Ezetimibe

This page contains recent news articles, when available, and an overview of Ezetimibe but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Ezetimibe
(when available)

Pharmacology and use:
Ezetimibe is in a class of lipid-lowering compounds that selectively inhibits the intestinal absorption of cholesterol and related phytosterols. Ezetimibe, administered alone is indicated as adjunctive therapy to diet for the reduction of elevated total-C, LDL-C, and Apo B in patients with primary (heterozygous familial and non-familial) hypercholesterolemia. It is also used in combination therapy with HMG-CoA reductase inhibitors. Ezetimibe has a mechanism of action that differs from those of other classes of cholesterol-reducing compounds (HMG-CoA reductase inhibitors, bile acid sequestrants, fibric acid derivatives, and plant stanols). Ezetimibe does not inhibit cholesterol synthesis in the liver, or increase bile acid excretion but instead localizes and appears to act at the brush border of the small intestine and inhibits the absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver. This causes a reduction of hepatic cholesterol stores and an increase in clearance of cholesterol from the blood; this distinct mechanism is complementary to that of HMG-CoA reductase inhibitors. For use as adjunctive therapy to diet for the reduction of elevated total-C, LDL-C, and Apo B in patients with primary (heterozygous familial and non-familial) hypercholesterolemia.

Mechanism Of Action:
Ezetimibe localizes and appears to act at the brush border of the small intestine and inhibits the absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver.

News Articles on Ezetimibe

Abbott's next step for Niaspan  -  05 Jan 2010
In the case of HALTS, the study found that Niaspan did a better job than Merck's ezetimibe at lessening atherosclerosis. ... Medical Marketing and Media

FDA panel says Vytorin and Zetia probably don't cause cancer  -  ‎Dec 24, 2009‎
Zetia is the brand name for the drug ezetimibe, which blocks the absorption of cholesterol in the intestines. Vytorin is a combination of ezetimibe and ... Los Angeles Times (blog)

Mylan sued over plans for generic Vytorin  -  ‎Dec 22, 2009‎
Mylan asked for Food and Drug Administration approval for a range of doses of Ezetimibe and Simvastatin tablets, or Vytorin. That triggered a patent lawsuit ... The Associated Press

Treating Coronary Heart Disease: Is Niaspan Better than Ezetimibe?  -  ‎Jan 1, 2010‎
Because ezetimibe interferes with cholesterol absorption from the intestine, this drug lowers blood levels of harmful LDL-C but has little effect on HDL-C. ... Ethiopian Review

SEAS: Increased cancer risk unlikely  -  ‎Dec 28, 2009‎
Combination therapy with simvastatin and ezetimibe did not increase a patient's risk for cancer or cancer-related death, the FDA determined after reviewing ... Cardiology Today

FDA Review of Vytorin Deems Cancer Risk “Unlikelyâ€?  -  ‎Dec 28, 2009‎
...s Vytorin, a popular cholesterol medication that combines Zocor (simvastatin) with Zetia (ezetimibe), does not necessarily raise the risk of cancer or ... DrugWatch.com

Comparison of the efficacy of administering a combination of ezetimibe plus ...  -  ‎Dec 17, 2009‎
Conclusions: The combination of ezetimibe plus fenofibrate appeared to produce nearly identical alterations in serum lipoprotein levels when compared to ... 7thSpace Interactive (press release)

Glenmark may settle with Merck on cholesterol drug  -  ‎Dec 14, 2009‎
Glenmark's US subsidiary Glenmark Generics Ltd had said in April that the tentative approval granted by FDA is for the 10 mg tablets of ezetimibe. ... Livemint

Niacin may be effective in lowering cholesterol  -  ‎Dec 18, 2009‎
A: In a November study in the New England Journal of Medicine, niacin was compared with ezetimibe (Zetia), one part of the combination medicine Vytorin. ... Los Angeles Times

ARBITER leaves some lasting marks on Merck  -  ‎Dec 21, 2009‎
The study showed that Abbott Labs' Niaspan, an extended-release niacin, bested ezetimibe—an ingredient in Merck's cholesterol-lowering drugs Zetia and ... Medical Marketing and Media

Study links cheap statin use with poor outcomes  -  ‎Dec 22, 2009‎
...also suggests that practices achieving good outcomes with high use of low-cost statins may be making use of additional therapies such as ezetimibe. ... Healthcare Republic

Model system for the analysis of cell surface expression of human ABCA1  -  ‎Dec 21, 2009‎
Here we demonstrate that ezetimibe affects ABCA1 cell surface expression only in the case of a functional ABCA1. Conclusions: Our model system allows a ... 7thSpace Interactive (press release)

Sign Up and Be In The Know!! AGRT,AVII,PRGS,LIFE,CNQR,MYL  -  ‎Dec 22, 2009‎
...(ANDA) with the US Food and Drug Administration (FDA) for Ezetimibe and Simvastatin Tablets, 10 mg/10 mg, 10 mg/20 mg, 10 mg/40 mg and 10 mg/80 mg. ... TMC Net

FDA, 머í?¬ì‚¬ì—? ë°”ì?´í† ë¦° 관련 í?¬ë¦¬ìŠ¤ë§ˆìŠ¤ 선물  -  ‎Dec 29, 2009‎
...즉, FDAê°€ 제티아(ezetimibe)와 ì¡°ì½”(simvastatin)ì?˜ 복합 í•­ 콜레스테롤 약물ì?¸ ë°”ì?´í† ë¦°ì?´ ì•”ì?´ë‚˜ ì•” 관련 사ë§? 위험ì?„ ì¦?가하지 않는다고 발표한 것ì?´ë‹¤. ... 메디포뉴스

Mylan Labsé?­Schering与MSP控告侵æ?ƒ  -  ‎Dec 22, 2009‎
...率先å?‘美国FDAæ??交学å??è?¯Ezetimibe与Simvastatin上市申请,è?¯å‰‚é‡?有10 mg/10 mg丶10 mg/20 mg丶10 mg/40 mg丶10 mg/80 mg,该产å“?为Vytorinå­¦å??版,治疗胆固醇。 ... 凤凰网

'ë°”ì?´í† ë¦°' ì•” 유발 ì¦?ê±° 없다  -  ‎Dec 23, 2009‎
...미국 FDAê°€ 머í?¬ì?˜ 콜레스테롤 저하제 'ë°”ì?´í† ë¦°'(Vytorin, simvastatin+ezetimibe)ì—? 대해 ì•”ì?„ 유발하지 않는다는 검토결과를 발표했다. FDA는 ë°”ì?´í† ë¦°ì?´ ì•” 발병률 ... 메디파나뉴스

FDA sieht kein erhöhtes Krebsrisiko unter Ezetimib  -  ‎Dec 28, 2009‎
So konnte in der ENHANCE-Studie (Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosklerosis Regression) das Fortschreiten von ... DAZ.online

"심바스타틴 ì—?제티밉 병용시 암위험  -  ‎Dec 24, 2009‎
...김준호 기ìž? 심바스타틴과 ì—?제티밉 병용ì—? 따른 심혈관 예방효과를 í?‰ê°€í•œ SEAS(SEAS(Simvastatin and Ezetimibe in Aortic Stenosis) 시험ì—?서 ì•” ë°? 암사ë§?ì?´ ì¦?ê°€ ... 메디칼트리뷴

FDA: Kein Krebsrisiko durch Ezetimib  -  ‎Dec 23, 2009‎
Für Verwirrung hatten im August 2008 die Ergebnisse der Simvastatin and Ezetimibe in Aortic Stenosis (SEAS)-Studie gesorgt. Dort waren unter der Behandlung ... Deutsches Ärzteblatt

Schede patologia  -  ‎Dec 18, 2009‎
...l'eliminazione degli acidi biliari), ezetimibe, che contrasta l'assorbimento di colesterolo dall'intestino, fibrati e derivati dell'acido nicotinico. ... Dica 33

진료패턴ì?„ 바꿀 최신 ìž„ìƒ?연구Ⅲ  -  ‎Dec 27, 2009‎
...올리는 ì „ëžµì?´ ë?” 좋ì?€ê°€ 아니면 ì—?제티미브(ezetimibe)를 추가하여 LDL-C를 ë?” 낮추는 ì „ëžµì?´ 나ì?€ê°€ë¥¼ 비êµ?하기 위한 연구로서 오픈 ë?¼ë²¨ ë””ìž?ì?¸ìœ¼ë¡œ ì§„í–‰ë??다. ... KMA Times

Generic Name: Ezetimibe/Simvastatin, Inegy  -  ‎Nov 11, 2009‎
Vytorin (generic name: Ezetimibe / Simvastatin; brand name: Inegy) is a combination of two cholesterol medicines, Ezetimibe (a medicine that reduces the ... Pattaya Daily News

Addition of Ezetimibe Helps More Elderly Achieve LDL Cholesterol Goal Than ...  -  ‎Oct 29, 2009‎
EDMONTON, Alberta -- October 29, 2009 -- Adding a 10-mg dose of ezetimibe to an atorvastatin regime is more effective for bringing elderly patients to lipid ... DG News

$41.5 Million Settlement Okayed in Ezetimibe Suit  -  ‎Oct 23, 2009‎
Under an agreement approved by a federal court today, the makers of ezetimibe, which is marketed as ... MedPage Today

Heart valve changes don't always warrant treatment  -  ‎Nov 3, 2009‎
A: Zetia (generic name ezetimibe) lowers cholesterol by blocking its absorption from the digestive tract. This is a mode of action different from other ... Herald & Review

Low dose Vytorin listed on PBS  -  ‎Nov 1, 2009‎
Two low doses of Vytorin (ezetimibe/simvastatin) have been listed on the PBS at the start of this month, aimed at helping patients with statin intolerance. ... Pharmacy News

What's going to be hot at AHA 2009?  -  ‎Nov 11, 2009‎
...niacin with add-on ezetimibe in statin-treated patients, to be presented by Dr Allen Taylor (Washington Hospital Center, Washington DC) on Monday. ... TheHeart.Org

FDA Turns Down Merck's Application For Combo Cholesterol Pill Involving Lipitor  -  ‎Nov 2, 2009‎
Inc. (MRK: News ) announced that the Food and Drug Administration recently refused to file the application for MK-0653C, a combination of ezetimibe, ... RTT News

Aortic stenosis and statins  -  ‎Oct 19, 2009‎
The recent publication of the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study 2 prompted us to do a meta-analysis on the same question to see ... The Journal of Thoracic and Cardiovascular Surgery

Merck & Co earnings climb as Januvia and Isentress impress  -  ‎Oct 23, 2009‎
On the negative side, combined sales of Vytorin (ezetimibe plus simvastatin) and Zetia (ezetimibe), sold with Schering-Plough, fell 7% to $1.03 billion, ... Pharma Times

Merck Announces Third-Quarter 2009 Financial Results  -  ‎Oct 22, 2009‎
Combined global sales of ZETIA (ezetimibe) and VYTORIN (ezetimibe/simvastatin), as reported by the Merck/Schering-Plough partnership, were $1.0 billion for ... Reuters

Imaging study shows plaque regression with niacin vs placebo  -  ‎Oct 30, 2009‎
ARBITER-HALTS 6 is an imaging study comparing changes in carotid intima-media thickness in patients treated with ezetimibe (Zetia, Merck/Schering-Plough) or ... TheHeart.Org

Red Yeast Rice and Hyperlipidemia: How Strong Is the Evidence?  -  ‎Oct 28, 2009‎
...[4] Ezetimibe could be helpful among patients with a lower target level of low-density lipoprotein (LDL) cholesterol. Coenzyme Q10. ... Medscape

US FDA slammed over post-marketing studies  -  ‎Oct 28, 2009‎
...like� Schering-Plough/Merck & Co's cholesterol-lowerer Vytorin (ezetimibe and simvastatin) and GlaxoSmithKline's diabetes drug Avandia (rosiglitazone). ... Pharma Times

PBS listings in effect  -  ‎Nov 2, 2009‎
Further additions to the PBS include Vytorin, which allows patients to have a combination of Ezetimibe with simvastatin in the one product; ... Pharmacy News

Effetti benefici della terapia con Inegy su un marker di aterosclerosi  -  ‎Nov 3, 2009‎
...mg ed Ezetimibe 10 mg, i pazienti del gruppo 2 Simvastatina 80 mg, ei pazienti nel gruppo 3 venivano trattati con Simvastatina 40 mg ed Ezetimibe 10 mg. ... XagenaSalute

스타틴+니아스íŒ?, ê²½ë?™ë§¥ 플ë?¼í?¬ ê°?소  -  ‎Nov 2, 2009‎
...ì?´ì™€ 관련, 머í?¬ëŠ” 최근 FDAì—? '제티아'(Zetia, ezetimibe)와 '리피토'(Lipitor, atorvastatin) 복합제ì?˜ 승ì?¸ì‹ ì²­ì?„ 제출했으나 추가ì ?ì?¸ 제조 ë°? 안정성 ë?°ì?´í„°ê°€ ... 디지틀보사

La terapia con statine nei pazienti con stenosi aortica è associata a una più ...  -  ‎Nov 3, 2009‎
Lo studio SEAS ( Simvastatin and Ezetimibe in Aortic Stenosis ), non solo ha trovato che le statine non hanno un significativo effetto sulla progressione ... XagenaSalute

The Evidence Gap For Widely Used Drug, Question of Usefulness Is...  -  Sep 2, 2008
The companies say that ezetimibe, the generic name for Zetia, showed no cancer risk in ... By then tens of millions of people will have taken ezetimibe. ... New York Times

Study of new cholesterol drug  -  Mar 31, 2008
Ezetimibe is a new kind of cholesterol medicine that stops your body absorbing cholesterol ... It's called ezetimibe, sold under the brand name Ezetrol. ... guardian.co.uk

Editors: Cancer link may be real  -  Sep 3, 2008
Vytorin is the combination of two drugs, ezetimibe and simvastatin. ... Partly on the strength of those ads, ezetimibe, which is also sold separately in ... USA Today

Ezetimibe/simvastatin (vytorin) for hypercholesterolemia.  -  Nov 15, 2005
Ezetimibe/simvastatin (vytorin) is a combination of ezetimibe (Zetia), which inhibits the absorption of cholesterol by the small intestine, and simvastatin ... Free with registration - American Family Physician - AccessMyLibrary.com

Merck And Schering Seek To Co-opt Lipitor  -  Mar 26, 2007
Zetia, known generically as ezetimibe, was invented in Schering's labs (see: "Behind Zetia's Curtain") and is co-marketed with Merck. ... Forbes

Is combined treatment with fenofibrate and ezetimibe safe and...  -  Jun 1, 2006
McKenney JM et al. (2006) Safety and efficacy of long-term co-administration of fenofibrate and ezetimibe in patients with mixed hyperlipidemia. ... Nature.com

Trial Intensifies Concerns About Safety of Vytorin  -  Jul 22, 2008
If ezetimibe did cause cancer, it would be more likely to cause a single type than many types, he said. But other doctors said the data from Improve-It and ... New York Times

… triglyceride transfer protein alone or with ezetimibe in patients...  -  Nov 12, 2007
Results Ezetimibe monotherapy led to a 20–22% decrease in ... In treatment group 1, patients received 10 mg ezetimibe daily plus placebo for 12 weeks. ... Nature.com

The Speech That Maimed Schering And Merck  -  Apr 3, 2008
In this study, the addition of ezetimibe to a statin did not slow the progression of ... Now this is still just one study of ezetimibe and one that employed ... Forbes

WelChol and Ezetimibe Combination Therapy Provides Significant LDL-C …  -  Nov 13, 2006
A new study found that taking WelChol(R) (colesevelam HCI) in combination with ezetimibe reduced LDL-C by 32%, reducing mean LDL-C levels by an additional ... RedOrbit

ACC: ENHANCE Data on Ezetimibe/Simvastatin (Vytorin) Reveal Wavy …  -  Mar 30, 2008
By Peggy Peck, Executive Editor, MedPage Today. CHICAGO, March 30 -- The take home message from the ENHANCE trial reported here today is a simple one: it's ... MedPage Today

Study Identifies Patients Less Likely to Respond to Statins vs Ezetimi...  -  Jun 12, 2007
...[4] The report said the benefits of ezetimibe treatment were ... Ezetimibe was co-developed by Schering-Plough and Merck and is available worldwide. ... Medscape

Statin Therapy With or Without Ezetimibe in High-Risk Patients  -  Jul 28, 2006
The results of 2 studies presented at the 2006 symposium of the International Society of Atherosclerosis in Rome, Italy, have demonstrated the benefit of ... Medscape

… Hepatitis During Combination Therapy With Atorvastatin and Ezetimib...  -  Oct 8, 2005
Ezetimibe inhibits the intestinal absorption of cholesterol and has ... Several studies on the efficacy and safety of ezetimibe co-administered with a ... RedOrbit

No Definitive Link Seen Between Vytorin and Cancer  -  Sep 2, 2008
..."Overall, the three ezetimibe trials show no credible evidence of any effect on cancer ... "This study reduces our worry that ezetimibe might cause cancer, ... Washington Post

Ezetimibe/Simvastatin Better Than a Statin Alone  -  Mar 20, 2006
March 20, 2006 (Atlanta) — A combination of the cholesterol-lowering drugs ezetimibe and simvastatin is more effective at lowering C-reactive protein (CRP) ... Medscape

Combination ezetimibe and simvastatin lowers LDL cholesterol to a …  -  Jan 1, 2007
Combination therapy with ezetimibe and simvastatin for 6 weeks provides greater reductions in low-density lipoprotein cholesterol (LDL-C) compared with ... Free with registration - Formulary - AccessMyLibrary.com

Study Showed VYTORIN-TM- -ezetimibe/simvastatin- Superior to Lipitor ...  -  Mar 8, 2005
ORLANDO, Fla. -- Greater LDL Cholesterol Reduction with VYTORIN(TM) Compared to Lipitor Resulted in Greater Goal Attainment At Most Common Doses ... Free with registration - Business Wire - AccessMyLibrary.com

Patients advised to keep taking Inegy cholesterol therapy despite...  -  Sep 3, 2008
The Simvistatin and Ezetimibe in Aortic Stenosis (SEAS) study also cast doubt on ... “If you have been prescribed ezetimibe you should continue to take it," ... Times Online

Glenmark in patent challenge over cholesterol drug  -  Mar 29, 2007
Mumbai March 28 After Zocor and Lipitor, another blockbuster cholesterol drug, Ezetimibe, has come under a patent challenge. Schering Corporation and MSP ... Hindu Business Line

FDA Approves New Label for Vytorin(R) (Ezetimibe/Simvastatin)  -  Oct 5, 2006
WHITEHOUSE STATION, KENILWORTH, NJ -- October 5, 2006 -- Merck/Schering-Plough Pharmaceuticals announced today that the US Food and Drug Administration ... DG News

… Canada Endorses Important Safety Information on Ezetrol (Ezetimibe)  -  Feb 8, 2005
The new safety information is based on reports of the following conditions in patients taking Ezetrol (ezetimibe), some of which may be serious: muscle ... DG News

Ezetimibe approved by NICE.(National Institute for Clinical Excellence...  -  Sep 20, 2007
By Christian Duffin. Ezetimibe - a cholesterol absorption inhibitor - has been cleared for NHS use by NICE as an add-on therapy with statins. ... Free with registration - Pulse - AccessMyLibrary.com

Heart Groups Call for Time Out In Ezetimibe/Simvastatin (Vytorin)...  -  Jan 16, 2008
By Peggy Peck, Executive Editor, MedPage Today. WASHINGTON, Jan. 16 -- Both the American College of Cardiology and the American Heart Association have ... MedPage Today

Ezetimibe and Simvastatin ( Systemic).  -  Oct 27, 2005
Ezetimibe and Simvastatin(e-ZET-e-mibe and SIM-va-stat-in ) is used to lower cholesterol and triglyceride (fat-like substances) levels in the blood. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

… Study Showed VYTORIN(R) (ezetimibe/simvastatin) Significantly More...  -  Jun 19, 2006
ROME, June 19 /PRNewswire-FirstCall/ -- Results from a new clinical study which included 2855 patients with high cholesterol showed that VYTORIN(R) ... Free with registration - PR Newswire - AccessMyLibrary.com

Cholesterol-lowering drug 'may increase cancer risk'  -  Aug 22, 2008
It is a combination of the statin simvastatin and ezetimibe for use in patients whose cholesterol cannot be controlled by one drug alone. ... Telegraph.co.uk

New Analysis Showed VYTORIN(R) (ezetimibe/simvastatin) Superior to …  -  Mar 13, 2006
Results from a new post-hoc analysis of the previously presented VYtorin Versus Atorvastatin (VYVA) study of 1902 patients with high cholesterol showed that ... Lifescience-online

NICE Publishes Guidance On EZETROL (Ezetimibe) For The Treatment …  -  Nov 28, 2007
Doubling the dose of statin therapy or switching to an alternative statin generally leads to a further reduction in baseline LDL-cholesterol concentrations ... Medical News Today - Medical News Today (press release)

Ezetimibe and muscle disorders.(Safety and Efficacy Issues)  -  Jun 22, 2005
Australia -- Ezetimibe (Ezetrol[R]) lowers lipids by inhibiting the intestinal absorption of cholesterol and is indicated for the treatment of ... Free with registration - WHO Drug Information - AccessMyLibrary.com

Clinical News: Ezetimibe trial fails to show atheroma benefit.(Brief...  -  Jan 26, 2008
Adding ezetimibe to simvastatin has failed to reduce atheroma as measured by ultrasound in the ENHANCE trial, according to a news release from ... Free with registration - Chemist & Druggist - AccessMyLibrary.com

Utah study may help diabetics  -  Mar 13, 2006
They were also randomized to receive either ezetimibe or a placebo. Muhlestein says ezetimibe works differently, operating in the digestive tract to help ... Deseret News

Heart experts clash on Vytorin and cancer risk  -  Sep 2, 2008
..."At the moment, I would not take ezetimibe myself." Ezetimibe is one of the two ingredients in Vytorin, alongside the established statin drug simvastatin. ... Reuters India

Ezetimibe/Simvastatin May Be More Effective at Lowering Cholesterol …  -  Mar 14, 2005
March 14, 2005 (Orlando) -- A head-to-head comparison of ezetimibe and simvastatin -- the polypill marketed as Vytorin -- to atorvastatin (40 mg) found that ... Medscape

With Ezetimibe, the novel MTP Inhibitor, AEGR-733, Lowers LDL-C in …  -  Oct 7, 2007
By Crina Frincu-Mallos, PhD. NEW YORK, NY -- October 7, 2007 -- Statin intolerance or suboptimal response to standard-of-care therapy results in failure to ... DG News

Ezetimibe/Simvastatin Lowers LDL-C More Than Atorvastatin in Diabetics  -  Dec 26, 2006
Patients treated with ezetimibe/simvastatin, 10/20 mg/d achieved significantly greater mean reductions in LDL-C levels (-53.6%) than those treated with ... Diabetes In Control

Canadian Doctors Cautious On Cholesterol Drug  -  Mar 31, 2008
US doctors have been quick to prescribe Ezetimibe, a powerful new drug to ... JOANNE SILBERNER: The new drug is Ezetimibe. It's an active ingredient in two ... NPR

… Cholesterol Absorption and Hepatic Cholesterol Production by Ezetim...  -  Oct 12, 2007
Percent decrease in plasma LDL-C levels were 55.0% for ezetimibe in combination with ... Looking at the geometric mean ratio, ezetimibe in combination with ... DG News

… Two Sources of Cholesterol – Ezetrolâ„¢ (ezetimibe) Co-administered...  -  Apr 24, 2005
EZETROL (ezetimibe), the first specific cholesterol absorption inhibitor, works by inhibiting intestinal ... In Europe, ezetimibe is indicated for treatment in: sourcewire.com

Ezetimibe (Systemic).(Drug overview)  -  May 1, 2006
Ezetimibe (e-ZET-e-mibe) is used to lower cholesterol and triglyceride (fat-like substances) levels in the blood. Using this medicine may help prevent ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Ads for ineffective drugs reel in the dollars  -  Apr 5, 2008
Ezetimibe was launched in the US as Zetia in 2002, and in Canada under the name Ezetrol in 2003. Prescriptions of the drug accelerated in the US after July ... New Scientist

Fluvastatin-Ezetimibe Combination Reduces C-reactive Protein in High-...  -  Jun 14, 2007
By Thomas S. May. HELSINKI, FINLAND -- June 14, 2007 -- Combination therapy with fluvastatin and ezetimibe significantly reduces high-sensitivity C-reactive ... DG News

Biotechnology; Molecular mechanisms of Ezetimibe elucidated  -  Apr 4, 2005
..."Ezetimibe is a specific inhibitor of intestinal cholesterol absorption recently ... "Ezetimibe neither influences the release of cholesterol from mixed ... Pay-Per-View - Gastroenterology Week - Factiva, from Dow Jones

Combination of Simvastatin/Ezetimibe Reduces C-Reactive Protein...  -  Mar 15, 2006
By Ed Susman. ATLANTA, GA -- March 15, 2006 -- A combination of the anticholesterol drugs simvastatin (Zocor) and ezetimibe (Zetia) work together to reduce ... DG News

Ezetimibe Favourably Affects All LDL Subfractions in Patients with …  -  Jun 11, 2007
By Thomas S. May. HELSINKI, FINLAND -- June 11, 2007 -- Ezetimibe, a drug that blocks the absorption of cholesterol in the digestive tract, reduces total, ... DG News

Biotechnology; Molecular mechanisms of Ezetimibe elucidated  -  Apr 4, 2005
..."Ezetimibe is a specific inhibitor of intestinal cholesterol absorption recently ... "Ezetimibe neither influences the release of cholesterol from mixed ... Pay-Per-View - Pharma Business Week - Factiva, from Dow Jones

Congress Requests Ezetimibe/Simvastatin (Vytorin) Cancer Data from …  -  Aug 1, 2008
By Emily P. Walker, Washington Correspondent, MedPage Today. WASHINGTON, Aug. 1 -- Members of a House committee with a keen interest in the safety of ... MedPage Today

Ezetimibe gets LDL to goal in high-risk patients.(low density...  -  Oct 15, 2006
BARCELONA -- The addition of 10 mg/day of ezetimibe to maximum-dose rosuvastatin in a high-risk population enabled 94% of the patients to achieve an ... Free with registration - Family Practice News - AccessMyLibrary.com

Ezetimibe-induced acute pancreatitis.  -  Apr 1, 2007
Abstract: Ezetimibe is a lipid-lowering agent that inhibits the intestinal absorption of cholesterol and other related phytosterols. ... Free with registration - Southern Medical Journal - AccessMyLibrary.com

ENHANCE Finds No Slowing of Plaque Burden With Ezetimibe/ …  -  Jan 14, 2008
14 -- The combination of ezetimibe/simvastatin (Vytorin) did not appear to slow progression of atherosclerosis among patients with heterozygous familial ... MedPage Today

… Lipid Lowering With Simvastatin and Ezetimibe in Aortic Stenosis  -  Sep 9, 2008
Author(s): Rossebø AB, Pedersen TR, Boman K, et al., on behalf of the SEAS Investigators. Study Question: Does intensive lipid-lowering therapy with the ... Cardiosource

Simvastatin and Ezetimibe in Aortic Stenosis (SEAS)  -  Aug 22, 2008
Some preliminary data suggest that statin therapy may have a beneficial effect on calcific aortic stenosis (AS). Accordingly, the goal of SEAS, ... Medscape

Survey Report: Many Doctors Stand by Ezetimibe (Zetia)  -  Apr 11, 2008
By Marianne Mattera, Managing Editor, MedPage Today. A sizeable minority of doctors continues to believe that ezetimibe (Zetia) is a powerful agent for ... MedPage Today

Study Showed VYTORINâ„¢ (ezetimibe/simvastatin) Superior to Lipitor at ...  -  Mar 12, 2005
...(I-Newswire) - Results from a clinical trial conducted in 1902 patients with high cholesterol showed that VYTORINâ„¢ ( ezetimibe/simvastatin ) provided ... i-newswire.com

New EXPLORER Results Show Patients Achieved Dramatic Reductions …  -  Sep 6, 2006
...--CRESTOR and ezetimibe reduced CRP levels by 46% compared with just 29% with ... --CRESTOR and ezetimibe also reduced mean LDL-C by an unprecedented 70%. ... Free with registration - Business Wire - AccessMyLibrary.com

Ezetimibe/Simvastatin, Atorvastatin, or Rosuvastatin All Lower C...  -  Oct 15, 2007
By Crina Frincu-Mallos, PhD. NEW YORK, NY -- October 15, 2007 -- Therapy using ezetimibe/simvastatin, atorvastatin, or rosuvastatin results are equally ... DG News

Vytorin is safe to take  -  Mar 18, 2008
Vytorin is a combination product containing simvastatin and ezetimibe. Zocor contains simvastatin alone. (Ezetimibe alone is available as Zetia.) ... Albany Times Union

… Investigating Possible Link Between Ezetimibe/Simvastatin and...  -  Aug 21, 2008
ROCKVILLE, Md -- August 21, 2008 -- The US Food and Drug Administration (FDA) is informing healthcare professionals that it is investigating a report from ... DG News

ENHANCE: Effect of ezetimibe on atherosclerosis remains unknown  -  Mar 30, 2008
CHICAGO — Although ezetimibe plus simvastatin combination therapy lowers LDL cholesterol, its effects on intima-media thickness are not significant in ... Endocrine Today

… Study Showed VYTORIN(R) (ezetimibe/simvastatin) Significantly More...  -  Jun 18, 2006
VYTORIN, which contains ezetimibe and simvastatin, is the first and only product ... Due to the unknown effects of increased exposure to ezetimibe (an ... Free with registration - Business Wire - AccessMyLibrary.com

Learn about Ezetimibe from Consumer Reports Health.  -  Jan 5, 2008
Pending revision, the material in this section should be considered in light of more recently available information in the MedWatch notification at the ... consumerreports.org

Intestinal expression of P-glycoprotein (ABCB1), multidrug resistance...  -  Jul 6, 2005
Background and Aims: Ezetimibe is an inhibitor of the cholesterol uptake ... Methods: Serum concentrations of ezetimibe, as well as its glucuronide, ... Nature.com

FAT FOR CELLS CAN ALSO CLOG ARTERIES  -  May 22, 2007
In contrast, ezetimibe (eh-ZET-eh-mibe), sold as Zetia, prevents the intestine from delivering cholesterol to the bloodstream. ... Pay-Per-View - St. Petersburg Times - ProQuest Archiver

'Prescribe ezetimibe despite cancer link'  -  Sep 3, 2008
GPs should continue to prescribe ezetimibe despite research linking the drug to an increased risk of cancer. The findings of the SEAS trial, ... Healthcare Republic - Healthcare Republic

Ezetimibe's rapid US adoption called flawed.(Cardiovascular Medicine)(...  -  May 1, 2008
..."Amid an aggressive marketing campaign, ezetimibe was rapidly adopted into ... S. prescriptions for lipid-lowering drugs were either for ezetimibe alone ... Pay-Per-View - Internal Medicine News - HighBeam Research

Rapid adoption of ezetimibe called flawed.(News) | Article from...  -  Apr 15, 2008
Rapid adoption of ezetimibe called flawed.(News) ... find Family Practice News articles. CHICAGO -- When data on ezetimibe's missing antiatherosclerotic ... Pay-Per-View - Family Practice News - HighBeam Research

Cancer concerns over ezetimibe linger for some.(News) | Article from ...  -  Oct 1, 2008
Cancer concerns over ezetimibe linger for some.(News) ... find Internal Medicine News articles. MUNICH--Many experts have been reassured that the signal of ... Pay-Per-View - Internal Medicine News - HighBeam Research

Add-On Cholesterol Therapy Using Ezetimibe May Be More Effective …  -  Sep 18, 2008
By Maggie Schwarz. PHILADELPHIA -- September 18, 2008 -- "Prescribing ezetimibe along with a statin affords more than just additivity, but perhaps synergy ... DG News

Simvastatin Plus Ezetimibe Reduces Ischaemic Cardiovascular Events in...  -  Sep 5, 2008
By Chris Berrie. MUNICH, Germany -- September 5, 2008 -- Combination therapy with simvastatin and ezetimibe is well tolerated and safe and reduces the risk ... DG News

Good News for Ezetimibe? Not!  -  Dec 5, 2008
...by GoozNews ~ 05 Dec 2008 10:28pm. The headlines sounded impressive: "Study Says Zetia May Help Fight Heart Disease" (Wall Street Journal), "Statins, ... GoozNew

New Analysis Showed VYTORIN(R) (ezetimibe/simvastatin) Superior to …  -  Mar 13, 2006
The active ingredients in VYTORIN are ezetimibe and simvastatin. ... Due to the unknown effects of increased exposure to ezetimibe (an ingredient in ... Free with registration - Business Wire - AccessMyLibrary.com

… , Inc. Announces Filing for WelChol Label Change to Include Ezetimib...  -  Mar 28, 2007
..."This data demonstrates the value of combining WelChol plus ezetimibe," said Harold E. Bays, MD, FACP, Louisville Metabolic and Atherosclerosis Research ... RedOrbit

… Society of Cardiology Conference News - Experts play down ezetimibe...  -  Sep 8, 2008
Clinicians should continue to prescribe ezetimibe despite research linking the drug to an ... A meta-analysis of three ezetimibe studies, including SEAS, ... Healthcare Republic - Healthcare Republic

Ezetimibe Flunks Inflammation Tests  -  Dec 24, 2008
...by GoozNews ~ 24 Dec 2008 01:03pm. Atherosclerosis is a chronic inflammatory process, and some of the benefits of statins are thought to be related to their ... GoozNew

Cholesterol; Data shows Crestor plus ezetimibe reduces LDL cholesterol...  -  Dec 13, 2005
2005 DEC 13 - (NewsRx.com) -- New data presented at the American Heart Association Scientific Sessions show that AstraZeneca's Crestor (rosuvastatin ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Promising trial on statin add-in falls flat; studies continue  -  Feb 4, 2008
Given the study's two-year duration and doses -- 10 mg of ezetimibe and 80 mg of ... Ezetimibe "is still recommended for patients who cannot meet their ... American Medical News

Doubts grow over NICE guidance on ezetimibe.  -  Jan 30, 2008
By Nigel Praities. Doubts over the controversial decision by NICE to recommend ezetimibe as an add-on option to statins have intensified after a trial found ... Free with registration - Pulse - AccessMyLibrary.com

Does Ezetimibe ENHANCE the Benefits of Statins?  -  Jun 30, 2008
Ezetimibe, a novel cholesterol-absorption inhibitor marketed in the US since October 2002, lowers LDL cholesterol levels. However, little is known about its ... Medscape

… Analyses of the SEAS, SHARP and IMPROVE-IT Studies of Ezetimibe  -  Jul 21, 2008
Two other large trials of ezetimibe + statin are still in progress: (i) SHARP (ezetimibe + simvastatin vs placebo in 9000 patients; recruitment completed, ... Genetic Engineering News - Genetic Engineering News (press release)

FIRST PATIENT ENROLLED IN ASTRAZENECA.  -  Sep 7, 2007
Ezetimibe is a cholesterol absorption inhibitor and this study is ... In a previous clinical trial, EXPLORER, CRESTOR 40mg with ezetimibe 10mg helped high ... Free with registration - AsiaPulse News - AccessMyLibrary.com

New Study Showed VYTORIN(R) (Ezetimibe/Simvastatin) Superior to …  -  Jun 10, 2006
Results from a new clinical study conducted in 1229 patients with type 2 diabetes mellitus and high cholesterol showed that VYTORIN(R) ... RedOrbit

Vytorin: Using medical reports for media hype and political attention  -  Aug 11, 2008
Vytorin is a combination of cholesterol-lowering Zetia (ezetimibe) and the statin ... Ezetimibe inhibits cholesterol absorption, as opposed to removing ... emaxhealth.com

Merck and Schering-Plough Respond To Issues Raised About ENHANCE …  -  Jan 25, 2008
This imaging trial looked at the effects of ezetimibe/simvastatin versus ... In ENHANCE, ezetimibe/simvastatin achieved significantly greater LDL ... HealthNewsDigest.com

Reductions in LDL by Fluvastatin XL/Ezetimibe Correlate With Decreased...  -  Oct 16, 2007
By Crina Frincu-Mallos, PhD. NEW YORK, NY -- October 16, 2007 -- Adding ezetimibe to fluvastatin XL therapy results in significant reduction of plasma lipid ... DG News

Ezetimibe/simvastatin combo safe, effective in kidney disease.(Disease...  -  Jun 15, 2006
Adding ezetimibe to simvastatin was found to be safe in a pilot study of patients with chronic kidney disease, and the combined regimen decreased LDL ... Free with registration - Internal Medicine News - AccessMyLibrary.com

Ezetimibe/Simvastatin Pill Superior to Atorvastatin in Reducing LDL...  -  Dec 21, 2006
WHITEHOUSE STATION, KENILWORTH, NJ -- December 21, 2006 -- Results from a clinical study conducted in 1229 patients with type II diabetes mellitus and high ... DG News

Crestor and ezetimibe reduce CRP levels in CD study  -  Sep 7, 2006
Data from a study of AstraZeneca's Crestor (rosuvastatin), show that the drug, in combination with ezetimibe, brought about a 46% reduction in C-reactive ... Pay-Per-View - Pharma Marketletter - Factiva, from Dow Jones

PEOPLE'S PHARMACY  -  Feb 23, 2007
Zetia (ezetimibe) works differently from statin drugs such as Lipitor or Zocor. Instead of blocking the creation of cholesterol, Zetia interferes with ... Pay-Per-View - The Sun - ProQuest Archiver

No link found between ezetimibe and cancer incidence in meta-analysis  -  Oct 8, 2008
Data from three trials are insufficient to conclude that ezetimibe causes adverse effects on rates of cancer, according to researchers from Oxford ... HemOncToday

INEGYâ„¢ (ezetimibe/simvastatin) Is Superior To Crestorâ„¢ (rosuvastatin)...  -  Oct 20, 2006
INEGYâ„¢ (ezetimibe/simvastatin) provides significantly greater LDL ("bad") cholesterol (LDL-C) reduction compared with rosuvastatin (Crestorâ„¢) in patients ... Medical News Today - Medical News Today (press release)

Ezetimibe And Twice-Weekly Atorvastatin Effective for Statin-Intoleran...  -  Mar 18, 2008
Ezetimibe plus twice-weekly atorvastatin is effective in high-risk patients intolerant to daily statin monotherapy, according to a new report. ... Diabetes In Control

… /New Study Showed VYTORIN(R) (Ezetimibe/Simvastatin) Superior to …  -  Jun 12, 2006
Results from a new clinical study conducted in 1229 patients with type 2 diabetes mellitus and high cholesterol showed that VYTORIN(R) ... RedOrbit

… following initiation of simvastatin and ezetimibe therapy.(CASE...  -  Sep 1, 2007
The combination of simvastatin and ezetimibe has previously demonstrated ... Ezetimibe is the first member of a new class of lipid lowering compounds that ... $4.95 - Journal of Drugs in Dermatology - ECNext

How to take Ezetimibe from Consumer Reports Health.  -  Jan 5, 2008
Pending revision, the material in this section should be considered in light of more recently available information in the MedWatch notification at the ... consumerreports.org

Ezetimibe added to statins improves cholesterol: study  -  Feb 5, 2007
A NEW Australian study supports the use of Ezetrol (ezetimibe) in combination with statin therapy to lower cholesterol levels. ... Pharmacy News

… Analyses Demonstrate that INEGYâ„¢ (ezetimibe/simvastatin) was more ...  -  Apr 24, 2005
Prague, Czech Republic, 24 April 2005 – Results from clinical studies presented at the 2005 European Atherosclerosis Society (EAS) annual meeting show that ... sourcewire.com

… Study Showed VYTORIN(R) (Ezetimibe/Simvastatin) Significantly More...  -  Jun 19, 2006
Results from a new clinical study which included 2855 patients with high cholesterol showed that VYTORIN(R) (ezetimibe/simvastatin) was significantly more ... RedOrbit

UK's NICE approves cholesterol drug ezetimibe  -  Sep 18, 2007
The UK's National Institute for Health and Clinical Excellence (NICE) has approved ezetimibe to reduce cholesterol levels in some patients. ... Pharmacy Europe

Biggest LDL-C Reduction Ever Shown In Patients Is Achieved With A …  -  Jun 26, 2006
At six weeks, CRESTOR and ezetimibe reduced mean LDL-C from 4.9 mmo/L (190 mg/dL) to 1.5 mmol/L (57 mg/dL), representing an unprecedented 70 per cent ... Medical News Today - Medical News Today (press release)

… .(NEWS FROM THE FDA)(Effect of Combination Ezetimibe and High-D  -  Feb 15, 2008
Next steps on ezetimibe, if any, may take months.(NEWS FROM THE FDA)(Effect of Combination Ezetimibe and High-Dose Simvastatin vs. Simvastatin Alone on the ... Pay-Per-View - Family Practice News - HighBeam Research

Brand Names/Synonyms:
Ezetimibe is also known by the following brand names and/or synonymsEzedoc; Ezetimibe; Ezetimibe [Usan:Inn]; Ezetimibe [Usan]; Vytorin; Zetia

Drug Category:
Ezetimibe is categorized under the following by the FDA: Anticholesteremic Agents; Cholesterol Absorption Inhibitors; ATC:C10AX09

Dosage Forms:
TABLET

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxy-propyl]-4-(4-hydroxyphenyl)-azetidin-2-one





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