Diltiazem

This page contains recent news articles, when available, and an overview of Diltiazem but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Diltiazem (when available)

Pharmacology and use:
Diltiazem, a benzothiazepine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Diltiazem is similar to other peripheral vasodilators. Diltiazem inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload. For the treatment of Hypertension

Mechanism Of Action:
Possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, dilitiazem, like verapamil, inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The resultant inhibition of the contractile processes of the myocardial smooth muscle cells leads to dilation of the coronary and systemic arteries and improved oxygen delivery to the myocardial tissue.

News Articles on Diltiazem

FDA Approves Labeling Update for REYATAZ® (atazanavir sulfate) Capsules to ...  -  ‎Nov 5, 2009‎
When used with REYATAZ, a 50% dose reduction of diltiazem should be considered, and ECG monitoring is recommended. ... WELT ONLINE

New Data Presented at ACR Meeting Demonstrates Colcrys(TM) (Colchicine, USP ...  -  ‎Oct 19, 2009‎
Colchicine dosing should be reduced by 50 percent when administered chronically and concomitantly with verapamil or diltiazem (another calcium channel ... Reuters

A 37-Year-Old Man Trying to Choose a High-Quality Hospital  -  ‎Nov 3, 2009‎
Mr A's current medications include extended-release diltiazem, 180 mg/d; aspirin, 81 mg/d; nasal steroid spray; and warfarin, adjusted to an INR of 2 to 3. ... Journal of American Medical Association (subscription)

Inilah Penyebab Penyakit Jantung Koroner!  -  ‎Oct 31, 2009‎
Sebagai gantinya, bisa diberikan golongan antagonis kalsium seperti diltiazem. Obat lain yang juga diberikan adalah penghambat enzim pengubah ... Portal CBN

Jakie jest średnie obniżenie ciśnienia tętniczego w leczeniu skojarzonym w ...  -  ‎Oct 22, 2009‎
...peryndopryl [1]) lub blokery kanału wapniowego (diltiazem [6], werapamil [6], amlodypina [2], lacydypina [2], nifedypina [2], felodypina [1], ... Medycyna Praktyczna

Pharmacist - Heart's 'butterflies' can be soothed  -  ‎Aug 11, 2009‎
Some medications can help you, especially those that slow heart rate like atenolol, metoprolol, verapamil, digoxin and diltiazem. StarNewsOnline.com

Detenidos en Logroño dos hermanos por tráfico de drogas  -  ‎Aug 10, 2009‎
...hacia España de 28940 kg. de efedrina, 10862 kg. de cafeína y 3638 kg. de diltiazem, que fue interceptado por las autoridades policiales francesas. Rioja2.com | Diario digital : Noticias de actualidad de La Rioja

Insuficiencia suprarrenal  -  ‎Aug 24, 2009‎
El uso concomitante de glucocorticoides con inhibidores de CYP3A4, (itraconazol, diltiazem mibefradil y aun el jugo de pomelo), la enzima del citocromo P450 Intramed.net (Suscripción)

Equivalenza clinica tra farmaci cardiovascolari generici e branded  -  ‎Aug 25, 2009‎
Sette riguardavano i calcio-antagonisti: amlodipina (n=3), verapamile a rilascio immediato (n=2) o ritardato (n=2) e diltiazem (n=1). Pillole.org

United States: Requests To Stay ITC Investigations Pending ...  -  ‎Jun 17, 2009‎
A similar instance occurred in Diltiazem, where the respondent petitioned the PTO to reexamine the asserted patent roughly one month after the notice of Mondaq News Alerts (registration)

COMMENTARY: Where Are the Smith Brothers When We Need Them?  -  ‎Jun 26, 2009‎
Let's take a look at some heart medications (just typing the letters gives me a headache): Verapamil, Nicardipine, Cardizem, Diltiazem, Coreg, Nadolol, HNN Huntingtonnews.net

�?남임�?초�?�파학회 제4회 연수강좌  -  ‎Jul 8, 2009‎
Are all statins the same(�?�아대 김�?대), Clinical benefit of Diltiazem(�?�제대 김�?�?�)특강�?� �?심세션으로 구연�?� 연수강좌는 250여회�?�?� 참�?, 디지틀보사

Merknamen veranderen van naam  -  ‎Jun 21, 2009‎
Voorbeelden daarvan zijn het in Nederland geregistreerde Dilacor dat in de US voor diltiazem staat en in Servië voor digoxine. Of Norprim dat in Nederland Knack

Antihypertensiva og amming.  -  ‎Jul 2, 2009‎
Andre alternativer er verapamil og diltiazem. Det er mindre erfaring med ACE-hemmere enn med betablokkere. ACE-hemmere har vært brukt med forsiktighet RELIS

GAZZETTA UFFICIALE: SOMMARIO (2)  -  ‎Jun 19, 2009‎
Modificazione dell'autorizzazione all'immissione in commercio del medicinale per uso umano "Diltiazem Pensa". Modificazione dell'autorizzazione ANSA Valle d'Aosta

Paramedic's Corner: Atrial fibrillation, Part II  -  20 Apr 2009
The most common treatment in the pre-hospital phase by the paramedics would most likely be a calcium channel blocker such as the medication diltiazem Pulaski County Daily News

Pill-swap fiasco leads to prescription review  -  ‎Apr 19, 2009‎
At least nine patients out of 63 given Glibenclamide diabetes pills at Lady Trench General Outpatient Clinic were given diltiazem, a drug for hypertension. The Standard

Drugs recalled after clinic mix-up  -  ‎Apr 18, 2009‎
The Hospital Authority said today Diltiazem was found in a pack of Glibenclamide this morning during checks by a pharmacist. As the incident was related to News.gov.hk

Upgraded Canberra sewage treatment plant will still let ...  -  ‎Apr 7, 2009‎
The studies found instances of fish living in treated effluent release areas that were contaminated with Diltiazem, a high blood pressure medication and Fluid Handling

Five US Rivers Tainted with Pharmaceutical and Chemical Residues  -  ‎Apr 4, 2009‎
Other substances that tested positive in the study included diphenhydramine (a common antihistamine and sedative), diltiazem (Cardizem, a blood pressure Natural News.com

蘇利民：全世界都會派錯藥  -  ‎Apr 18, 2009‎
...�?��?�戴麟趾夫人普通科門診診所，藥房�?�員將糖尿藥格列苯脲（ Glibenclamide ），混入�?血壓藥地爾硫醶（ Diltiazem ），最少63 �??病人�?�影響。蘋果動新聞

戴麟趾诊所错派�?�物  -  ‎Apr 18, 2009‎
...该诊所1�??�?�剂师今天（ 4月17日）早上检查病人�?�物时，�?�现1包糖尿病�?�格列苯（Glibenclamide）中，混有�?血压�?�地尔硫（Diltiazem）。涉�?�的�?�房已�?�络63�?�?�能�?� 香港政府新闻网

港戴麟趾夫人診所疑派錯藥  -  ‎Apr 17, 2009‎
...（Diltiazem））。藥房隨�?��?�絡六�??三�?有機會�?�影響的病人，�?�時�?�用該藥物並安排�?�領藥物。至今，從回收的藥物中，有�?包糖尿病藥物混有�?血壓藥物。大公報

09年执业西�?�师�?��?�学辅导：第二�??一章第三节常用钙拮抗�?�  -  ‎Apr 15, 2009‎
...地尔硫（diltiazem）�?��?30～60mg/次，3次/日。氟桂嗪（flunarizine） �?��?10mg/日，晚上顿�?。开始时早�?晚�?�一次。普尼拉明（prenylamine） �?��?15～30mg/次，3次/ 青年人

Hány tabletta van egy halban?  -  ‎Mar 30, 2009‎
A halakban talált gyógyszerhatóanyagok közt szerepelt a norfluoxetine, mely egy antidepresszáns, a diltiazem, mely vérnyomáscsökkentők hatóanyaga valamint HáziPatika.com

A 76-Year-Old Man With Recurrent Clostridium difficile–Associated ...  -  ‎Mar 3, 2009‎
Mr S's medications include prednisone, 4 mg daily; cyclosporine, 50 mg daily; and diltiazem, trazodone, atenolol, minoxidil, furosemide, long-acting Journal of American Medical Association (subscription)

Fitness fanatic killed by cocaine and steroid cocktail  -  ‎Mar 5, 2009‎
Tests also revealed anabolic steroids and a higher than therapeutic level of Diltiazem, a drug used to treat hypertension and angina, in his system. Maidenhead Advertiser

The habit that's costing the earth  -  ‎Feb 28, 2009‎
He can tell you how the traffickers cut their product with industrial quantities of the blood-pressure drug diltiazem to open up the coronary arteries in Daily Mail

Hépatotoxicité des antirétroviraux  -  ‎Mar 13, 2009‎
D’autres médicaments ont un effet similaire (clarithromycine, érythromycine, isoniazide, irinotécan, dihydralazine, vérapamil ou diltiazem…). Hépato-Gastro (Abonnement)

Neu auf dem Markt  -  ‎Mar 3, 2009‎
Angina) wurde das Medikament zusätzlich zur Basistherapie mit 50 mg Atenolol, 5 mg Amlodipin oder 180 mg Diltiazem, jeweils einmal täglich, gegeben. Pharmazeutische Zeitung online

Treatments to slow down your heart  -  Jan 21, 2009
Injections of verapamil or diltiazem can help to slow down a heart that is beating very quickly.[5] [6] [7] You may need one or more injections. guardian.co.uk,

What treatments work for anal tears?  -  Jan 21, 2009
...[15] Diltiazem and nifedipine are drugs called calcium channel blockers. They're usually used to treat high blood pressure. Some research has shown that guardian.co.uk,

Generics manufacturer pulls plug on nearly its entire product line  -  Jan 29, 2009
On the list of suspended drugs are preparations of amlodipine, diltiazem, isosorbide mononitrate, nitroglycerin, and propafenone along with potassium TheHeart.Org,

Calcium channel blockers  -  Jan 21, 2009
The calcium channel blocker known as diltiazem increases their chances of having another heart attack by 40 percent.[4] Calcium channel blockers can also guardian.co.uk,

READERS RESPOND  -  Feb 3, 2009
Mr S's medications include prednisone, 4 mg daily; cyclosporine, 50 mg daily; and diltiazem, trazodone, atenolol, minoxidil, furosemide, long-acting Journal of American Medical Association (subscription),

What's the evidence for beta-blockers?  -  Jan 21, 2009
Long term efficacy of diltiazem controlled release versus metoprolol in patients with stable angina pectoris. Journal of Cardiovascular Pharmacology. guardian.co.uk,

What treatments work for Raynaud's disease?  -  Jan 21, 2009
Diltiazem can cause side effects such as ankle swelling, flushing or headaches.[8] One brand name for this medicine is Cardene. There's not much research guardian.co.uk,

Cerebrovascular response to continuous cold perfusion and ...  -  Jan 30, 2009
Finally, diltiazem solution (5 x 10 –5 mol/L in PSS, devoid of calcium) was added to establish the fully dilated diameter. Because of varying vessel sizes, The Journal of Thoracic and Cardiovascular Surgery

High blood pressure  -  Jan 21, 2009
Calcium channel blockers: nifedipine (Adalat), amlodipine (Istin), diltiazem (Calcicard) and verapamil (Cordilox). Diuretics: bendroflumethiazide (Aprinox) guardian.co.uk,

Stable angina  -  Jan 21, 2009
Examples include: diltiazem (Dilzem), nifedipine (Adalat) and verapamil (Cordilox). Calcium channel blockers can cause flushing, swelling of ankles, guardian.co.uk,

Drugs to lower blood pressure  -  Jan 21, 2009
Calcium channel blockers (sometimes called calcium channel antagonists): These include diltiazem (Tildiem) and nicardipine (Cardene). guardian.co.uk,

What treatments work for unstable angina?  -  Jan 21, 2009
Common ones (and their brand names) include diltiazem (Adizem, Dilzem, Tildiem), felodipine (Plendil), nifedipine (Adalat, Coracten SR) and verapamil guardian.co.uk,

Ди�?функци�? �?ину�?ового узла  -  Feb 3, 2009
лекар�?твенных препаратов: �?ердечных гликозидов, ß-адреноблокаторов, хинидина и других антиаритмиче�?ких веще�?тв, верапамила или дилтиазема (Diltiazem). Украин�?кий медицин�?кий портал,

La somministrazione di Atorvastatina o di Simvastatina assieme ...  -  Jan 12, 2009
I più comuni inibitori CYP3A4 prescritti erano: Diltiazem ( Dilzene; 86 eventi ), Verapamil ( Isoptin, n=72 ), Eritromicina ( Eritrocina, XagenaSalute,

Cytokinetics Announces Phase IIa Clinical Trial Results Relating ...  -  Dec 18, 2008
...subjects with PM genotype for CYP2D6 as compared to subjects with EM genotype for CYP2D6 and to evaluate the effect of diltiazem (a moderate inhibitor MarketWatch

Generic Drugs are as Good as Brand Names for Heart Problems  -  Dec 2, 2008
For example, the brand-name drug Cardizem, a calcium channel blocker, was no more effective than its generic version, diltiazem. A long-acting beta-blocker HealthNewsDigest.com,

Complaints about pharmacies find system with little outside oversight  -  Nov 29, 2008
By ALBERT McKEON Staff Writer John Karagianis poured a glass of water one day and gulped down what he thought was Diltiazem, a medication that treats an Nashua Telegraph,

“고혈압약 드시는 분, �?�런 �?��?�?� 피하세요�?  -  Dec 2, 2008
...딜티아젬(Diltiazem), 베�?�파밀(Verapamil) 등�?� ‘칼슘통로 차단제’는 협심�? 환�?, 노�?�환�?들�?� 선�?하게 �?�는 약�?�다. 복용�?� 갑�?기 중단하면 치명�?�?� 고혈압 긴 아�?�비타임즈,

Analysis Suggests That Improvements In Kidney Function In Patients ...  -  Nov 19, 2008
...colestipol, †OATP1B1 transporter inhibitors, eg cyclosporin, erythromycin/ clarithromycin, protease inhibitors, †diltiazem hydrochloride, †itraconazole, Medical News Today (press release),

Health And Family Good news for 'high blood' patients  -  Nov 10, 2008
Other medicines like Captopril and Diltiazem are less effective than Amlodipine because they only control your blood pressure for eight hours. Philippine Star,

Calcium-Channel Blockers Reduce the Antiplatelet Effect of Clopidogrel  -  Oct 27, 2008
In vitro incubation with CCBs (nimodipine, verapamil, amlodipine, and diltiazem) did not alter the PRI or the adenosine diphosphate–induced platelet Cardiosource,

Health Chat  -  21 Oct 2008
These include: naftidrofuryl, vitamin E, verapamil, diltiazem, painkillers, aspirin, orphenadrine, magnesium, calcium, and sodium chloride. Mmegi Online,

Justiça manda prefeitura fornecer remédios para munícipe  -  21 Oct 2008
...e Endofolin 5mg e ao Secretário Municipal de Saúde, que forneça os medicamentos Caltrate 600 + D, Monocordil 200mg, Cloridrato de Diltiazem 60mg, Jornal de Barretos,

Organización B’nai B’rith y Fundación OSDE donaron medicamentos  -  Oct 19, 2008
El cargamento actual está valuado en U$S 1.300.000 y corresponde a la droga Dilacor XR cápsulas de 120 mg (diltiazem) cuya acción terapéutica es El Diario de Paraná,

Dr. Gott: Allergy pills refuse to digest properly  -  Aug 28, 2008
Dear Dr. Gott: For the past 10 or 12 years, I have been on diltiazem for high blood pressure. I read in a book that this medication can cause liver damage, Northwest Herald,

FDA Safety Changes: Evamist, Caduet, Emtriva  -  Sep 3, 2008
...and coadministration of atorvastatin 40 mg with diltiazem 240 mg was also associated with higher plasma concentrations of atorvastatin. Medscape (subscription)

Drugs Used in Disorders of the Heart  -  Aug 30, 2008
Do not take verapamil or diltiazem along with these drugs (discussed later). The safety of these drugs has not been established in pregnancy. American Chronicle,

FDA Safety Changes: Reyataz and Invanz  -  Jul 30, 2008
Describe the appropriate use of diltiazem in patients receiving atazanavir therapy. Describe a drug interaction between carbapenems and valproic acid. Medscape (subscription)

Time to Buy Elan?  -  Aug 4, 2008
It reformulated ordinary drugs like calcium channel blockers and naproxen, and extended the patent lives of compounds like Diltiazem, Nifedipine; Seeking Alpha,

AHA Releases Guidelines for Hypertension Management in Adults With ...  -  Jul 16, 2008
Several drugs are contraindicated in patients with heart failure, including verapamil (Calan), diltiazem (Cardizem), clonidine (Catapres), and moxonidine RedOrbit,

China Sky One Medical, Inc. Has 11 New Drugs in Clinic Trials  -  Jul 10, 2008
...and obstetric hemorrhage; -- Diltiazem Hydrochloride Injection: for treatment of paroxysmal supraventricular tachycardia and unstable angina pectoris. RedOrbit,

Take control of your blood pressure  -  Jul 9, 2008
Calcium channel blockers, such as diltiazem (Cardizem), work by dilating the arteries, he said. ACE inhibitors, such as quinapril (Accupril), LubbockOnline.com,

FDA Safety Changes: Ultram ER, Reyataz, Duragesic  -  Jul 9, 2008
3A4 inhibitors (amprenavir, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, and verapamil) can increase fentanyl plasma concentrations. Medscape (subscription)

Optimizing Pain Control With Fentanyl Patches  -  Jul 15, 2008
Therefore, potent inhibitors such as azole antifungals, protease inhibitors, diltiazem, and macrolide antibiotics should be used cautiously in patients Medscape (subscription)

MI in Pregnancy: Numbers Increasing but Management Improving  -  Jul 10, 2008
Of calcium-channel blockers (category C), nifedipine appears safe, but diltiazem and verapamil data are limited. ACE inhibitors and angiotensin-receptor Medscape (subscription)

Ipertensione resistente: che fare?  -  Aug 4, 2008
...oppure associare un calcio-antagonista diidropiridinico a verapamil (o diltiazem), o un aceinibitore con un sartano, oppure aggiungere farmaci oggi meno Pillole.org,

Brand Names/Synonyms:
Diltiazem is also known by the following brand names and/or synonyms:
Acalix; Anoheal; Adizem; Altiazem; Anginyl; Angizem; Apo-Diltiaz; Britiazim; Bruzem; Calcicard; Cardizem; Cardizem CD; Cardizem SR; Cardizen LA; Cartia XT; Citizem; Cormax; Deltazen; Dilacor; Dilacor-XR; Diladel; Dilcontin; Dilpral; Dilrene; Dilt-cd; Dilta-Hexal; Diltia; Dilticard; Dilzem; Dilzen; Endrydil; Herbesser; Incoril AP; Masdil; Novo-Diltazem; Nu-Diltiaz; Syn-Diltiazem; Tiazac Tildiem; d-cis-Diltiazem

Drug Category:
Diltiazem is categorized under the following by the FDA: Vasodilator Agents; Cardiovascular Agents; Antihypertensive Agents; Calcium-channel blocking agents; ATC:C08DB01

Dosage Forms:
SOLUTION

Absorption:
Diltiazem is well absorbed from the gastrointestinal tract but undergoes substantial hepatic first-pass effect.

Interactions:
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Chemical IUPAC Name:
[2-(2-dimethylaminoethyl)-5-(4-methoxyphenyl)-3-oxo-6-thia-2-azabicyclo[5.4.0]undeca-7,9,11-trien-4-yl]ethanoate

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