Cytoxan

This page contains recent news articles, when available, and an overview of Cytoxan but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Cytoxan
(when available)

Pharmacology and use:
Cyclophosphamide is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death. For management of malignant lymphomas, multiple myeloma,leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma and carcinoma of the breast

Mechanism Of Action:
Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.

News Articles on Cyclophosphamide

Ofatumumab, Fludara®, Cytoxan® Regimen Highly Effective for Initial Treatment ...  -  05 Jan 2010
Researchers involved in an international multicenter clinical trial have reported that a regimen of ofatumumab, Fludara® (fludarabine), and Cytoxan® ... Cancer Consultants

Arzerraâ„¢, Fludara®, Cytoxan® Combination Effective for Newly Diagnosed CLL  -  ‎Dec 23, 2009‎
...with Fludara® (fludarabine) and Cytoxan® (cyclophosphamide)—FC—is highly effective for previously untreated patients with chronic lymphocytic leukemia. ... Cancer Consultants

An Overall Survival Benefit In Chronic Lymphocytic Leukemia (CLL)  -  ‎Dec 10, 2009‎
Rituxan) provided a modest, but statistically significant survival benefit over FC (Fludarabine, Cytoxan) in patients with chronic lymphocytic leukemia. ... Gerson Lehrman Group

Herceptin® Given Concurrently with Chemotherapy May Provide Most Benefit in ...  -  ‎Dec 18, 2009‎
Patients in this study were randomly allocated to one of three regimens: AC—T--H (Adriamycin and Cytoxan followed by Taxol followed by Herceptin for 52 ... Cancer Consultants

Addition Of Thalidomide To Induction Therapy Increases Response Rates In ...  -  ‎Dec 29, 2009‎
The younger patients, median age 59 years, were randomized to receive one of two induction therapies – either cyclophosphamide (Cytoxan), thalidomide, ... The Myeloma Beacon

Treatment Updates  -  ‎Dec 23, 2009‎
...—MW Combining Fludara (fludarabine), Cytoxan (cyclophosphamide), and Rituxan (rituximab) was safer and produced a higher response than pairing Campath ... Curetoday.com (press release)

SABCS: Trastuzumab Dosing During Chemo Vindicated  -  ‎Dec 13, 2009‎
...and cyclophosphamide [Cytoxan] followed by paclitaxel [Taxotere]); to the same chemotherapy with trastuzumab started concurrently with the paclitaxel, ... MedPage Today

Post-treatment pain remains clinically significant in breast cancer patients  -  ‎Dec 28, 2009‎
...patients underwent antiestrogen treatment and standard chemotherapy with cyclophosphamide (Cytoxan), epirubicin (Ellence), and 5-fluorouracil. ... Cancer Network

Revlimid® Delays Progression of Multiple Myeloma After Stem Cell Transplantation  -  ‎Dec 21, 2009‎
Peripheral blood stem cells were harvested after Cytoxan® (cyclophosphamide) and Neupogen® (filgrastim). Four courses of consolidation Revlimid was given ... Cancer Consultants

SABCS: No Need for Anthracycline with Trastuzumab  -  ‎Dec 12, 2009‎
...compared standard anthracycline-based chemotherapy -- doxorubicin (Adriamycin), cyclophosphamide (Cytoxan), docetaxel (Taxotere) -- with the same ... MedPage Today

The International Myeloma Foundation Says Important Studies May Offer New ...  -  ‎Dec 10, 2009‎
VELCADE-cyclophosphamide-dexamethasone, VELCADE-THALOMID-dexamethasone, and the four-drug combination VELCADE-CYTOXAN®-REVLIMID-low dose dexamethasone. ... Medical News Today (press release)

Succesful new treatment for Lupus  -  ‎Nov 11, 2009‎
And if a possible alternative to more toxic therapies like cytoxan can be found and approved, this could make a significant impact in the treatment of ... Gerson Lehrman Group

Alliance for Lupus Research Walk: Tomorrow 9:00 am  -  ‎Nov 13, 2009‎
Typically, cytoxan, imuran or methotrexate is employed (chemotherapy). The treatments typically have side effects that require additional medication or ... Houstonist

Nikki Patrick tells of her triumph over breast cancer  -  ‎Oct 20, 2009‎
To start, I had four cycles of adriamycin, often called the “red devil� because it's bright red and just as mean as cancer, and cytoxan. ... Pittsburg Morning Sun

Updated NCCN Guidelines for Breast Cancer Discourages Prophylactic Mastectomy ...  -  ‎Oct 28, 2009‎
The NCCN Guidelines now include FEC [fluorouracil (Adrucil(R), Pfizer Inc.) / epirubicin (Ellence(R), Pfizer Inc.) / cyclophosphamide (Cytoxan(R), ... Reuters

Human Genome Sciences Shares Rise on Lupus Drug Data  -  ‎Nov 2, 2009‎
Cytoxan, approved in 1959, is a cancer therapy that may work to suppress the immune system's attack on the body in lupus patients. ... Bloomberg

Drug Shows Limited Promise Against Perilous Skin Disease  -  Jun 22, 2006
The drug is cyclophosphamide, or Cytoxan, which has been used for years to treat cancer and ... One group of 79 was to take Cytoxan pills daily for a year. ... New York Times

Cytoxan for Multiple Sclerosis - WebMD  -  Nov 2, 2006
Cytoxan is a therapy that may be given to people with multiple sclerosis. It works by suppressing the immune system. It's given to people with MS because MS ... WebMD

SABCS: Taxotere-Cytoxan Combo Shows Survival Advantage in Breast …  -  Dec 12, 2005
By Michael Smith,. SAN ANTONIO, Dec. 12 - Adjuvant chemotherapy with Taxotere (docetaxel) and Cytoxan (cyclophosphamide) delivers 33% better disease-free ... MedPage Today

Breast Cancer Chemotherapy - Breast Cancer Health Information - NY …  -  Nov 10, 2008
..."T." Cyclophosphamide (Cytoxan), fluorouracil (5-FU), and methotrexate (MTX) are standard cancer drugs used in many breast cancer chemotherapy regimens. ... New York Times

Cytoxan.(Drug overview)  -  Jan 22, 2007
Cytoxan, an anticancer drug, works by interfering with the growth of malignant cells. It may be used alone but is often given with other anticancer ... Free with registration - PDR Family Guide to Prescription Drugs - AccessMyLibrary.com

New drug CellCept far more effective in treating kidney problems in...  -  Nov 24, 2005
It is also understood that two patients in the Cytoxan group died, while there were no ... Ginzler estimates though, that when the cost of giving Cytoxan ... News-Medical.net

Breast Cancer,Metastatic or Recurrent - Medications  -  Aug 31, 2007
The most commonly used combinations are AC (which combines Adriamycin and Cytoxan) and CMF (which combines Cytoxan, methotrexate, and 5-FU). ... WebMD

Drug shows promise in lupus patients  -  Nov 30, 2005
Two patients taking Cytoxan died. "CellCept is a general immunosuppressive drug, and it appears to be useful for other features of lupus as well, ... Pay-Per-View - Newsday - ProQuest Archiver

Taxotere Plus Adriamycin and Cytoxan Improves Outcomes in Breast …  -  Jun 1, 2005
By Rabiya Tuma, Ph.D.,. MADRID, June 1-Substituting Taxotere (docetaxel) for fluorouracil in a common adjuvant chemotherapy regimen showed improved outcomes ... MedPage Today

Cytoxan.(Anticancer medications)(Drug overview)  -  Dec 1, 2005
Cytoxan, an anticancer drug, works by interfering with the growth of malignant cells. It may be used alone but is often given with other anticancer ... Free with registration - PDR Family Guide to Prescription Drugs - AccessMyLibrary.com

SABCS: Anthracycline May Be Superfluous in Breast Cancer Regimens  -  Dec 15, 2006
The patients were randomized to receive adjuvant therapy consisting of Herceptin-Paraplatin-Taxotere or Adriamycin-Cytoxan-Taxotere-Herceptin or the control ... MedPage Today

ATS: Cancer Drug Retards Scleroderma's Lung Function Decline  -  May 24, 2005
SAN DIEGO, May 24-The alkylating cancer drug Cytoxan (cyclophosphamide) appears ... Because Cytoxan was already being used off-label to treat scleroderma, ... MedPage Today

Treatments and drugs  -  Nov 14, 2008
Other people may require another immunosuppressive drug, such as cyclophosphamide (Cytoxan), azathioprine (Imuran) or methotrexate (Rheumatrex, Trexall), ... MayoClinic.com

New Research Questions Taxol's Efficacy for Common Breast Cancer  -  Oct 15, 2007
...research and clinical trials, Taxol became a new standard in breast cancer chemotherapy, frequently given in conjunction with Adriamicyn and Cytoxan. ... HealthCentral.com

Keri's Metastatic Breast Cancer Story: Insurance Problems Getting …  -  Jan 14, 2008
Epirubicin, Cytoxan, Abraxane, and Neupogen. Neupogen is a cell boosting shot that I get four times after my chemo one day at a time. ... HealthCentral.com

ALSO NOTED: Generic Plavix to arrive soon;Alzheimer's drug effective ...  -  Aug 7, 2006
New treatments like Cytoxan offer patients with scleroderma, or hard skin, new options, says this feature in The New York Times. Stem cell transplants are ... FierceBiotech

Medical News: General Nephrology  -  Nov 23, 2005
23 - The oral immunosuppressant CellCept (mycophenolate mofetil) is more effective and more tolerable than IV Cytoxan (cyclophosphamide) for inducing ... MedPage Today

Chemo Regimen FAQs: AC Chemotherapy  -  Jul 3, 2007
AC includes two drugs: doxorubicin (Adriamycin), and cyclophosphamide (Cytoxan). But you don't have to remember the names; just the initials, because anyone ... HealthCentral.com

Does Taxol cause menopause?  -  Aug 28, 2008
My guess is that it would not be high on the list of drugs that cause menopausal symptoms, such as Cytoxan (chemical name: cyclophosphamide). ... Breastcancer.org

Back to last page  -  Jan 24, 2006
Other therapies being studied are cyclosporine (Sandimmune), cyclophosphamide (Cytoxan), methotrexate, azathioprine (Imuran), and total lymphoid irradiation ... Intelihealth.com

Chemo Regimen FAQs: AC + Taxol/Taxotere chemotherapy (ACT, TAC)  -  Jul 17, 2007
It includes two drugs: doxorubicin (Adriamycin), and cyclophosphamide (Cytoxan). Paclitaxel (Taxol) or docetaxel (Taxotere) is added to AC for women with ... HealthCentral.com

FDA and Genentech Issue Cardiotoxicity Advisory for Herceptin  -  Aug 31, 2005
The chemotherapy regimen consisted of four cycles of Adriamycin (doxorubicin) and Cytoxan (cyclophosphamide) followed by four cycles of Taxol every three ... MedPage Today

How to take Tamoxifen from Consumer Reports Health.  -  Jan 10, 2006
...cancer chemotherapy medication such as cyclophosphamide (Cytoxan, Neosar) letrozole (Femara); medroxyprogesterone (Depo-Provera, Provera, in Prempro); ... consumerreports.org

Osteoporosis after Breast Cancer  -  Jun 22, 2007
...methotrexate (Trexall), cyclophosphamide (Cytoxan) and 5-fluorouracil, and multi-drug combinations that include these medicines. ... HealthCentral.com

How to take Sorafenib from Consumer Reports Health.  -  Jan 8, 2007
...carbamazepine (Equetro, Tegretol), cyclophosphamide (Cytoxan, Neosar), dexamethasone, doxorubicin (Doxil, Adriamycin), efavirenz (Sustiva), ifosfamide, ... consumerreports.org

Positive ABRAXANE(R) Data in Early-Stage (Adjuvant) Breast Cancer …  -  Dec 9, 2005
Cytoxan and Taxol are registered trademarks of Bristol-Myers Squibb Company. Adriamycin is a registered trademark of Pharmacia. ... RedOrbit

A Grief Observed  -  Jun 13, 2005
...("Cytoxan drove her into extremes of nausea, stomach pain, and fatigue. Mouth pain began, as Cytoxan killed the quick–growing cells of her mouth and ... ChristianityToday.com

Organ Rejection Drug May Treat Lupus Side Effect  -  Dec 13, 2005
They were randomly given monthly injections of the chemotherapy drug Cytoxan (cyclophosphamide) or daily oral doses of CellCept (micophenolate mofetil). ... RedOrbit

Scleroderma - Overview - NY Times Health  -  Sep 6, 2008
Among them is cyclophosphamide, or Cytoxan, a powerful but highly toxic cancer ... But cytoxan has dangerous side effects, including an increased risk of ... New York Times

Article: Anti-rejection medication 'promising' for lupus. - Messenger...  -  Jan 26, 2006
Cytoxan , trade name for the drug cyclophosphamide, used to inhibit growth ... A drug of great specificity, Cytoxan is activated in the body by the enzymes ... Pay-Per-View - Messenger-Inquirer - HighBeam Research

The Unfolding Mystery of Scleroderma  -  Sep 11, 2008
Among them is cyclophosphamide, or Cytoxan, a powerful but highly toxic cancer ... But cytoxan has dangerous side effects, including an increased risk of ... New York Times

American BioScience Licenses Japanese Rights To Abraxane.  -  Nov 17, 2005
These include a Phase II trial of dose dense Abraxane given as an adjuvant therapy following Adriamycin plus Cytoxan in early stage breast cancer. ... Pay-Per-View - BIOWORLD Today - Factiva, from Dow Jones

Fiercest Of Loves.  -  Oct 27, 2007
He prescribed steroids and an immediate intravenous infusion of Cytoxan, ... By autumn, a visiting nurse was administering Chelsey's Cytoxan at home, ... Free with registration - Hartford Courant - AccessMyLibrary.com

Aspreva Readies for Prime Time  -  Aug 28, 2006
Cytoxan is a long-time chemotherapy agent from Bristol-Myers Squibb (BMY Quote) that has been the standard for treating lupus nephritis. ... TheStreet.com - TheStreet.com (subscription)

New standard treatment for the most common form of leukemia in adults  -  Jul 31, 2007
The drugs used to treat CLL consist of Fludara, Cytoxan and chlorambucil. Recent studies have shown that Fludara in combination with Cytoxan to be the most ... TopCancerNews.com

Reversing Scleroderma  -  Jul 19, 2006
HIGH-DOSE CHEMOTHERAPY: Researchers are now studying how well high doses of the chemotherapy drug Cytoxan works for people with severe scleroderma. ... WFtv.com

Experimental Drug Makes Living With Scleroderma Manageable  -  Sep 5, 2005
The Cytoxan therapy is very intense and is still considered experimental, ... Cytoxan has been used by rheumatologists to treat scleroderma patients in the ... RedOrbit

Chemotherapy a Positive for ER-Negative Breast Cancer  -  Apr 12, 2006
Three regimens of various dose-intensity regimens of Cytoxan ... And sequential Adriamycin, Taxol, and Cytoxan concurrent Adriamycin and Cytoxan, ... MedPage Today

Loislaw Federal District Court Opinions - IN RE PHARMACEUTICAL …  -  Sep 26, 2008
...[As for Cytoxan], the injectable form had spreads of over 100% on certain NDCs in every single year from 1993 until 2002, peaking at 676% in 1999. ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Clinical Trial Supports Better Treatment For Lupus Patients Suffering...  -  Nov 24, 2005
..."That's despite being treated with Cytoxan, and so we are very motivated to find new drugs to better treat these patients." ... sciencedaily.com

Anti-rejection medication 'promising' for lupus.  -  Jan 26, 2006
Its side effects are preferable to Cytoxan, a more potent drug that leads to severe ... But she will try it before she goes through Cytoxan again, she said. ... Free with registration - Messenger-Inquirer - AccessMyLibrary.com

Rethinking Rituximab for refractory pediatric SLE.(Clinical Rounds)  -  Aug 1, 2007
..."Athough Cytoxan has long been considered the 'standard of care' in treating SLE nephritis because of its efficacy, the primary cause of death in lupus ... $4.95 - Pediatric News - ECNext

Allogeneic stem cell transplantation in Fanconi anemia patients …  -  Nov 5, 2007
17 recently reported their experience using fludarabine with cytoxan and ATG; of the 11 transplanted patients, 1 presented with myelodysplasia and ... Nature.com

Lupus drug may cause sperm damage  -  Jun 29, 2007
But this study suggests that about five years of treatment with Cytoxan is associated with severe sperm damage and reinforces the need to discuss storing ... 新�网

Chemo Drug and Virus Work Together  -  Aug 31, 2006
Cytoxan, a chemotherapy drug, helps a virus used against incurable brain tumors ... Rats that were pretreated with Cytoxan had only half as many NKs and ... RedOrbit

GIRL IN MEDICAL DISPUTE DIES  -  Mar 12, 2008
Castro did not want any more Cytoxan or the alternative drug, Cellcept. The drugs, she said, were killing her daughter. After a lot of angry back-and-forth, ... Pay-Per-View - Hartford Courant - ProQuest Archiver

Halfway man participated in scleroderma research study  -  Nov 6, 2006
A higher-dose of Cytoxan chemotherapy treatment was given to each patient to eliminate the abnormal immune system, Medsger says. In all, Dill received six ... Herald-Mail - The Herald-Mail

THE NATION; Deaths Halt Chemotherapy Study; Two patients die and …  -  May 18, 2005
627 women treated with either doxorubicin plus docetaxel or the more conventional combination of doxorubicin plus cyclophosphamide, marketed as Cytoxan. ... Pay-Per-View - Los Angeles Times - ProQuest Archiver

SCIENCE FILE; Genetic study questions breast cancer drug  -  Oct 13, 2007
All the women had been given four cycles of the drugs Adriamycin and Cytoxan. Half them received four cycles of paclitaxel, commonly known by its brand name ... Pay-Per-View - Los Angeles Times - ProQuest Archiver

Herceptin Halves Risk of HER2-Positive Breast Cancer Recurrence  -  Oct 20, 2005
The NSABP B-31 study compared Adriamycin (doxorubicin) and Cytoxan (cyclophosphamide) followed by Taxol (paclitaxel) every three weeks (group 1) with the ... MedPage Today

Fertility compromised due to chemo?  -  Sep 23, 2008
In general, the combination that involves CMF (Cytoxan, methotrexate, 5-Fluorouracil) tends to have a higher rate of ovarian failure and infertility ... Breastcancer.org

lupus A transplant rejectio ... | Article from The Washington Post | ...  -  Dec 6, 2005
They were randomly given monthly injections of the chemotherapy drug Cytoxan (cyclophosphamide) or daily oral doses of CellCept (micophenolate mofetil). ... Pay-Per-View - Washington Post - HighBeam Research

lupus A transplant rejectio ...  -  Dec 6, 2005
They were randomly given monthly injections of the chemotherapy drug Cytoxan (cyclophosphamide) or daily oral doses of CellCept (micophenolate mofetil). ... Pay-Per-View - Washington Post - ProQuest Archiver

Clinical trials for triple-negative?  -  Aug 18, 2008
This trial randomized patients to one of two older chemotherapy regimens, AC (Adriamycin [chemical name: doxorubicin] and Cytoxan [chemical name: ... Breastcancer.org

American Pharmaceutical Partners and American Bioscience Announce …  -  May 3, 2005
Cytoxan and Taxol are registered trademarks of Bristol-Myers Squibb Company. CONTACT: Nicole Williams, Executive Vice President & CFO of American ... $4.95 - PR Newswire - ECNext

Ben Franklin to Invest $530,950 in Support of Regional Economic …  -  Oct 12, 2005
Cytoxan is the most commonly used chemotherapeutic drug and is often used in the ... In the first year Saladax generated novel antibodies for Cytoxan which ... $4.95 - Business Wire - ECNext

Abraxane Ph II trial finishes recruitment.(pharmaceutical industry)(Br...  -  May 16, 2005
Its primary goal is to evaluate the safety of Adriamycin plus Cytoxan administered every two weeks for four cycles, which is the most commonly-used regimen ... $4.95 - Pharma Marketletter - ECNext

Loislaw Federal District Court Opinions - IN RE PHARMACEUTICAL …  -  Nov 1, 2007
With respect to Cytoxan, by 1999 only 6 percent of sales were made at WLP, and the spread reached 676%. Similarly, in 2001, only 7 percent of sales were ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Loislaw Federal District Court Opinions - BAILEY v. COMMISSIONER OF …  -  Feb 25, 2008
Dr. Clowney diagnosed SLE and Plaintiff began a regimen of intravenous Cytoxan therapy. A portacath central venous access to the right internal jugular vein ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Many variations on same illness; Differences in symptoms, sources …  -  Jan 24, 2006
Novantrone, an immunosuppressant, and medications used in chemotherapy, such as Cytoxan, are used in some forms of progressive MS. ... $4.95 - Washington Times - ECNext

Heavy Women Shortchanged on Chemotherapy  -  Jun 13, 2005
The most common side effect of the Adriamycin-Cytoxan therapy is febrile neutropenia. Overall, she said, obese and severely obese women were no more likely ... MedPage Today

Greg Lipski's e-mail log to his classmates  -  Dec 26, 2005
Cytoxan, Monday was a day off to clear the drug out of my body, and today I received my sister's cells. I feel pretty normal, nothing momentous occurs when ... Seattle Post-Intelligencer - Seattle Post Intelligencer

Arkansas Regulations - 272.113 Chemotherapy Drugs Restricted by …  -  Apr 2, 2008
450mg S0108 Z1851 Mercaptopurine Tab 50mg (Purinethol) S0177 Z1855 Levamisole Tab 50mg (Ergamisol) J8530 Z1869 Cytoxan Tab 25mg J8530 Z1870 Cytoxan Tab ... Pay-Per-View - Arkansas Regulations - Loislaw

::대한민국 No.1 ì?˜ë£Œì „문뉴스 KMAtimes::  -  Feb 1, 2005
...그러ë?˜ 중 í•´ê°€ 지나 1995ë…„ 2ì›” 9ì?¼ 환ìž?기ë¡?ì?„ 정리하ë?˜ ì§?ì›?ì—? ì?˜í•´, 항암제 Cytoxan 치료용량ì?˜ 4ë°° 용량ì?´ 투여ë??ì?Œì?´ 발견ë?˜ì—ˆë‹¤. 펠로∼수련ì?˜ 닥터 Fê°€ 용량ì?„ ... KMA Times

Chemotherapy Underdosed for Obese Breast Cancer Patients  -  Aug 24, 2005
Thirty-nine percent of these 249 obese patients received less than 85% of the protocol-specified dose for the first round of Cytoxan (cyclophosphamide), ... MedPage Today

chemo round 3  -  Dec 16, 2007
But we keep chugging the cytoxan and on and on we go forward... Hope everyone has a nice and comfy holiday and a Happier New year. Thanks for the support. ... HealthCentral.com

Should Breast Cancer Patients get the Flu Vaccine?  -  Nov 16, 2006
For example, for women receiving adjuvant chemotherapy on a 21-day regimen such as AC - Adriamycin/cytoxan or TAC - taxotere/adriamycin/cytoxan the white ... HealthCentral.com

SABCS: Dose-Dense Chemotherapy Called Safe and Effective  -  Dec 12, 2005
In the sequential arm, they were given in that order; in the concurrent arm, Adriamycin and Cytoxan were given together, followed by Taxol. ... MedPage Today

Studies of Nipent(R) in Combination Cancer Therapies for Treatment of...  -  Dec 9, 2005
Abstract #4750 A Multi-Center, Open-Label Study To Evaluate the Safety and Efficacy of Pentostatin, Cytoxan, and Rituxan (PCR) in the Treatment of ... RedOrbit

A Roundup of the Week in the Medical Journals  -  Jun 6, 2005
The Breast Cancer International Research Group reported that Taxotere, Adriamycin (doxorubicin), and Cytoxan (cyclophosphamide) (TAC) is superior to ... MedPage Today

Taxol reduces breast cancer recurrence  -  Dec 28, 2005
Those experiencing the Taxol regimen received four cycles of Cytoxan, accompanied by weekly Taxol treatments. The median follow-up for all women in the ... DentalPlans.com

Hopkins Treating 3-Year-Old For Rare Disease  -  Mar 1, 2006
Cytoxan has only been given to two other patients who also suffer from Bradley's disease, and doctors said they're doing very well. ... WBAL Channel.com

Analysis of: FDA Approves Two New Indications for Rituxan in Patients...  -  Oct 3, 2006
The question asked is Rituxan/Cytoxan/Oncovin/Prednisone (R-COP) better than Rituxan/Cytoxan/Adriamycin/Oncovin/Prednisone (R-CHOP). ... Gerson Lehrman Group

TRANSPLANT DRUG MAY HELP STEM KIDNEY DISEASE  -  Dec 17, 2005
They were randomly given monthly injections of the chemotherapy drug Cytoxan (cyclophosphamide) or daily oral doses of CellCept (micophenolate mofetil). ... $2.95 - Myrtle Beach Sun News - NewsBank

The Prognosis for Elizabeth Edwards  -  Mar 24, 2007
...in addition to surgery and radiation, she's already received three of the most commonly used drugs — Adriamycin, Cytoxan and either Taxol or Taxotere. ... TIME

Some women can reduce breast cancer chemo: study  -  Oct 11, 2007
The researchers had been studying a group of women for years, many of whom got Taxol after going through four cycles of the drugs adriamycin and cytoxan for ... Reuters India

Article: 'First new polymer this millennium' is a polyamide from...  -  Oct 1, 2007
March 29 /U.S. Newswire/ -- A new polymer derived from an antibacterial drug has ... cytoxan, adriamycin and cisplatin. The new polymer-drug combination ... Pay-Per-View - British Plastics & Rubber - HighBeam Research

Article: DSM to invest in new polymer plant in Jiangsu.(NEWSDESK: …  -  Oct 6, 2006
March 29 /U.S. Newswire/ -- A new polymer derived from an antibacterial drug has ... cytoxan, adriamycin and cisplatin. The new polymer-drug combination ... Pay-Per-View - China Chemical Reporter - HighBeam Research

Press Release: Studies of Nipent(R) in Combination Cancer Therapies...  -  Dec 9, 2005
Abstract #4750 A Multi-Center, Open-Label Study To Evaluate the Safety and Efficacy of Pentostatin, Cytoxan, and Rituxan (PCR) in the Treatment of ... Pay-Per-View - PR Newswire - HighBeam Research

New York Miscellaneous Reports - MIDLER v. CRANE, 0116891/2004 ( …  -  Dec 3, 2007
Ms. Midler was unwilling to take Cytoxan because she was concerned about toxicities, hair loss and nausea. Id. (citing Tr., at 692-693). ... Pay-Per-View - New York Miscellaneous Reports - Loislaw

Interview: Musa Mayer discusses breast cancer treatment, physical...  -  Apr 13, 2005
I had 12 cycles of CMF; that's Cytoxan, methotrexate and 5-FU. ... And I think that I would have been given Adriamycin and Cytoxan, were I to be diagnosed ... $3.95 - National Public Radio - NewsBank

Antioxidant shows promise for "chemo-brain"  -  Sep 10, 2008
The researchers first exposed one group of rats to two drugs commonly used to treat cancer, Adriamycin and Cytoxan. They found that compared with a group of ... Reuters UK

US judge levies damages in drug pricing case  -  Jun 21, 2007
N) overcharged for its cancer drugs Taxol, Vepesid, Cytoxan, Blenoxane and Rubex. She levied damages of $183454 for one group of plaintiffs and is ... Reuters

Secondary Aplastic Anemia - Symptoms, Diagnosis, Treatment of …  -  Nov 23, 2008
Other medications to suppress the immune system, such as cyclosporine, tacrolimus, and cyclophosphamide (Cytoxan) also may be used. ... New York Times

Rheumatoid arthritis  -  Sep 18, 2008
Sandimmune) and cyclophosphamide (Cytoxan). These medications can have potentially serious side effects such as increased susceptibility to infection. ... CNN International

UNPACKING THE BOXES A Memoir of a Life in Poetry  -  Nov 9, 2008
The books established him as a reluctant bard of prednisone, Cytoxan and bone marrow, as he told the tale of how a 23-year marriage and idyllic life in his ... New York Times

12 toxic tales: the poison paradox too much can kill; a little can...  -  May 1, 2005
The ingredients of his cocktail included cytoxan, adriamycin, vincristine, prednisone, and Retuxan--toxic enough to cause side effects ranging from vomiting ... Free with registration - National Geographic - AccessMyLibrary.com

Takayasu's arteritis  -  Nov 2, 2006
...such as methotrexate (Rheumatrex), azathioprine (Imuran) or cyclophosphamide (Cytoxan). These drugs suppress the inflammation in your blood vessels. ... cnn.com

Behcet's disease  -  Oct 30, 2006
...that may play a role in controlling Behcet's disease include azathioprine (Imuran, Azasan), cyclosporine (Sandimmune) and cyclophosphamide (Cytoxan). ... cnn.com

Wegener's granulomatosis  -  Sep 25, 2006
However, most people require another immunosuppressive drug, such as cyclophosphamide (Cytoxan), azathioprine (Imuran) or methotrexate (Rheumatrex), ... cnn.com

Churg-Strauss syndrome  -  Nov 14, 2006
However, other people require another immunosuppressive drug, such as cyclophosphamide (Cytoxan) azathioprine (Imuran) or methotrexate (Rheumatrex), ... cnn.com

Thrombocytopenia (low platelet count)  -  Feb 22, 2006
...or medications that suppress the immune system to reduce antibody formation, such as cyclophosphamide (Cytoxan) or azathioprine (Imuran). Surgery. ... cnn.com

US judge levies damages in drug pricing case  -  Jun 25, 2007
Saris ruled that Bristol-Myers Squibb overcharged for its cancer drugs Taxol, Vepesid, Cytoxan, Blenoxane and Rubex. She levied damages of $183454 for one ... Reuters

Stem Cells Tame Type 1 Diabetes in Pilot Study  -  Apr 10, 2007
The patients were first treated with cyclophosphamide (Cytoxan) 2.0 g/m 2 ) and G-CSF (10 μg/kg per day) to mobilized the stem cells, which were then ... MedPage Today

He wants to use biotech against Alzheimer's  -  Jul 23, 2007
This led to seven years of post-doc work at Harvard Medical School, where he was a major contributor to the development of the cancer drug Cytoxan. ... Boston Globe

Loislaw Federal District Court Opinions - IN RE PHARMACEUTICAL …  -  Jun 21, 2007
I find liability for Bristol-Myers Squibb's drugs Taxol (with spreads as high as 500%), Vepesid injectable (with spreads as high as 1000%), Cytoxan ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

The Charlotte Observer, NC, health business column.  -  Jan 29, 2005
The benefit also excludes diabetic supplies and some specific drugs, including the cancer drug Cytoxan and the multiple sclerosis drug Avenox. ... Free with registration - Charlotte Observer - AccessMyLibrary.com

Idiopathic thromobocytopenic purpura (ITP)  -  Oct 30, 2008
Medications that suppress the immune system, such as rituximab (Rituxan) — the most commonly used of this group — cyclophosphamide (Cytoxan) and ... CNN

Special to CNN.com  -  Oct 10, 2005
...or that don't respond well to corticosteroids may need treatment with cytotoxic drugs, such as azathioprine (Imuran) and cyclophosphamide (Cytoxan). ... cnn.com

Mom blogs through son's cancer battle  -  Jul 20, 2008
The next day, doctors administer Cytoxan, the most aggressive medicine so far. Chase becomes violently ill. He forces himself to swallow scraps of a bagel. ... Pay-Per-View - Chicago Tribune - ProQuest Archiver

Brand Names/Synonyms:
Cytoxan is also known by the following brand names and/or synonymsASTA; Asta B 518; B 518; CB 4564; CB-4564; CP; CPA; CTX; CY; Clafen; Claphene; Cyclophosphamid; Cyclophosphamide; Cyclophosphamide Monohydrate; Cyclophosphamide Sterile; Cyclophosphamidum; Cyclophosphan; Cyclophosphane; Cyclophosphoramide; Cyclostin; Cyklofosfamid; Cytophosphan; Cytoxan; Cytoxan Lyoph; Endoxan; Endoxan R; Endoxan-Asta; Endoxana; Endoxanal; Endoxane; Enduxan; Genoxal; Hexadrin; Lyophilized Cytoxan; Mitoxan; Neosar; Procytox; Rcra Waste Number U058; Semdoxan; Sendoxan; Senduxan; Zyklophosphamid

Drug Category:
Cytoxan is categorized under the following by the FDA: Antineoplastic Agents; Antirheumatic Agents; Immunosuppressive Agents; ATC:L01AA01

Dosage Forms:
oral tablets, oral liquid, parenteral solution

Absorption:
90-100%

Interactions:
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Chemical IUPAC Name:
N,N-bis(2-chloroethyl)-2-oxo-1-oxa-3-aza-2u{5}-phosphacyclohexan-2-amine





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