 29, 2005
7-hydroxylation, while a preincubation step in the presence of NADPH was needed to inhibit chlorzoxazone 6-hydroxylation," according to the report. ... Pay-Per-View - Hematology Week - Factiva, from Dow Jones

Sims v. Astrue, No. 07-4085-CV-C-REL-SSA (WDMo. 06/13/2008)  -  Jun 13, 2008
...[127], MEDICATIONS: The patient takes Nitroglycerin sublingual p.r.n. [as needed], Lisinopril [for hypertension], Chlorzoxazone [muscle relaxer], ... $2.95 - U.S. District Court, Western District... - VersusLaw

Article: Generator produces mixtures containing up to 48 compounds.( …  -  Sep 1, 2006
Article: Simultaneous determination of chlorzoxazone and ketoprofen in ... Journal of AOAC International; May 1, 2007 ; 700+ words ... ... and ketoprofen ... Pay-Per-View - Laboratory Equipment - HighBeam Research

Article: impurity - The Oxford Pocket Thesaurus of Current English | ...  -  Jul 12, 2006
Article: Simultaneous determination of paracetamol, chlorzoxazone, and ... Journal of AOAC International; January 1, 2007 ; 700+ words ... Pay-Per-View - Oxford Pocket Thesaurus of Current... - HighBeam Research

Article: Supply deficit of m-aminophenol.(MARKET REPORT: Intermediate...  -  Apr 6, 2007
Article: Simultaneous determination of paracetamol, chlorzoxazone, and ... Journal of AOAC International; January 1, 2007 ; 700+ words . ... Pay-Per-View - China Chemical Reporter - HighBeam Research

Article: Analyzer measures up to 12 impurities.(Environmental & Field...  -  Jun 1, 2008
Article: Simultaneous determination of paracetamol, chlorzoxazone, and ... Journal of AOAC International; January 1, 2007 ; 700+ words ... Pay-Per-View - Laboratory Equipment - HighBeam Research

Article: Utilizing XBridge[TM] HPLC columns for method development at...  -  Nov 1, 2005
Article: Simultaneous determination of paracetamol, chlorzoxazone, and ... Journal of AOAC International; January 1, 2007 ; 700+ words ... ... bulk raw ... Pay-Per-View - Laboratory Equipment - HighBeam Research

Brand Names/Synonyms:
Chlorzoxazone is also known by the following brand names and/or synonymsBiomioran; Chloroxazone; Chlorzoxane; Chlorzoxazon; Chlorzoxazone; EZE-DS; Escoflex; Flexazone; Mioran; Miotran; Myoflexin; Myoflexine; Neoflex; Paraflex; Parafon Forte Dsc; Pathorysin; Relaxazone; Remular; Remular-S; Solaxin; Strifon Forte Dsc; Usaf Ma-10

Drug Category:
Chlorzoxazone is categorized under the following by the FDA: Muscle Relaxants, Central; ATC:M03BB03

Dosage Forms:
Tablet (500 mg)

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
5-chloro-3H-benzooxazol-2-one





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