Felbatol

This page contains recent news articles, when available, and an overview of Felbatol but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Felbatol (when available)

Pharmacology and use:
Felbamate is an antiepileptic indicated as monotherapy or as an adjunct to other anticonvulsants for the treatment of partial seizures resulting from epilepsy. Receptor-binding studies in vitro indicate that felbamate has weak inhibitory effects on GABA-receptor binding, benzodiazepine receptor binding, and is devoid of activity at the MK-801 receptor binding site of the NMDA receptor-ionophore complex. However, felbamate does interact as an antagonist at the strychnine-insensitive glycine recognition site of the NMDA receptor-ionophore complex. Felbamate is not a first line antiepileptic. It is for use only in those patients who respond inadequately to alternative treatments and whose epilepsy is so severe that a substantial risk of aplastic anemia and/or liver failure is deemed acceptable in light of the benefits conferred by its use.

Mechanism Of Action:
The mechanism by which felbamate exerts its anticonvulsant activity is unknown, but in animal test systems designed to detect anticonvulsant activity, felbamate has properties in common with other marketed anticonvulsants. In vitro receptor binding studies suggest that felbamate may be an antagonist at the strychnine-insensitive glycine-recognition site of the N-methyl-D-aspartate (NMDA) receptor-ionophore complex. Antagonism of the NMDA receptor glycine binding site may block the effects of the excitatory amino acids and suppress seizure activity. Animal studies indicate that felbamate may increase the seizure threshold and may decrease seizure spread.

News Articles on Felbamate

Vigabatrin (Sabril®): A New Epilepsy Drug -- With Strings Attached  -  ‎Dec 31, 2009‎
...[1] Vigabatrin joined the 11 antiepileptic drugs that have received FDA approval since 1993: felbamate (Felbatol®), gabapentin (Neurontin®), ... Medscape

No insurance leaves reader in a bind  -  Jun 24, 2008
Specifically, Keppra is from UCB, Carbatrol ER is from Shire US, and Felbatol is from Meda Pharmaceuticals. Perhaps this is the basis from which to start. ... $2.95 - Erie Times-News - NewsBank

… of antiepileptic drugs be restricted?(Keppra, Lamictal,Topamax,Felb...  -  Aug 6, 2007
Topamax (September 2008), and Felbatol (September 2009). The Epilepsy Foundation in Illinois is supporting that state's bill, according to Scott Meyers, ... Free with registration - Drug Topics - AccessMyLibrary.com

FDA standards for generics are questioned  -  Mar 17, 2008
The same story incorrectly identified the brand name of the anti-seizure drug valproic acid as Felbatol. The correct brand name is Depakote. ... Los Angeles Times

Advocacy follows after drug eases boy's epilepsy  -  Feb 28, 2008
Felbatol is a drug of last resort for epilepsy because it can cause serious side effects. During the past six months of guarded relief, Emmett's parents, ... $2.95 - Evanston Review - NewsBank

Mãe de criança com paralisia cerebral reclama de atraso na entrega de...  -  Jul 10, 2008
Mas agora ela está muito mais apagadinha, com dores no corpo e com crises convulsivas", conta a mãe, que diz não ter condições de comprar o Felbatol com ... Diário do Grande ABC

FDA Warns Epilepsy Drugs May Raise Suicide Risk  -  Feb 1, 2008
The drugs included in the warning are: Carbamazepine (marketed as Carbatrol, Equetro, Tegretol, Tegretol XR), Felbamate (marketed as Felbatol), ... Washington Post

FDA Adds Suicide Warning to Epilepsy Drugs  -  Dec 15, 2008
Depakene); ethosuximide (Zarontin); ethotoin (Peganone); felbamate (Felbatol); gabapentin (Neurontin); lamotrigine (Lamictal); lacosamide (Vimpat); ... Forbes

Article: Epilepsy; Key Q&A. - NWHRC Health Center - Epilepsy | …  -  Sep 14, 2005
Article: Felbatol may cause acute liver failure. (side ... ... Patients taking the anti-epilepsy drug Felbatol may develop acute liver ... to limit its use ... Pay-Per-View - NWHRC Health Center - Epilepsy - HighBeam Research

FDA Advisers Don't Back 'Black Box' Warning for Epilepsy Drugs  -  Jul 10, 2008
The drugs reviewed by the FDA were: Carbamazepine (marketed as Carbatrol, Equetro, Tegretol, Tegretol XR), Felbamate (marketed as Felbatol), ... Washington Post

St. Paul Pioneer Press : LIVER TESTS MANDATED TO AVOID SUDDEN …  -  Apr 13, 2005
Arthrotec), efavirenz (Sustiva), ethotoin (Peganone), ethosuximide (Zarontin), felbamate (Felbatol), fenofibrate (Tricor), fluconazole (Diflucan), ... $2.95 - St. Paul Pioneer Press - NewsBank

St. Paul Pioneer Press : MANY MEDS DON'T MIX WITH THE SUN  -  Sep 21, 2005
Anticonvulsants: Carbamaze-pine (Tegretol), felbamate (Felbatol), gabapentin (Neurontin), lamotrigine (Lamictal), oxcarbazepine (Trileptal), ... $2.95 - St. Paul Pioneer Press - NewsBank

Frank Berger  -  Apr 8, 2008
...developing the pain reliever carisoprodol (brand-named Soma) and the epilepsy drug felbamate (brand-named Felbatol), among other drugs. ... Telegraph.co.uk

Acetaminophen poisoning is on the increase | Article from The Record...  -  Dec 27, 2005
The Record (Bergen County, NJ); October 5, 1994 ; 700+ words ... ... epilepsy drug Felbatol be restricted due to risks of liver failure and aplastic anemia, ... Pay-Per-View - The Record - HighBeam Research

FDA panel opposes Depakote warning  -  Jul 11, 2008
Additional products included in the FDA's review are Meda AB's Felbatol, UCB SA's Keppra, Novartis AG's Trileptal, Cephalon Inc.'s Gabitril, Eisai Co. ... Pay-Per-View - Chicago Tribune - ProQuest Archiver

ON THE PULSE | Article from Chicago Sun-Times | HighBeam Research  -  Sep 5, 2005
...said it mailed letters with the Food and Drug Administration to 240000 physicians advising the immediate withdrawal of patients from the drug, Felbatol. ... Pay-Per-View - Chicago Sun-Times - HighBeam Research

Anticonvulsant hypersensitivity syndromes can manifest on skin.(Clinic...  -  Dec 1, 2006
Aromatic anticonvulsants include felbamate (Felbatol), fosphenytoin (Cerebyx), and primidone. Cross-reactivity can be avoided by choosing a nonaromatic ... Free with registration - Skin & Allergy News - AccessMyLibrary.com

Treatment of Comorbid Sleep Disorders Improves Seizure Control  -  Jun 1, 2007
..."One that's really problematic is felbamate [Felbatol], which is only used in very difficult cases of epilepsy. But among all of the drugs that are on the ... Psychiatric Times

Accident changes girl's life: She's out to change law  -  Jun 19, 2006
Among the decisions Miller has had to make include one to allow a doctor to prescribe Felbatol. The drug, which helps stop seizures, comes with a price. ... Online Athens

Etonogestrel and Ethinyl Estradiol ( Vaginal).(Drug overview)  -  May 1, 2006
Anticonvulsants (medicine for seizures) such as: Carbamazepine (eg, Epitol, Tegretol) or Felbamate (eg, Felbatol) or Oxcarbazepine (eg, Trileptal) or ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Sun Herald : Photosensitive medicines listed  -  Aug 23, 2007
Anti-convulsants: carbamazepine (Tegretol); felbamate (Felbatol); gabapentin (Neurontin); lamotrigine (Lamictal); oxcarbazepine (Trileptal); ... $2.95 - Sun Herald - NewsBank

Dr. Frank M. Berger, 1913 - 2008; Miltown creator launched new era of...  -  Mar 22, 2008
...the pain reliever carisoprodol (brand-named Soma) and the epilepsy drug felbamate (brand-named Felbatol), as well as a method for purifying penicillin. ... Pay-Per-View - Los Angeles Times - ProQuest Archiver

Norelgestromin and Ethinyl Estradiol ( Systemic).(Drug overview)  -  Aug 1, 2006
Ampicillin or Barbiturates (eg, Amytal, Nembutal) or Carbamazepine (eg, Tegretol) or Felbamate (eg, Felbatol) or Griseofulvin (eg, Fulvicin-P/G) or HIV ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

The reason for those liver tests.  -  Mar 25, 2005
Arthrotec), efavirenz (Sustiva), ethotoin (Peganone), ethosuximide (Zarontin), felbamate (Felbatol), fenofibrate (Tricor), fluconazole (Diflucan), ... Free with registration - Sun Herald - AccessMyLibrary.com

FDA requires suicide warning on some drugs  -  Dec 17, 2008
Klonopin, Tranxene, Depakote, Depakote ER, Depakene, Zarontin, Peganone, Felbatol, Neurontin, Lamictal, Vimpat, Keppra, Mesantoin, Celontin, Trileptal, ... Money Times - The Money Times

Norelgestromin and Ethinyl Estradiol ( Systemic).  -  Feb 1, 2006
Ampicillin or Barbiturates (eg, Amytal, Nembutal) or Carbamazepine (eg, Tegretol) or Felbamate (eg, Felbatol) or Griseofulvin (eg, Fulvicin-P/G) or HIV ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Press of Atlantic City, The : Question & Answer from the pharmacy:...  -  Aug 27, 2007
Anticonvulsants: carbamazepine (Te-gretol); felbamate (Felbatol); gabapentin (Neurontin); lamotrigine (Lamictal); oxcarbazepine (Trileptal); ... $2.95 - Press of Atlantic City, The - NewsBank

For the Record  -  Mar 21, 2008
The same story incorrectly identified the brand name of the anti-seizure drug valproic acid as Felbatol. The correct brand name is Depakote. ... Pay-Per-View - Los Angeles Times - ProQuest Archiver

Divalproex sodium, Depakote, Depakene valproic acid (generic) (brand)...  -  Jun 1, 2005
Other drugs that may interact with valproate are aspirin (Empirin), felbamate (Felbatol), rifampin (Rifadin), clonazepam (Klonopin), diazepam (Valium), ... Free with registration - Brown University Child and Adolescent... - AccessMyLibrary.com

Dog functions as early warning system for boy held in grip of...  -  Oct 22, 2007
Jason Weasel, a coal miner, goes to the kitchen for a dose of felbatol, one of several antiseizure medications his son takes. ... Henderson Gleaner - Henderson Gleaner

For the record  -  Mar 24, 2008
The same story incorrectly identified the brand name of the anti-seizure drug valproic acid as Felbatol. The correct brand name is Depakote. ... Pay-Per-View - Los Angeles Times - ProQuest Archiver

Washington Administrative Code - WAC 260-70-680 This section …  -  Mar 17, 2006
Organon Ethylnorepinephrine Bronkephrine Etodolac Lodine Felbamate Felbatol Fenbufen Cincopal Fenoldopam Corlopam Fenoprofen Nalfon Fenoterol Berotec ... Pay-Per-View - Washington Administrative Code - Loislaw

"Old" Versus "New" Antiepileptic Drugs  -  Nov 1, 2005
The best-known example of this phenomenon in the epilepsy community is felbamate (Felbatol, MedPointe), the first of the new AEDs to receive FDA approval in ... Psychiatric Times

New data on antiepileptic drugs.(DRUGS, PREGNANCY, AND …  -  Oct 15, 2006
The human pregnancy experience is too limited to assess the embryo/fetal risk for the other second-generation agents: felbamate (Felbatol), ... $4.95 - Internal Medicine News - ECNext

Etonogestrel and Ethinyl Estradiol ( Vaginal).  -  Oct 27, 2005
Anticonvulsants (medicine for seizures) such as: Carbamazepine (eg, Epitol, Tegretol) or Felbamate (eg, Felbatol) or Oxcarbazepine (eg, Trileptal) or ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

First-generation anticonvulsants.(Drugs, Pregnacy, And Lactation)( …  -  Sep 1, 2006
The human pregnancy experience is too limited to assess the embryo/fetal risk for the other second-generation agents: felbamate (Felbatol), ... Pay-Per-View - Family Practice News - Factiva, from Dow Jones

A Guide to Interventions for Pediatric Seizure Disorders  -  Jul 1, 2005
...serious adverse effects attributed to the newer drugs may not be evident until they have been more widely used, as in the case of felbamate (Felbatol, ... Psychiatric Times

Think twice before buying cough medicine | Article from The Record ( …  -  Oct 28, 2008
The Record (Bergen County, NJ); October 5, 1994 ; 700+ words ... ... involving the epilepsy drug Felbatol as well as a prescription cough medicine that had ... Pay-Per-View - The Record - HighBeam Research

Southern Illinoisan : Lifestyles<br>  -  Sep 20, 2005
...dapsone, diclofenac (Voltaren, Arthrotec), efavirenz (Sustiva), ethotoin (Peganone), ethosuximide (Zarontin), felbamate (Felbatol), gemfibrozil (Lopid), ... $2.95 - Southern Illinoisan - NewsBank

抗癫痫�?��?�能引起患者自�?�  -  Feb 29, 2008
...被纳入分�?的抗癫痫�?�包括:�?�马西平(商�?�??Carbatrol�?Equetro�?Tegretol和Tegretol XR)�?�?�尔安酯(商�?�??Felbatol)�?加巴喷�?(商�?�??Neurontin)�?拉莫三嗪(商�? ... 浙江在线

Southern Illinoisan : Lifestyles<br>  -  Mar 29, 2005
Arthrotec), efavirenz (Sustiva), ethotoin (Peganone), ethosuximide (Zarontin), felbamate (Felbatol), fenofibrate (Tricor), fluconazole (Diflucan), ... $2.95 - Southern Illinoisan - NewsBank

Medicaid drug restrictions concern advocates  -  Dec 11, 2005
For instance, with anticonvulsants and antipsychotic medications, all the available drugs are preferred, except Felbatol, Zyprexa and Symyax. ... $3.50 - Bucks County Courier Times - NewsBank

Contraception for Adolescent Women With Coexisting Medical Conditions  -  Jul 10, 2008
...barbiturates [phenobarbital, primidone], carbamazepine [Tegretol], oxcarbazepine [Trileptal], felbamate [Felbatol], topiramate [Topamax], vigabatrin). ... Medscape

How to take Norelgestromin and Ethinyl Estradiol Transdermal from …  -  Jan 3, 2008
...felbamate (Felbatol), phenobarbital (Luminal, Solfoton), oxcarbazepine (Trileptal), phenytoin (Dilantin), and topiramate (Topamax); morphine (Kadian, ... consumerreports.org

SAM  -  Feb 6, 2008
The brand names of the drugs include Equetro, Tegretol, Felbatol, Neurontin, Lamictal, Keppra, Trileptal, Lyrica, Gabitril, Topamax, Depakote and Zonegran. ... Pay-Per-View - Winston-Salem Journal - ProQuest Archiver

Keppra.(New & Approved) | Article from Pediatric News | HighBeam …  -  Aug 1, 2005
Depakote, Depakote ER), felbamate (Felbatol), gabapentin (Neurontin), lamotrigine (Lamictal), levetiracetam (Keppra), oxcarbazepine (Trileptal), ... Pay-Per-View - Pediatric News - HighBeam Research

Article: Bipolar drugs may raise risk of osteoporosis.(Adult Psychiatr...  -  Feb 1, 2005
The AEDs in the meta-analysis were carbarmazepine (Carbatrol, Equetro), divalproex sodium (Depakote, Depakote ER), felbamate (Felbatol), ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Federal Register 2008 - 73 FR 32588 Joint Meeting of the Peripheral...  -  Jun 9, 2008
...(2) felbamate (marketed as FELBATOL, Meda Pharmaceuticals, Inc.); (3) gabapentin (marketed as NEURONTIN, Pfizer, Inc.); (4) lamotrigine (marketed as ... Pay-Per-View - Federal Register 2008 - Loislaw

Check choices for women with epilepsy  -  Oct 1, 2005
Agents that induce liver enzymes and may compromise OC efficacy include carbamazepine (Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), ... Pay-Per-View - Contraceptive Technology Update - Factiva, from Dow Jones

Article: FDA seeks suicide data for 14 anticonvulsants.(News) -...  -  Jun 15, 2005
Felbatol), gabapentin (Neurontin), lamotrigine (Lamictal ... Russell Katz, director of the FDA's division of neurology products ... ... Pay-Per-View - Family Practice News - HighBeam Research

FDA has issued an alert for the anti-epileptic drugs.  -  Mar 1, 2008
Tegretol, Novartis; generic carbamazepine), felbamate (Felbatol, MedPointe), gabapentin (Neurontin, Pfizer; generic gabapentin), lamotrigine (Lamictal, ... $9.94 - Formulary - Alacra Store

Press of Atlantic City, The : QUESTION & ANSWER FROM THE …  -  Mar 28, 2005
Arthrotec), efavirenz (Sustiva), ethotoin (Peganone), ethosuximide (Zarontin), felbamate (Felbatol), fenofibrate (Tricor), fluconazole (Diflucan), ... $2.95 - Press of Atlantic City, The - NewsBank

FDA has issued an alert for the anti-epileptic drugs.  -  Mar 1, 2008
Tegretol, Novartis; generic carbamazepine), felbamate (Felbatol, MedPointe), gabapentin (Neurontin, Pfizer; generic gabapentin), lamotrigine (Lamictal, ... $9.94 - Formulary - Alacra Store

FDA seeking suicidality data on 14 anticonvulsants.(News) | Article...  -  Jun 1, 2005
Felbatol), gabapentin (Neurontin), lamotrigine (Lamictal ... Russell Katz, director of the FDA's division of neurology products ... ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

항전간 치료약, �?살충�?� 등 '강력한 경고문' 추가  -  Jul 9, 2008
...현재 FDA가 시�? 허가 심사중�?� 제품으로 화�?��?사�?� 뉴론틴(Neurontin)과 리리카 (Lyrica), 메다 AB사�?� 휄바톨(Felbatol), UCB�?� 케프�?�(Keppra), 노바티스�?� 트리 ... 메디�?�뉴스

¡Ojo con las medicinas!  -  Feb 2, 2008
Carbatrol, Equetro, Tegretol, Tegretol XR, Felbatol, Neurontin, Lamictal, Keppra, Trileptal, Lyrica, Gabitril, Topamax, Depakote, Depakote ER, Depakene, ... Primera Hora

美 항간질제 �?살위험 경고  -  Feb 1, 2008
...�?�번 분�?�? �?�함�?� 항간질제는 '카바트롤'(Carbatrol, carbamazepine), '펠바톨'(Felbatol, felbamate), '뉴론틴'(Neurontin, gabapentin), '�?�믹탈'(Lamictal, ... 디지틀보사

Brand Names/Synonyms:
Felbatol is also known by the following brand names and/or synonymsADD-03055; Felbamate; Felbamyl; Felbatol; Taloxa; W-554

Drug Category:
Felbatol is categorized under the following by the FDA: Antiepileptic Agents; Anticonvulsants; Neuroprotective Agents; ATC:N03AX10

Dosage Forms:
tablet; suspension

Absorption:
>90%

Interactions:
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Chemical IUPAC Name:
trideca-1,3,11-trien-5,7,9-triyne

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