Dextromethorphan

This page contains recent news articles, when available, and an overview of Dextromethorphan but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Dextromethorphan
(when available)

Pharmacology and use:
Suppresses the cough reflex by a direct action on the cough center in the medulla of the brain. For treatment and relief of dry cough

Mechanism Of Action:
Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the NMDA glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. The first-pass through the hepatic portal vein results in some of the drug being metabolized into an active metabolite of dextromethorphan, dextrorphan, the 3-hydroxy derivative of dextromethorphan.

News Articles on Dextromethorphan

Trading Outlook for Avanir Pharmaceuticals Inc. Issued by InvestorSoup.com  -  ‎Nov 4, 2009‎
Its principal product candidate, Zenviatm (dextromethorphan hydrobromide/quinidine sulfate), is in phase III clinical development for the treatment of ... CNNMoney.com (press release)

Potentially Lethal Drug Combinations Used By Many Teens  -  ‎Nov 9, 2009‎
He had an addiction to Dextromethorphan, or DXM. The ingredient is commonly found in over-the-counter cough and cold medicine, usually in pill or syrup form ... 10TV

Avanir Pharmaceuticals Announces Zenvia Safety and Efficacy Data from Star ...  -  ‎Nov 10, 2009‎
Zenviaâ„¢ (dextromethorphan/quinidine) is a combination of two well-characterized compounds: the therapeutically active ingredient dextromethorphan and the ... WELT ONLINE

DIY Southern Comfort Cold and Flu Elixir  -  ‎Nov 10, 2009‎
In place of Acetaminophen (pain and fever reliever), Dextromethorphan HBr (cough suppressant), and Doxylamine succinate (sleep aid) we used green chile, ... Lifehacker

Piersee's family convinced drugs led to murders  -  ‎Oct 29, 2009‎
Vaughan, the mother of admitted LaGrange murderer Christopher M. Piersee, is certain her son's abuse of dextromethorphan led him to kill his wife and infant ... Hannibal.net

Substance Abuse Expert Dr. Drew Joins Forces with the Five Moms to Raise ...  -  ‎Oct 20, 2009‎
While OTC cough medicines containing dextromethorphan (DXM) are safe and effective when used as directed, they can be dangerous when abused in extreme ... Reuters

When Over-the-Counter Isn't OK  -  ‎Nov 2, 2009‎
They're mostly interested in getting the highest dose of dextromethorphan (DXM) possible – that's the drug that they use in 25-50 times the recommended dose ... MSN Health & Fitness

Community leaders take action to prevent teen cough medicine abuse  -  ‎Oct 28, 2009‎
Cough medicine high is caused by dextromethorphan and there are more than 100 cough medicines that contain DXM, either as the only active ingredient or in ... Reno Gazette Journal

Ohio mom pushes for cough-syrup controls  -  ‎Oct 21, 2009‎
...the drug dextromethorphan and restricting distribution of the drug, which has dangerous side effects when used other than as directed, in its raw form. ... Columbus Dispatch

Avanir Pharmaceuticals unveils Star trial results for Zenvia in the treatment ...  -  ‎Nov 11, 2009‎
III STAR trial evaluating the investigational drug Zenviaâ„¢ (dextromethorphan/quinidine) in the treatment of patients with pseudobulbar affect (PBA). ... News-Medical.net

Never “Too Muchâ€? Information About the Dangers of DXM Abuse  -  ‎Oct 28, 2009‎
DXM (Dextromethorphan), a cough suppressant found in over-the-counter cough and cold remedies which is approved by the Food and Drug Administration, ... TransWorldNews (press release)

Don't let flu throw off your diabetes treatment schedule  -  ‎Nov 4, 2009‎
Dextromethorphan is the active ingredient in many cough medicines and is safe for diabetics at recommended doses. Guaifenesin (Mucinex) breaks up and ... Corpus Christi Caller Times

Kids Converge on Capitol to Rise above Drugs  -  ‎Oct 21, 2009‎
...increase since 2006 in secondary students who had abused over-the-counter cough medicines containing dextromethorphan, or DXM, in the previous 30 days. ... Anahuac Progress

How to beat the winter sniffles: Top pharmacists reveal how to really cure a cold  -  ‎Oct 26, 2009‎
More powerful formulations contain dextromethorphan or pholcodine - these work in the brain to help suppress the cough reflex. They might also have other ... Daily Mail

Nothing to Sneeze At  -  ‎Nov 3, 2009‎
Dry, Hacking Cough: Both Dr. Engle and Dr. Pray recommend Dextromethorphan. Loose Cough (Mucus In The Lungs): Dr. Pray recommends Guiafenesin. ... ABC2 News

Complementary and Alternative Medicine Therapies for Cold and Flu Season: What ...  -  ‎Nov 4, 2009‎
Abstract Paul IM, Beiler J, McMonagle A, Shaffer ML, Duda L, Berlin CM Jr. Effect of honey, dextromethorphan, and no treatment on nocturnal cough and sleep ... Medscape

Ban on over-the-counter medicines in schools fails to gain support  -  ‎Oct 18, 2009‎
Examples are substances that contain ephedrine or pseudoephedrine, dextromethorphan or alcohol." Superintendent Matt Gibson said principals will use ... Brookfield Elm Grove Now

Teens turn to OTC, prescription meds as illicit drug use declines  -  ‎Oct 20, 2009‎
Other drugs on the list include central nervous system depressants such as dextromethorphan, an active ingredient in many over-the-counter cough medicines, ... Pediatric SuperSite

Pill popping is up  -  ‎Oct 21, 2009‎
Teens commonly are seeking out dextromethorphan (DXP), an active ingredient in more than 100 OTC cough and cold medicines, to create euphoric and ... Chesterfield Observer (subscription)

AAP: Prescription and OTC Drugs Use on the Rise  -  ‎Oct 21, 2009‎
If they're taking products that contain dextromethorphan, they might refer to it as "dex," "robo," "tussin," or "velvet," while the drug coricidin is called ... MedPage Today

Brand and Generic TRAMADOL (Ultram). FDA approved. Fast Delivery. Ultram.  -  ‎Oct 31, 2009‎
MISSED DOSE as dextromethorphan lithium St. Talk with your medication. Acute abdominal conditions. The overall analgesic in an overdose in rats! ... Newstalk ZB

Lumajang Siaga Satu Peredaran Pil Koplo  -  ‎Nov 11, 2009‎
Kabupaten Lumajang menyatakan wilayah itu telah masuk dalam kategori siaga satu bahaya peredaran dan penyalahgunaan pil koplo jenis Dextromethorphan. ... Tempo Interaktif

Lulusan Farmasi Jualan Pil Koplo  -  ‎Nov 8, 2009‎
Kabupaten Lumajang ini dikenal marak peredaran pil dextromethorphan. Pada Oktober lalu, ada tiga pelaku pengedar pil ini yang ditangkap polisi. ... Tempo Interaktif

Không đơn giản khi dùng thuốc ho  -  ‎Nov 10, 2009‎
Trong thuốc ho thưá»?ng chứa thành phần ức chế trung tâm ho (như codein, dextromethorphan) hay ức chế thần kinh trung ương (cao opium). ... Báo Hoà Bình

Pil Koplo Renggut Nyawa Seorang Anak  -  ‎Nov 9, 2009‎
Anak seorang ketua RT di dusun setempat tersebut diduga tewas setelah menenggak 30 butir pil Dextromethorphan bersama dua orang temannya, Mochamad Budi ... Tempo Interaktif

Studeren onder invloed  -  ‎Oct 19, 2009‎
Naast deze gangbare drugs experimenteren een aantal studenten ook met hoge doses Ritalin (methylfenidaat) en hoestdrank (dextromethorphan). ... C2W

Do Warning Labels Work?  -  ‎Aug 29, 2009‎
Dextromethorphan (DXM) — a cough suppressant available in nearly 150 OTC products — is the biggest target of misuse. Now, the Consumer Healthcare Products Brain Blogger

Christopher Piersee pleads guilty  -  ‎Aug 26, 2009‎
We've learned Piercee was on dextromethorphan at the time of the murders. Dextromethorphan is also called DXM or DM, and it's a common ingredient in cold ConnectTriStates.com powered by KHQA

Device industry's Q2 lobbying spend nears $8 million  -  ‎Aug 19, 2009‎
...over bills covering the federal budget, the drug dextromethorphan, amendments to the Federal Food, Drug & Cosmetic Act and clean energy, among others. Mass Device

New designer drugs dangerous to health: DOH  -  ‎Aug 25, 2009‎
The chemical and pharmaceutical ingredients found in the drugs included cough suppressants Dextromethorphan and Dyphylline, camphor and substances affecting eTaiwan News

Ask Dr. Weil : A teaspoon of honey at bedtime can ease kids' coughs  -  ‎Aug 19, 2009‎
In this study, honey worked better than giving kids cough medicine containing dextromethorphan or giving them nothing at all. If you have children, Arizona Daily Star

Avanir's pseudobulbar affect drug Zenvia meets endpoint in phase ...  -  ‎Aug 17, 2009‎
Avanir Pharmaceuticals, Inc announced that the investigational drug Zenvia (dextromethorphan/quinidine) met its primary efficacy endpoint in the treatment pharmabiz.com

Avanir's Results for Neurological Drug Triggers Outburst in Trading  -  ‎Aug 11, 2009‎
CA, announced the positive Phase III study results of its reformulated drug dextromethorphan/quinidine, or DMQ, before the market opened today. Xconomy

Pharm parties: kids know about them  -  ‎Aug 17, 2009‎
When an excessive amount of the cough and cold medicine containing dextromethorphan is taken it produces a hallucinogenic high, and its abuse has risen Winona Post

Cold Medicine Drug Abuse  -  ‎Aug 4, 2009‎
These drugs contain dextromethorphan (DXM) and DXM is what makes a person high. A person can get high to the point of hallucinating by taking doses larger TransWorldNews (press release)

Program targets prescription drug abuse  -  ‎Aug 28, 2009‎
Over-the-counter cough medications with dextromethorphan as an ingredient are also commonly abused, Howerton said. The program presented to students this Pekin Daily Times

Wyeth spent $901K in 2Q lobbying on health issues  -  ‎Aug 21, 2009‎
1 drugmaker Pfizer ( PFE - news - people ), lobbied on government rules and strategies to limit abuse of cough suppressant dextromethorphan and decongestant Forbes

Biotechs Go Back to the Future by Re-Innovating Old Drugs  -  ‎Aug 26, 2009‎
It hopes to market a tablet for a side effect of ALS and Parkinson's disease that contains two existing drugs - dextromethorphan, an ingredient in Xconomy

J&J spent nearly $1.6M lobbying government in 2Q  -  ‎Aug 20, 2009‎
The company lobbied on a bill meant to limit abuse of the cough suppressant dextromethorphan, an ingredient in its Tylenol Cold medicines, and on amendments Forbes

Murder: Michael Jackson and Doctors Not the Only Ones Guilty of ...  -  ‎Aug 24, 2009‎
Teens are using the active ingredient (DXM) or dextromethorphan which is found in more than 120 non-prescription cough and cold remedies to get high. Hollywood Today Newsmagazine

Consumer Reports: Prescriptions for what ails you  -  ‎Aug 21, 2009‎
Those are better choices than cough suppressants that contain dextromethorphan, which provide little if any relief. If necessary, CR suggests trying to dry Newton Daily News

How to Keep Prescription Drugs Away From Your Kids  -  ‎Aug 14, 2009‎
Non-prescription medications with dextromethorphan, dimenhydrinate and diphenhydramine hydrochloride should also be removed. • Lock up all prescription and HealthNewsDigest.com

Survey helps discern characteristics of pediatric medication use  -  ‎Aug 18, 2009‎
...ibuprofen and various cough/cold ingredients (pseudoephedrine, dextromethorphan and various first-generation antihistamines,� Vernacchio et al wrote. Pediatric SuperSite

Centrix Pharmaceutical Announces Clofera(TM), a Unique Antitussive ...  -  ‎Aug 14, 2009‎
Clofera(TM) contains no dextromethorphan, antihistamines, sugar, alcohol, or dyes and is gluten free. Clofera(TM) will be available in grape flavor. PR Newswire (press release)

Mommy, What's a Spliff?  -  ‎Aug 10, 2009‎
Oxycontin), ADHD drugs (some kids resell them as weight-loss aids), steroids, and the cough suppressant dextromethorphan (which the kids call “Robo�). Tablet Magazine

The Toxicity of Recreational Drugs  -  ‎Aug 14, 2009‎
This phenomenon routinely occurs with dextromethorphan (found in cough medicines), GHB and MDMA. Overdose quantities that are based on acute toxicity also Ethiopian Review

Commonly used cough medicines to be off-limits for infants this fall  -  ‎Aug 4, 2009‎
However, it will apply to drugs whose active ingredients include pseudoephedrine, guaifenesin and dextromethorphan (such as Histafed, Sinufed Triaminic, Ha'aretz

CVS Caremark spent $2M to lobby gov't in 2Q  -  ‎Aug 17, 2009‎
...equipment and laws intended to fight abuse of the cough medicine dextromethorphan, according to the form filed July 20 with the House clerk's office. CNBC

Hyland's Offers Insight To Cautious Parents Looking To Relieve ...  -  ‎Aug 21, 2009‎
...including phenylephrine, diphenhydramine, pseudoephedrine, clorpheniramine, brompheniramine, dextromethorphan, guaifensisin, doxylamine. Medical News Today (press release)

AVANIR Raises $10.6 Million Through the Sale of Common Stock  -  ‎Aug 27, 2009‎
The net proceeds are primarily intended to fund the development and commercialization of Zenvia(TM) (dextromethorphan/quinidine) for the pseudobulbar affect FOXBusiness

SmallCapReview.com: Stocks on the Move - NAEY, BEXP, AVNR, SDTH  -  ‎Aug 12, 2009‎
Today announced that the investigational drug Zenvia (dextromethorphan/quinidine) met its primary efficacy endpoint in the treatment of pseudobulbar affect Trading Markets (press release)

在第3期試驗中 å?‡æ€§å»¶é«“效應的新治療方法ç?²å¾—æ­£é?¢çµ?æžœ  -  ‎Aug 22, 2009‎
August 14, 2009 — Avanir Pharmaceuticals Incå…¬å?¸å®£å¸ƒä¸€é …第3期試驗的正é?¢å„ªç§€çµ?果,以較低劑é‡?的實驗藥物ã€?併用dextromethorphanå’Œquinidine(Zenvia)治療å?‡æ€§å»¶é«“ 臺灣新浪網

Pesta Minuman Oplosan, Tiga Orang Tewas  -  ‎Aug 10, 2009‎
Liputan6.com, Simalungun: Tiga orang tewas dan seorang lainnya kritis usai berpesta minuman keras oplosan yang dicampur obat batuk, dextromethorphan di Liputan 6

æš—è—?安é?žä»–命類等多é‡?æˆ?分,勿輕忽彩色å°?藥丸å?±éšªæ€§  -  ‎Aug 19, 2009‎
...安眠劑Nimetazepam�Phenobarbital,解熱鎮痛劑Acetaminophen�局部麻醉劑Lidocaine�Procaine,止咳劑Dextromethorphan�Dyphylline�Camphor等(如圖四-圖六)。 eTaiwan News

Brand Names/Synonyms:
Dextromethorphan is also known by the following brand names and/or synonyms:
&Laquo;Delta&Raquo;-Methorphan; Antussan; Ba 2666; Balminil Dm; Balminil Dm Children; Benylin Adult Formula Cough Suppressant; Benylin Dm; Benylin Dm 12 Hour; Benylin Dm for Children; Benylin Dm for Children 12 Hour; Benylin Pediatric Cough Suppressant; Calmylin #1; Canfodion; Cosylan; Cough-X; Creo-Terpin; D-Methorphan; D-Methorphan Hydrobromide; Dea No. 9210; Delsym; Delsym Cough Formula; Delta-Methorphan; Demorphan; Demorphan Hydrobromide; Demorphine; Destrometerfano [Dcit]; Dextromethorfan; Dextromethorfan [Czech]; Dextromethorphan; Dextromethorphan Bromhydrate; Dextromethorphan Bromide; Dextromethorphan [Ban:Inn]; Dextrometorfano [Inn-Spanish]; Dextrometorphan; Dextromorphan; Dexyromethorphan; Diabe-Tuss Dm Syrup; Dormetan; Dormethan; Hihustan M.; Hold Dm; Koffex Dm; L-Methorphan; Levomethorphan; Levomethorphan [Ban:Dcf:Inn]; Levomethorphane [Inn-French]; Levomethorphanum [Inn-Latin]; Levometorfano [Inn-Spanish]; Medicon; Methorate Hydrobromide; Methorphan; Metrorat; Novahistex Dm; Novahistine Dm; Pertussin Cs Children's Strength; Pertussin Dm Extra Strength; Racemethorphan [As D-Form]; Robitussin Maximum Strength Cough Suppressant; Robitussin Pediatric; Robitussin Pediatric Cough Suppressant; Romilar; Sucrets 4 Hour Cough Suppressant; Triaminic Dm Long Lasting for Children; Trocal; Tusilan; Tussade; Vicks 44 Cough Relief

Drug Category:
Dextromethorphan is categorized under the following by the FDA: Antitussives; Analgesics; Antitussives; ATC:R05DA09

Dosage Forms:
SYRUP

Absorption:
Not Available

Interactions:
Not Available



Chemical IUPAC Name:
Not Available





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