Clomocycline

This page contains recent news articles, when available, and an overview of Clomocycline but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Clomocycline (when available)

Pharmacology and use:
Clomocycline is a tetracycline antibiotic that is commonly prescribed by medical doctors for infections and to treat acne. It may also be used to treat urinary tract infections, gum disease, and other bacterial infections such as gonorrhea and chlamydia. Clomocycline is also used commonly as a prophylactic treatment for infection by Bacillus anthracis (anthrax). It is also effective against Yersinia pestis and malaria and is also prescribed for the treatment of Lyme disease. Clomocycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Cells become resistant to Clomocycline by at least two mechanisms: efflux and ribosomal protection. In efflux, a resistance gene encodes a membrane protein that actively pumps Clomocycline out of the cell. This is the mechanism of action of the tetracycline resistance gene on the artificial plasmid pBR322. In ribosomal protection, a resistance gene encodes a protein which binds to the ribosome and prevents Clomocycline from acting on the ribosome. For the treatment and management of Brucellosis;Mycoplasma infection;Acne vulgaris;Chlamydial infection;Chronic bronchitis

Mechanism Of Action:
Clomocycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Clomocycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane.

News Articles on Clomocycline

Brand Names/Synonyms:
Clomocycline is also known by the following brand names and/or synonymsChlormethylenecycline; Clomociclina [Inn-Spanish]; Clomocycline; Clomocycline [Ban:Inn]; Clomocyclinum [Inn-Latin]

Drug Category:
Clomocycline is categorized under the following by the FDA: Anti-bacterial Agents; ATC:J01AA11

Dosage Forms:
Not Available

Absorption:
Not Available

Interactions:
Not Available

Chemical IUPAC Name:
7-chloro-4-dimethylamino-6,10,11,12a-tetrahydroxy-2-[hydroxy-(hydroxymethylamino)methylidene]-6-methyl-4,4a,5,5a,6,12a-hexahydrotetracene-1,3,12-trione

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