|
 |
CisplatinThis page contains recent news articles, when available, and an overview of Cisplatin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Cisplatin (when available) Cisplatin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death. For the management of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer. Mechanism Of Action: Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations. News Articles on Cisplatin Reduced pulmonary function is a late effect from cisplatin-based chemotherapy ... - Nov 11, 2009 1 Since the introduction of cisplatin-based chemotherapy in the late 1970s, treatment for germ cell cancer has improved significantly, ... American Journal of Hemotology and Oncology Mesothelioma Treatment Improved with Addition of Sirolimus - Nov 12, 2009 Researchers at the Brigham and Women's Hospital in Boston, Massachusetts have found that adding sirolimus to chemotherapy with cisplatin was more effective ... Asbestos.com Wedgewood Pharmacy Now Compounds Implantable Cisplatin Beads Using Matrix III ... - Nov 10, 2009 SWEDESBORO, NJ - (Business Wire) Wedgewood Pharmacy now is compounding implantable cisplatin beads using patented Matrix IIIâ„¢ drug-delivery technology under ... Earthtimes (press release) Hearing loss in chemo kids has genetic link - Nov 9, 2009 Cisplatin, a lifesaving anti-cancer drug used to treat more than one million patients worldwide each year, is often given to children with brain, ... CBC.ca Accelerated concomitant radiation combined with cisplatin did not improve ... - Nov 6, 2009 In patients with locally advanced head and neck carcinoma, accelerated concomitant fractionation boost radiotherapy combined with cisplatin did not improve ... HemOncToday Cisplatin Alone Effective in Children With Hepatoblastoma Also, study finds ... - Oct 21, 2009 WEDNESDAY, Oct. 21 (HealthDay News) -- Cisplatin alone is just as effective as, but less toxic than, cisplatin plus doxorubicin in children with ... ModernMedicine Cancer News 'Impressive' new lung cancer drug revealed - Nov 13, 2009 When combined with chemotherapy drug cisplatin, PD173074 helped to slow down tumour growth significantly faster than through the use of either cisplatin or ... Cancer Research UK Erbitux® Improves Survival of Patients with Unresectable Head and Neck Cancer ... - Nov 10, 2009 Researchers affiliated with ECOG 3303 have reported that the addition of Erbitux® (cetuximab) to concurrent Platinol® (cisplatin) and radiotherapy improves ... Cancer Consultants Cisplatin alone safe and effective for patients with standard-risk hepatoblastoma - Oct 22, 2009 Cisplatin monotherapy was noninferior to cisplatin plus doxorubicin and achieved similar complete resection and survival rates in children with ... HemOncToday Norwegian Team IDs Gene Dosage, Expression Changes Linked To Cervical Cancer ... - Nov 13, 2009 Locally advanced cervical cancer is typically treated with radiotherapy combined with adjuvant cisplatin chemotherapy. Even so, nearly a third of cases ... GenomeWeb Daily News Gold Nanoparticles Delivery Platinum Warheads to Tumors - Oct 30, 2009 Cisplatin is one of the most powerful and effective drugs for treating a wide variety of cancers, but serious side effects ultimately limit the drug's use ... Nanotechwire.com Featured Clinical Trial: Combining Chemotherapy and a PARP Inhibitor for ... - Nov 3, 2009 Phase I Study of PARP Inhibitor AZD2281 in Combination with Cisplatin and Gemcitabine Hydrochloride in Patients with Unresectable or Metastatic Solid Tumors ... National Cancer Institute - NCI Cancer Bulletin Metals Could Treat Colon and Ovarian Cancer - Oct 20, 2009 The compounds were also effective against ovarian cancer cells which are resistant to the drug Cisplatin, the most successful transition metal drug, ... Laboratory Equipment Unusual metals might lead to better drugs - Oct 21, 2009 Cisplatin was discovered in the 1970s and is one of the most effective cancer drugs on the market, with a 95 percent cure rate against testicular cancer. ... United Press International Potential New Lung Cancer Drug Shrank Tumors In Mice - Nov 11, 2009 The chemotherapy drug the researchers used was cisplatin, which is frequently used to treat patients with the disease. They found that both PD173074 and ... Medical News Today Partial victory for Hycamtin after final 'yes' from NICE - Oct 28, 2009 Appraisal documents published by the Institute claim that previous use of cisplatin has “a significant effect on response rates to subsequent ... Pharma Times S-1 may be alternative to fluorouracil for treatment of metastatic gastric cancer - Oct 21, 2009 They randomly assigned patients aged 20 to 75 years to a continuous infusion of fluorouracil every four weeks (n=234), IV irinotecan and cisplatin every ... HemOncToday Current Treatment Options for Peritoneal Mesothelioma - Oct 28, 2009 Chemotherapy drugs for peritoneal patients have included but are not limited to cisplatin, doxorubicin, carboplatin and pemetrexed (Alimta). ... Asbestos.com Imatinib Reported to Prevent Chemotherapy-induced Oocyte Death - Oct 27, 2009 Cisplatin and its analogs, mainly indicated for the treatment of endometrial and ovarian tumors, have been identified to play specific roles in inducing ... IVF NEWS.Direct! What is Testicular Cancer? - Nov 12, 2009 Cisplatin, bleomycin, and etoposide are the medications most commonly used. They are often used in combination. What are the side effects of the treatments? ... 24 Medica Platinol® and Surgery Optimal Therapy for Standard-risk Hepatoblastoma in Children - Oct 23, 2009 Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma. New England Journal of Medicine. 2009;361:1662-1670. Cancer Consultants NICE Recommends Topotecan For Cervical Cancer - Nov 3, 2009 Women who have previously received cisplatin and are currently being treated with topotecan in combination with cisplatin for recurrent and stage IVB ... Medical News Today (press release) Concurrent Radiotherapy, Chemotherapy Shows Promise In Small Cell Lung Cancer - Nov 3, 2009 ...concurrent VP-16 (etoposide) and cisplatin (platinum-based drugs) improved five-year survival rates. But this treatment often causes other side effects. ... Science Daily (press release) NICE recommends topotecan for cervical cancer - Oct 29, 2009 ...recommending that it be used in combination with the platinum-based chemotherapy drug cisplatin for women with recurrent or stage IVB cervical cancer ... Cancer Research UK Cancer transition - Oct 31, 2009 Cisplatin, an organometallic compound made using the precious metal platinum to form cis-diamminedichloroplatinum(II), is perhaps one of the most familiar ... spectroscopyNOW.com Unusual Metals Could Forge New Cancer Drug - Oct 19, 2009 The compounds were also effective against ovarian cancer cells which are resistant to the drug Cisplatin, the most successful transition metal drug, ... Science Daily (press release) ASCO Releases Annual Progress Report on Top Cancer Research Advances - Nov 11, 2009 ...combination gemcitabine ( Gemzar ) and cisplatin treatment increases survival and slows cancer progression, compared with gemcitabine treatment alone. ... Media Newswire (press release) Report Highlights Cancer Advances - Nov 9, 2009 The combination of gemcitabine (Gemzar) and cisplatin significantly improved progression-free survival and overall survival compared with gemcitabine alone. ... MedPage Today Adjuvant Erbitux® May Improve Survival of High-risk Resected Head and Neck Cancer - Nov 11, 2009 ...cell head and neck carcinoma and have involved combining Erbitux with chemotherapeutic agents such as Platinol® (cisplatin) or Taxotere® (docetaxel). ... Cancer Consultants High-precision radiation therapy improves cervical cancer outcomes - Nov 11, 2009 More than 80 percent of the patients received concurrent cisplatin, a chemotherapy drug commonly used for cervical cancer. The patients also received ... Webnewswire.com This Week in PNAS - Nov 10, 2009 ...cleavage events linked to methionine aminopeptidases and signal peptide peptidases, and proteins that are cleaved after cisplatin-induced apoptosis. ... GenomeWeb Daily News Pharmaceutical Companies Offer Financial Support to Mesothelioma and Other ... - Nov 10, 2009 Bristol-Myers is the maker of Platinol, generically known as Cisplatin, one of the primary chemotherapy drugs used in the treatment of malignant ... MesotheliomaHelp.net BUYINS.NET: ANSW, NEWS, ANX, WPTE, ZAP, PGTI Expected To Be Lower After ... - Nov 2, 2009 ...emulsion formulation of chemotherapy drug vinorelbine to treat advanced non-small cell lung cancer as a single agent or in combination with cisplatin, ... TMC Net Attacking Cancer With Specific Anti-Tumor Pathways - Oct 19, 2009 The data presented at the AACR showed that Kevetrin was less cytotoxic than paclitaxel, cisplatin and 5FU while having more potent anti-tumor activity in ... Reuters Dose-dense Chemotherapy for Disseminated Thymoma Reported - Nov 5, 2009 One study reported good results with neoadjuvant and adjuvant chemotherapy with cisplatin, epidoxorubicin, and etoposide followed by radiotherapy and ... Cancer Consultants Comparing notes: UK's cancer leaders discuss the latest advances - Oct 28, 2009 Among recent trials of first-line targeted therapy, Professor Thatcher highlighted Scagliotti's work on cisplatin plus pemetrexed (an inhibitor of ... Pharmafocus Curse of the nocebo effect - Oct 31, 2009 Some cancer drugs cause severe vomiting, eg cisplatin. Others cause moderate nausea and vomiting. Others still cause very mild nausea, if any, ... Malaysia Star Long-term outcome of chemotherapy for advanced testicular and extragonadal ... - Oct 22, 2009 All patients underwent induction chemotherapy including cisplatin. The median follow-up period was 36.1 months (0 - 288.5) for all patients and 52.6 months ... UroToday Long-term Follow-up Validates Effectiveness of Neoadjuvant Chemotherapy for ... - Oct 27, 2009 Chemotherapy consisted of two cycles of treatment with 5-FU and Platinol® (cisplatin). At the time of initial publication, the two-year survival rates were ... Cancer Consultants The Role of Pectoralis Major Muscle Flap in Salvage Total Laryngectomy - Oct 19, 2009 10, 14, 20 Although radiotherapy with concurrent administration of cisplatin was found to be superior to radiotherapy alone for larynx preservation and ... Archives of Otolaryngology Reconstruction of the pulmonary artery for lung cancer: Long-term results - Oct 19, 2009 Patients who had biopsy–proven N2 disease received neoadjuvant chemotherapy with a cisplatin-based regimen and were subsequently reassessed. ... The Journal of Thoracic and Cardiovascular Surgery New Bcl-2 Inhibitor Shows Promise In Cell Death In Prostate Cancer - Oct 27, 2009 Shortly after the surgery, the live tissue was placed in TTARC's incubation environment, where it was tested with ABT-737, the chemotherapy agent cisplatin, ... Medical News Today (press release) Testicular Cancer Survivors Face Other Ills - Oct 28, 2009 Cisplatin-based chemotherapy can damage nerves in many patients, and one in five survivors suffers from hearing loss and tinnitus, also known as ringing in ... Atlanta Journal Constitution New Report Just Published Multiplex Assays in Translational Medicine ... - Oct 23, 2009 StaRT-PCR to Assess Genes Associated with Cisplatin Chemoresistance 5.1. Translating Discoveries Made in Animal Models to Humans Francesco M. Marincola, MD, ... Live-PR.com (Pressemitteilung) Med BioGene Announces Positive Results From Validation Study of LungExpress DXTM - Oct 19, 2009 ...in an adjuvant chemotherapy (cisplatin / vinorelbine) clinical trial showed that those patients classified by LungExpress Dx TM as high risk benefitted, ... PR-CANADA.net (press release) ä¸å¤§ç™¼æ˜Žé˜²å?å®®é ¸ç™Œæ²»ç™‚ç–«è‹— - Nov 10, 2009 ...ä¸å¤§å…§ç§‘å?Šè—¥ç‰©æ²»ç™‚å¸ç³»åŠ©ç?†æ•™æŽˆé™³æ?šè¶…說，將化療藥CisplatinåŠ å…¥E6-E7蛋白，é€?é?Žã€Œæ¨™é?¶è—¥ã€?æ³¨å…¥äººé«”æ²»ç™‚è…«ç˜¤ï¼ŒåŠ å¼·è—¥ç‰©çš„æ²»ç™‚æ•ˆç”¨ã€‚ï¼ˆæœ±æ°¸å€«æ”?） ã€?æ˜Žå ±å°ˆè¨Šã€‘å¼•ç™¼å? ... 香港新浪網 è‚?æ¯?ç´°èƒžç˜¤ç—…æ‚£ä¸ Cisplatin單一療法和併用治療效果一樣好 - Oct 29, 2009 ...義大利Padua大å¸é†«é™¢çš„Giorgio Perilongoé†«å¸«æ‰€é ˜å°Žçš„åœ‹éš›ç ”ç©¶åœ˜éšŠæŒ‡ç¨±ï¼Œä½¿ç”¨cisplatinçš„å°?å©çš„完整切除率和å˜æ´»çŽ‡ï¼Œèˆ‡æŽ¥å?—併用治療的å°?å©ç›¸ä¼¼ã€‚ ... 臺灣新浪網 ä¸å¤§ç ”å?‘æˆ?功治疗å?宫颈癌疫苗 - Nov 10, 2009 ...æ¤é¡¹ç–«è‹—是从HPV病毒抽å?–ç¼–ç ?E6-E7的蛋白，注入“绿脓æ?†è?Œå¤–æ¯’ç´ â€?（PE），å†?é…?å?ˆåŒ–ç–—è?¯Cisplatin，制æˆ?â€œæ ‡é?¶è?¯â€?，有效缩å°?肿瘤，将是女性å?宫颈癌的一大ç¦?音。 ... 大纪元 Testicular Cancer Survivors Face Life-Long Health Risks - Oct 19, 2009 Miami, FL (AHN) - Testicular cancer survivors face an increased risk of life-long illnesses because of the effective treatment they receive to combat the ... Gant Daily Vier neue Arzneistoffe im November - Oct 30, 2009 Das Vinca-Alkaloid wird jedoch erst nach Versagen einer vorangegangenen Cisplatin-haltigen Behandlung angewendet. (ss) Pharmazeutische Zeitung online Cisplatin not effective in anal cancer trial: study - Apr 22, 2008 CHICAGO (Reuters) - Treating anal cancer patients with the cancer-fighting drug cisplatin to try to shrink tumors before beginning standard therapy did not ... Reuters UK GSK says US FDA accepts Hycamtin, Cisplatin combination application - Feb 17, 2006 PHILADELPHIA (AFX) - GlaxoSmithKline said its supplemental New Drug Application (sNDA) for Hycamtin (topotecan HCl) for Injection submitted on Dec 15, ... Forbes Gene Boosts Resistance to Chemo Drug - Sep 15, 2008 In cancer patients, the gene appears to promote cisplatin resistance by ... Cisplatin, which is used to treat many kinds of cancer, slows or stops the ... Washington Post … , vinblastine, doxorubicin and cisplatin combination regimen as... - Aug 23, 2007 We investigated the safety and efficacy of a methotrexate, vinblastine, doxorubicin and cisplatin (M-VAC) combination regimen as second-line chemotherapy ... Nature.com Effects of cisplatin on olfactory function in cancer patients - Apr 12, 2005 Correspondence: Dr MR Pfeffer, Oncology Institute, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel. E-mail: raphipf@sheba.health.gov.il ... Nature.com Cisplatin alone or in combination versus hydroxyurea during pelvic … - Sep 6, 2007 Rose PG et al. (2007) Long-term follow-up of a randomized trial comparing concurrent single agent cisplatin, cisplatin-based combination chemotherapy, ... Nature.com Children being made deaf by cancer treatment - Oct 10, 2005 Cisplatin is used in a third of childhood cancers and substantially adds to ... Every year, 68000 people are treated with cisplatin but hearing loss is not ... Telegraph.co.uk FDA OKs Cervical Cancer Drug Combo - Jun 15, 2006 Hycamtin's use with cisplatin in late-stage cervical cancer is a new indication ... With the new FDA ruling, the combination of Hycamtin and cisplatin is ... WebMD Is the addition of cisplatin to S-1 better than S-1 alone for... - Apr 7, 2008 This study, although small, is likely to change the standard of care in Japan; however, a much larger global study will be required for rest of the world to ... Nature.com … of irinotecan plus cisplatin vs irinotecan, cisplatin plus etoposide... - Oct 15, 2007 Patients with previously untreated extensive-disease small-cell lung cancer were treated with irinotecan 60 mg m -2 on days 1 and 8 and cisplatin 60 mg m -2 ... Nature.com Intrapleural hypotonic cisplatin treatment for malignant pleural... - Feb 13, 2006 To assess the effect and toxicity of hypotonic cisplatin treatment (HPT) consisting of the intrapleural administration of cisplatin in distilled water for ... Nature.com … with irinotecan, 5-fluorouracil and leucovorin for taxane- and... - Jan 26, 2005 Other combination regimens investigated include epirubicin, cisplatin and infusional FU ... Combination of irinotecan with cisplatin showed the RR of 48% in ... Nature.com … polymorphisms and individual sensitivity to the ototoxic effect of... - Apr 24, 2007 On the assumption that the mechanisms of cisplatin-induced nephro- and ototoxicity ... We found no association between cisplatin-induced ototoxicity and any ... Nature.com Enhancement of tumor cell death by combining cisplatin with an... - Oct 21, 2008 The aim of this study was to creatively implement a novel chemo-gene-virotherapeutic strategy and further strengthen the antitumor effect in cancer cells by ... Nature.com Neoadjuvant cisplatin and radical cesarean hysterectomy for cervical ... - Nov 21, 2006 Background A 28-year-old Hispanic gravida 1 was found to have a 4–5 cm cervical mass when she presented at 23 weeks gestation. ... Nature.com Which should be added to cisplatin for advanced non-small-cell lung … - Feb 8, 2005 Correspondence University of Turin, Department of Clinical and Biological Sciences Head, Thoracic Oncology Unit, S. Luigi Hospital—Regione, Gonzole 10, ... Nature.com Gene Tests Match Up Lung Tumors, Best Treatment - Oct 3, 2007 ..."We found the strongest inverse correlation between tumors that were sensitive to cisplatin and those that were sensitive to pemetrexed," senior author and ... Washington Post … as effective as fluorouracil and cisplatin for gastroesophageal... - Feb 25, 2008 The epirubicin, cisplatin and fluorouracil (ECF) regimen is widely used for the treatment of esophageal and gastric cancers. However, the infusion of ... Nature.com … p53 gene therapy in osteosarcoma cell lines: sensitization to... - Oct 7, 2005 Multidrug chemotherapeutic regimens that typically include cisplatin and ... Doses of cisplatin and doxorubicin were also used that would produce a similar ... Nature.com GlaxoSmithKline granted EU marketing approval for Hycamtin for... - Dec 1, 2006 However, EMEA added that 'patients with prior exposure to cisplatin require a sustained treatment free interval to justify treatment with the combination'. ... Forbes NO.1 ê²½ì œí?¬í„¸ :: 매ì?¼ê²½ì œ - Jun 3, 2007 In the AVAiL study patients received treatment with either Avastin at 7.5mg/kg or 15mg/kg + cisplatin-gemcitabine or placebo + cisplatin-gemcitabine and a ... 매ì?¼ê²½ì œ … study of SPI-77 (sterically stabilised liposomal cisplatin) in... - Sep 12, 2006 Cisplatin has been demonstrated to impact positively on survival in advanced ... Liposomal encapsulation of cisplatin has the attraction of potentially ... Nature.com Small-cell lung cancer with lymphadenopathy in an 18-year-old female ... - Oct 31, 2005 Management Etoposide plus cisplatin chemotherapy with concurrent accelerated ... In a recent phase II trial, concurrent etoposide and cisplatin plus ... Nature.com European Trial Slows Genentech's Avastin - Apr 21, 2008 The AVAIL study tested two doses of Avastin in combination with the chemotherapy drugs gemcitabine and cisplatin compared to chemotherapy alone in patients ... TheStreet.com - TheStreet.com (subscription) Genentech's avastin helps in lung cancer; mixed sales news - Jun 2, 2007 The new study tested Avastin in combination with cisplatin and gemcitabine. Non-small-cell lung cancer is the most common form of lung cancer, ... MarketWatch Three-week schedule of irinotecan plus cisplatin in patients with … - Nov 28, 2006 Correspondence: Dr K Park, Division of Hematology/Oncology, Department of Medicine, Samsung Medical center, Sungkyunkwan University School of Medicine, ... Nature.com Cisplatin plus oral etoposide (EoP) combination is more effective... - Feb 22, 2005 This work was presented at the 27th ESMO Congress. Bristol Myers Squibb (Turkey) supplied limited number of paclitaxel for this trial ... Nature.com A comparison of cisplatin and fluorouracil alone or with docetaxel in... - Jan 2, 2008 Posner MR et al. (2007) Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. N Engl J Med 357: 1705–1715 PubMed ... Nature.com HK experts reveals lupeol in fruits helps combat cancer - Oct 16, 2007 Besides, when lupeol was used in combination with cisplatin, the anti-tumour activity of the chemotherapeutic drug could be enhanced by 40-fold. ... æ–°å?Žç½‘ Apoptosis regulation in tetraploid cancer cells - May 4, 2006 ...(A, B) Comparison of the IC 50 values of cisplatin and staurosporine (STS) for diploid (D) and ... Reduced cisplatin-induced apoptosis in tetraploid cells. ... Nature.com Adjuvant bleomycin, vincristine and cisplatin (BOP) for high-risk... - May 31, 2005 Correspondence: Professor DP Dearnaley, Academic Radiotherapy, Institute of Cancer Research/Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK. ... Nature.com … , When Combined With Cisplatin, Demonstrates Significant Improvement... - Jun 3, 2007 ..."This study demonstrates that the combination of S-1 and cisplatin brings to the patient with advanced gastric cancer an acceptable benefit/risk ratio," ... Free with registration - PR Newswire - AccessMyLibrary.com Study reveals why certain ovarian cancers develop resistance to... - Feb 11, 2008 They found that when exposed to cisplatin, some ovarian-cancer cells develop secondary mutations on their BRCA2 gene that restore the gene's ability to ... The Hindu Roche says Xeloda filed in Europe for treatment of advanced stomach … - Jul 21, 2006 The filing was based on results from a phase III study into the efficacy and safety of Xeloda and chemo treatment cisplatin compared to the current standard ... Forbes A new p38 MAP kinase-regulated transcriptional coactivator that … - Mar 22, 2007 ...(E) SK-Mel-103 cells were treated with cisplatin for the indicated times and ... After puromycin selection, cells were treated for 24 h with cisplatin or UV ... Nature.com Cancer specialist accuses NHS of putting money before lives - Jul 3, 2006 Trials had shown, he said, that when used with cisplatin, pemetrexed prolonged patients' lives by an average of three months, and sometimes up to a year. ... Telegraph.co.uk Combination of Cisplatin and Raltitrexed Improves Survival with … - Oct 7, 2005 According to the results of a phase III clinical trial published in the Journal of Clinical Oncology, treatment with both cisplatin and raltitrexed results ... emaxhealth.com Lilly's Alimta OK'd as front-line lung cancer drug - Sep 29, 2008 The drugmaker said the US Food and Drug Administration has approved the drug in combination with cisplatin for patients with locally advanced and metastatic ... Reuters Eli Lilly seeks expanded European approval for Alimta - Sep 20, 2007 ...for its cancer drug Alimta to include first-line treatment of advanced non-small cell lung cancer in combination with the chemotherapy drug cisplatin. ... Reuters A case of T2 muscle-invasive bladder cancer treated with neoadjuvant ... - Apr 5, 2006 Although cisplatin-based chemotherapy regimens are the standard of care for metastatic ... Gemcitabine plus cisplatin has recently emerged as an alternative ... Nature.com Sanofi's Taxotere wins US FDA priority review for gastric cancer... - Dec 2, 2005 ...lung and prostate cancer, will be studied for its effectiveness when used in conjunction with current treatment of cisplatin and 5-fluorouracil. ... Forbes Protein linked to chemo-drug resistance - Aug 28, 2008 28 (UPI) -- US researchers say they have linked a genetic variant of a protein to resistance to the chemotherapy drug cisplatin. ... United Press International New Treatments for Tough Cancers Show Promise - Jun 2, 2007 The new study looked at Avastin with chemotherapy drugs cisplatin and gemcitabine. The study was funded by Hoffman-La Roche, parent company of Genentech, ... Washington Post FDA OKs drug for head, neck cancer - Oct 18, 2006 Taxotere, also called docetaxel, now may be used in combination with the chemotherapy drugs cisplatin and fluorouracil before radiation therapy for the ... msnbc.com ImClone's Future Gets Brighter - Sep 11, 2007 Ratain is not involved with any of the Erbitux lung cancer studies, but his best guess is that Erbitux could be working synergistically with cisplatin to ... TheStreet.com - TheStreet.com (subscription) Bladder Cancer Treatment (PDQ®) - Stage IV Bladder Cancer - May 16, 2008 3] Results from a randomized trial that compared M-VAC with single-agent cisplatin in advanced bladder cancer also showed a significant advantage with M-VAC ... WebMD Adjuvant Vinorelbine and Cisplatin May Be Helpful in... - Jun 22, 2005 June 22, 2005 — Adjuvant chemotherapy with vinorelbine and cisplatin prolongs survival for patients with completely resected early stage non–small-cell lung ... Medscape … treatment approved for use with cisplatin. | Article from Philadelp... - Jun 15, 2006 Glaxo lung-cancer treatment approved for use with cisplatin. ... find Philadelphia Inquirer (Philadelphia, PA) articles. Byline: Thomas Ginsberg Jun. Pay-Per-View - Philadelphia Inquirer - HighBeam Research … I study of S-1, docetaxel and cisplatin combination chemotherapy... - May 31, 2007 The aim of this dose escalation study was to determine the maximum-tolerated dose (MTD), dose-limiting toxicities (DLTs) and preliminary efficacy of ... Nature.com Genistein protects the kidney from cisplatin-induced injury - Aug 20, 2008 Correspondence: Dae Young Kwon, Korea Food Research Institute, Food Function Research Center, 516, Baekhyun-Dong, Bundang-Ku, Songnam, Gyeongki 463-746, ... Nature.com RNID keen to make cisplatin work - Oct 10, 2005 Tens of thousands of cancer patients in the UK are having their hearing unnecessarily placed at risk by cancer treatments, a new report claims. ... Platinum today Japan's Takeda may scrap licensing deal for BioNumerik's Tavocept drug - Jul 31, 2006 ...significant effectiveness of Tavocept in reducing the incidence of severe neuropathy caused by the administration of paclitaxel and/or cisplatin. ... Forbes Docetaxel boosts survival in head and neck cancers - Oct 26, 2007 The 255 treated with Taxotere, cisplatin and fluorouracil survived a median of 71 months. That compared to 30 months for the 246 treated with cisplatin and ... Cancerfacts.com Should irinotecan or etoposide be used in combination with carboplatin... - Oct 21, 2008 Superiority of combined irinotecan–cisplatin over standard ... The combination of cisplatin or carboplatin plus etoposide has remained standard therapy for ... Nature.com Taxotere improves survival in head-neck cancer - Oct 24, 2007 In the Posner study, 48 percent of patients who received the standard regimen of cisplatin and fluorouracil as their initial treatment survived for three ... Reuters Stronger Chemo Dose Won't Improve Bone Cancer Outcomes - Jan 19, 2007 One group received six cisplatin-doxorubicin treatments at three-week intervals (standard treatment) and the other group of patients received the treatments ... Washington Post Weekly cisplatin, epirubicin, and paclitaxel with granulocyte colony-... - Apr 3, 2006 The present study aimed at evaluating whether a weekly cisplatin, epirubicin, and paclitaxel (PET) regimen could increase the pathological complete response ... Nature.com Combination of Cisplatin and Raltitrexed Improves Survival with … - Oct 5, 2005 According to the results of a phase III clinical trial published in the Journal of Clinical Oncology, treatment with both cisplatin and raltitrexed results ... Mesothelioma.com Sanofi's Taxotere gets US nod for head, neck cancer - Oct 1, 2007 It said the FDA approved Taxotere Injection Concentrate in combination with cisplatin and 5-fluorouracil, for induction therapy of locally advanced squamous ... Reuters DFF45/ICAD restores cisplatin-induced nuclear fragmentation but not … - Mar 12, 2007 Correspondence: Dr A Nakagawara, Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan. ... Nature.com Pre-Surgery Cisplatin-Gemcitabine More Effective Than Surgery Alone... - Jun 2, 2008 By Cameron Johnston. CHICAGO -- June 2, 2008 -- Preoperative chemotherapy with gemcitabine and cisplatin appears to offer better progression-free survival ... DG News Cisplatin is more effective than carboplatin for treating nonsmall... - Jun 5, 2007 Some patients with advanced non–small-cell lung cancer (NSCLC) have slightly higher survival rates when treated with the chemotherapy drug cisplatin than ... eurekalert.org … in non-small cell lung cancer initially treated with cisplatin: a... - Feb 12, 2007 Patients failing during the initial cisplatin chemotherapy presented with the ... Patients with stabilised disease (PR or NC) on initial cisplatin who ... Nature.com Genetic Test Shows Who Benefits From Chemo - Sep 6, 2006 The patients in this study were treated with platinum-based drugs such as cisplatin, carboplatin or oxaliplatin, so the finding only applies to this class ... ABC News … research may help identify patients most likely to benefit from... - Apr 20, 2007 Cisplatin was found to break up the binding of p63 to p73 and reactivate the cell-death process. "The most important finding was that, if the tumor cells ... News-Medical.net Molecular Signature May Identify Cisplatin-sensitive Breast Tumors - Apr 22, 2007 Researchers at the Massachusetts General Hospital (MGH) Cancer Center have identified a subgroup of hard-to-treat breast cancers that may be sensitive to ... Medical News Today - Medical News Today (press release) A phase II study of capecitabine plus 3-weekly oxaliplatin as first... - Mar 21, 2006 5-FU in combination with cisplatin (FP regimen) is commonly used in advanced ... Some European centres consider epirubicin, cisplatin and 5-FU (ECF) to be ... Nature.com Cisplatin - MSN Health & Fitness - Medications - May 25, 2007 Cisplatin is an intravenous (IV) medication usually given in a dose that is based on body surface area. The type and extent of a cancer determines the exact ... MSN Health & Fitness Roche phase III trial on Xeloda in stomach cancer met primary endpoint - Apr 6, 2006 The data show that Xeloda, added to another chemotherapy called cisplatin, is at least as effective as the current standard treatment in terms of time to ... Forbes Cisplatin Is More Effective Than Carboplatin For Treating Nonsmall... - Jun 10, 2007 Some patients with advanced non-small-cell lung cancer (NSCLC) have slightly higher survival rates when treated with the chemotherapy drug cisplatin than ... Medical News Today - Medical News Today (press release) Is cetuximab active in patients with cisplatin-refractory squamous... - Jul 27, 2007 Vermorken JB et al. (2007) Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in ... Nature.com Genistein May Help Overcome Cisplatin-Resistance in Ovarian Cancer - Apr 18, 2005 By Megan Rauscher. ANAHEIM, California APR 18, 2005 (Reuters Health) - Genistein, a soy isoflavone, enhances the cytotoxic effects of cisplatin in ... Cancerpage.com … combined modality therapy with paclitaxel, cisplatin, 5-fluorouraci... - Feb 1, 2006 Cisplatin and 5-fluorouracil have long been recognized as having activity in esophageal carcinoma. Paclitaxel has significant antitumor activity in ... The Journal of Thoracic and Cardiovascul... Aspirin Derivative Active Against Cisplatin-Resistant Ovarian Cancer ... - Feb 13, 2006 NEW YORK FEB 13, 2006 (Reuters Health) - A derivative of aspirin called NCX-4016 can destroy ovarian cancer cells that have developed resistance to ... Cancerpage.com Chemo drugs may help treat mesothelioma - Feb 9, 2007 Patients receiving pemetrexed and cisplatin -- along with the vitamin ... "Pemetrexed used in combination with cisplatin significantly increases the length ... United Press International Oncolytics Biotech Inc. Collaborators to Present REOLYSIN(R) - Nov 14, 2008 Xenografts Alone and in Combination with Cisplatin and Radiation" is scheduled to ... or REOLYSIN(R) in combination with either cisplatin or radiation. ... Bloomberg Xeloda(R) Plus Cisplatin Combination Effective in Patients with... - Jun 5, 2006 ATLANTA, June 5 /PRNewswire/ -- In the first-ever Phase III trial of oral Xeloda (capecitabine) as first-line treatment for gastric cancer, ... Free with registration - PR Newswire - AccessMyLibrary.com Xeloda® Plus Cisplatin Combination Effective in Patients With... - Jun 15, 2006 ATLANTA -- In the first-ever Phase III trial of oral Xeloda (capecitabine) as first-line treatment for gastric cancer, Xeloda plus cisplatin (XP) was found ... EndoNurse Adding Docetaxel to Cisplatin/5-Fluorouracil Significantly Improves … - Jun 5, 2006 By Cameron Johnston. ATLANTA, GA -- June 5, 2006 -- Use of sequential induction treatment with docetaxel added to cisplatin and 5-fluorouracil (5-FU) prior ... DG News Regulation of PUMA- by p53 in cisplatin-induced renal cell apoptosis - Feb 20, 2006 Correspondence: Dr Z Dong, Department of Cellular Biology and Anatomy, Medical College of Georgia, 1459 Laney Walker Blvd, CB2917, Augusta, GA 30912, USA. ... Nature.com Oncogene - Abstract of article: Cisplatin induces PKB//Akt activation... - Jun 19, 2006 Correspondence: Dr A Levitzki, Unit of Cellular Signaling, Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, ... Nature.com San Diego company testing treatment on congestive failure. - Jul 14, 2006 Though cisplatin worked well on various cancers, it also came with serious ... KW-3902 was designed to ease the toxic effects of cisplatin on the kidneys. ... Free with registration - San Diego Union - Tribune - AccessMyLibrary.com Pemetrexed combined with cisplatin or carboplatin shows promise as a ... - Jun 7, 2007 The results of a recent medical study confirmed results from earlier studies demonstrating that the chemotherapy drug pemetrexed combined with either ... Mesothelioma News … in Phase 2 Study of Gemcitabine, Cisplatin, and Bevacizumab:... - Jan 30, 2006 ..."The combination of fixed-dose rate gemcitabine, low-dose cisplatin, and bevacizumab ... Patients were given gemcitabine 1000 mg/m 2 , cisplatin 20 mg/m 2 ... DG News … to Present Combination Reovirus and Cisplatin Treatment Results at - Mar 16, 2007 The results of the preclinical study showed that the combination of reovirus and cisplatin was significantly more effective than cisplatin or reovirus alone ... Free with registration - PR Newswire - AccessMyLibrary.com Cell type–specific delivery of siRNAs with aptamer-siRNA chimeras - Jun 25, 2006 In left panels, cells were treated with cisplatin as a positive control for apoptosis. Cisplatin-treated casp3-PE stained cells (green) are compared to ... Nature.com Bladder Cancer - Medications - May 25, 2007 Cisplatin is a heavy metal that causes cell death by interfering with the ... It is often combined with another drug called cisplatin for treating bladder ... WebMD Seeing Cisplatin - Nov 12, 2007 CISPLATIN HAS BEEN USED to treat cancer for decades. But the drug's detailed molecular interactions with the enzymes it aims to interrupts have remained ... Environmental Science & Technology … Preclinical Combination REOLYSIN(R) and Cisplatin Research at EO - Oct 22, 2008 Hardev Pandha of The Royal Surrey Hospital, UK, entitled "Synergistic Anti-Tumour Activity of Oncolytic Reovirus and Cisplatin in a B16. ... International Business Times Precious metal may yield cancer treatment - Dec 9, 2008 While cisplatin is successful treatment, it isn't useful for all kinds of cancer, said professor Peter Sadler, adding, "It is also quite a toxic therapy, ... United Press International Fatal chemo overdose prompts Alberta reforms - May 8, 2007 Inability to mitigate from the lethal dose of fluorouracil with cisplatin. Written instructions given to the nurses about how to administer the drug were ... CBC.ca New Insights Into Molecular Mechanisms of Cisplatin DNA - Nov 19, 2007 November 19, 2007 — Platinum-based cisplatin is a widely prescribed chemotherapy agent used to treat various types of cancers and has been in use for ... Medscape Cisplatin Is More Effective Than Carboplatin For Treating Nonsmall... - Jun 6, 2007 ScienceDaily (June 6, 2007) — Some patients with advanced non--small-cell lung cancer (NSCLC) have slightly higher survival rates when treated with the ... sciencedaily.com Bloomberg Printer-Friendly Page - Apr 13, 2008 This time, researchers tried the drug in combination with cisplatin, a chemotherapy agent. Mice in a study had their tumors disappear for a longer time than ... Bloomberg Cisplatin-induced renal injury - Aug 1, 2005 Seven groups of eight rats each were used for the study. The 1st group was administered gum acacia solution (2% w/v) for 15 days. The 2nd group was treated ... Free with registration - Phytomedicine: International Journal of... - AccessMyLibrary.com Nanoparticles Boost Delivery of Cisplatin to Tumor Cells, Nanoparticle... - Sep 23, 2006 Cisplatin is one of the most powerful and effective drugs for treating a wide variety of cancers, but many tumors develop resistance to this drug, ... Nanotechwire.com Cisplatin slightly better than carboplatin - Jun 12, 2007 BETHESDA, MD – June 12, 2007 – Some patients with advanced non-small-cell lung cancer (NSCLC) have slightly higher survival rates when treated with the ... Cancerfacts.com New Publication Report -- Hyperthermia Plus Cisplatin as a Treatment... - Oct 9, 2007 SALT LAKE CITY -- BSD Medical Corp. (AMEX:BSM) today announced that the newest issue of the International Journal of Hyperthermia has published an article ... Free with registration - Business Wire - AccessMyLibrary.com New Therapy For Patients With Platinum-resistant Ovarian Cancer - Oct 24, 2007 Thirty-three percent of study participants achieved either complete or partial tumor regression from the therapy, which combines flavopiridol and cisplatin. ... sciencedaily.com New class of compounds can kill cancer cells with fewer side effects - Nov 20, 2008 Unlike cisplatin, which can decompose quickly and create additional toxic side effects through the decomposition products, the new compounds show no signs ... TopNews Brand Names/Synonyms: Cisplatin is also known by the following brand names and/or synonymsAbiplatin; Biocisplatinum; Briplatin; CACP; CPDC; CPDD; Carboquone; Cis Pt Ii; Cis-Ddp; Cis-Diaminedichloroplatinum; Cis-Diamminedichloroplatinum; Cismaplat; Cisplatin; Cisplatine; Cisplatyl; Citoplationo; DDP; Ddpt; Diamminedichloroplatinum; Dichlorodiammineplatinumiiyelloworangextl; Lederplatin; Neoplatin; P4394; Plastin; Platamine; Platiblastin; Platidiam; Platinex; Platinol; Platinol-Aq; Platinoxan; Platinum Ammine Chloride; Platinum Ammonium Chloride; Platinum Diamine Dichloride; Randa; Trans-Ddp; Trans-Diaminedichloroplatinum; Trans-Diamminedichloroplatinum; Trans-Dichlorodiammine Platinum; Trans-Platinumdiammine Dichloride Drug Category: Cisplatin is categorized under the following by the FDA: Radiation-Sensitizing Agents; Antineoplastic Agents; ATC:L01XA01 Dosage Forms: SOLUTION Absorption: Not Available Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: dichloroplatinum;azanide |
|
Health Home | Conditions | Cancer | Medications | Surgery | Vaccines The Cancer News Network
COPYRIGHT 2009 CANCERNEWSNETWORK | Privacy |