Clozapine

This page contains recent news articles, when available, and an overview of Clozapine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Clozapine
(when available)

Pharmacology and use:
Clozapine is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives and is indicated for the treatment of schizophrenia. Clozapine is a selective monoaminergic antagonist with high affinity for the serotonin Type 2 (5HT2), dopamine Type 2 (D2), 1 and 2 adrenergic, and H1 histaminergic receptors. Clozapine acts as an antagonist at other receptors, but with lower potency. Antagonism at receptors other than dopamine and 5HT2 with similar receptor affinities may explain some of the other therapeutic and side effects of Clozapine. Clozapine's antagonism of muscarinic M1-5 receptors may explain its anticholinergic effects. Clozapine's antagonism of histamine H1 receptors may explain the somnolence observed with this drug. Clozapine's antagonism of adrenergic a1 receptors may explain the orthostatic hypotension observed with this drug. For the management of severely ill schizophrenic patients who fail to respond adequately to standard drug treatment for schizophrenia

Mechanism Of Action:
The mechanism of action of Clozapine, as with other drugs used to treat schizophrenia, is unknown. However, it has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of dopamine Type 2 (D2) and serotonin Type 2 (5HT2) receptor antagonism.

News Articles on Clozapine

Corcept Therapeutics Announces Four Anticipated Milestones for 2010  -  05 Jan 2010
The group of medications known as atypical antipsychotics, including olanzapine, risperidone, clozapine and quetiapine, are widely used to treat ... CNNMoney.com (press release)

Monongalia County Man Caught Shoplifting, Again  -  ‎Dec 31, 2009‎
When the police caught Foster they found heroin and the controlled prescription medicine Clozapine in his possession. Foster is also a fugitive from justice ... WBOY-TV

Clinical Data, German Heart Institute Seek New Markers for Anti-Platelet Response  -  ‎Jan 4, 2010‎
The company already markets PGxPredict:Clozapine, which gauges patients at risk of clozapine-induced agranulocytosis, and PGxPredict:Rituximab, ... GenomeWeb Daily News

Antipsychotic Use and Risk for Hyperglycemia in Elderly Patients With DM  -  ‎Dec 14, 2009‎
An analysis of a large adverse events database on diabetes-related adverse events within the group of atypical APDs—aripiprazole, clozapine, olanzapine, ... Archives of Internal Medicine

The Genome Generation  -  ‎Dec 15, 2009‎
Genetic tests are used to determine whether certain drugs are prescribed, and in what dose, for HIV-AIDS (the drug abacavir), psychosis (clozapine), ... Newsweek

Pharmacotherapy for borderline personality disorder: Cochrane systematic ...  -  ‎Dec 31, 2009‎
Additionally, there are findings from lower-level evidence studies on further FGAs and SGAs (eg trifluoperazine, clozapine, quetiapine, risperidone), ... British Journal of Psychiatry

Nature Neuroscience:生物传感器æ?­ç¤ºäº†æŠ—精神病è?¯ä½œç”¨æœºåˆ¶  -  ‎Dec 16, 2009‎
We used chronic implantation of M1-CNiFERs in frontal cortex of the adult rat to elucidate the muscarinic action of the atypical neuroleptics clozapine and ... 生物谷

Doctor gives risky drugs at high rate  -  ‎Nov 9, 2009‎
His unusually heavy reliance on the drug clozapine -- a potent psychotropic medication that carries five "black box" warnings -- has been linked to at least ... Chicago Tribune

Revelations on the mall preacher  -  ‎Nov 11, 2009‎
According to Gould, he has undergone a good number of treatment methods in his effort to overcome his illness, including the use of Clozapine, ... Minnesota Daily

Research reports from University of Sydney, Faculty of Pharmacy provide new ...  -  ‎Nov 9, 2009‎
Current study results from the report, 'In vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformation,' have ... Behavioral Health Central (blog)

Corcept Therapeutics Announces Recent Highlights and Third Quarter 2009 ...  -  ‎Nov 10, 2009‎
The group of medications known as atypical antipsychotics, including olanzapine, risperidone, clozapine and quetiapine, are widely used to treat ... CNNMoney.com (press release)

Children on antipsychotic drugs more prone to diabetes: Canadian study  -  ‎Nov 11, 2009‎
The medications include risperidone, quetiapine, olanzapine and clozapine, used to treat aggression or mood changes, attention deficit, developmental delays ... Vancouver Sun

Doctor-drugmaker ties: Psychiatrist Dr. Michael Reinstein received nearly ...  -  ‎Nov 10, 2009‎
On one hand, Chicago psychiatrist Dr. Michael Reinstein was bringing the company a small ... Chicago Tribune

Generic Name: Catapres, Dixarit, adhd, Duraclon, Apo-Clonidine, Novo-Clonidine ...  -  ‎Nov 11, 2009‎
...glaucoma; diabetes-associated diarrhea; impulse control disorder, attention-deficit/hyperactivity disorder (ADHD), clozapine-induced sialorrhea. ... Pattaya Daily News

Implications of Marked Weight Gain Associated With Atypical Antipsychotic ...  -  ‎Oct 27, 2009‎
2-3,5 All the atypical antipsychotic medications, with the exception of clozapine, are commonly prescribed to youth for a variety of problems. ... Journal of American Medical Association (subscription)

IDF: Diabetes Plus Schizophrenia Increases Risk of Heart Disease  -  ‎Oct 22, 2009‎
The current first-line treatments for schizophrenia are the atypical antipsychotic agents, such as clozapine, olanzapine, quetiapine, risperidone, ... MedPage Today

Antipsychotic long-acting injections: mind the gap  -  ‎Oct 31, 2009‎
It may also be that when clozapine fails, owing to lack of efficacy or non-adherence, prescribers look to LAIs to provide adherence and then add another ... British Journal of Psychiatry

Generics vs. brand drugs: Is there a difference?  -  ‎Oct 20, 2009‎
The antipsychotic medication clozapine has shown significant differences between generic and branded versions. And research suggests generic versions of the ... Connect Savannah.com

Schizophrenia drug 'health risk'  -  Jul 1, 2006
Patients who take the antipsychotic drug clozapine risk a group of health ... More than half of the patients taking clozapine had metabolic syndrome ... BBC News

Dilated cardiomyopathy: an unusual complication of clozapine therapy  -  Oct 26, 2007
Background A 42-year-old obese man presented with acute pulmonary edema. He had a history of chronic residual schizophrenia for which he had been taking ... Nature.com

Clozapine for schizophrenia  -  Feb 5, 2008
The US Food and Drug Administration (FDA) recently approved clozapine for treating suicidal behavior associated with schizophrenia, or for treating severe ... WebMD

Clozapine, Olanzapine May Increase Risk of Insulin Resistance  -  Jan 4, 2005
Jan. 4, 2005 -- Use of clozapine and olanzapine is associated with a significantly higher risk of developing insulin resistance than is use of risperidone, ... Medscape

The Nation; Older Drug Is Best for Schizophrenia; But no option...  -  Apr 1, 2006
The study found that clozapine was able to control some of the symptoms of ... This time the researchers included clozapine, a drug that is rarely used now ... Pay-Per-View - Los Angeles Times - ProQuest Archiver

Drug Safety: There's No Magic Pill, Study Says  -  May 8, 2007
The odds of dying from aspirin, clozapine, Tysabri and Vioxx are about equal to the corresponding risk for driving in a passenger car. ... Washington Post

Puzzle of antipsychotic drug weight gain solved  -  Feb 12, 2007
..."Unfortunately, Zyprexa, which everybody agrees is the best therapeutic agent, gives the worst weight gain, along with clozapine, the parent drug in the ... Reuters

Modelling the impact of clozapine on suicide in patients with...  -  Jun 1, 2008
Background Schizophrenia is a major cause of suicide, and symptoms characteristic of treatment-resistant disease are strong risk factors. Clozapine reduces ... British Journal of Psychiatry (subscript...

Clozapine-induced agranulocytosis in schizophrenic Caucasians: …  -  Oct 17, 2006
Correspondence: Dr M Dettling, Department of Psychiatry and Psychotherapy, Charité-University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, ... Nature.com

Clozapine Augmented With Risperidone in the Treatment of …  -  Jan 22, 2005
Method: In a randomized, double-blind, placebo-controlled 12- week trial, 40 patients unresponsive or partially responsive to clozapine monotherapy received ... RedOrbit

Multiple drug therapy questioned  -  Feb 2, 2006
Half the group took clozapine and Risperdal, an antipsychotic drug produced by Johnson & Johnson . The other half were given clozapine and a placebo. ... Boston Globe

Using clozapine in agitated dementia patients.(INPATIENT PRACTICE)( …  -  Nov 1, 2007
Patients with dementia brought into the inpatient unit because of pronounced treatment-resistant agitation can be extremely difficult to manage. ... Free with registration - Clinical Psychiatry News - AccessMyLibrary.com

Clozapine (generic): Clozaril (brand).(YOUR MEDICATION …  -  Jul 1, 2005
COMMON USAGE: Clozapine is indicated for treatment-resistant psychosis and for suicidal behavior in patients with schizophrenia or schizoaffective disorder ... Free with registration - Brown University Psychopharmacology... - AccessMyLibrary.com

Management of clozapine-resistant schizophrenia  -  Jul 1, 2008
Rob W. Kerwin is Professor and Head of the Section of Clinical Neuropharmacology at the Institute of Psychiatry (De Crespigny Park, London SE5 8AF, UK. ... Adv Psychiatric Treat (subscription)

… and GH-IGF-IGFBP axis in clozapine-treated schizophrenic obesity ve  -  Oct 30, 2006
Obese patients with schizophrenia being treated with clozapine and non-psychiatric obese are ... Insulin homeostasis and lipid profiles in clozapine-treated ... Nature.com

… of clozapine works! Risperidone augmentation of clozapine doesn't...  -  May 1, 2005
...wisdom, it was the age of foolishness, it was the epoch of belief, it was the epoch of incredulity, it was the season of Light, it was the season of ... Free with registration - Clinical Psychiatry News - AccessMyLibrary.com

For drugmakers, finding a name is more art than science  -  Oct 7, 2007
A 19-year-old man showed signs of potentially fatal complications after he was given clozapine instead of olanzapine. A 50-year-old woman was hospitalized ... ABC News

Dispute over schizophrenia drugs  -  Nov 24, 2006
Atypical antipsychotics, which include risperidone, quetiapine, clozapine and olanzapine, cost at least 10 times more than their predecessors. ... BBC News

Drugs for schizophrenia tested in teens  -  Mar 3, 2008
MINNEAPOLIS, March 3 (UPI) -- The long-term risk of clozapine and olanzapine need ... The study, published in Biological Psychiatry, found clozapine to be ... United Press International

… and Metabolic Effects of Olanzapine and Clozapine Related to Body ...  -  Mar 22, 2005
Vance L. Albaugh * , Cathy R. Henry * , Nicholas T. Bello † , Andras Hajnal † , Susan L. Lynch * , Beth Halle * and Christopher J. Lynch * ... Nature.com

Schizophrenia - Treatment Overview  -  Feb 5, 2008
Clozapine, such as Clozaril or Leponex, is usually considered a second-generation antipsychotic. This drug is approved in the United States for treating ... WebMD

Clozapine 'wins again' in phase II of CATIE.(drug usage)(clinical...  -  May 1, 2006
SAN JUAN, PR -- Clozapine fared better than other antipsychotics in terms of discontinuation rates and survival for people with schizophrenia in the second ... Free with registration - Clinical Psychiatry News - AccessMyLibrary.com

'Waking Nightmares' - A Law Professor on Living with Schizophrenia  -  Aug 13, 2007
Clozapine and Prozac. Clozapine is like the Cadillac of anti-psychotics. It's cumbersome but it's the best one we have. It is so risky that you have to have ... $2.95 - Newsweek - NewsBank

Psychiatric Times. Coffee, Cigarettes and Meds: What Are the Metabolic...  -  May 1, 2005
Clozapine. The breadth of therapeutic index for a drug determines the clinical ... Clozapine has a much narrower therapeutic index compared to olanzapine. ... Psychiatric Times

Clozapine treatment following blood dyscrasia  -  Jun 1, 2008
Department of Psychiatry, Bicêtre, Assistance Publique - Hôpitaux de Paris, Paris XI University, INSERM U 669, 8 rue du Général Leclerc, ... British Journal of Psychiatry (subscript...

Comparison of Schizophrenia Drugs Often Favors Firm Funding Study  -  Apr 12, 2006
..."Clozapine is better by far than the other antipsychotics," said Carol Tamminga, a psychiatry ... "Clozapine is less marketed," she said. "It is off patent. ... Pay-Per-View - Washington Post - ProQuest Archiver

… of treatment in recurrent clozapine-induced severe neutropenia  -  Jul 1, 2008
None with respect to Novartis (manufacturers of clozapine). ... The use of clozapine is limited by the potential for haematological adverse effects (Young ... British Journal of Psychiatry (subscript...

… Pharmacogenetic Test for Clozapine-Induced Agranulocytosis on …  -  Jan 23, 2007
Clinical Data, Inc. (NASDAQ: CLDA), announced today that its PGxHealth(TM) division, provider of Therapeutic Diagnostics(TM), has launched a new test, ... Genetic Engineering News - Genetic Engineering News (press release)

… Validation of Genetic Biomarker for Determining Risk of Clozapine ...  -  Apr 19, 2006
Clozapine, a generic drug with a lower cost than most drugs in its class, ... However, concerns regarding the side effects of clozapine have negatively ... Genetic Engineering News - Genetic Engineering News (press release)

Hematological adverse events in clozapine-treated children and …  -  Oct 1, 2005
Objective: To retrospectively examine rates of hematological adverse events (HAEs) in psychiatrically ill, hospitalized children treated with clozapine. ... Pay-Per-View - Journal of the American Academy of... - Factiva, from Dow Jones

Metabolic syndrome common with clozapine.(Adult Psychiatry) | Article...  -  Oct 1, 2008
Metabolic syndrome common with clozapine.(Adult Psychiatry) ... find Clinical Psychiatry News articles. BARCELONA -- Metabolic syndrome was present in 61% ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

… of Genetic Associations with Clozapine-Induced Agranulocytosis at...  -  Mar 28, 2007
CIA is a rare but serious side effect of clozapine, an antipsychotic indicated for ... The PGxPredict:CLOZAPINE test is intended for practitioner use as an ... $4.95 - Business Wire - ECNext

Hormonal correlates of clozapine-induced weight gain.(WHAT'S NEW IN …  -  Nov 1, 2005
An exploratory study is the first to examine the hormonal correlates of weight gain and clozapine (Clozaril) treatment in children with childhood-onset ... Free with registration - Brown University Child and Adolescent... - AccessMyLibrary.com

Ziprasidone as Effective as Clozapine in Study of Difficult-to-Treat ...  -  May 30, 2006
TORONTO, CANADA -- May 30, 2006 -- Results from a randomized, double-blind, 18-week study (called MOZART: Monitoring Oral Ziprasidone As Rescue Therapy in ... DG News

Learn about Clozapine from Consumer Reports Health.  -  Jan 4, 2007
Clozapine can cause a serious blood condition. Your doctor will order certain lab tests before you ... Full Alert. Clozapine is used to treat the symptoms ... consumerreports.org

Many treatments available for clozapine-related drooling.(EVIDENCE- …  -  Nov 1, 2008
Many treatments available for clozapine-related drooling.(EVIDENCE-BASED PSYCHIATRIC MEDICINE) ... find Clinical Psychiatry News articles. Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Clozapine underused for black patients with psychosis.(Adult Psychiatr...  -  Sep 1, 2005
BOCA RATON, FLA. -- Clozapine is underused as a treatment for schizophrenia in African Americans, compared with white patients, despite similar baseline ... Free with registration - Clinical Psychiatry News - AccessMyLibrary.com

Amisulpride and clozapine.(Drug-Drug Interactions)  -  Mar 1, 2006
S The atypical antipsychotic amisulpride, a selective dopamine D2 and D3 receptor antagonist, (1) has been shown effective in managing both positive and ... Free with registration - Brown University Psychopharmacology... - AccessMyLibrary.com

Clozapine Better Than "High-Dose" Olanzapine for the Treatment of …  -  Mar 24, 2008
NEW YORK -- March 24, 2008 -- The results of a 12-week, double-blind, randomised study published in the March issue of Biological Psychiatry suggest that ... DG News

Hormonal correlates of clozapine-induced weight gain in psychotic …  -  Sep 1, 2005
Objective: Weight gain is a serious side effect of atypical antipsychotics, especially in childhood. In this study, the authors examined six weight ... Pay-Per-View - Journal of the American Academy of... - Factiva, from Dow Jones

Effects of clozapine during pregnancy and lactation: possible delayed...  -  Aug 1, 2007
Case: The child was born to a mother who was treated with clozapine throughout her pregnancy and during lactation. The mother had suffered from ... Free with registration - Brown University Child and Adolescent... - AccessMyLibrary.com

… Comparative Efficacy and Safety With Clozapine in Treatment...  -  Sep 22, 2006
By Chris Berrie. PARIS, FRANCE -- September 22, 2006 -- The second generation antipsychotic ziprasidone has comparable efficacy to the current gold standard ... DG News

Azur Sues Barr to Block Generic Form of Schizophrenia Drug  -  Aug 25, 2008
FazaClo, whose active ingredient is Clozapine, generated about $34 million in US sales in the 12 months ended in June for the 25-milligram and 100-milligram ... Bloomberg

IVAX Receives Final Approval on Clozapine Tablet.  -  Apr 26, 2005
MIAMI -- IVAX Corporation (AMEX:IVX) (LSE:IVX.L) (WSE:IVX) announced today that it has received final approval from the US Food and Drug Administration ... $4.95 - Business Wire - ECNext

How to take Clozapine from Consumer Reports Health.  -  Jan 4, 2007
Clozapine can cause a serious blood condition. Your doctor will order certain lab tests before you ... Full Alert. tell your doctor and pharmacist if you ... consumerreports.org

Clozapine (Systemic).  -  Aug 1, 2006
Clozapine (KLOE-za-peen) is used to treat schizophrenia in patients who have not been helped by or are unable to take other medicines. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

FDA tells Aryx Therapeutics it can test schizophrenia drug  -  Apr 22, 2008
This drug, ATI-9242, based on clozapine, is meant to treat the symptoms of schizophrenia without interacting with other drugs or causing side effects like ... Bizjournals.com

Diabetes risk does vary with choice of antipsychotic drug.  -  Jan 14, 2005
Patients with schizophrenia who are taking either clozapine (Clozaril) or ... They found patients taking clozapine or olanzapine had more markers of insulin ... Free with registration - GP - AccessMyLibrary.com

Psychiatrists encouraged to stop underprescribing clozapine.(Adult …  -  Oct 1, 2007
SACRAMENTO -- The Clinical Antipsychotic Trials of Interventional Effectiveness clearly showed the effectiveness of clozapine, but the drug is seldom ... Free with registration - Clinical Psychiatry News - AccessMyLibrary.com

CATIE Phase 2: Clozapine Most Effective, Followed by Risperidone, …  -  Jun 1, 2006
Phase 2 results of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study have been released and appear to demonstrate hopeful signs ... Pay-Per-View - Psychiatric Times - Factiva, from Dow Jones

Effect of clozapine on d-fenfluramine-evoked neuroendocrine responses...  -  Mar 1, 2008
BACKGROUND. Clozapine is an effective antipsychotic that has high affinity for serotonin type 2 (5-HT2) receptors. The importance of 5-HT antagonism in the ... British Journal of Psychiatry (subscript...

… Cognitive Effects With Ziprasidone or Clozapine: Presented at ECNP  -  Oct 19, 2007
Clozapine is often used in treatment-resistant patients, ... A total of 144 patients were randomised to either clozapine or ziprasidone and were assessed at ... DG News

FDA approves two monitoring changes for clozapine patients.(Food and ...  -  Sep 1, 2005
ROCKVILLE, MD. -- The Food and Drug Administration has approved two major changes to the schedule for monitoring people on clozapine for agranulocytosis: ... Free with registration - Clinical Psychiatry News - AccessMyLibrary.com

Most Effective Antipsychotic Drug Has Serious Health Consequences  -  Jul 5, 2006
More than half the clozapine patients studied had metabolic syndrome while ... Physicians should monitor closely people who receive clozapine with regular ... Medical News Today - Medical News Today (press release)

Clozapine Promotes Employability and Reduces Re-Offending Among …  -  Sep 9, 2008
By Thomas S. May. VANCOUVER -- September 9, 2008 -- The atypical antipsychotic clozapine helps promote institutional adjustment and reduces the probability ... DG News

Taking Clozapine from Consumer Reports Health.  -  Jan 4, 2007
Clozapine can cause a serious blood condition. Your doctor will order certain lab tests before you ... Full Alert. Clozapine may cause side effects. ... consumerreports.org

Clozapine 'wins again' in phase II of CATIE.(drug usage)(clinical...  -  May 1, 2006
Clozapine 'wins again' in phase II of CATIE.(drug usage)(clinical trials) ... find Clinical Psychiatry News articles. SAN JUAN, PR -- Clozapine fared better ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

… Efficacy and Safety of Ziprasidone and Clozapine in Treatment...  -  May 26, 2006
TORONTO, CANADA -- May 26, 2006 -- Ziprasidone and clozapine show equivalent improvement in treatment-resistant/intolerant patients with schizophrenia, ... DG News

… Therapy; Chronic effects of clozapine on nucleus accumbens...  -  Apr 11, 2005
2005 APR 11 - (NewsRx.com) -- The effects of chronic clozapine treatment on nucleus accumbens (NAcc) dopamine (DA) levels have been characterized in a rat ... Pay-Per-View - Proteomics Weekly - Factiva, from Dow Jones

Clozapine-resistant mutism in noncatatonic schizophrenia.(Letters)(Let...  -  Jan 1, 2007
Clozapine was started, as he had not responded to risperidone, olanzapine and three courses ... The dose of clozapine was gradually increased to 450 mg/day. ... Free with registration - Journal of Postgraduate Medicine - AccessMyLibrary.com

… 2 Government Schizophrenia Study Names Clozapine Most Effective...  -  Apr 3, 2006
...(While clozapine can cause potentially serious side effects or a drop in ... FazaClo(R) (clozapine, USP) Orally Disintegrating Tablets are a product of ... Free with registration - PR Newswire - AccessMyLibrary.com

Use of clozapine in a child with treatment-resistant schizophrenia  -  Oct 1, 2005
BACKGROUND. Schizophrenia can be diagnosed in adults and requires treatment with antipsychotic medication. Clozapine is used effectively in adults with ... British Journal of Psychiatry (subscript...

Rechallenge with clozapine following leucopenia or neutropenia during...  -  Jul 1, 2008
Correspondence: Dr LR Dunk, Histopathology Department, Leicester Royal Infirmary, Infirmary Square, Leicester LE1 5WW, UK. ... British Journal of Psychiatry (subscript...

Association of autonomic dysfunction and clozapine Heart rate...  -  Aug 1, 2007
Correspondence: Hagit Cohen, Anxiety and Stress Research Unit, Ministry of Health Mental Health Center, Faculty of Health-Sciences, Ben-Gurion University of ... British Journal of Psychiatry (subscript...

Management of clozapine-resistant schizophrenia  -  Jul 1, 2008
Rob W. Kerwin is Professor and Head of the Section of Clinical Neuropharmacology at the Institute of Psychiatry (De Crespigny Park, London SE5 8AF, UK. ... Adv Psychiatric Treat (subscription)

FDA approves changes to clozapine blood monitoring.(Rx)  -  Oct 1, 2005
ROCKVILLE, MD. -- The Food and Drug Administration has approved two major changes to the schedule for monitoring people on clozapine for agranulocytosis: ... Free with registration - Internal Medicine News - AccessMyLibrary.com

Label-printing software eases management of patients on clozapine  -  Feb 22, 2005
Mental health patients being treated with the drug clozapine need regular blood tests — every week for 18 weeks and then fortnightly — and detailed ... bjhcim

Clozapine calms aggression.(CLINICAL CAPSULES)(Brief Article)  -  Feb 1, 2005
In a retrospective study of clozapine, 20 children and adolescents with treatment-refractory schizophrenia showed significant decreases in three indices of ... Free with registration - Clinical Psychiatry News - AccessMyLibrary.com

Guidance for Industry on Clozapine Tablets: In Vivo Bioequivalence...  -  Jun 20, 2005
SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of a guidance for industry entitled "Clozapine Tablets: In Vivo ... Pay-Per-View - Federal Register - Factiva, from Dow Jones

Avanir Receives FDA Approvable Letter for New Formulation of Currently...  -  Jan 30, 2007
FazaClo is the only orally disintegrating form of clozapine which is ... FazaClo(R) (clozapine, USP), is indicated for the management of severely ill ... RedOrbit

Antipsychotic Therapy; Clozapine-induced weight gain linked to 5HT2C ...  -  Apr 12, 2005
2005 APR 12 - (NewsRx.com) -- Clozapine-induced weight gain is associated with the 5HT2C receptor -759C/T polymorphism. "Weight gain has been documented as ... Pay-Per-View - Science Letter - Factiva, from Dow Jones

Dementia patients warned off new drugs  -  Jun 16, 2005
The warning relates to four drugs - olanzapine (Zyprexa), risperidone (Risperdal), quetiapine (Seroquel) and clozapine (Clozaril) - and was issued yesterday ... Pay-Per-View - Toronto Star - ProQuest Archiver

Antipsychotics; Adherence to clozapine therapy improved by weekly …  -  Oct 31, 2005
2005 OCT 31 - (NewsRx.com) -- Adherence to clozapine therapy is improved by weekly visits with a clinician. In a recently published article, scientists in ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones

Antipsychotics; Adherence to clozapine therapy improved by weekly …  -  Nov 6, 2005
2005 NOV 6 - (NewsRx.com) -- Adherence to clozapine therapy is improved by weekly visits with a clinician. In a recently published article, scientists in ... Pay-Per-View - Medical Letter on the CDC & FDA - Factiva, from Dow Jones

… Monthly WBC Monitoring for FazaClo(R) (clozapine, USP). - PR...  -  May 18, 2005
FDA Grants Monthly WBC Monitoring for FazaClo(R) (clozapine, USP). from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

Antipsychotic Therapy; Clozapine-induced weight gain linked to 5HT2C ...  -  Apr 15, 2005
2005 APR 15 - (NewsRx.com) -- Clozapine-induced weight gain is associated with the 5HT2C receptor -759C/T polymorphism. "Weight gain has been documented as ... Pay-Per-View - Genomics & Genetics Weekly - Factiva, from Dow Jones

Antipsychotic Therapy; Clozapine-induced weight gain linked to 5HT2C ...  -  Apr 16, 2005
2005 APR 16 - (NewsRx.com) -- Clozapine-induced weight gain is associated with the 5HT2C receptor -759C/T polymorphism. "Weight gain has been documented as ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

Diabetes Risk Factor; Clozapine does not increase diabetes risk in …  -  Jan 10, 2005
2005 JAN 10 - (NewsRx.com & NewsRx.net) -- Chronic treatment with clozapine did not increase the risk of diabetes in patients with Parkinson disease. ... Pay-Per-View - Obesity & Diabetes Week - Factiva, from Dow Jones

… 2 Government Schizophrenia Study Names Clozapine Most Effective...  -  Apr 3, 2006
As CATIE Part 2 Government Schizophrenia Study Names Clozapine Most Effective Anti-psychotic, A Young Company Provides Ways to Enhance Its Safe Usage. from ... Pay-Per-View - PR Newswire - HighBeam Research

FDA Grants Monthly WBC Monitoring for FazaClo(R) (clozapine, USP).  -  May 18, 2005
PARSIPPANY, NJ, May 18 /PRNewswire/ -- In a move that will bring added convenience to thousands of clozapine patients and healthcare providers, ... $4.95 - PR Newswire - ECNext

Schizophrenia: An Expert Interview With Herbert Y. Meltzer, MD  -  Jan 20, 2006
Prior to the advent of clozapine, it was believed that all antipsychotic drugs ... I came to the conclusion after looking at clozapine that it had to be ... Medscape

… ; Gi/o dependent mechanism is behind clozapine downregulation of TH...  -  Oct 26, 2005
Chronic clozapine has been reported to significantly reduce the expression of ... "To characterize the mechanisms of action of clozapine on TH expression, ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones

… encouraged to stop underprescribing clozapine.(Adult Psychiatry) |...  -  Oct 1, 2007
Psychiatrists encouraged to stop underprescribing clozapine.(Adult Psychiatry) ... find Clinical Psychiatry News articles. Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Oregon Regulations - 410-121-0190 Clozapine Therapy  -  Aug 9, 2005
Clozapine Supervision is the management and record keeping of clozapine dispensings ... (2) Clozapine supervision: (a) Pharmacists are to bill for Clozapine ... Pay-Per-View - Oregon Regulations - Loislaw

… ; Gi/o dependent mechanism is behind clozapine downregulation of TH...  -  Oct 29, 2005
Chronic clozapine has been reported to significantly reduce the expression of ... "To characterize the mechanisms of action of clozapine on TH expression, ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

AVANIR Pharmaceuticals Receives Marketing Approval From FDA for …  -  May 31, 2007
FazaClo is the only orally disintegrating form of clozapine for the management of severely ill schizophrenic patients who fail to respond adequately to ... Free with registration - M2 Presswire - AccessMyLibrary.com

Antipsychotics Effective and Safe in Patients With Chronic Schizophren...  -  Sep 20, 2006
For primary, any-cause, outcome, after 18 months, clozapine showed significant ... With discontinuations for lack of efficacy, clozapine was again preferred ... DG News

Diabetes Risk Factor; Clozapine does not increase diabetes risk in …  -  Jan 15, 2005
2005 JAN 15 - (NewsRx.com & NewsRx.net) -- Chronic treatment with clozapine did not increase the risk of diabetes in patients with Parkinson disease. ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

Article: Rate of myocarditis from clozapine higher.(adverse drug...  -  Nov 1, 2006
Rate of myocarditis from clozapine higher.(adverse drug-reaction ) ... find Clinical Psychiatry News articles. BARCELONA -- About 1% of patients treated ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Article: Data on clozapine augmentation are scarce but do exist.(Adult...  -  Aug 1, 2006
Data on clozapine augmentation are scarce but do exist.(Adult Psychiatry)(care and alternative treatment to schizophrenia) ... find Clinical Psychiatry News ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Clozapine. | Practice | Nursing Times  -  Feb 18, 2005
Advertise with the UK's leading nursing weekly and the biggest nursing website outside the US, with an audience of 150000 unique users a month. ... Nursing Times

Warnings for clozapine.(From the FDA)(Brief article)  -  Mar 1, 2006
On January 13 the FDA and Novartis posted a notification for healthcare professionals and patients regarding label changes for Clozaril (clozapine) tablets, ... Free with registration - Brown University Psychopharmacology... - AccessMyLibrary.com

… Laboratories, Ltd. Announces FDA Approval For Additional Clozapine...  -  Aug 24, 2005
Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval For Additional Clozapine Strength. from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

… Therapy; Astrocytes mediate suppressive effects of clozapine on...  -  Jul 26, 2005
..."Astrocyte cultures treated for 48 h with clozapine exhibited a reduction in ... "Our findings indicate that clozapine reduces GLT-1 expression and function ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Clozapine patients exhibit higher risk for metabolic syndrome.(News …  -  Oct 1, 2006
Patients taking clozapine for schizophrenia should be regularly monitored because of an increased risk for metabolic abnormalities, according to a study ... $4.95 - Formulary - ECNext

Drug Development; US FDA grants approval for additional Clozapine …  -  Sep 20, 2005
..."This approval is an additional strength to our already approved 25mg and 100mg Clozapine and should drive value for our current marketing strategy for ... Pay-Per-View - Science Letter - Factiva, from Dow Jones

World pharma: Azur, Elan sign deal on Clozapine  -  Nov 11, 2008
Azur Pharma Limited ("Azur") today announced that it has entered into an agreement to develop and commercialise once-daily formulations of clozapine using ... $34.00 - EIU Country Analysis - Alacra Store

Article: Clozapine calms aggression.(CLINICAL CAPSULES)(Brief...  -  Feb 1, 2005
Clozapine calms aggression.(CLINICAL CAPSULES)(Brief Article) ... find Clinical Psychiatry News articles. In a retrospective study of clozapine, ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Drug Development; US FDA grants approval for additional Clozapine …  -  Sep 24, 2005
..."This approval is an additional strength to our already approved 25mg and 100mg Clozapine and should drive value for our current marketing strategy for ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

Cardiology; Clozapine-induced hypersensitivity myocarditis led to...  -  Jan 2, 2005
2005 JAN 2 - (NewsRx.com & NewsRx.net) -- According to a recent case study, clozapine-induced hypersensitivity myocarditis led to a man's death. ... Pay-Per-View - Heart Disease Weekly - Factiva, from Dow Jones

Brand Names/Synonyms:
Clozapine is also known by the following brand names and/or synonymsAsaleptin; Clozapin; Clozapine; Clozaril; Fazaclo ODT; HF-1854; Iprox; Leponex; Lepotex; W-801

Drug Category:
Clozapine is categorized under the following by the FDA: Antipsychotics; Antipsychotics; ATC:N05AH02

Dosage Forms:
TABLET

Absorption:
rapid and almost complete

Interactions:
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Chemical IUPAC Name:
Not Available





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