Comtan

This page contains recent news articles, when available, and an overview of Comtan but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Comtan
(when available)

Pharmacology and use:
Entacapone is used in the treatment of Parkinson’s disease as an adjunct to levodopa/carbidopa therapy. Entacapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT). In mammals, COMT is distributed throughout various organs with the highest activities in the liver and kidney. COMT also occurs in the heart, lung, smooth and skeletal muscles, intestinal tract, reproductive organs, various glands, adipose tissue, skin, blood cells and neuronal tissues, especially in glial cells. COMT catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the phenolic group of substrates that contain a catechol structure. Physiological substrates of COMT include dopa, catecholamines (dopamine, norepinephrine, and epinephrine) and their hydroxylated metabolites. The function of COMT is the elimination of biologically active catechols and some other hydroxylated metabolites. In the presence of a decarboxylase inhibitor, COMT becomes the major metabolizing enzyme for levodopa, catalyzing the metabolism to 3-methoxy-4-hydroxy-L-phenylalanine (3-OMD) in the brain and periphery. For as an adjunct to levodopa / carbidopa to treat patients with idiopathic Parkinson's Disease who experience the signs and symptoms of end-of-dose "wearing-off".

Mechanism Of Action:
The mechanism of action of entacapone is believed to be through its ability to inhibit COMT and alter the plasma pharmacokinetics of levodopa. When entacapone is given in conjunction with levodopa and an aromatic amino acid decarboxylase inhibitor, such as carbidopa, plasma levels of levodopa are greater and more sustained than after administration of levodopa and an aromatic amino acid decarboxylase inhibitor alone. It is believed that at a given frequency of levodopa administration, these more sustained plasma levels of levodopa result in more constant dopaminergic stimulation in the brain, leading to greater effects on the signs and symptoms of Parkinson's disease.

News Articles on Entacapone

Orion Group Interim Report January-September 2009  -  ‎Oct 26, 2009‎
Deliveries of the Parkinson's disease drugs Stalevo and Comtan to Novartis and sales of Simdax heart failure drug, Easyhaler pulmonary drugs and Precedex ... Trading Markets (press release)

Orion net profit up to EUR118.4m in 9-mo '09  -  ‎Oct 26, 2009‎
Sales of Orion's Parkinson's disease drugs Stalevo and Comtan increased to EUR182.2m from EUR155.7m. Sales of the Easyhaler product for the treatment of ... Therapeutics Daily (press release) (registration)

Finnish Orion sues Wockhardt in US over patents  -  Sep 14, 2007
Orion said Wockhardt seeks to market in the United States generic entacapone, which is the active ingredient in Orion's Parkinson disease drug Comtan, ... Reuters

Comtan.(Used for Parkinson's disease)(Drug overview)  -  Dec 1, 2005
Comtan is used for Parkinson's disease. It is prescribed when doses of the combination drug levodopa/carbidopa (Sinemet) begin to wear off too soon. ... Free with registration - PDR Family Guide to Prescription Drugs - AccessMyLibrary.com

Comtan Oral : User Ratings covering uses, effectiveness, interactions...  -  Mar 16, 2008
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088. ... WebMD

DR. PAUL DONOHUE GOOD HEALTH  -  Feb 27, 2005
Even newer are Comtan and Tasmar, two medicines used in conjunction with Sinemet. Perhaps your wife heard of Apokyn, an injectable drug approved by the Food ... Pay-Per-View - South Florida Sun - Sentinel - ProQuest Archiver

Orionin voitto ja osinko ylittivät odotukset  -  Feb 10, 2006
Orionin omat Parkinson-lääkkeet Stalevo ja Comtess/Comtan toivat kolmasosan koko Pharman liikevaihdosta. Pharman liikevaihto kasvoi kuusi prosenttia. ... Kauppalehti - Kauppalehti

Orion Profit Falls Short of Estimates as Costs Rise  -  Aug 5, 2008
Orion gets about one-third of its revenue from Stalevo and Comtan, which are marketed by Switzerland's Novartis AG in the US, Asia, Africa and much of ... Bloomberg

Orion tahkosi huipputuloksen  -  Feb 7, 2007
Markkinoiden painotus onkin siirtynyt vahvasti Stalevoon, vaikka myös toinen entakaponi-valmiste Comtess/Comtan pystyi kasvattamaan liikevaihtoaan runsaalla ... MediUutiset

Finnish Orion files US lawsuit to protect key drug  -  Nov 13, 2008
HE: Quote, Profile, Research) said on Wednesday it has filed a patent infringement lawsuit in the United States to protect its key drug Comtan, ... Reuters India

Orion sues Wockhardt in US to block generic version of key drug  -  Sep 14, 2007
Wockhardt's application for 30 months. Consequently, that a generic version of Comtan would come to market is 'neither certain nor imminent', it said. Forbes

Orionilta ei yllätyksiä  -  Oct 24, 2007
Parkinson-lääkkeet Stalevo ja Comtess/Comtan toivat liikevaihtoa yhteensä 152,6 miljoonaa euroa vuoden takaiseen 137,2 miljoonaan euroon verrattuna. ... Arvopaperi Online

Drug May Cut Parkinson's Disease Disability  -  Mar 10, 2005
The new study pitted one of those drugs, Comtan, against rasagiline, ... Rasagiline and Comtan both reduced "off-time" by about the same amount -- 1.18 ... WebMD

Orion in patent row with Sun  -  Nov 14, 2008
Orion had filed a similar suit against Wockhardt, another Indian company that sought regulatory approval for marketing the low-cost version of Comtan in the ... Rediff

Sorting out drug plans still not simple // Web can help answer...  -  Dec 19, 2005
The Republican tried five common drugs at each Web site: Comtan, Fosamax, ... Tufts' formulary covered Lipitor, Fosamax, Comtan and Paxil as tier 2 drugs. ... Pay-Per-View - The Republican - Factiva, from Dow Jones

Stalevo 50 Oral : Uses, Side Effects, Interactions, Pictures,...  -  Aug 10, 2006
Comtan (entacapone) US prescribing information. Novartis Pharmaceuticals Corporation February, 2009. 4.Comtan (entacapone) Canadian prescribing information. ... WebMD

Orion mulling lawsuit in US to protect drug patent  -  Aug 14, 2007
Orion said it is mulling options to protect its patents on entacapone, the active ingredient in Comtan, its best-selling drug for Parkinson's Disease. ... Forbes

Crunch Time at Teva  -  Aug 1, 2005
Novartis (NVS - commentary - Cramer's Take) offers two COMT inhibitors -- Comtan and Stalevo, which combines Comtan with levodopa/carbidopa. ... TheStreet.com - TheStreet.com (subscription)

Orion considers lawsuit to protect patent  -  Aug 13, 2007
Orion's two best-selling drugs for Parkinson's disease, Stalevo and Comtess/Comtan, are based on the patent of entacapone. ... Reuters

Crunch Time at Teva  -  Aug 4, 2005
Novartis (NVS:NYSE) offers two COMT inhibitors -- Comtan and Stalevo, which combines Comtan with levodopa/carbidopa. Several companies are conducting ... TheStreet.com - TheStreet.com (subscription)

Orion mulling legal options to protect patents on Stalevo in US  -  Oct 1, 2007
Orion recently launched a lawsuit against Indian pharmaceuticals group Wockhardt in the US to prevent it from marketing a generic version of Comtan, ... Forbes

Parkinson's medicine in patent tangle  -  Nov 4, 2008
Orion had previously sued Wockhardt for challenging the patents on Comtan (entacapone), another version of Parkinson's disease drug marketed by Novartis. ... Rediff

Zyvox Oral: Dosage, Uses and Warnings  -  Aug 10, 2006
Comtan (entacapone) US prescribing information. Novartis Pharmaceuticals Corporation February, 2009. 4.Comtan (entacapone) Canadian prescribing information. ... Medscape

entacapone Orion submitted for approval, Japan (Parkinson disease).  -  Apr 10, 2006
Novartis submitted entacapone (COMTAN) for marketing approval in Japan, ... entacapone, OR 611, COMTAN, COMTESS, N4A, Antiparkinson Drugs, Orion, ... Pay-Per-View - R & D Focus Drug News - Factiva, from Dow Jones

Treating festinating speech with altered auditory feedback in...  -  Dec 1, 2008
Amantadine 3 70M 2 3323Sinemet, Comtan 4 52F 2 2013Sinemet, Comtan Sinemet CR, Mirapex 6 71M 3 2612Stalevo 7 81M 3 3110Sinemet CR, Selegiline Mean ... Pay-Per-View - Journal of Medical Speech - Language... - HighBeam Research

Orion sues Sun Pharmaceuticals to protect patent on Parkinson's...  -  Nov 14, 2007
Orion recently launched a similar lawsuit in the US against India's Wockhardt to prevent it from marketing a generic version of Comtan, another best-selling ... ABCmoney.co.uk

Orion sues generic drug companies in the US to enforce patents for …  -  Sep 17, 2007
Entacapone is the active ingredient in Comtan®, a product originated by Orion Corporation and marketed in the United States for the treatment of Parkinson's ... chemie.de

13 new drugs added to Japan's NHI list.(Central Social Insurance...  -  Mar 19, 2007
Comtan (entacapone), Swiss drug major Novartis Pharma's Parkinson's disease treatment in combination with levodopa/carbidopa and levodopa/benserazide, ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

Novartis Q1 net beats expectations on underlying growth, divestments ...  -  Apr 24, 2006
Net sales in Europe were down 7 pct in usd but rose 1 pct in local currencies with strong performances from Diovan, Glivec, Femara, Comtan/Stalevo and ... Forbes

Sujet: PARKINSON le tasmar  -  Mar 20, 2005
Est-ce que le TASMAR m'aiderait. car J,ai essayé comtan et toutes les semblables, il n'y a rien qui faisait... Veuillez s.vp. me répondre le plus tot ... E-Santé.fr

Orion Q4 profit misses consensus, shares down  -  Feb 7, 2008
The drugmaker's key patent on entacapone, on which the company's two best-selling Parkinson's disease drugs, Stalevo and Comtess/Comtan, are based, ... Reuters

Loislaw Federal District Court Opinions - BREEN v. PENDERGRAPH ( …  -  Dec 28, 2007
Dr. Putman prescribed Comtan to help the Sinemet work longer. [Id. at 26]. Dr. Putman testified that these medications "have a substantial symptomatic ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Dans le magazine en ce moment :  -  Sep 20, 2005
Il est sous sinemet et Comtan;. A partir du 1er octobre il n'aura plus de comtan qui ne lui fesait pas grand chose. Sa neurologue lui a prescrit du TASMAR à ... E-Santé.fr

Article: Football: SPORTSWIRE - Pitch tribute by Gunners.(Sport) -...  -  Aug 5, 2006
Article: New Comtan DTC push combines pitch, tribute; Ads ... Advertising Age; June 5, 2000 ; 700+ words ...Actor Michael J. Fox's public battle with ... Pay-Per-View - The Mirror - HighBeam Research

COMT inhibitors for Parkinson's disease  -  Dec 8, 2008
This warning and legal requirement does not apply to entacapone (Comtan) or Stalevo. They are considered very safe drugs and have not been associated with ... WebMD

Orion files suit against Wockhardt  -  Dec 12, 2008
Orion had also sued Wockhardt and Sun for challenging the patent on Comtan, another drug for treating Parkinson's disease. Such suits, meant to delay the ... Rediff

Helsinki shares end lower, led by Nokia; UPM-Kymmene gains UPDATE  -  Aug 14, 2007
...authorisation in the US to produce a generic version of entacapone, the active ingredient in Comtan, its best-selling drug for Parkinson's Disease. ... Forbes

Orion Pharma Selects ChemDiv as A Partner in Drug Discovery Services  -  Nov 30, 2007
Stalevo(R) and Comtess(R) / Comtan(R), treatmentsoriginated by Orion for Parkinson 's disease, are the largest products bysales in Orion's portfolio. ... Reuters

Orionin lääkkeet purivat  -  Aug 8, 2006
Stalevo- ja Comtess/Comtan-tuotemerkeillä myytävät Parkinson-lääkkeet muodostavat kolmanneksen yhtiön kokonaisliikevaihdosta. ... Kauppalehti - Kauppalehti

Semnele neputintei  -  Apr 14, 2005
Este total dependent de aceste medicamente, a caror suma este de aproximativ 12 milioane pe luna: Comtan, Requip 2 mg, Zimox. Toate figureaza pe lista C de ... HotNews

New Guidelines Update Diagnosis and Treatment of Parkinson's Disease  -  Apr 4, 2006
Rajesh Pahwa, MD, noted that there is strong evidence supporting the use of entacapone (Comtan) and rasagiline (Azilect) to reduce "off" time in patients ... Medscape

India pharma: Eli Lilly sues Sun Pharma over Cymbalta patent  -  Dec 12, 2008
Sun Pharma was also sued by Orion Corporation, following its application for a generic version of Orion's Comtan, used for treating Parkinson's disease. ... $34.00 - EIU Country Analysis - Alacra Store

OUTI JÄRVINEN/KL-ARKISTO  -  Feb 16, 2005
Orionin kehittämät, Parkinsonin taudin hoitoon tarkoitetut entakaponi-tuotteet Comtess/Comtan ja vuonna 2003 markkinoille tuotu Stalevo kasvattivat ... Kauppalehti - Kauppalehti

Sanofi-Aventis sues Torrent, Sun Pharma  -  Sep 27, 2007
During this month, Finland-based Orion has sued Wockhardt in the US to prevent it from marketing a generic of Comtan, a drug for Parkinson's Disease. Expressindia.com

New evidence demonstrates early use of Stalevo® improves …  -  Oct 31, 2006
...and critical care and hormonal and urological therapies. Stalevo® and Comtess® / Comtan®, treatments originated by Orion for Parkinson's Disease, ar. webwire.com

Neljän tuloksen viikko  -  Aug 8, 2008
Parkinson-lääkkeet Stalevo ja Comtess/Comtan toivat liikevaihtoa 31 prosenttia lääkeliiketoiminnan liikevaihdosta. Kun ihmisille suunnattujen lääkkeiden ... MediUutiset

New laboratory approach to treat Parkinson's  -  Mar 27, 2006
Comtan (entacapone), a so-called COMT inhibitor, has the same effect as carbidopa when taken along with levodopa. It blocks a key enzyme responsible for ... LabTechnologist.com

FPIN's Clinical Inquiries  -  Aug 1, 2005
The combination of levodopa and carbidopa, with entacapone ([Comtan] a selective and reversible catechol O-methyltransferase inhibitor) is suggested for ... AAFP News Now

Orion jäi odotuksista reilusti  -  Oct 28, 2008
Novartiksen varastotasojen alenemisen takia Orionin Stalevo- ja Comtan-toimitukset ovat olleet kokonaisuutena hieman edellisvuotta alhaisemmat. ... MediUutiset

NOVARTIS JAPAN REORGANIZES MEDICAL REPS ALONG …  -  May 16, 2006
In the area of drugs for the central nervous system, Novartis Pharma is gearing up to tout Clozaril for schizophrenia and Comtan for Parkinson's disease. ... Free with registration - AsiaPulse News - AccessMyLibrary.com

Orionin tutkimuskulut nousevat yli 100 miljoonaan euroon  -  Aug 6, 2008
Parkinson-lääkkeet Stalevo ja Comtess/Comtan toivat liikevaihtoa 31 prosenttia lääkeliiketoiminnan liikevaihdosta. Kun ihmisille suunnattujen lääkkeiden ... MediUutiset

Medication may improve symptoms in Parkinson's disease.(POEMs and …  -  Nov 1, 2005
Adjuvant medications such as pergolide (Permax) or entacapone (Comtan) can provide partial improvement but may require complex schedules and careful dosage ... Free with registration - American Family Physician - AccessMyLibrary.com

Anti-Alzheimer's Disease Drugs (Cholinesterase Inhibitors, and NMDARA...  -  Nov 27, 2006
Comtan (Canada) Desitin Arzneimittel GmbH (Germany) Draxis Health, Inc (Canada) Eisai Co, Ltd (Japan) Eisai, Inc (USA) Eli Lilly and Company (USA) ... Free with registration - Business Wire - AccessMyLibrary.com

Bisnis Indonesia Online » Edisi Cetak » Edisi Harian » Hukum Bisnis  -  Nov 20, 2008
Dalam pernyataan resmi yang dirilis produsen obat penyakit Parkinson bermerek Stavelo dan Comtan itu, pihak manajemen tengah bernegosiasi dengan para ... Bisnis Indonesia

New guidelines issued for Parkinson's disease.(RX CARE)(Report)  -  Jul 24, 2006
In fact, the QSS found that both rasagiline and entacapone (Comtan, Orion) were effective in reducing "off time," a term used to describe the return of PD ... Free with registration - Drug Topics - AccessMyLibrary.com

CeNeS and Tripos advances COMT research  -  Apr 12, 2005
Novartis' entacapone (Comtan) and Roche's Tolcapone (Tasmar) and are the two well-established COMT inhibitors. Whilst effective, they both suffer from side ... DrugResearcher.com

Investigation concludes 17 killed in shootings An Iraqi panel...  -  Oct 8, 2007
Iraqi comtan in a tank patrol the area near Baghdad's Firdos square on Sunday. At least nine Iraqis died in blasts. reported Thursday that the Iraqi panel's ... Eugene Register-Guard - Google News Archive

Orion Group Interim Report 7-9/2006 and Financial Review (proforma) 1...  -  Nov 2, 2006
The products for Parkinson's Disease, ie Stalevo and Comtess/Comtan, contributed EUR 42.2 million, or 30% of the total net sales The Pharmaceuticals ... Free with registration - Europe Intelligence Wire - AccessMyLibrary.com

Two new treatments funded for Parkinson's disease  -  Oct 27, 2005
Ropinirole (Requip) and entacapone (Comtan) provide alternatives to treatments that are already funded, but which can cause serious side effects in some ... scoop.co.nz

Orionin tulos laski odotettua vähemmän  -  Apr 25, 2007
Parkinson-lääkkeet Stalevo ja Comtess/Comtan toivat liikevaihtoa yhteensä 54,6 miljoonaa euroa, eli noin 33 prosenttia liikevaihdosta. ... MediUutiset

Orion vie lääkeyhtiöitä oikeuteen Yhdysvalloissa  -  Sep 14, 2007
Entakaponi on vaikuttavana aineena Orionin Comtan-nimisessä Parkinsonin taudin hoitoon käytettävässä alkuperälääkkeessä, jota Orionin lisenssikumppani ... MediUutiset

Orionilta ei yllätyksiä  -  Oct 25, 2007
Parkinson-lääkkeet Stalevo ja Comtess/Comtan toivat liikevaihtoa yhteensä 152,6 miljoonaa euroa vuoden takaiseen 137,2 miljoonaan euroon verrattuna. ... MediUutiset

Focus on the World Alzheimer's and Parkinson's Disease Market  -  Sep 15, 2008
COMT Inhibitors II-31 Tolcapone (Tasmar) II-31 Entacapone (Comtan) II-32 MAO-B Inhibitors II-32 Dopamine Amplifiers II-32 Anticholinergics II-32 7. ... marketwire.com

Italy OKs 79 new drugs, plans R&D promotion.(pharmaceutical …  -  Mar 7, 2005
In addition, Orion Pharma's Comtan (entacapone), for the treatment of Parkinson's disease, has been switched from Category C to Category A and will now be ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

Orion Selects Medidata Rave(R) as Standard for Electronic Data...  -  Feb 5, 2007
Its biggest selling products are Stalevo(R) and Comtess(R)/Comtan(R), both for Parkinson's Disease, and it is the leader in the animal health market for the ... Genetic Engineering News - Genetic Engineering News (press release)

Neural stem cells as a potential therapy for neurological diseases  -  Dec 9, 2007
Comtan (Novartis, sales represented in 2006 m$56 ex-US and m$46 US, respectively) and Tasmar (Roche) are Catechol O-methyltransferase (COMT) inhibitors ... Lifescience-online

AAN Releases Recommendations on Treatment of Parkinson's Disease  -  Mar 15, 2007
Entacapone (Comtan) and rasagiline (Azilect) can be recommended to reduce "off" time for patients with Parkinson's disease who have motor fluctuations. ... AAFP News Now

FDA Approves New Dosage Strength Of Stalevo(R) For People With …  -  Aug 8, 2007
200 mg levodopa, 200 mg entacapone) with 2 tablets of Sinemet(R) 100/25 mg (levodopa/carbidopa) taken concomitantly with Comtan(R) (entacapone 200 mg). ... Medical News Today - Medical News Today (press release)

Netherlands Corporate News - Orion kiest voor Medidata Rave als …  -  May 2, 2007
Its biggest selling products are Stalevo(R) and Comtess(R)/Comtan(R), both for Parkinson's Disease, and it is the leader in the animal health market for the ... Netherlands Corporate News - Netherlands Corporate News (persbericht)

Q3 2005 Orion Corporation Earnings Conference Call - Final.  -  Nov 8, 2005
JUKKA VIINANEN: Well, we have licensed France -- or we have agreed with Novartis that they will sell alone Comtan and Stalevo in France. ... Free with registration - America's Intelligence Wire - AccessMyLibrary.com

Anti-Alzheimer's Disease Drugs (Cholinesterase Inhibitors, and NMDARA...  -  Nov 27, 2006
Comtan (Canada) Desitin Arzneimittel GmbH (Germany) Draxis Health, Inc (Canada) Eisai Co, Ltd (Japan) Eisai, Inc (USA) Eli Lilly and Company (USA) ... $4.95 - Business Wire - ECNext

India pharma: Eli lilly sues Sun pharma over Cymbalta patent  -  Dec 15, 2008
Sun Pharma was also sued by Orion Corporation, following its application for a generic version of Orion's Comtan, used for treating Parkinson's disease. ... $34.00 - EIU Country Analysis - Alacra Store

India generics: Sun pharma eyes pie of Clarinex  -  Dec 3, 2008
Earlier, Sun was sued by Finland-based Orion Corporation after the former sought marketing approval for a generic version of Orion's drug Comtan, ... $34.00 - EIU Country Analysis - Alacra Store

Parkinson's disease: diagnosis and treatment.(Disease/Disorder...  -  Dec 15, 2006
COMT inhibitors (e.g., entacapone [Comtan], tolcapone [Tasmar]) decrease the degradation of levodopa and extend its half-life, thus relieving the ... Pay-Per-View - American Family Physician - Factiva, from Dow Jones

Parkinson's disease: diagnosis and treatment.(Disease/Disorder...  -  Dec 15, 2006
COMT inhibitors (e.g., entacapone [Comtan], tolcapone [Tasmar]) decrease the degradation of levodopa and extend its half-life, thus relieving the ... $4.95 - American Family Physician - ECNext

Untitled  -  Feb 29, 2008
Comtan......................................................................... ............98. Exelon. ... $4,560.00 - ESPICOM HEALTHCARE INTELLIGENCE - Alacra Store

Research and Markets: Parkinson's Disease -- Increased Focus on...  -  Mar 24, 2005
...the catechol-O- methyltransferase inhibitor class has witnessed the greatest year-on-year revenue growth, driven by Novartiss Comtan and the company's ... $4.95 - PR Newswire - ECNext

Parkinson's Disease Market analysis and forecasts, 2008- 2012, 2017 &...  -  Jan 8, 2008
Comtan (Entacapone) Leading COMT. Inhibitors Captures Tasmar's Market Share. 4.15. Orions' Comtess. 4.16. Stalevo Combination Therapy Drives Sales ... $4,422.00 - VISIONGAIN A - Alacra Store

Press Release: Orion Pharma Selects ChemDiv as A Partner in Drug …  -  Nov 30, 2007
Stalevo(R) and Comtess(R) / Comtan(R), treatments originated by Orion for Parkinson 's disease, are the largest products by sales in Orion's portfolio. ... Pay-Per-View - PR Newswire - HighBeam Research

Agência Sergipe de Notícias - Sergipe - Governo de Todos  -  Jun 19, 2007
Além do Sifrol e Mantidan, a unidade disponibiliza outros remédios para o tratamento dos parkinsonianos, a exemplo do Comtan, Parkidopa, Prolopa, ... se.gov.br

Trattamento farmacologico della malattia di Parkinson  -  May 27, 2008
Gli inibitori COMT, Entacapone ( Comtan ) e Tolcapone ( Tasmar ), sono impiegati in associazione alla Levodopa e alla Carbidopa per prolungare l'effetto ... XagenaSalute

Orionilta 0,85 euron osinko  -  Feb 9, 2006
Toisen Parkinson-lääkkeen Comtan/Comtessin myynti kasvoi 49 prosenttia 15,9 miljoonaan euroon. Oriolan laskutus kasvoi loka-joulukuussa vajaat kolme ... Arvopaperi Online

КомпаниÑ? Orion Ñ?удитÑ?Ñ? Ñ? Sun Pharmaceuticals  -  Nov 15, 2007
Ð?едавно финÑ?каÑ? компаниÑ? выÑ?тупила Ñ? подобным иÑ?ком против индийÑ?кой Wockhardt в отношении патента на препарат Comtan, также применÑ?ющийÑ?Ñ? длÑ? лечениÑ? ... ФармацевтичеÑ?кий веÑ?тник

Canal Digital Satelliet también abandonará la codificación Seca 2  -  Nov 7, 2008
...algun satcesc.comas informaciones satcesc.com no oficiales satcesc.com apun satcesc.comtan a que el grupo suizo Kudelski ya es satcesc.comtá preparando ... SatCesc

Orionilla ei uutta kerrottavaa  -  Aug 7, 2006
Parkinson-lääkkeet Stalevo ja Comtess/Comtan toivat liikevaihtoa yhteensä 94,9 miljoonaa euroa vuoden takaiseen 71,5 miljoonaan euroon verrattuna. ... Arvopaperi Online

Alzheimer : forum E-santé  -  Mar 19, 2005
...lE TASMAR EST 5 FOIS PLUS ACTIF QUE LE COMTAN et seulement en 3 prises par 24 heures. Allez voir sur internet il ya plusieurs sites sur le tasmar. à bientôt ... E-Santé.fr

×›×™ מציון תצ×? תרופה  -  Mar 13, 2005
...×?פקט ×–×” נמצ×? דומה לזה של ×” - ( entacapone (= COMTAN , תרופה הנתנת במשולב ×¢×? לבודופה במצבי×? ... מרכז הרופ×?×™×? המומחי×?

I nuovi farmaci spingono Novartis  -  Oct 18, 2005
...per le terapie anti-rigetto; Comtan (entacapone) per il trattamento del Parkinson, entrato nella classe dei prodotti interamente rimborsabili, ... Pharma Marketing

Jukka Viinanen: Näitä lukuja ei tarvitse hävetä  -  Aug 7, 2006
Orionin lääkkeistä voimakkaimmin myyntiään kasvattivat alkuvuonna Parkinson lääkkeet eli Stalevo ja Comtess/Comtan, joiden myynti kasvoi alkuvuonna lähes 33 ... Arvopaperi Online

Orionin Comtanille ehkä 10 % markkinoista Japanissa  -  Feb 6, 2007
OKOn analyytikko Anita Kostermaa arvioi uutistoimisto Reutersille, että Orionin (osake, tiedotteet) Parkinson-lääke Comtan voi saavuttaa Japanissa noin ... Arvopaperi Online

Malattia di Parkinson: trattamento farmacologico delle complicanze …  -  Sep 4, 2007
Pertanto, i farmaci che bloccano la catecol-O-metiltransferasi, come Tolcapone ( Tasmar ) ed Entacapone ( Comtan ), aumentano l'emivita di eliminazione ... XagenaSalute

Geneerinen uhka Orionin Parkinson-lääkkeelle  -  Aug 13, 2007
Entakaponi on vaikuttavana aineena Orionin kehittelemässä Parkinsonin taudin hoitoon tarkoitetussa Comtan-alkuperälääkkeessä. ... Arvopaperi Online

Las diferencias entre pescado de extracción y de piscifactoría  -  Aug 3, 2005
...ha sido elaborado por el panel de expertos sobre contaminantes en la cadena alimentaria (COMTAN) de la EFSA, a requerimiento del Parlamento Europeo, ... Consumer

Malattia di Parkinson in fase iniziale: trattamento farmacologico  -  Sep 11, 2007
Studi preclinici hanno indicato che l'aggiunta dell'inibitore COMT, Entacapone ( Comtan ), alla Levodopa, è associato a minori complicanze motorie rispetto ... XagenaSalute

Orionin liikevaihto laskee 2005  -  May 11, 2005
Suurin yksittäinen tuotemerkki oli Parkinson-lääke Comtess/Comtan, josta kertyneet myyntituotot laskivat 24,1 miljoonasta 17,6 miljoonaan. ... Arvopaperi Online

79 nuovi farmaci nel prontuario del SSN  -  Feb 25, 2005
Si tratta dell'Entacapone (Comtan) precedentemente classificato in fascia C ed ora dispensato gratuitamente dal Servizio Sanitario Nazionale a tutti i ... Sanihelp.it

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Brand Names/Synonyms:
Comtan is also known by the following brand names and/or synonymsComtan; ENTACAPONE; Entacapona [Inn-Spanish]; Entacapone; Entacapone [Usan:Inn]; Entacaponum [Inn-Latin]

Drug Category:
Comtan is categorized under the following by the FDA: Antiparkinson Agents; Antidyskinetics; Central Nervous System Agents; ATC:N04BX02

Dosage Forms:
TABLET

Absorption:
Entacapone is rapidly absorbed (approximately 1 hour). The absolute bioavailability following oral administration is 35%.

Interactions:
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Chemical IUPAC Name:
2-cyano-3-(5-dihydroxyamino-3,4-dioxo-1-cyclohexa-1,5-dienyl)-N,N-diethyl-prop-2-enamide





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