Fenfluramine

This page contains recent news articles, when available, and an overview of Fenfluramine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Fenfluramine
(when available)

Pharmacology and use:
Used to treat diabetes and obesity, Fenfluramine decreases caloric intake by increasing serotonin levels in the brain’s synapses. Fenfluramine acts as a serotonin reuptake inhibitor. It also causes release of serotonin from the synaptosomes. For the management of exogenous obesity as a short-term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction.

Mechanism Of Action:
Fenfluramine binds to the serotonin reuptake pump. This causes inhbition of serotonin uptake and release of serotonin. The increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates.

News Articles on Fenfluramine

Lorcaserin, nouvelles données sur la pilule lorcaserin de Arena  -  14 Nov 2009
La pilule lorcaserin fonctionne d'une manière similaire à la fenfluramine. Lorcaserin est conçu pour bloquer les signaux d'appétit dans le cerveau, ... RegimesMaigrir.com

The Mulligan Law Firm is Investigating Injury Claims: The Weight Loss Drugs ...  -  ‎Oct 23, 2009‎
It is a combination of two drugs: fenfluramine and phentermine. Not approved by the FDA ("off label"), it was nevertheless widely prescribed as the result ... PR Web (press release)

Nurse took Fen-phen, Diagnosis PPH  -  ‎Oct 26, 2009‎
...(Pondimin is the brand name for fenfluramine. Fen phen, which was withdrawn from the market in 1997, is a combination of fenfluramine and phentermin. ... Lawyers and Settlements

Brand and Generic ADIPEX (Phentermine). FDA approved. Fast Delivery ...  -  ‎Oct 31, 2009‎
Metric conversions are as a single daily administered before fenfluramine. During or within a phentermine with few weeks. Primary pulmonary hypertension. ... Newstalk ZB

Arena: 2nd weight loss trial shows cardiac benefit  -  ‎Oct 27, 2009‎
Lorcaserin works in a way similar to fenfluramine, which was part of the fen-phen diet cocktail before it was withdrawn in 1997 after being linked to heart ... Reuters India

Going Off-label Without Venturing Off-Course  -  ‎Oct 26, 2009‎
For example, fenfluramine hydrochloride and phentermine hydrochloride were approved by the FDA as individual agents for short-term use in the medical ... Archives of Internal Medicine

Companies Race To Bring Diet Drugs To Market  -  ‎Oct 28, 2009‎
The medicine stimulates a receptor in the brain that curbs appetite while sparing a related receptor in the heart that was the downfall of fenfluramine, ... NPR

PPH and Fen-Phen Research Ongoing  -  ‎Nov 7, 2009‎
Although the disease is rare, it is 100 times more likely to occur among former users of Fen-Phen and other fenfluramine drugs like Redux and Pondimin. ... Lawyers and Settlements

Phentermine para adelgazar, contraindicaciones  -  ‎Nov 10, 2009‎
Tampoco pueden ingerirlo los que tomen fenfluramine (Phen-Fen) o dexfenfluramine (Redux), anorexígenos, ya que en estos casos se estarían arriesgando a ... Nutricion.pro

上海交大教授获新è?¯ç ”ç©¶æ–°æˆ?æžœ  -  ‎Nov 4, 2009‎
Antinociceptive properties of fenfluramine, a serotonin reuptake inhibitor, in a rat model of neuropathy. J. Pharmacol. Exp. Ther. 291: 1008-1016. 33. ... 生物通

Diet-Drug Lawyers Get 20, 25 Years for Stealing Funds  -  ‎Aug 17, 2009‎
Home Products Corp., now Wyeth, which was the manufacturer of the drugs fenfluramine and dexfenfluramine under the trade names Pondimin and Redux. Bloomberg

2 Kentucky product liability lawyers steal millions!  -  ‎Aug 20, 2009‎
The diet pills used in a combination dosing for obese patients needing to loose weight, known as Pondimin (fenfluramine) and Redux (dexfenfluramine), Justice News Flash

Hissey Kientz Announces the Launch of Herbal Fen Phen Lawyers Website  -  ‎Aug 8, 2009‎
After Pondimin (fenfluramine) and Redux (dexfenfluramine)—two drugs that were prescribed as part of the diet drug combination Fen Phen—were recalled in Emediawire (press release)

Buy Adipex. Buy cheap Adipex online without a prescription  -  13 Jul 2009
If co-administered with additional weight loss drugs such as Fenfluramine, it was demonstrated that the two medications add to the resistance to blood flow Cleveland Indy Media

BEST PHENTERMINE PILL ON THE INTERNET  -  ‎Jul 12, 2009‎
Another appetite suppressant, fenfluramine, acts on a different neurotransmitter, serotonin. Serotonin is involved in controlling mood and reduces the Cleveland Indy Media

Buy Phentermine. Buy cheap Phentermine online without a prescription  -  ‎Jul 12, 2009‎
Taking phentermine together with other diet medications such as fenfluramine (Phen-Fen) or dexfenfluramine (Redux) can cause a rare fatal lung disorder Cleveland Indy Media

Zicam recall: Manufacturer pulls intranasal cold remedy  -  ‎Jun 24, 2009‎
It should be noted that the Food and Drug Administration has recalled a number of FDA-approved medications over the years, notably Fenfluramine. Examiner.com

Napoli Bern Ripka & Associates Announces Lawsuits Continue to be ...  -  ‎Jul 9, 2009‎
The firm has successfully litigated claims of thousands of persons injured by the diet drugs Fenfluramine and dexfenfluramine (Redux(tm)), Rezulin, GlobeNewsWire (press release)

Anti-obesity drugs: Improving sleep may promote weight loss  -  ‎Jul 3, 2009‎
...with a comparable antagonist, TTA-A7, in DIO rats: body composition was improved beyond that observed with the appetite suppressant fenfluramine. Nature.com (subscription)

Judge Says Feds Can Seize $30 Million from Kentucky Diet Scam Lawyers  -  ‎Jun 20, 2009‎
Although fen-phen, a combination of fenfluramine and phentermine, was the subject of a massive national financial settlement, Gallion and Cunningham's Insurance Journal

Napoli Bern Ripka & Associates, LLP Announces Lawsuits Continue to ...  -  20 Apr 2009
The firm has successfully litigated claims of thousands of persons injured by the diet drugs Fenfluramine and dexfenfluramine (Reduxtm), Rezulin, Trading Markets (press release)

Research and Markets: China Pharmaceuticals and Healthcare Report ...  -  ‎Apr 16, 2009‎
The State Food and Drug Administration (SFDA) has finally banned a dangerous weight loss drug (fenfluramine), and a delegation of regulators took the Business Wire (press release)

Arena Defends Obesity Drug as Stock Plunges  -  ‎Mar 30, 2009‎
Lorcaserin has been under close scrutiny for heart valve damage because the drug is a close chemical cousin to fenfluramine, or the "fen" in the effective TheStreet.com

On Speed: The Many Lives of Amphetamine  -  ‎Mar 31, 2009‎
...which, with its numerous sister compounds, including methamphetamine, MDMA (ecstasy), methylphenidate and fenfluramine, are pivotal in the history of British Journal of Psychiatry

Politie houdt grote controle op traditionele Chinese medicijnen  -  ‎Apr 15, 2009‎
Vaak gaat het hierbij om verouderde, gevaarlijke middelen, zoals fenfluramine, al jaren verboden in de meeste Westerse landen. Medical facts

Courtroom View Network to Webcast Diet Drug Trial  -  ‎Mar 2, 2009‎
The case involves the diet drugs fenfluramine, phentermine, and dexfenfluramine, commonly known as Fen-Phen. The Food and Drug Administration asked drug dBusinessNews Atlanta (press release)

Don't count on pill to lose weight  -  ‎Mar 3, 2009‎
One of the most high-profile was Fen-phen, a cocktail of fenfluramine and phentermine, which was taken off the market in 1997 after it was linked to Stuff.co.nz

Weight loss centres cop a pounding from consumer group  -  ‎Feb 25, 2009‎
Most doctor prescribed phentermine, an appetite suppressant to held reduce weight and control appetite, and fenfluramine, which gives a feeling of fullness เดอะ เนชั่น

Other diet pills  -  Jan 21, 2009
Fenfluramine is an appetite suppressant. It is no longer available in the UK. Fenfluramine helped people lose weight by making them feel less hungry. guardian.co.uk,

China bans diet drug, says it can harm heart  -  Jan 9, 2009
BEIJING (AP) — China's top food and drug regulator has ordered a halt to the sale and production of the weight-loss drug fenfluramine hydrochloride, The Associated Press

Arena CEO expects to partner obesity drug  -  Jan 12, 2009
The drug, lorcaserin, is a serotonin activator like fenfluramine, half of the infamous fen-phen diet pill that was recalled a decade ago after being linked guardian.co.uk,

What treatments work for obesity?  -  Jan 21, 2009
They include fenfluramine, phenylpropanolamine and phentermine. More... National Institute for Health and Clinical Excellence. Understanding NICE guidance: guardian.co.uk,

Verizonwireless ringtones  -  Jan 17, 2009
...medication verizonwireless ringtones description the brain investigate. verizonwireless ringtones phone fenfluramine verizonwireless ringtones help you Griggs County Courier,

Multi-billion dollar industry Don't count on pills to lose weight  -  Jan 22, 2009
One of the most high-profile was Fen-phen, a cocktail of fenfluramine and phentermine, which was taken off the market in 1997 after it was linked to WELT ONLINE,

Weight-Loss Potions Have Hidden Surprises  -  Dec 23, 2008
...fail miserably when used on a chronic basis—like the notorious combination of two FDA-approved drugs called "fen-pfen" (fenfluramine and phentermine), U.S. News & World Report,

Researchers Seek Safer Obesity Drug  -  Dec 1, 2008
25 issue of Neuron, the researchers define a circuit in the brain that explains the ways fenfluramine, a component of Fen-phen, suppresses appetite. Consumer Affairs

Despite failures, search for obesity drugs still looks golden  -  Dec 9, 2008
Eleven years ago, the search for an obesity drug ran into controversy when fenfluramine, an appetite suppressant, was banned in the United States over fears Macau Daily Times,

Study: New Diet Drug Shows Promise  -  Dec 12, 2008
The Food and Drug Administration recalled Fen-phen because of reports that the other half of the drug’s component, fenfluramine, caused heart damage. FOXNews

Experimental Weight-Loss Pill Passes Early Test  -  Dec 12, 2008
The drug Fen-phen, a combination of fenfluramine and dexfenfluramine, worked for many but was withdrawn from the market in 1997 when it was linked with Washington Post,

Drug trial success a boost for Arena  -  Dec 9, 2008
But one of the two components of that drug made by Wyeth, fenfluramine, also hit a second target in the heart, which was linked to heart valve problems. San Diego Union Tribune,

Vivus to Roll Out Key Obesity Drug Data  -  Dec 3, 2008
...(And yes, it's the "phen" in fen-phen but it was "fen" or fenfluramine and not phentermine that was later discovered to be toxic drug in the combination. TheStreet.com

Mechanism Behind Regulation of Food Intake Identified  -  Nov 29, 2008
Further, 5-HT2CRs are known to contribute to the appetite suppressant effects of d-fenfluramine, a drug widely prescribed to combat obesity in the 1990s MedIndia,

Diet pills a dangerous way to lose  -  21 Nov 2008
The product was a mix of two other diet drugs, fenfluramine and phentermine. It was pulled from the market after otherwise healthy users began developing MSU The Trail Blazer Online,

Valvular regurgitation and surgery associated with fenfluramine ...  -  Nov 6, 2008
Valve surgery was performed on 38 patients (0.66% of 5743), 25 (0.44%) with clear evidence of fenfluramine-related etiology. 7thSpace Interactive (press release),

Lasting Damage From Fen-Phen Drug?  -  Nov 5, 2008
The study shows that heart valve problems linked to the banned obesity drugs fenfluramine and/or dexfenfluramine typically last years after stopping those WebMD

Diet Drug Fen/Phen Still Causing Damage  -  Nov 6, 2008
Fenfluramine, part of the fen/phen obesity drug that was banned in the US in 1997 after it was linked to heart problems, is still causing damage, FoxReno.com,

Banned Obesity Drug Tied to Heart Risks Long After Use  -  Nov 7, 2008
The appetite suppressant fenfluramine has been banned in the United States since 1997, because of its links to heart damage. Thousands of lawsuits have been Washington Post,

Despite failures, search for obesity drugs still looks golden  -  Nov 15, 2008
Eleven years ago, the search for an obesity drug ran into controversy when fenfluramine, an appetite suppressant, was banned in the United States over fears AFP

Valve Problems from Banned Diet Drug Persist  -  Nov 5, 2008
5 -- Heart valve damage from the banned diet drugs fenfluramine and dexfenfluramine can persist for many years, researchers here said. MedPage Today,

Fen-Phen Left Long-Lasting Damage to the Heart  -  Nov 6, 2008
Problems linked to the banned obesity drugs fenfluramine and dexfenfluramine, which together formed the blockbuster diet drug Fen-Phen, lasted for years Attorney at Law

Fen/phen diet drug now tied to heart valve damage  -  Nov 8, 2008
Banned in the US since 1997, the appetite suppressant fenfluramine was eliminated from the marketplace due to its links to heart damage. CaymanMama.com (press release),

How to Choose the Right Weight Loss Pills For You?  -  Nov 3, 2008
Some ingredients may be very like fen-phen or fenfluramine and phentermine. Studies show that these two affect the heart and nervous system adversely. Best Syndication,

Vicar tells of diet drug hell  -  Nov 5, 2008
By Chris Visser An overweight Lancashire vicar has told how his life was made hell by a banned diet pill linked to suicide. Father Timothy Lipscomb took the Lancashire Evening Post,

Local study explores dangers of fen-phen over time  -  Nov 6, 2008
The appetite suppressant fenfluramine -- the "fen" half of the drug -- was banned by the US Food and Drug Administration in September 1997 over fears it Daily Herald,

Composition Comprising Licorice Polyphenol  -  Nov 20, 2008
...but are not limited to, fenfluramine, fluoxetine, mazindol and the like as pharmaceutical products that suppress appetite, and acarbose, voglibose, FLEXNEWS,

Médicaments amaigrissants retirés il ya 11 ans: séquelles toujours ...  -  Nov 8, 2008
Charles Dahl et ses collègues de la Central Utah Clinic (É.-U.) ont étudié la condition cardiaque de 5743 utilisateurs de la fenfluramine. PsychoMédia,

불법 다ì?´ì–´íŠ¸ì„±ë¶„ ë?Šì?€ ì§€ 7ë…„ 후ì—?ë?„ '심장장애' 유발  -  Nov 6, 2008
...국내�서 다�어트 제품� 불법�으로 혼입�는 대표� 성분� '펜플루�민(fenfluramine)'��는 �욕억제성분� 11년전 중단한 사람�서� 7년� 지나서까지 심장 Medical Today,

GAZETA: Pesquisa sobre obesidade pode estar em risco  -  Oct 27, 2008
...fenfluramine e phentermine, prescritas 6 milhões de vezes antes de ser recolhido por causa dos efeitos colaterais fatais há mais de uma década. Gazeta Mercantil,

Health Canada Warns Against ARMA  -  Sep 24, 2008
Fenfluramine was previously used in the treatment of obesity but is currently prohibited for sale in Canada. Use of sibutramine may cause headaches, eMaxHealth.com,

House call with Dr. Andy: Weigh the pros, cons of diet pills  -  Sep 29, 2008
Several years ago the Fen part (Fenfluramine) was pulled from the market due to adverse health risks. Phentermine is a very effective weight loss medication The News-Press,

The Gossip Page  -  Oct 16, 2008
The 21 year old former world champion tested positive for the stimulant fenfluramine, used a weightloss drug, on 5 July at the U23 European championships in Podium Cafe

An Obesity Drug Pipeline Report: The Development of Therapies for ...  -  Oct 6, 2008
...notable safety failures of several late-stage and marketed obesity drugs (such as the notorious case of Fen-Phen [fenfluramine/phentermine]), Business Wire (press release),

Aggression, Suicide, and Lithium Treatment  -  Oct 1, 2008
Actually, positron emission tomography studies have shown reduced response in the prefrontal cortex and anterior cingulate gyrus after fenfluramine Am J Psychiatry (subscription)

Lawsuits Filed in the Wake of Bayer Pulling Trasylol From the ...  -  Sep 25, 2008
The firm has successfully litigated claims of thousands of persons injured by the diet drugs Fenfluramine and dexfenfluramine (Redux(tm)), Rezulin, Trading Markets (press release),

La Psicologia a Tavola. – "Mangio quel che sono" – influenze psico ...  -  Sep 25, 2008
...individuali verso la nutrizione risentono dell'assunzione di 5-idrossitriptofano, fluoxetina e d-fenfluramina, ma non delle altre fenfluramine. Scienza e Psicoanalisi,

Brand Names/Synonyms:
Fenfluramine is also known by the following brand names and/or synonyms:
Acino; Adipomin; CHEMBANK1560; Dea No. 1670; F1884; Fenfluramina [Dcit]; Fenfluramine; Fenfluramine Hydrochloride; Fenfluraminum [Inn-Latin]; HSDB 3080; Obedrex; Pesos; Ponderax Pa; Ponderex; Pondimin; Rotondin; S 768

Drug Category:
Fenfluramine is categorized under the following by the FDA: Serotonin reuptake inhibitor; Anorexigenic Agents; Stimulants; ATC:A08AA02; ATC:A08AA04

Dosage Forms:
TABLET

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
N-ethyl-1-[3-(trifluoromethyl)phenyl]-propan-2-amine





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