Fentanyl

This page contains recent news articles, when available, and an overview of Fentanyl but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Fentanyl
(when available)

Pharmacology and use:
Fentanyl is an opioid analgesic. Fentanyl interacts predominately with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, spinal cord, and other tissues. In clinical settings, Fentanyl exerts its principal pharmacologic effects on the central nervous system. Its primary actions of therapeutic value are analgesia and sedation. Fentanyl may increase the patient's tolerance for pain and decrease the perception of suffering, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Fentanyl depresses the respiratory centers, depresses the cough reflex, and constricts the pupils. For the treatment of cancer patients with severe pain that breaks through their regular narcotic therapy.

Mechanism Of Action:
Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Fentanyl's analgesic activity is, most likely, due to its conversion to morphine. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

News Articles on Fentanyl

Man charged with murder in 2008 death of Magnolia Springs woman  -  14 Nov 2009
At some point in the evening, she applied a fentanyl adhesive patch to her skin, Baker said. "We believe the drug was administered through the patch to her ... al.com

$150000 of drugs dumped in collection effort  -  14 Nov 2009
They dropped off medications including Fentanyl patches, Oxycontin, methadone, morphine, Vicodin and others. One bottle contained 240 Vicodin pills. ... Midland Daily News

Enforcement, regulation of Rx medicines lacking  -  14 Nov 2009
Combinations of illicit drugs such as Xanax, Oxycodone, methadone, Fentanyl, cocaine, Prozac, Vicodin, methamphetamine, Alprazolam, ... Colusa County Sun Herald

Taking a year off  -  14 Nov 2009
...and a young woman died of overdoses of drugs that included prescription methadone used to control pain, Fentanyl, another potent painkiller and alcohol. ... The Keene Sentinel

Covidien Receives FDA Approval for Oral Transmucosal Fentanyl Citrate Product  -  ‎Oct 30, 2009‎
It is a solid formulation of fentanyl that resembles a lozenge on a handle. Oral Transmucosal Fentanyl Citrate, a Class II controlled substance, ... Reuters

Updated: Police investigate robbery of Waimea pharmacy  -  ‎Nov 13, 2009‎
An unidentified man wearing camouflage clothing and armed with a handgun entered the pharmacy off Kawaihae Road and demanded Fentanyl and Oxycontin. ... Hawaii 24/7

County official in Missouri faces drug charges  -  ‎Nov 6, 2009‎
The sheriff's department said Friday that Bass bought the prescription painkillers morphine and fentanyl from an informant on Wednesday in the parking lot ... Kansas City Star

Hepatitis Scare In Colorado Not Over Yet  -  ‎Nov 2, 2009‎
Parker, 26, is infected with hepatitis C and recently agreed to a plea agreement on charges stemming from her alleged theft of Fentanyl syringes and was ... Newsinferno.com

Woman gets up to 6 years in overdose death case  -  ‎Nov 6, 2009‎
Dawn Cote was sentenced in Berkshire Superior Court on Thursday after being convicted in September of manslaughter for selling Fentanyl patches to ... Boston Herald

Commissioner Bass arrested for purchasing narcotics  -  ‎Nov 9, 2009‎
4, 2009, narcotics investigators observed Bass illegally purchasing morphine and the highly potent prescription painkiller fentanyl. The fentanyl patch is ... Lincoln County Journal

Woman sentenced for stealing nursing home meds  -  ‎Nov 10, 2009‎
Staff said Fentanyl patches, used for pain management, had been removed from three female residents. Fentanyl is a powerful pain medication similar to ... Clinton Herald

NJ cops prod parents to protect teens from prescription-drug abuse  -  ‎Nov 12, 2009‎
...on the abuse of prescription drugs, a sobbing woman came up to him and told of her daughter's near death from an overdose of the painkiller fentanyl. ... The Star-Ledger - NJ.com

Pharmaceutical Journal - Instanyl gets green light from SMC  -  ‎Nov 12, 2009‎
Fentanyl nasal spray (Instanyl) is one of five medicines accepted for use within NHS Scotland; a further two have been rejected in the latest round of ... DeHavilland (press release) (subscription)

Drug-swapping nurse tests negative for HIV  -  ‎Nov 5, 2009‎
Daigle admitted he stole the drug Fentanyl to feed a years-long painkiller addiction, at times using dirty needles to replace the drug with saline solution ... 9NEWS.com

Illegal Painkillers Land One County Commissioner in Prison  -  ‎Nov 11, 2009‎
Matthew Bass of Lincoln County Mo. was busted for purchasing the highly addictive painkillers morphine and fentanyl outside of his restaurant “Krumbly ... PublicCEO.com (blog)

DA: Drug overdose deaths staggering  -  ‎Nov 7, 2009‎
Capeless said that prescription opiates like OxyContin, Fentanyl, Percocet and Percodan pose a much deadlier problem than heroin in the Berkshires. ... Berkshire Eagle

You Almost Made It, Frankie  -  ‎Oct 24, 2009‎
He overdosed on his pain medication and the medics found him on the floor with seven Fentanyl patches pressed to his skin. Fentanyl is a powerful narcotic ... Seattle Post Intelligencer

biodelivery Sciences to Present at the Lazard Capital Markets 6th Annual ...  -  ‎Nov 12, 2009‎
Dr. Sirgo will be providing an update on the October 2009 commercial launch of ONSOLIS (fentanyl buccal soluble film) as well as an update on bdsi's product ... Earthtimes (press release)

Mallinckrodt painkiller gets FDA OK  -  ‎Nov 2, 2009‎
The Oral Transmucosal Fentanyl Citrate is an opiod analgesic designed for cancer patients to place inside the cheek for pain relief. ... St. Louis Business Journal

Woman gets 8 years in drug death  -  ‎Nov 7, 2009‎
...sentenced to eight years in prison -- the maximum outlined in her plea agreement -- for injecting a Hobart man with fentanyl, which caused his death. ... Gary Post Tribune

Cephalon Announces Deal With Barr To Settle Patent Infringement Suit - Update  -  ‎Nov 12, 2009‎
...and methods of use of solid solution formulations of fentanyl and other compounds, and methods of use, and does not expire until 2019. ... RTT News

Search warrant results in several drug related arrests  -  ‎Nov 5, 2009‎
Leonard HOLLETT, 45 years old of Fisher St. is charged with 2 counts of trafficking in Fentanyl and 2 counts of Breach of Probation. ... Bay Today

Nurse who stole painkillers still waiting to learn fate  -  ‎Oct 26, 2009‎
BOULDER - A former surgical nurse at Boulder Community Hospital will wait a little longer before learning his fate for stealing the drug fentanyl from ... 9NEWS.com

Apotex to Distribute Important Transdermal System for Management of Chronic ...  -  ‎Oct 20, 2009‎
Apotex will sell to the US healthcare market, Hisamitsu's recently FDA approved matrix Fentanyl Transdermal System for the management of chronic pain. ... Reuters

AC grand jury returns 12 indictments  -  ‎Nov 4, 2009‎
Daniel John Osgood - possession of Fentanyl, state jail felony; on or about Aug. 26, 2009; possessed Fentanyl in an amount of less than one gram; ... Rockport Pilot

Sharing Prescriptions Can Bring Harm, Not Healing  -  ‎Nov 11, 2009‎
In one tragic case, a 6-year-old with neck pain was found unconscious in bed the day after her foster mother placed a leftover fentanyl patch on the girl's ... U.S. News & World Report

Russia Expands Its Chemical Arsenal, Exposing Treaty's Faults  -  ‎Nov 2, 2009‎
To some, the use of fentanyl was a resounding success; Crowley quotes a NATO report saying that “although it may seem excessive that 16% of the 800 hostages ... Wired News

Mylan Reports Third Quarter Adjusted Diluted EPS of $0.32  -  ‎Oct 29, 2009‎
Mylan's Fentanyl Transdermal System (Fentanyl), Mylan's AB-rated generic alternative to Duragesic®, continued to contribute significantly to both revenue ... Reuters

Auxilium Pharmaceuticals to Present at the Credit Suisse 18th Annual Global ...  -  ‎Nov 10, 2009‎
Auxilium's transmucosal film product candidate for the treatment of overactive bladder (AA4010) and its fentanyl pain product using its transmucosal ... CNNMoney.com (press release)

Drugs stolen from ambulance station  -  ‎Oct 25, 2009‎
A police spokesman said the drugs - adrenaline, morphine and fentanyl - were dangerous if administered incorrectly. "Members of the public are advised to be ... Illawara Mercury

Judge finds evidence of perjury; binds Scott over to circuit court  -  ‎Oct 22, 2009‎
During Scott's plea, he also implicated his 63-year-old mother by stating that she had him sell her prescription Fentanyl patches to Cox for $40 a piece. ... Petoskey News-Review

Pivotal Data Published in the Journal Cancer Demonstrate that TREANDA Induced ...  -  ‎Nov 5, 2009‎
PROVIGIL® (modafinil) Tablets [C-IV] and ACTIQ® (oral transmucosal fentanyl citrate) [C-II]. The company also markets numerous products internationally. ... Reuters

Alexza Reports 2009 Third Quarter Financial Results and Updates AZ-004 ...  -  ‎Nov 9, 2009‎
Product candidates that have completed Phase 1 testing are AZ-003 (Staccato fentanyl) for the treatment of breakthrough pain, and AZ-007 (Staccato zaleplon) ... CNNMoney.com (press release)

Cephalon, Inc. to Webcast R&D Day  -  ‎Nov 4, 2009‎
GABITRIL® (tiagabine hydrochloride) and ACTIQ® (oral transmucosal fentanyl citrate) [C-II]. The company also markets numerous products internationally. ... Reuters

Orexo AB (STO:ORX) to Release Q3 2009 Earnings November  -  ‎Nov 4, 2009‎
The product is a sublingual form of fentanyl used to help cancer patients with breakthrough pain episodes. Once the approval process has been completed, ... TransWorldNews (press release)

Island runs short of cancer drug  -  ‎Nov 6, 2009‎
But the patches contain a potent narcotic called Fentanyl, which is on a list of controlled substances which require an international permit under the ... Bermuda Sun

Today: Slight Chance Rain/Snow  -  ‎Nov 3, 2009‎
Inside were needles and several Fentanyl patches, a controlled substance. Snyder did not have a prescription for the patches. The original charge of theft ... WCBC Radio

Mayo Clinic Proceedings Publishes Study of NUVIGIL in Patients with Shift Work ...  -  ‎Nov 2, 2009‎
TREANDA(R) (bendamustine hydrochloride) for Injection, AMRIX(R) (cyclobenzaprine hydrochloride extended-release capsules), FENTORA(R) (fentanyl buccal ... Reuters

YM BioSciences Q1 Loss Widens - Update  -  ‎Nov 11, 2009‎
...currently developing two late-stage products namely nimotuzumab, an Affinity-Optimized Antibody and AeroLEF, a liposome-encapsulated fentanyl compound. ... RTT News

Meda AB (publ) - Interim report, January -September 2009  -  ‎Nov 2, 2009‎
The FDA approved Onsolis (fentanyl). This new patented drug is indicated for the management of breakthrough pain in cancer patients. ... WELT ONLINE

FDA Aims To Cut Drug Errors, Issues Liquid Medicine Guidelines  -  ‎Nov 4, 2009‎
Such opioid drugs, formulated in extended-release versions of OxyContin, morphine and fentanyl patches, are meant for round-the-clock pain management for ... Wall Street Journal

Marijuana and my husband's struggle with cancer  -  ‎Oct 23, 2009‎
In addition to help controlling his nausea, marijuana did a great job on breakthrough pain that his 200-milligram Fentanyl patch and oral pain medications ... Bangor Daily News

State marijuana law clashes with federal authority  -  ‎Nov 10, 2009‎
It has improved her quality of life by reducing the amount of prescribed opiates she takes, such as Vicodin, fentanyl and morphine. ... The South End

Sentencing Rescheduled For Nurse Guilty Of Infecting 16 With Hepatitis  -  ‎Oct 21, 2009‎
7 Jones admitted to an addiction to Fentanyl, a highly addictive narcotic used in hospitals. In doing so, he infected the patients with a rare strain of ... KFOXtv.com

Stakeholders Get Second Chance to Comment on Proposed Opioid REMS  -  ‎Oct 21, 2009‎
...of brand and generic drugs formulated with the following active ingredients: fentanyl, hydromorphone, methadone, morphine, oxycodone and oxymorphone. FDA news (subscription)

Cephalon Appoints Bob Repella as Senior Vice President of U.S. Pharmaceutical ...  -  ‎Oct 27, 2009‎
AMRIX® (cyclobenzaprine hydrochloride extended-release capsules), FENTORA® (fentanyl buccal tablet) [C-II], TRISENOX® (arsenic trioxide) injection, ... Reuters

Cephalon Net Sales Increase 9% and Net Cash from Operations Surpasses $200 ...  -  ‎Oct 27, 2009‎
...trioxide) injection, GABITRIL® (tiagabine hydrochloride), NUVIGIL® (armodafinil) Tablets [C-IV] and ACTIQ® (oral transmucosal fentanyl citrate) [C-II]. ... Reuters

WASHINGTON COUNTY SHERIFF'S OFFICE NEWS RELEASES FOR TUESDAY 10 NOV 09  -  ‎Nov 10, 2009‎
...residence from noon until 4 pm and at some point during that time frame an unknown suspect(s) entered his home and stole a box of ten Fentanyl patches. ... Marietta Register Online

drug crime results in stiff sentence  -  ‎Nov 8, 2009‎
Investigators said Arnold sold a fentanyl patch, a painkiller commonly used to treat cancer patients, to Anderson and another man who ended up in the ... Asheville Citizen-Times

Alexza to Announce 2009 Third Quarter Financial Results and Update Its AZ-004 ...  -  ‎Nov 2, 2009‎
Product candidates that have completed Phase 1 testing are AZ-003 (Staccato fentanyl) for the treatment of breakthrough pain, and AZ-007 (Staccato zaleplon) ... Reuters

Police plan fentanyl fight: Joint effort targets Mexican suppliers.  -  Jun 16, 2006
Jun. 16--At the end of a two-day conference on the painkiller fentanyl, police and federal drug investigators said they are better informed about the ... Free with registration - Chicago Tribune - AccessMyLibrary.com

Fentanyl deaths topped 1,000 over two years  -  Jul 24, 2008
ATLANTA - More than 1000 people died over two years from an illegal version of the painkiller fentanyl, the government reported Thursday in its first ... msnbc.com

Deaths Seen With Fentanyl Narcotic Pain Patch  -  Jul 15, 2005
By Michael W. Smith. The FDA today has issued a health advisory regarding the safe use of fentanyl skin patches (brand name Duragesic) in response to ... FOXNews

FDA Warns Again on Fentanyl Patches  -  Dec 21, 2007
By Miranda Hitti. Dec. 21, 2007 -- Spurred by patient deaths and life-threatening side effects, the FDA today issued its second warning about misuse of skin ... WebMD

Fentanyl Painkiller Patches Recalled  -  Feb 13, 2008
By NATASHA T. METZLER, AP Writer. WASHINGTON — Patches containing the prescription painkiller fentanyl were recalled Tuesday, because of a flaw that could ... FOXNews

Key source of lethal heroin reported: Pennsauken mill mixed in fentany...  -  Dec 21, 2006
Police and federal agents discovered 300 grams of fentanyl and nearly a ... Fentanyl flooded drug corners across the nation in the spring and summer, ... Free with registration - Philadelphia Inquirer - AccessMyLibrary.com

US fentanyl pain patch recall grows  -  Feb 18, 2008
Another US company that markets fentanyl patches has recalled some of the painkillers as a precaution. Actavis Inc. said Sunday that it was recalling 14 ... CBC.ca

… homicide arrested again: Heroin charge follows fentanyl-tied...  -  Feb 2, 2007
Packets of fentanyl-laced heroin were found with his body, investigators said. Roti, the police commander, said Thursday that problems with fentanyl-laced ... Free with registration - Chicago Tribune - AccessMyLibrary.com

Raids target gang ring behind deadly heroin  -  Jun 22, 2006
Since then, heroin mixed with fentanyl has been linked to hundreds of ... The DEA suspects the fentanyl was smuggled into the USA from clandestine labs in ... USA Today

Fentanyl deaths rise: mom: cops failed to act on OD: son died last...  -  May 25, 2006
May 25--When Justin Wortmann's life ended in December in a White Castle parking lot after he took a dose of heroin, it was a silent warning about an ... Free with registration - Detroit Free Press - AccessMyLibrary.com

Hospital: Nurse Tampered With Painkiller Fentanyl  -  Mar 10, 2008
MINNEAPOLIS — A Mankato hospital suspended a nurse for tampering with its stock of fentanyl, a powerful pain medication, and has notified 335 patients that ... FOXNews

… deaths: Mickey Cobras members sold fentanyl-laced drug: indictment  -  Mar 2, 2007
Thirteen others are charged with conspiracy to make fentanyl at a ... The Mickey Cobras were among those who bought the fentanyl, according to the Drug ... $2.95 - Chicago Sun-Times - NewsBank

… drug war: 'the best high they've ever had'.(the fentanyl-heroin...  -  Jun 12, 2006
Cops know it as a deadly mix of heroin and fentanyl, an anesthetic and ... For cancer patients racked with pain, legally prescribed fentanyl can be a ... Free with registration - Newsweek - AccessMyLibrary.com

Watson recalls single lot of fentanyl patches  -  Apr 4, 2008
NEW YORK (Reuters) - Watson Pharmaceuticals has recalled one lot, or about 28000 units, of its fentanyl pain patch after ingredient levels were found to ... Reuters

Mylan Holds Ground on Forecast  -  Jul 19, 2005
Mylan has been selling a generic version of the fentanyl transdermal patch for six months. The brand-name patch is called Duragesic, which is made by ... TheStreet.com - TheStreet.com (subscription)

A Deadly Heroin Mixture Is Claiming Dozens of Lives  -  May 28, 2006
The disease control centers have no national statistics on fentanyl deaths ... In Chicago, 30 people have died from fentanyl or fentanyl-laced heroin from ... New York Times

Law ups the prison time for those selling fentanyl  -  Aug 23, 2007
Cook County prosecutors applauded the signing last week of a state bill to increase prison sentences for dealers caught selling the deadly drug fentanyl. ... Pay-Per-View - Chicago Tribune - ProQuest Archiver

Teen OD's, Dies After Stealing Fentanyl  -  Mar 19, 2008
A 17-year-old high school football player died Sunday morning after he overdosed on fentanyl, The Citizen-Times of Asheville, NC, reported. ... FOXNews

Pain Patch Wins High Marks In Children  -  Nov 14, 2005
Consider the Duragesic (fentanyl transdermal system) patch for managing ... Fifty percent of children who were switched to the Duragesic (fentanyl ... CNN

Addicts keep using Fentanyl in US despite hundred deaths  -  Jun 18, 2006
BEIJING, June 18 (Xinhuanet) -- Fentanyl-laced heroin has killed over one hundred in the United States, but that does not stop hardened drug addicts from ... 新�网

Fentanyl cases cited for rise in drug deaths in '06.(Brief article)  -  Jan 26, 2007
Jan. 26--Drug deaths soared by at least 20% in Wayne County last year, the result of a deadly mix of heroin and cocaine laced with fentanyl that received ... Free with registration - Detroit Free Press - AccessMyLibrary.com

… Sciences: FDA accepts for filing BEMA Fentanyl new drug application  -  Jan 10, 2008
SAN FRANCISCO (Thomson Financial) - BioDelivery Sciences International Inc. said Thursday the Food and Drug Administration has accepted for filing its new ... Forbes

Fentanyl tied to homicide ; 1st case in Illinois related to painkiller  -  Aug 25, 2006
On June 6, Krecker went to a friend's home and the friend heard Krecker call [Corey Crump] and arrange to buy $50 worth of heroin, [Lamas] said. ... Pay-Per-View - Chicago Tribune - ProQuest Archiver

Regulators Probe Pain Patches  -  Jul 18, 2005
The Duragesic patch contains the opioid painkiller fentanyl, which is also available in a generic formulation made by Mylan Laboratories (MYL Quote). ... TheStreet.com - TheStreet.com (subscription)

Fentanyl: Fatal euphoria: How this chemist in Mexico and this...  -  Jun 24, 2007
Ricardo Valdez, rogue chemist, never met Bloomfield Township teenager Lauren Jolly. Or retired Detroit autoworker Fred Lee Rogers. ... Free with registration - Detroit Free Press - AccessMyLibrary.com

Lethal form of heroin takes steep toll here  -  Jun 6, 2006
Fentanyl might also be coming from other sources, he said. ... The US Drug Enforcement Administration is testing samples of fentanyl seized in a May 28 raid ... Pittsburgh Post-Gazette - Pittsburgh Post Gazette

Fentanyl pain patches recalled in Canada  -  Feb 15, 2008
In the latest of several alerts on the safety of fentanyl pain-relief patches, Health Canada has announced the recall of two brands of the powerful patches. ... CTV.ca

Potent Painkiller Cited in Bounty Hunter's Death  -  Sep 3, 2005
Raffi Djabourian, deputy medical examiner, wrote that [Laurence Harvey] "didn't fit" the profile of the typical fentanyl user: a chronic pain or cancer ... Pay-Per-View - Los Angeles Times - ProQuest Archiver

Opiate fentanyl gaining foothold; region's overdose rate on the rise  -  Jul 16, 2006
By Suzanne Smalley, Globe Staff | July 16, 2006. A deadly synthetic opiate estimated to be about 50 times more potent than heroin is increasingly showing up ... Boston Globe

Warning issued on Cephalon painkiller.  -  Sep 27, 2007
The FDA stressed that Fentora, also known as fentanyl buccal, is not the same as other fentanyl products and cannot be substituted for Actiq, ... Free with registration - Philadelphia Inquirer - AccessMyLibrary.com

Despite warnings, fatal overdoses continue with misuse of fentanyl...  -  Feb 2, 2008
Overdoses have occurred when the fentanyl patch was used to treat pain in opioidnaïve ... Exposure to heat promotes release of fentanyl from the patch, ... AAP News - AAP News (subscription)

Medical patch users discover danger beneath the surface.  -  Feb 1, 2005
The total number of fentanyl patch prescriptions written in the United States rose ... Fentanyl patches were approved for managing severe, chronic pain that ... Free with registration - Trial - AccessMyLibrary.com

Deadly Fentanyl May Come from Mexico  -  Jun 5, 2006
A deadly mix of heroin and the powerful painkiller fentanyl has felled drug users across the country, and officials say the fentanyl may have come from a ... JoinTogether.org

4 painkiller deaths blamed on wrong use - More health news- msnbc.com  -  Sep 14, 2007
Fentora contains fentanyl, which is similar to morphine, but far more potent. Besides the two headache patients, the other deaths involved a suicide and a ... msnbc.com

… ; DAILY MAIL REPORTER; FENTANYL; EVERYTHING YOU NEED TO …  -  Dec 6, 2005
A IT RELIEVES longer term pain and is used for conditions from cancer to back pain. The active ingredient, fentanyl, binds to opioid receptors in the brain ... Pay-Per-View - Daily Mail - Factiva, from Dow Jones

Fentanyl pain patches are recalled  -  Feb 18, 2008
WASHINGTON, Feb. 18 (UPI) -- The US Food and Drug Administration announced the recall of Fentanyl transdermal system patches due to a potential safety ... United Press International

Fentanyl-laced heroin suspected in Grundy deaths.  -  Aug 31, 2006
Aug. 31--The Grundy County coroner will start screening for homemade fentanyl after two deaths in a week that might be linked to fentanyl-laced heroin. ... Free with registration - Chicago Tribune - AccessMyLibrary.com

Arrests tie drug to Mexican lab: Fentanyl-laced heroin blamed in...  -  Mar 2, 2007
Arrests tie drug to Mexican lab: Fentanyl-laced heroin blamed in deaths of 5 people in Chicago. ... find Chicago Tribune (Chicago, IL) articles. Pay-Per-View - Chicago Tribune - HighBeam Research

Fentanyl-laced heroin suspected in Grundy deaths. | Article from...  -  Aug 31, 2006
Fentanyl-laced heroin suspected in Grundy deaths. ... find Chicago Tribune (Chicago, IL) articles. Byline: Matthew Walberg Aug. Pay-Per-View - Chicago Tribune - HighBeam Research

Fentanyl transdermal patch recall expanded  -  Mar 3, 2008
WASHINGTON, March 3 (UPI) -- The US Food and Drug Administration announced the expansion of a recall of Fentanyl transdermal system CII patches sold in the ... United Press International

Pharmacokinetics of midazolam, propofol, and fentanyl transfer to...  -  Oct 3, 2005
2 Department of Anesthesiology and Mary Beth Donnelley Clinical Pharmacology Core Facility of Robert H. Lurie Comprehensive Cancer Center of Northwestern ... Nature.com

Mylan Labs quarterly profitmore than doubles  -  Feb 1, 2007
The fentanyl pain patch accounted for more than 15 percent of net revenue for the ... Investors have been bracing for competition to Mylan's fentanyl patch, ... Reuters

Painkiller Patch Abuse Blamed for Deaths  -  Jun 16, 2006
Fentanyl has been abused for years. But recently there has been an increase. ... Fentanyl, a synthetic narcotic, was introduced in the 1960s, but it was not ... FOXNews

BDSI to expand BEMA Fentanyl partnership  -  Jan 14, 2008
BioDelivery Sciences International plans to expand its drug-development deal with a Swedish partner, it said Monday. Raleigh-based BDSI (Nasdaq: BDSI) said ... Bizjournals.com

Danger of drug patches often overlooked  -  Aug 27, 2007
His patch provided the second-highest available dose of fentanyl. ... That's why the FDA said in July 2005 that in the case of fentanyl, patches should be ... Pay-Per-View - Los Angeles Times - ProQuest Archiver

FATALITY IS FOCUS OF FENTANYL ABUSE PROBE  -  Jan 26, 2005
State police are investigating the death of a 41-year-old Wellsville man who is believed to have died after licking or chewing on a fentanyl pain medication ... $2.95 - Buffalo News - NewsBank

Deaths, overdoses ebbing from fentanyl-laced heroin  -  Aug 14, 2006
By Michael A. Fuoco, Pittsburgh Post-Gazette. The explosion of drug overdoses and deaths in the area this summer has dissipated, indicating fentanyl-laced ... Pittsburgh Post-Gazette - Pittsburgh Post Gazette

Teva's generic Fentanyl patch OK'd  -  Oct 20, 2008
The US Food and Drug Administration on Monday granted approval to Teva Pharmaceuticals Industries Ltd. for its Fentanyl transdermal system for chronic pain. ... Bizjournals.com

Fentanyl timeline: 1950 through today  -  Jun 24, 2007
Fentanyl synthesized in Belgian lab as a fast-acting anesthetic up to 80 times stronger than morphine. Introduced as intravenous anesthetic for surgery; ... Detroit Free Press

Authorities say user led to fentanyl arrests - Woman found in car on ...  -  Jun 24, 2006
Woman found in car on Detroit street helped point to alleged source of drug that has killed 133. DETROIT -- A suburban woman found earlier this month with a ... $2.95 - Detroit News - NewsBank

Potent Drug Patch Increasingly Misused  -  Nov 26, 2005
Hauler's patch was delivering fentanyl. a narcotic many times more ... Like morphine and other opioid drugs, fentanyl controls pain hut also reduces ... Spokesman-Review - Google News Archive

Fentanyl probe nets 3 suspects - Detroit men thought to be dealing...  -  Jun 23, 2006
DETROIT -- Wayne County Sheriff's investigators today will announce a major breakthrough in the investigation into the sale of fentanyl-laced heroin with ... $2.95 - Detroit News - NewsBank

Deadly Drug Mix Resurfaces in New York  -  Aug 30, 2006
He said the police believed that most of the fentanyl found in the drugs used by ... Fentanyl is a synthetic compound that is typically used by doctors to ... New York Times

Fentanyl problem realized in Jan. - Group deaths and 12 fatal cases...  -  Jul 1, 2006
Group deaths and 12 fatal cases in 48 hours in May alerted medical office there was a trend. Author: The Detroit NewsRonald J. Hansen, Norman Sinclair and ... $2.95 - Detroit News - NewsBank

Heroin-fentanyl combination kills 43 in past year: 'It's starting to...  -  May 23, 2006
More than 40 overdose deaths in Cook County over the past year have been linked to fentanyl, a powerful drug that has turned up in the heroin supply in ... $2.95 - Chicago Sun-Times - NewsBank

… drug emerges in city: Alone or with heroin, fentanyl has killed...  -  Sep 29, 2006
Sep. 29--A powerful drug that when mixed with heroin has been traced to hundreds of deaths nationwide has surfaced in Milwaukee, authorities said Thursday. ... Free with registration - Milwaukee Journal Sentinel - AccessMyLibrary.com

Fentanyl may be tied to 2 deaths: overdoses in Wayne Co. top 50.  -  Jun 1, 2006
Jun. 1--The fentanyl scare that has gripped Wayne County for the past two weeks is not over: Two more people died of suspected overdoses associated with the ... Free with registration - Detroit Free Press - AccessMyLibrary.com

Backstory: officials gather to fight deadly fentanyl outbreak.  -  Jan 25, 2007
Jan. 25--Originally published June 16, 2006 CHIGAGO -- Just one hundred and twenty-five micrograms -- the equivalent of six grains of salt -- is enough ... Free with registration - Detroit Free Press - AccessMyLibrary.com

Deadly heroin mix tightens grip on city: Across Chicago, police and …  -  Jun 8, 2006
She said she wants nothing more to do with fentanyl, but short of stopping her drug use, the decision is not within her control, she said. ... Free with registration - Chicago Tribune - AccessMyLibrary.com

Rahul could have used Fentanyl, also called synthetic heroin  -  Jun 7, 2006
NEW DELHI: Rahul Mahajan, son of the slain Bharatiya Janata Party leader, Pramod Mahajan, could have used Fentanyl, also called `synthetic heroin,' that is ... The Hindu

Big hurdles in bid to curb a potent heroin  -  Jun 29, 2006
Use of fentanyl-laced heroin is rising, as law officers work to ID the origin ... Many of his friends, though, seek out fentanyl-laced heroin for its potent ... Christian Science Monitor

City stand on heroin antidote risks lives: the drug combats overdoses,...  -  Aug 20, 2006
Unclear on treatment Even though the fentanyl-poisoned heroin had been on ... "My feeling is that fentanyl needs a much higher dosage," said Parrish. ... Free with registration - Philadelphia Inquirer - AccessMyLibrary.com

YM BioSciences says FDA puts AeroLEF pain drug study on hold, …  -  Jan 17, 2008
The additional requested data is limited to a small group of patients that experienced oxygen desaturation, a class effect of opioids including fentanyl, ... Forbes

US charges Detroit man in fentanyl deaths; he could face 20 years to...  -  Nov 16, 2006
Nov. 16--Nearly six months after the fatal overdose of Birmingham high school junior Lauren Jolly, a 36-year-old Detroit man on Wednesday became the first ... Free with registration - Detroit Free Press - AccessMyLibrary.com

A Painkiller's Deadly Results  -  Nov 25, 2005
CBS News correspondent Jerry Bowen reports the drug is Fentanyl, ... A patch that delivers Fentanyl – a narcotic many times more powerful than morphine to ... CBS News

FENTANYL IS DEADLY MIX ; LACED HEROIN BLAMED FOR BOOST IN …  -  Sep 3, 2006
Despite the high-profile bust of a Mexican lab suspected of producing clandestine fentanyl and arrests of key members of an entrenched Chicago drug gang ... Pay-Per-View - The Sun - ProQuest Archiver

FENTANYL FOUND IN SEIZED HEROIN - POLICE FEAR DEALERS MAY …  -  Jun 10, 2006
At least one unmarked stamp bag of heroin confiscated by police has tested positive for fentanyl, adding weight to the possibility that drug dealers might ... $2.95 - Pittsburgh Post-Gazette - NewsBank

Man who sold fentanyl-laced heroin sentenced to 30 years in prison  -  Feb 23, 2007
A Detroit man who admitted selling a fentanyl-laced drug cocktail that killed two people was sentenced today to more than 30 years in prison. ... $2.95 - Detroit News - NewsBank

… heroin makes rounds ; Task force chief says many overdose with...  -  May 29, 2006
Investigators believe most of the Fentanyl in Chicago is coming from illicit ... Heroin laced with the prescription painkiller Fentanyl has killed more than ... Pay-Per-View - Chicago Tribune - ProQuest Archiver

PAIN RX KILLS KID  -  May 20, 2008
Joanne Alvarez, 54, allegedly applied a fentanyl patch to little Taylor Webster at ... The fentanyl had been prescribed to the 260-pound Alvarez to treat ... New York Post

Heroin, cancer drug mix kills 12: Wayne Co. warning issued.  -  May 20, 2006
Fentanyl is supposed to be used only by those suffering from ... Like heroin, fentanyl can act as a strong sedative, giving users a drowsy high. ... Free with registration - Detroit Free Press - AccessMyLibrary.com

Heroin toll in nation climbs  -  Jun 10, 2006
He made the fentanyl, which was distributed by Donald Sunkin, a heroin addict ... It was the largest fentanyl ring ever prosecuted in the United States and ... Pittsburgh Post-Gazette - Pittsburgh Post Gazette

Article: Fentanyl-laced heroin found in Ohio: Mansfield, Columbus...  -  Jun 16, 2006
Fentanyl-laced heroin found in Ohio: Mansfield, Columbus labs identify fatal combo. ... find Columbus Dispatch (Columbus, OH) articles. Pay-Per-View - Columbus Dispatch - HighBeam Research

Police plan fentanyl fight: Joint effort targets Mexican suppliers. |...  -  Jun 16, 2006
Police plan fentanyl fight: Joint effort targets Mexican suppliers. ... find Chicago Tribune (Chicago, IL) articles. Byline: David Heinzmann and Jeff Coen ... Pay-Per-View - Chicago Tribune - HighBeam Research

… drug emerges in city: Alone or with heroin, fentanyl has killed...  -  Sep 29, 2006
Deadly drug emerges in city: Alone or with heroin, fentanyl has killed hundreds. ... find Milwaukee Journal Sentinel (Milwaukee, WI) articles. Pay-Per-View - Milwaukee Journal Sentinel - HighBeam Research

Prescriptions for painkillers are harder to get  -  May 10, 2005
Schleigh is fighting to get workman's compensation to pay for the narcotic fentanyl skin patches that are the only drug so far to offer relief. ... USA Today

Some not aware heroin tainted: US agents making buys to find source....  -  Jun 2, 2006
In some of those recent purchases, the DEA has found Fentanyl in samples that were sold on the ... Fentanyl has been found in five of those samples so far. ... Pay-Per-View - Chicago Tribune - HighBeam Research

Article: Palliative easily a killer. - Chicago Tribune (Chicago, IL)...  -  Jun 6, 2006
6--Fentanyl is an extraordinarily effective drug when it comes to pain. ... 6--Fentanyl is an extraordinarily effective drug when it comes to pain relief. ... Pay-Per-View - Chicago Tribune - HighBeam Research

Daughter wins patch case.  -  Jul 8, 2006
Fentanyl is a commonly used anesthetic that in high doses can turn off the ... The private-lab test showed the level of fentanyl in her blood was about 10 ... Free with registration - Houston Chronicle - AccessMyLibrary.com

New rash of deadly heroin overdoses.  -  Apr 21, 2006
In February, 10 people died near the Dearborn Homes after taking heroin that, authorities said, was cut with Fentanyl, a prescription drug often used in ... Free with registration - Chicago Tribune - AccessMyLibrary.com

J&J Units Ordered to Pay $5.5 Million in Patch Case  -  Jun 19, 2007
The patches, introduced in 1990, release fentanyl into the skin. Researchers say fentanyl, a painkiller more powerful than morphine, can cause addiction or ... Bloomberg

… Task force chief says many overdose with Fentanyl-laced drug. -...  -  May 29, 2006
May 29--Heroin laced with the prescription painkiller Fentanyl has killed more than 40 people ... Fentanyl has hit several big cities hard in recent months. ... Pay-Per-View - Chicago Tribune - HighBeam Research

Epidurals bad for breast-feeding?  -  Dec 11, 2006
The fentanyl question certainly seems worth exploring further. I'm already wondering whether fentanyl findings apply to all opioids and what percentage of ... Salon

… Additional Generic Transdermal Fentanyl Approvals During Fiscal...  -  Aug 7, 2006
Mylan's Fentanyl Transdermal System is the only FDA approved, AB-rated generic alternative to Ortho-McNeil's Duragesic(R) patch. An FDA filing from PriCara ... RedOrbit

Jilted nurse held over facelift death  -  Oct 27, 2006
At a court hearing last month police in Charlotte, North Carolina, said that Ms Hill had poisoned the patient with fentanyl, a painkiller. ... Times Online

… homicide arrested again: Heroin charge follows fentanyl-tied...  -  Feb 2, 2007
Packets of fentanyl-laced heroin were found with his body, investigators said. Roti, the police commander, said Thursday that problems with fentanyl-laced ... Pay-Per-View - Chicago Tribune - HighBeam Research

… Emerges In City .Alone Or With Heroin, Fentanyl Has Killed...  -  Sep 29, 2006
Milwaukee vice detectives seized grams of pure fentanyl - a legally pro ... Fentanyl has surfaced in Chicago. Detroit and other cities with deadly results. ... Milwaukee Journal Sentinel - Google News Archive

Drug taking doctor is suspended  -  Apr 12, 2005
David Moorman, 31, of Fareham, Hants, said stress caused him to steal the painkiller Fentanyl from Dorset County Hospital, Dorchester, in October 2003. ... BBC News

… - Romeo physician unlawfully distributed fentanyl, other drugs,...  -  Mar 30, 2007
Fentanyl, which experts say is 30 to 100 times more powerful than ... But fentanyl is also widely used -- and sometimes abused -- as a prescription drug. ... $2.95 - Detroit News - NewsBank

Police: Ex-nurse disabled alarm: Detective also tells court a more...  -  Sep 26, 2006
Hill has said she gave Joyner 5 cubic centimeters of fentanyl in the operating ... An autopsy showed she died of drug poisoning, likely caused by fentanyl. ... Free with registration - Charlotte Observer - AccessMyLibrary.com

Approval for inhalable fentanyl looking painless  -  Jun 28, 2007
By Katrina Megget, 28-Jun-2007. YM BioSciences is the latest company to join the race in developing innovative pain relief products with its Investigational ... In-PharmaTechnologist.com

Article: Fentanyl is deadly mix: Laced heroin blamed for boost in...  -  Sep 3, 2006
Fentanyl is deadly mix: Laced heroin blamed for boost in fatal overdoses in US ... find Baltimore Sun (Baltimore, MD) articles. Byline: Gail Gibson Sep. Pay-Per-View - Baltimore Sun - HighBeam Research

Killer drug overlooked, until flurry of deaths - Fentanyl deaths...  -  Jun 15, 2006
When the police arrived at the tiny bungalow in a middle-class Taylor neighborhood, they found pills on the bedroom floor. Their roommate told them the man ... $2.95 - Detroit News - NewsBank

Autopsy Finds That Soldier Under Army Medical Care Died From …  -  May 19, 2006
...in Lawton, Okla., succumbed to an accidental overdose of the powerful narcotic painkiller fentanyl, according to a military autopsy report released to ... New York Times

… Receives FDA Approval of FENTORA(TM) (fentanyl buccal tablet) for...  -  Sep 25, 2006
FRAZER, Pa., Sept. 25 /PRNewswire-FirstCall/ -- Cephalon, Inc. (Nasdaq: CEPH) announced today that it has received approval from the US Food and Drug ... Genetic Engineering News - Genetic Engineering News (press release)

Health agency issues alert about deadly heroin mix  -  Jun 9, 2006
The mixing of heroin with a powerful drug such as fentanyl is highly ... The DEA is investigating whether a fentanyl lab in Guadalajara that was shut down ... Pay-Per-View - USA TODAY - ProQuest Archiver

Mylan Labs Sees Higher Profit  -  Apr 10, 2007
Meanwhile, Mylan continues to generate steady sales of its generic painkiller fentanyl, in spite of market expectations that competition over that drug ... BusinessWeek

Fentanyl suspect to stand trial - Man accused of dealing heroin laced...  -  Jul 13, 2006
Man accused of dealing heroin laced with the painkiller is charged with drug, weapons violations. A man accused of being a major supplier of deadly ... $2.95 - Detroit News - NewsBank

Inland News | PE.com | Southern California News | News for Inland …  -  Dec 1, 2006
The discovery last month of more than four pounds of the drug fentanyl stashed, ... Fentanyl, a synthetic opiate, has been linked to a recent rash of ... Press-Enterprise

Coroner investigates high-risk painkiller  -  Sep 5, 2007
The news is drawing attention to the dangers of fentanyl patches, ... In Canada, there have been almost 600000 prescriptions for fentanyl patches in the ... Globe and Mail

Brand Names/Synonyms:
Fentanyl is also known by the following brand names and/or synonymsActiq; CHEMBANK1683; Dea No. 9801; Duragesic; Duragesic-100; Durogesic; F5886; Fentanest; Fentanil; Fentanil [Dcit]; Fentanila; Fentanila [Inn-Spanish]; Fentanyl; Fentanyl Citrate; Fentanyl Citrate Preservative Free; Fentanylum; Fentanylum [Inn-Latin]; HSDB 3329; Pentanyl; Phentanyl; R 4263; Sentonil; Sublimaze; Sublimaze Preservative Free

Drug Category:
Fentanyl is categorized under the following by the FDA: Anesthetics; Narcotics; Adjuvants; Analgesics; Opiate Agonists; ATC:N01AH01; ATC:N02AB03

Dosage Forms:
DISC (SUSTAINED-RELEASE); LIQUID; SOLUTION

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
N-(1-phenethyl-4-piperidyl)-N-phenyl-propanamide





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