Dexbrompheniramine

This page contains recent news articles, when available, and an overview of Dexbrompheniramine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Dexbrompheniramine (when available)

Pharmacology and use:
In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H₁-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Dexbrompheniramine is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies. For treatment and relief of symptoms of allergies, hay fever, and colds

Mechanism Of Action:
Dexbrompheniramine competitively binds to the histamine H₁-receptor. It competes with histamine for the normal H₁-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.

News Articles on Dexbrompheniramine

Federal Register 2007 - 72 FR 8184 Withdrawal of Approval of 128 …  -  Feb 23, 2007
85P-0140/ Dexbrompheniramine Maleate 6 mg, Central CP1 Pseudoephedrine Hydrochloride ... CP1 Dexbrompheniramine Maleate 1 mg/5 mL, Phenylpropanolamine ... Pay-Per-View - Federal Register 2007 - Loislaw

Antihistamines and Decongestants (Systemic).(Drug overview)  -  Aug 1, 2006
Dexbrompheniramine and Pseudoephedrine (dex-brom-fen-EER-a-meen and soo-doe-e-FED-rin) 10. Diphenhydramine and Pseudoephedrine (dye-fen-HYE-dra-meen and ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

United States Code of Federal Regulations - 21 CFR § 341.72 Labeling...  -  Jul 11, 2006
...(4) For products containing dexbrompheniramine maleate identified in §341.12(d). Adults and children 12 years of age and over: oral dosage is 2 milligrams ... Pay-Per-View - United States Code of Federal Regulation... - Loislaw

Antihistamines, Decongestants, and Analgesics (Systemic ).  -  Feb 1, 2006
Dexbrompheniramine , Pseudoephedrine, and Acetaminophen ... brompheniramine, chlorpheniramine, dexbrompheniramine, diphenhydramine, pheniramine, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Major Degradation Product Identified in Several Pharmaceutical …  -  Sep 27, 2006
During pharmaceutical development 3 in which phenylephrine HCl and dexbrompheniramine maleate were combined one at a time with various common tablet ... Environmental Science & Technology

Cough syrup left out in the cold ; Over-the-counter drugs don't help,...  -  Jan 10, 2006
...*New guidelines from the American College of Chest Physicians conclude that OTC sedating antihistamines, such as dexbrompheniramine, plus a decongestant, ... Pay-Per-View - USA TODAY - ProQuest Archiver

UPI NewsTrack Health and Science News  -  Dec 18, 2008
...--Antihistamines: brompheniramine maleate, chlorpheniramine maleate, clemastine hydrogen fumerate, dexbrompheniramine maleate, diphenhydramine hydrochloride ... United Press International

Ask The Mayo Clinic: Over-the-counter allergy medicine makes urinating...  -  Jun 29, 2008
...chlorpheniramine maleate (Actifed, Chlor-Trimeton, others) and dexbrompheniramine maleate (Drixoral, others) -- are within a class of medications that ... Seattle Post-Intelligencer - Seattle Post Intelligencer

Cough Medicines Dogged by Efficacy Concerns for Adults, Too  -  Jan 23, 2008
No significant relief of cough from the antihistamine dexbrompheniramine with pseudoephedrine in another study among adults. ... MedPage Today

Sciele Pharma Inc acquires Primus Pharmaceuticals Inc - Deal Snapshot...  -  Jul 30, 2007
Allergy (Dexbrompheniramine Maleate/Pseudoephedrine Hydrochloride) Sciele Pharma Inc. ( SCRX ) Products: Rondec Syrup… ... Pay-Per-View - deals - Alacra Store

Safeguard Scientifics Inc acquires Laureate Pharma LP - Deal Snapshot...  -  Jan 7, 2005
Dexbrompheniramine Maleate/Pseudoephedrine Hydrochloride) Sciele Pharma Inc. ( SCRX ) Products: Rondec Syrup…Healthcare Butalbital/Acetaminophen/Caffeine ... Pay-Per-View - deals - Alacra Store

Georgia Code - 16-13-71. (a) A "dangerous drug" means any drug other ...  -  Aug 4, 2005
...(255) Desoxycorticosterone; (256) Desoxyribonuclease; (257) Dexamethasone; (258) Dexbrompheniramine — See exceptions; (259) Dexchlorpheniramine; ... Pay-Per-View - Georgia Code - Loislaw

Competitors by Product Report  -  Oct 4, 2008
Claritin D (Loratadine/Pseudoephedrine); Drixoral Cold & Allergy (Dexbrompheniramine Maleate/Pseudoephedrine Hydrochloride) ... $75.00 - Revere - Alacra Store

FDA cracking down on unapproved prescription drugs.(Practice Trends)(...  -  Aug 15, 2006
Many of the drugs are cough and cold preparations that include pheniramine maleate and dexbrompheniramine maleate, or single-ingredient narcotics such as ... $4.95 - Internal Medicine News - ECNext

기침형 천�?, 스테로�?�드제 규칙�? �?�입 필요  -  May 28, 2005
...답변> �?�연유무를 확�?�하고 기침�?� 발작�?� �?장과 집사�?��?� 차�?��?�?� 관찰하고 �?��? �?� 없으면 우선�?으로 �?�부 사진�?� 검사하여 정�?�?� 경우�?는 Dexbrompheniramine ... 디지틀보사

Competitors by Product Report  -  Dec 20, 2008
Claritin D (Loratadine/Pseudoephedrine); Drixoral Cold & Allergy (Dexbrompheniramine Maleate/Pseudoephedrine Hydrochloride) ... $75.00 - Revere Reports - Revere

Cough meds - what works  -  May 18, 2006
These effective drugs include diphenhydramine -- the active ingredient in Benadryl, dexbrompheniramine -- an active ingredient in Drixoral, ... News 8 Austin

Competitors by Product Report  -  Mar 29, 2008
Claritin D (Loratadine/Pseudoephedrine); Drixoral Cold & Allergy (Dexbrompheniramine Maleate/Pseudoephedrine Hydrochloride) ... $75.00 - Revere Reports - Revere

Cough Meds -- What Works  -  May 11, 2006
These effective drugs include diphenhydramine -- the active ingredient in Benadryl, dexbrompheniramine -- an active ingredient in Drixoral, ... WFtv.com

Competitors by Product Report  -  Oct 4, 2008
Claritin D (Loratadine/Pseudoephedrine); Drixoral Cold & Allergy (Dexbrompheniramine Maleate/Pseudoephedrine Hydrochloride) ... $75.00 - Revere Reports - Revere

Drixoral cold & flu  -  May 1, 2006
The dexbrompheniramine component relieves sneezing, runny nose, itchy nose or throat, and itchy, watery eyes. The pseudoephedrine unclogs stuffy nose and ... Free with registration - PDR Family Guide to Over-The-Counter... - AccessMyLibrary.com

Competitors by Product Report  -  Aug 2, 2008
Claritin D (Loratadine/Pseudoephedrine); Drixoral Cold & Allergy (Dexbrompheniramine Maleate/Pseudoephedrine Hydrochloride) ... $75.00 - Revere Reports - Revere

Research Summary: Cough Medicine  -  Dec 11, 2006
These effective drugs include diphenhydramine -- the active ingredient in Benadryl, dexbrompheniramine -- an active ingredient in Drixoral, ... go.com

Competitors by Product Report  -  Aug 2, 2008
Claritin D (Loratadine/Pseudoephedrine); Drixoral Cold & Allergy (Dexbrompheniramine Maleate/Pseudoephedrine Hydrochloride) ... $75.00 - Revere - Alacra Store

You just can't trust the histories.(patient case history)(Column)  -  Sep 1, 2006
But they come in complaining about the sinus problems, and they often have these long-running prescriptions for dexbrompheniramine twice a day, every day, ... Free with registration - JAAPA-Journal of the American Academy... - AccessMyLibrary.com

Health Canada Releases Decision on the Labelling of Cough and Cold …  -  Dec 18, 2008
...clemastine hydrogen fumerate runny nose) dexbrompheniramine maleate diphenhydramine hydrochloride diphenylpyraline hydrochloride doxylamine succinate ... Pay-Per-View - Canadian Corporate News - HighBeam Research

Cough Meds - What Works  -  Nov 20, 2006
These effective drugs include diphenhydramine -- the active ingredient in Benadryl, dexbrompheniramine -- an active ingredient in Drixoral, ... go.com

United States Code of Federal Regulations - 21 CFR § 341.12 …  -  Jul 11, 2006
...(d) Dexbrompheniramine maleate. (e) Dexchlorpheniramine maleate. (f) Diphenhydramine citrate. (g) Diphenhydramine hydrochloride. (h) Doxylamine succinate. ... Pay-Per-View - United States Code of Federal Regulation... - Loislaw

United States Code of Federal Regulations - 21 CFR § 341.90 …  -  Jul 11, 2006
...(h) For products containing dexbrompheniramine maleate identified in §341.12(d). Children 2 to under 6 years of age: oral dosage is 0.5 milligram every 4 to ... Pay-Per-View - United States Code of Federal Regulation... - Loislaw

Competitors by Product Report  -  Sep 30, 2006
Claritin D (Loratadine/Pseudoephedrine); Drixoral Cold & Allergy (Dexbrompheniramine Maleate/Pseudoephedrine Hydrochloride) ... $75.00 - Revere Reports - Revere

Brand Names/Synonyms:
Dexbrompheniramine is also known by the following brand names and/or synonymsAntihistamine Compound; BROMPHENIRAMINE; Bromfeniramina [Inn-Spanish]; Bromopheniramine; Brompheniraminum [Inn-Latin]; D-Brompheniramine; Dexbrompheniramine; Dimetane; Disomer; HSDB 3017; Ilvin; Parabromdylamine; Parabromodylamine

Drug Category:
Dexbrompheniramine is categorized under the following by the FDA: Antihistamines; ATC:R06AB06

Dosage Forms:
TABLET

Absorption:
Antihistamines are well absorbed from the gastrointestinal tract after oral administration.

Interactions:
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Chemical IUPAC Name:
3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine

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