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DesyrelThis page contains recent news articles, when available, and an overview of Desyrel but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Desyrel (when available) Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of Trazodone's antidepressant action in man is not fully understood. In animals, Trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of Trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, Trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of Trazodone from the body is sufficiently variable, in some patients Trazodone may accumulate in the plasma. For the treatment of depression Mechanism Of Action: Trazodone binds at 5-HT2 receptor, it acts as a serotonin agonist at high doses and a serotonin antagonist at low doses. Like fluoxetine, trazodone's antidepressant activity likely results from blockage of serotonin reuptake by inhibiting serotonin reuptake pump at the presynaptic neuronal membrane. If used for long time periods, postsynaptic neuronal receptor binding sites may also be affected. The sedative effect of trazodone is likely the result of alpha-adrenergic blocking action and modest histamine blockade at H1 receptor. It weakly blocks presynaptic alpha2-adrenergic receptors and strongly inhibits postsynaptic alpha1 receptors. 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Free with registration - PDR Family Guide to Prescription Drugs - AccessMyLibrary.com Fluoxetine (Systemic). - Jul 28, 2005 MDMA [eg, ecstasy], marijuana) or Sumatriptan (eg, Imitrex) or Tramadol (eg, Ultram) or Trazodone (eg, Desyrel) or Tryptophan or Venlafaxine (eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Fatigue Fix -- In-Depth Doctor's Interview - Jun 3, 2005 You want to use things like Ambien or trazodone (Desyrel) for sleep and also natural herbals for sleep like the revitalizing sleep formula. ... Ivanhoe Broadcast News Many drugs prescribed for chronic insomnia are not approved for that ... - Jun 15, 2005 ...hypnotics declined by 54 percent between 1987 and 1996, "while the use of trazodone (Desyrel) and other sedating antidepressants rose by 146 percent. ... Medical News Today - Medical News Today (press release) Bupropion, bupropion sustained release, bupropion extended release ( … - Jun 1, 2006 Lithobid), loxapine (Loxitane), molindone (Moban), the phenothiazines, phenytoin (Dilantin), the thioxanthenes, or trazodone (Desyrel). ... Free with registration - Brown University Psychopharmacology... - AccessMyLibrary.com FDA Safety Labeling Changes: CombiPatch, Antidepressants - Mar 23, 2005 Inc.); trazodone HCl tablets (Desyrel, made by Apothecon, a Bristol-Myers Squibb company); chlordiazepoxide plus amitriptyline HCl tablets (Limbitrol, ... Medscape Nefazodone (Systemic).(Drug overview) - Aug 1, 2006 Tell your doctor if you have ever had any unusual or allergic reaction to nefazodone or trazodone (eg, Desyrel). Also tell your health care professional if ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Brand Names/Synonyms: Desyrel is also known by the following brand names and/or synonymsTrazodonum [Latin]; AF-1161; Beneficat; Bimaran; CHEMBANK850; Desirel; Desyrel; Molipaxin; Pragmazone; Sideril; T137; T6154; Thombran; Tombran; Trazalon; Trazodil; Trazodon; Trazodona [Inn-Spanish]; Trazodona [Spanish]; Trazodone; Trazodone Hcl; Trazodone Hydrochloride; Trazodonum [Inn-Latin]; Trazodonum [Latin]; Trazolan; Trazonil; Trialodine; Trittico Drug Category: Desyrel is categorized under the following by the FDA: Antidepressants, Second-Generation; Anti-anxiety Agents; Serotonin Uptake Inhibitors; ATC:N06AX05 Dosage Forms: TABLET Absorption: Well absorbed Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: 8-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-6,8,9-triazabicyclo[4.3.0]nona-2,4,9-trien-7-one |
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