Fentanyl Citrate

This page contains recent news articles, when available, and an overview of Fentanyl Citrate but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Fentanyl Citrate
(when available)

Pharmacology and use:
Fentanyl is an opioid analgesic. Fentanyl interacts predominately with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, spinal cord, and other tissues. In clinical settings, Fentanyl exerts its principal pharmacologic effects on the central nervous system. Its primary actions of therapeutic value are analgesia and sedation. Fentanyl may increase the patient's tolerance for pain and decrease the perception of suffering, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Fentanyl depresses the respiratory centers, depresses the cough reflex, and constricts the pupils. For the treatment of cancer patients with severe pain that breaks through their regular narcotic therapy.

Mechanism Of Action:
Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Fentanyl's analgesic activity is, most likely, due to its conversion to morphine. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

News Articles on Fentanyl

Cephalon, Inc. - Pharmaceuticals & Healthcare - Deals and Alliances Profile ...  -  ‎Dec 29, 2009‎
The product portfolio of the company includes modafinil tablets, fentanyl buccal tablets, arsenic trioxide injections, oral transmucosal fentanyl citrate ... PRMinds (press release)

Covidien Receives FDA Approval for Oral Transmucosal Fentanyl Citrate Product  -  ‎Oct 30, 2009‎
Oral Transmucosal Fentanyl Citrate, a Class II controlled substance, is an opioid analgesicindicated only for the management of breakthrough cancer pain in ... Reuters

Mallinckrodt painkiller gets FDA OK  -  ‎Nov 2, 2009‎
The Oral Transmucosal Fentanyl Citrate is an opiod analgesic designed for cancer patients to place inside the cheek for pain relief. ... St. Louis Business Journal

Pivotal Data Published in the Journal Cancer Demonstrate that TREANDA Induced ...  -  ‎Nov 5, 2009‎
PROVIGIL® (modafinil) Tablets [C-IV] and ACTIQ® (oral transmucosal fentanyl citrate) [C-II]. The company also markets numerous products internationally. ... Reuters

Cephalon, Inc. to Webcast R&D Day  -  ‎Nov 4, 2009‎
GABITRIL® (tiagabine hydrochloride) and ACTIQ® (oral transmucosal fentanyl citrate) [C-II]. The company also markets numerous products internationally. ... Reuters

Mayo Clinic Proceedings Publishes Study of NUVIGIL in Patients with Shift Work ...  -  ‎Nov 2, 2009‎
GABITRIL(R) (tiagabine hydrochloride), PROVIGIL(R) (modafinil) Tablets [C-IV], and ACTIQ(R) (oral transmucosal fentanyl citrate) (C-II). ... Reuters

Denbury Acquires Encore for $4.5 B; Ford Surges  -  ‎Nov 2, 2009‎
...said that its subsidiary, Mallinckrodt Inc., has received FDA approval of its Abbreviated New Drug Application for Oral Transmucosal Fentanyl Citrate. ... Ticker Magazine

Cephalon Appoints Bob Repella as Senior Vice President of U.S. Pharmaceutical ...  -  ‎Oct 27, 2009‎
...trioxide) injection, GABITRIL® (tiagabine hydrochloride), PROVIGIL® (modafinil) Tablets [C-IV], and ACTIQ® (oral transmucosal fentanyl citrate) (C-II). ... Reuters

Hot Stocks to Watch (COV, PGR, RKT) by Penny Stock Money  -  ‎Nov 2, 2009‎
...maker said it received US Food and Drug Administration approval of an abbreviated new drug application for oral transmucosal fentanyl citrate. ... TransWorldNews (press release)

Monday's biggest gaining and declining stocks  -  ‎Nov 2, 2009‎
...said that an abbreviated new-drug application by its Mallinckrodt subsidiary for oral transmucosal fentanyl citrate was cleared by the US Food and Drug ... Middle East North Africa Financial Network

Cephalon, Inc. - Pharmaceuticals & Healthcare - Deals and Alliances Profile ...  -  ‎Nov 9, 2009‎
The product portfolio of the company includes modafinil tablets, fentanyl buccal tablets, arsenic trioxide injections, oral transmucosal fentanyl citrate ... PR-Inside.com (Pressemitteilung)

Cephalon Appoints Bob Repella as Senior Vice President of US Pharmaceutical ...  -  ‎Oct 27, 2009‎
GABITRIL(R) (tiagabine hydrochloride), PROVIGIL(R) (modafinil) Tablets [C-IV], and ACTIQ(R) (oral transmucosal fentanyl citrate) (C-II). ... Trading Markets (press release)

Cephalon Net Sales Increase 9% and Net Cash from Operations Surpasses $200 ...  -  ‎Oct 28, 2009‎
...trioxide) injection, GABITRIL® (tiagabine hydrochloride), NUVIGIL® (armodafinil) Tablets [C-IV] and ACTIQ® (oral transmucosal fentanyl citrate) [C-II]. ... PharmaLive.com (press release)

Pharmalink AB Receives Patent for Nefecon(R) Principle  -  ‎Oct 26, 2009‎
The Group's lead development product is NasalFent(R), an innovative and highly differentiated fentanyl citrate nasal spray, for the rapid relief of ... PR Newswire (press release)

… 1 Clinical Trials of a Novel Fentanyl Citrate Transdermal Patch...  -  May 25, 2006
ATLANTA -- Altea Therapeutics announced today that it has commenced Phase 1 clinical trials in the US for AT3022, the Company's fentanyl citrate transdermal ... Free with registration - Business Wire - AccessMyLibrary.com

Fentanyl citrate.  -  Nov 6, 2006
Barr Laboratories, Woodcliff Lake, N.J., (800) 222-0190, has introduced a generic version of Cephalon's ACTIQ (oral transmucosal fentanyl citrate) C-II. ... $9.94 - Drug Topics - Alacra Store

Learn about Fentanyl Citrate Injection from Consumer Reports Health.  -  Jan 9, 2007
Your doctor has ordered fentanyl, an analgesic (painkiller), to relieve your pain. The drug will be added to an intravenous fluid that will drip through a ... consumerreports.org

How to take Fentanyl Citrate Injection from Consumer Reports Health.  -  Jan 9, 2007
...tell your doctor and pharmacist if you are allergic to fentanyl, morphine, codeine (or medications that contain codeine such as Tylenol with Codeine), ... consumerreports.org

Former Elliot Nurse Charged With Tampering With Medication  -  Jul 17, 2008
Prosecutors said that Vickie Worthington, 49, diluted vials of the painkiller fentanyl citrate with saline in March 2007. Fentanyl citrate is commonly given ... WMUR

… Administrative Code - 77 Ill. Adm. Code 790.3914 FENTANYL CITRATE...  -  Aug 10, 2005
77 Ill. Adm. Code 790.3914 FENTANYL CITRATE (Repealed) Repealed. (Source: Repealed at 17 Ill. Reg. 15916, effective September 20, 1993) ... Pay-Per-View - Illinois Administrative Code - Loislaw

Fentanyl citrate.(NEW GENERICS)(Brief article)  -  Nov 6, 2006
Barr Laboratories, Woodcliff Lake, NJ, (800) 222-0190, has introduced a generic version of Cephalon's ACTIQ (oral transmucosal fentanyl citrate) C-II. $4.95 - Drug Topics - ECNext

… Code - 77 Ill. Adm. Code 790.3440 DROPERIDOL; FENTANYL CITRATE …  -  Aug 10, 2005
77 Ill. Adm. Code 790.3440 DROPERIDOL; FENTANYL CITRATE (Repealed) Repealed. (Source: Repealed at 17 Ill. Reg. 15916, effective September 20, 1993) ... Pay-Per-View - Illinois Administrative Code - Loislaw

Taking Fentanyl Citrate Injection from Consumer Reports Health.  -  Jan 9, 2007
Fentanyl may cause side effects. Tell your health care provider if any of these symptoms are severe or do not go away:. If you experience a serious side ... consumerreports.org

Transmucosal fentanyl vs intravenous morphine in doses proportional...  -  May 22, 2007
On the other hand, studies of oral transmucosal fentanyl citrate (OTFC) have ... Oral transmucosal fentanyl citrate, given in doses proportional to the ... Nature.com

Article: Cephalon's painkiller promotion questioned: A Conn. probe...  -  Nov 22, 2006
PR Newswire; June 5, 1998 ; 700+ words ... ... assessment of the efficacy and safety of Actiq (oral transmucosal fentanyl citrate ... announced the ... Pay-Per-View - Philadelphia Inquirer - HighBeam Research

United States: Narrow Claim Construction Avoids Invalidity Based on …  -  Feb 2, 2005
The Court then turned to evidence intrinsic to the `580 patent to determine whether or not the term excludes fentanyl citrate. The Court examined both the ... Mondaq News Alerts - Mondaq News Alerts (Registration)

Competitors by Product Report  -  Dec 27, 2008
Sublimaze (Fentanyl Citrate); Sufenta (Sufentanil Citrate) ... Meperidine Hydrochloride; Oral Transmucosal Fentanyl Citrate [C-II] ... $75.00 - Revere - Alacra Store

Competitors by Product Report  -  Dec 27, 2008
Sublimaze (Fentanyl Citrate); Sufenta (Sufentanil Citrate) ... Actiq (Oral Transmucosal Fentanyl Citrate) [C-II]; Actiq Sugar-Free (Oral Transmucosal ... $75.00 - Revere Reports - Revere

Lollipop Painkiller  -  Jul 10, 2007
It is a formulation of fentanyl citrate that is most effective when consumed in ... Actiq's main ingredient, fentanyl citrate, is intended to be used as a ... WFtv.com

Press Release: Study finds 90 Percent of Actiq 'Lollipop' Prescription...  -  Jan 16, 2007
PR Newswire; January 17, 2000 ; 700+ words ... ... net loss resulted primarily from new revenue from Actiq(R) (oral transmucosal fentanyl citrate) product ... Pay-Per-View - PR Newswire - HighBeam Research

fentanyl -- Britannica Online Encyclopedia  -  Jun 5, 2008
The citrate salt, fentanyl citrate, is administered by injection, either intramuscularly or intravenously, sometimes in combination with a potent ... Subscription - Encyclopedia Britannica

… Federal Regulations - 21 CFR § 522.800 Droperidol and fentanyl...  -  Jul 11, 2006
21 CFR § 522.800 Droperidol and fentanyl citrate injection. (a) Specifications. Droperidol and fentanyl citrate injection is a sterile solution containing ... Pay-Per-View - United States Code of Federal Regulation... - Loislaw

Barr Reports Third Quarter 2007 GAAP Earnings of $0.36 Per Share; …  -  Nov 8, 2007
The increase also reflects strong sales of Fentanyl Citrate, a generic version of ACTIQ(R) that we launched in late September 2006. ... Free with registration - PR Newswire - AccessMyLibrary.com

FDA Approvals: Nevanac, Sugar-Free Actiq, Quinine Sulfate  -  Sep 15, 2005
9, the FDA approved a sugar-free formulation of oral transmucosal fentanyl citrate (Actiq, made by Cephalon, Inc.) for the management of breakthrough pain ... Medscape

Global top 300 multisource generic pharmaceuticals by sales, …  -  Apr 28, 2008
110 Sandoz Alprazolam 00781107905 111 Teva USA Amox Tr-potassium 00093227434 clavulanate 112 Barr Fentanyl citrate 00555108501 113 Barr Fentanyl citrate ... $20.00 - Chain Drug Review - Alacra Store

Cephalon Announces Positive Results for FENTORA(TM) (Fentanyl …  -  Oct 11, 2006
...when converting patients from other oral fentanyl products, including oral transmucosal fentanyl citrate (OTFC and Actiq(R)), to FENTORA, ... RedOrbit

Hisamitsu, Nippon to co-develop fentanyl  -  Apr 14, 2005
Hisamitsu Pharmaceutical Co, Ltd. and Nippon Shinyaku Co, Ltd have signed a co-development agreement for HFT-290 (fentanyl citrate) in the territory of ... pharmabiz.com

United States top 190 multisource generic drugs ranked by sales in …  -  Sep 29, 2008
Oxycodone HCl 143 Sandoz Atenolol 144 Barr Fentanyl citrate 145 Apotex ... Oxcarbazepine 176 Teva USA Gemfibrozil 177 Barr Fentanyl citrate 178 Teva USA ... $20.00 - Chain Drug Review - Alacra Store

Cephalon Receives Approvable Letter For FENTORA(TM) (fentanyl …  -  Jun 30, 2006
...and supply agreement with the company to have Cephalon manufacture for it a generic version of ACTIQ(R) (oral transmucosal fentanyl citrate) [C- II]. ... Medical News Today - Medical News Today (press release)

South Central CT Regional acquires BIW Ltd - Jan 17, 2008 - Deal …  -  Jun 29, 2007
Doparl Parkinson Disease M Benozil Central Nervous System Disorders M Neoperidol…fentanyl citrate) Cancer Pain II BIW-#### / potelligent-IL#R Asthma I… ... Pay-Per-View - deals - Alacra Store

Press Release: Cephalon Provides Update on Regulatory Status of the …  -  Jan 25, 2008
Inc. in connection with its Fentora(R) Tablets (fentanyl citrate ... certification for a generic Fentora product with the U.S. Food ... under the ... Pay-Per-View - PR Newswire - HighBeam Research

New Jersey Administrative Code - 10:58A-4.3 HCPCS procedure codes …  -  Aug 16, 2005
...up 7.88 to 1 mg J1810 Injection, droperidol and fentanyl citrate, 9.94 (Innovar), ... up to 1 gram 6.45 J3010 Injection, fentanyl citrate, (Sublimaze), ... Pay-Per-View - New Jersey Administrative Code - Loislaw

Cephalon Receives Approvable Letter for FENTORA(TM) (Fentanyl …  -  Jun 29, 2006
...and supply agreement with the company to have Cephalon manufacture for it a generic version of ACTIQ(R) (oral transmucosal fentanyl citrate) [C- II]. ... RedOrbit

Cephalon Announces Positive Results from Two Phase 3 Clinical Trials...  -  Jan 8, 2007
...when converting patients from other oral fentanyl products, including oral transmucosal fentanyl citrate (OTFC and Actiq(R)), to FENTORA, ... Free with registration - PR Newswire - AccessMyLibrary.com

Barr Reports First Quarter 2008 GAAP Earnings of $0.21 Per Share; …  -  May 8, 2008
These decreases were partially offset by increases in sales of Fentanyl Citrate and the launch of the Company's Alendronate product. ... Genetic Engineering News - Genetic Engineering News (press release)

RESEARCH & DEVELOPMENT NEWS IN BRIEF  -  Apr 18, 2005
Hisamitsu Pharmaceutical and Nippon Shinyaku announced on April 7 that they have signed a domestic codevelopment agreement for HFT-290 (fentanyl citrate), ... Pay-Per-View - Pharma Japan - Factiva, from Dow Jones

Opioids for management of breakthrough pain in cancer patients.( …  -  Dec 1, 2006
Oral transmucosal fentanyl citrate (OTFC [Actiq]), a rapid-acting opioid, has been shown to be an effective treatment for breakthrough cancer pain. ... Free with registration - American Family Physician - AccessMyLibrary.com

Companies Explore New, Safer Patch Technologies  -  Aug 29, 2008
It's using fentanyl citrate, the salt form of fentanyl, which stays in the patch. Its investigational product painlessly creates microscopic pores in the ... FDA news - FDA news (subscription)

Cephalon Announces Positive Results from a Pivotal Study of FENTORA …  -  Aug 16, 2007
...oral fentanyl products, including oral transmucosal fentanyl citrate (OTFC and Actiq(R)), to FENTORA, do not substitute FENTORA on a mcg per mcg basis. ... Free with registration - PR Newswire - AccessMyLibrary.com

Tuesday Sheriff's Beat  -  Mar 29, 2006
Zack Smith filed a report Saturday, stating someone took some Actiq Fentanyl Citrate suckers. A medical Web site, www.cancer.org, states Actiq contains ... Tahlequah Daily Press

Achieva Ltd acquires a minority stake in CS Vision Co Ltd (pending) -...  -  Apr 17, 2007
Hydrochloride Oral Transmucosal Fentanyl Citrate [C-II] Pliva Tramadol Hydrochloride Baxter…Actiq (Oral Transmucosal Fentanyl Citrate) [C-II] Actiq ... Pay-Per-View - deals - Alacra Store

Press Release: Cephalon Reinforces Important Prescribing and Dosing …  -  Sep 13, 2007
FENTORA is not bioequivalent to or a generic version of ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II]; therefore, FENTORA should not be substituted ... Pay-Per-View - PR Newswire - HighBeam Research

United States top 250 generic pharmaceuticals by sales, and …  -  Feb 4, 2008
Fentanyl citrate 114900228 107 Teva USA Meloxicam 114123858 108 Teva USA Cefdinir 114029007 109 Mylan Lovastatin 113845650 110 Lupin Meloxicam 113503953 111 ... $20.00 - Chain Drug Review - Alacra Store

Press Release: Cephalon Announces FDA Advisory Committee …  -  May 6, 2008
Cephalon, Inc. in connection with its Fentora(R) Tablets (fentanyl citrate buccal ... paragraph IV certification for a generic Fentora product with the U.S. ... Pay-Per-View - PR Newswire - HighBeam Research

Cephalon; Cephalon officials report on new developments  -  Dec 5, 2006
...than with Actiq (oral transmucosal fentanyl citrate) [C-II]. As such, Fentora delivers the therapeutic benefit of fentanyl at a lower dose than Actiq. ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Lollipop painkiller generated 47 deaths nationwide  -  Jun 8, 2007
It is a formulation of fentanyl citrate that is most effective when consumed in ... Actiq's main ingredient, fentanyl citrate, is intended to be used as a ... News 8 Austin

International Approvals: NovoRapid, Fentanyl, Atriance  -  Sep 24, 2007
On August 28, the Japanese Ministry of Health, Labor, and Welfare (MHLW) approved an expanded indication for fentanyl citrate 0.1- and 0.25-mg injections ... Medscape

Sosei Announces Successful Completion of AD 923 Pharmacokinetic …  -  May 21, 2007
...single dose, cross-over, randomised study of AD 923 versus Actiq(R) (oral transmucosal fentanyl citrate lozenge) and versus fentanyl citrate injection. ... Genetic Engineering News - Genetic Engineering News (press release)

Lollipop Painkiller |West Palm Beach News, South Florida Breaking...  -  Jun 1, 2007
It is a formulation of fentanyl citrate that is most effective when consumed in ... Actiq's main ingredient, fentanyl citrate, is intended to be used as a ... WPTV

Generics makers keep new products coming.(RX/GENERICS)(Statistical …  -  Sep 17, 2007
Amox TR-Potassium Clavulanate $198018118.31 Watson Labs Cartia xt $193614325.46 Barr Fentanyl Citrate $193389905.90 Teva USA Budeprion sr $190606160.83 Teva ... Free with registration - Chain Drug Review - AccessMyLibrary.com

Sosei Announces Successful Completion of AD 923 Pharmacokinetic …  -  May 22, 2007
...single dose, cross-over, randomised study of AD 923 versus Actiq(R) (oral transmucosal fentanyl citrate lozenge) and versus fentanyl citrate injection. ... $4.95 - PR Newswire - ECNext

Press Release: Sosei Announces Successful Completion of AD 923 …  -  May 22, 2007
...single dose, cross-over, randomised study of AD 923 versus Actiq(R) (oral transmucosal fentanyl citrate lozenge) and versus fentanyl citrate injection. ... Pay-Per-View - PR Newswire - HighBeam Research

ARCHIMEDES PHARMA BEGINS PHASE III FOR NASALFENT.  -  Mar 1, 2007
Nasalfent is an innovative fentanyl citrate nasal spray aimed at providing a fast, effective and convenient treatment for breakthrough cancer pain - sudden, ... $4.95 - Worldwide Biotech - ECNext

Barr Selling Generic Actiq  -  Sep 27, 2006
Under the terms of the agreement, Cephalon is currently supplying Barr with fentanyl citrate manufactured under Cephalon's New Drug Application, ... TheStreet.com - TheStreet.com (subscription)

Barr acquisition boosts revenues Business Courier of Cincinnati  -  Nov 8, 2007
...sales of Fentanyl Citrate, and sales of the Plan B contraceptive drug, which is manufactured by Duramed, Barr said in a news release. ... Bizjournals.com

Cephalon's Oravescent Fentanyl Hits Primary Endpoint In Phase III  -  May 6, 2005
Should it reach the market, the drug would complement Actiq (fentanyl citrate), Cephalon's already-marketed therapy for cancer pain that generated $101.9 ... BioWorld Online - BioWorld Online

Heroin, cancer drug mix kills 12: Wayne Co. warning issued.  -  May 20, 2006
FENTANYL (Oral transmucosal fentanyl citrate) -- A product of Cephalon Inc. (145 Brandywine Parkway, West Chester, PA 19380 | 800-896-5855) -- Sold as ... Free with registration - Detroit Free Press - AccessMyLibrary.com

Bloomberg Printer-Friendly Page  -  Jun 3, 2008
GABITRIL(R) (tiagabine hydrochloride), NUVIGIL(TM) (armodafinil) Tablets [C-IV] and ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II]. ... Bloomberg

Cephalon, Inc. Announces Agreement to Acquire Zeneus Holdings …  -  Dec 6, 2005
ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II] and TRISENOX(R) (arsenic trioxide) injection, and more than 20 products internationally. ... RedOrbit

Cephalon and Alkermes Announce Agreement for the Commercialization …  -  Jun 24, 2005
GABITRIL(R) (tiagabine hydrochloride) and ACTIQ(R)(oral transmucosal fentanyl citrate) [C-II] , and more than 20 products internationally. ... RedOrbit

Article: Fentanyl-laced heroin found in Ohio: Mansfield, Columbus...  -  Jun 16, 2006
Prehospital Emergency Care; October 1, 2004 ; 700+ words ... ... like to appeal for the expanded use of fentanyl citrate (sublimaze) in prehospital ... Pay-Per-View - Columbus Dispatch - HighBeam Research

Cephalon Announces FDA Advisory Committee Recommendation …  -  May 6, 2008
GABITRIL(R) (tiagabine hydrochloride), NUVIGIL(TM) (armodafinil) Tablets [C-IV] and ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II]. ... RedOrbit

Article: Deadly drug emerges in city: Alone or with heroin, fentanyl...  -  Sep 29, 2006
Prehospital Emergency Care; October 1, 2004 ; 700+ words ... ... like to appeal for the expanded use of fentanyl citrate (sublimaze) in prehospital ... Pay-Per-View - Milwaukee Journal Sentinel - HighBeam Research

Drug control on a bad trip with the environment  -  Dec 2, 2007
According to the current federal guidelines, only certain drugs should be flushed, including Actiq (fentanyl citrate), OxyContin tablets (oxycodone) and ... Pay-Per-View - Chicago Tribune - ProQuest Archiver

Fentora Cancer Pain Drug Linked To Deaths  -  Sep 14, 2007
Fentora should not be substituted for any fentanyl-containing pain medication, including Actiq (oral transmucosal fentanyl citrate). ... Medical News Today - Medical News Today (press release)

Cephalon, Inc. Announces Agreement with Teva Pharmaceutical …  -  Dec 9, 2005
ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II] and TRISENOX(R) (arsenic trioxide) injection, and more than 20 products internationally. ... Free with registration - PR Newswire - AccessMyLibrary.com

Patients' expectation and experience of visual sensations during …  -  May 26, 2006
16 patients), fentanyl (Fentanyl Citrate DBL ® , David Bull, Melbourne, Australia) (12.5–25 g, 10 patients), or a combination of these sedatives. ... Nature.com

WHEN DRUGS EXPIRE, DON'T TAKE THEM, BUT DON'T JUST TOSS …  -  Sep 3, 2008
These include strong narcotic pain relievers and other controlled substances, such as Actiq (fentanyl citrate), Daytrana Transdermal Patch (methylphenidate) ... $2.95 - St. Paul Pioneer Press - NewsBank

Paramedic at troubled ambulance service fired - Narcotics kept by the...  -  Jan 28, 2006
Police charge that Entenman removed morphine sulfate and fentanyl citrate, both controlled substances, from ambulances and replaced them with a saline ... $2.95 - Philadelphia Inquirer - NewsBank

Approval for inhalable fentanyl looking painless  -  Jun 28, 2007
Cephalon has marketed fentanyl citrate as Actiq, a solid formulation on a stick in the form of a lollipop that dissolves in the mouth, and last September ... In-PharmaTechnologist.com

Cephalon receives approvable letter to market sugar-free formulation...  -  Mar 25, 2005
...letter from the US Food and Drug Administration (FDA) to market a new sugar-free formulation of Actiq (oral transmucosal fentanyl citrate) [C-II]. ... Free with registration - Asia Africa Intelligence Wire - AccessMyLibrary.com

Prescription for abuse?, Insurer, officials concerned about marketing,...  -  Jan 31, 2007
The painkiller, Actiq, contains fentanyl citrate, a narcotic that packs more power than morphine. Some doctors have raised concerns that if patients misuse ... Pay-Per-View - Newsday - ProQuest Archiver

Cephalon (CEPH) Concludes All Outstanding Federal and State …  -  Sep 29, 2008
...in 2004 and involved three of the company's nine proprietary products in the United States -- Actiq(R) (oral transmucosal fentanyl citrate) [C-II], ... StreetInsider.com - StreetInsider.com (subscription)

Cephalon, Inc. at SG Cowen & Co. 25th Annual Health Care …  -  Mar 16, 2005
It contains fentanyl citrate, fentanyl is an opiate analgesic, a very potent one. Same active ingredient as in duragesic, in a unit, which allows the ... Free with registration - America's Intelligence Wire - AccessMyLibrary.com

Cephalon Files Marketing Application for Approval of a Fentanyl …  -  Mar 26, 2007
GABITRIL(R) (tiagabine hydrochloride), and ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II]; numerous products are marketed internationally. ... Free with registration - PR Newswire - AccessMyLibrary.com

Is Britney Spears licking Fentanyl (opiate) lollipops? They're not...  -  Aug 13, 2007
Approved by the FDA in 1998 to treat severe pain in cancer patients, they contain the powerful narcotic painkiller fentanyl citrate. ... TheInsider.com

Cephalon Receives FDA Approval for TREANDA, a Novel Chemotherapy …  -  Mar 21, 2008
GABITRIL ® (tiagabine hydrochloride), NUVIGIL™ (armodafinil) Tablets [C-IV] and ACTIQ ® (oral transmucosal fentanyl citrate) [C-II]. ... Press Media Wire - Press Media Wire (Press Release)

Old Prescription Drugs Can Be Dangerous  -  Dec 11, 2007
According to the current federal guidelines, only certain drugs should be flushed, including Actiq (fentanyl citrate), OxyContin tablets (oxycodone) and ... The Ledger

Cephalon, Inc. Moves Corporate Headquarters to Frazer, PA; Chester …  -  Mar 29, 2005
GABITRIL(R) (tiagabine hydrochloride) Tablets and ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II] and more than 20 products internationally. ... Free with registration - PR Newswire - AccessMyLibrary.com

Safety of low-dose radiocontrast for interventional AV fistula...  -  Mar 1, 2006
Intravenous fentanyl citrate (Cephalon Inc., West Chester, PA, USA) and midazolam hydrochloride (Faulding Pharmaceutical Company, Paramus, NJ, ... Nature.com

TREANDA Significantly Improves Clinical Outcomes in Patients with …  -  Dec 10, 2007
GABITRIL(R) (tiagabine hydrochloride), NUVIGIL(TM) (armodafinil) Tablets [C-IV] and ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II]. ... Free with registration - PR Newswire - AccessMyLibrary.com

Cephalon Notified of Generic Fentanyl Buccal Tablet Filing  -  Apr 28, 2008
GABITRIL(R) (tiagabine hydrochloride), NUVIGIL(TM) (armodafinil) Tablets [C-IV] and ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II]. ... Lifescience-online

Barr Pharmaceuticals  -  May 9, 2007
Additionally, Barr experienced strong sales of Fentanyl Citrate, a generic version of ACTIQ launched in September, along with higher generic oral ... Briefing.com

Studies Confirm Effectiveness Of Fentanyl Lozenges For 'Breakthrough'...  -  Jan 26, 2006
The fentanyl lozenge, known as oral transmucosal fentanyl citrate, or OTFC, is also known by the brand name Actiq. The review comprised four randomized ... Medical News Today - Medical News Today (press release)

IN THE SPOTLIGHT -- DRUG SAFETY - WHAT TO DO WITH LEFTOVER …  -  Dec 13, 2007
According to the federal guidelines, only certain drugs should be flushed, including Actiq (fentanyl citrate), OxyContin tablets (oxycodone) and Daytrana ... $2.95 - The State - NewsBank

Cephalon Says FDA Continues To Evaluate Rash Case Of Sparlon Study; …  -  Dec 7, 2006
ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II], GABITRIL(R) (tiagabine hydrochloride), TRISENOX(R) (arsenic trioxide) injection, and VIVITROL(R) ... Free with registration - M2 Presswire - AccessMyLibrary.com

Cephalon Receives Complete Response Letter Regarding Request for …  -  Sep 15, 2008
GABITRIL(R) (tiagabine hydrochloride), NUVIGIL(TM) (armodafinil) Tablets [C-IV] and ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II]. ... Genetic Engineering News - Genetic Engineering News (press release)

Cephalon, Inc. and ImmuPharma plc Sign a $15 Million Option …  -  Nov 25, 2008
GABITRIL® (tiagabine hydrochloride), NUVIGIL(TM) (armodafinil) Tablets [C-IV] and ACTIQ® (oral transmucosal fentanyl citrate) [C-II]. ... Lifescience-online

Raising the Barr Again  -  Aug 8, 2007
US generic sales grew to $296 million, up 33% on the inclusion of PLIVA and strong sales of Fentanyl Citrate, a generic version of ACTIQ launched in ... Briefing.com

Cephalon Receives FDA Approval of NUVIGIL(TM) for the Treatment of …  -  Jun 18, 2007
...(tiagabine hydrochloride), and ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II]. The Company also markets numerous products internationally. ... Free with registration - PR Newswire - AccessMyLibrary.com

Cephalon, Inc. Announces Agreement with Mylan Pharmaceuticals Inc. …  -  Jan 10, 2006
ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II] and TRISENOX(R) (arsenic trioxide) injection, and more than 20 products internationally. ... Free with registration - PR Newswire - AccessMyLibrary.com

Synthetic Narcotics-Safe or Addictive?  -  Jul 19, 2008
Duragesic®, for example, is a fentanyl transdermal patch used in chronic pain management, and Actiq® is a solid formulation of fentanyl citrate on a stick ... TransWorldNews - TransWorldNews (press release)

Cephalon Announces Record Sales and Earnings for 2006.  -  Feb 13, 2007
GABITRIL (tiagabine hydrochloride), and ACTIQ (oral transmucosal fentanyl citrate) [C-II], and numerous products internationally. ... Free with registration - M2 Presswire - AccessMyLibrary.com

PRESS RELEASE: Cephalon Announces Agreement to Acquire AMRIX  -  Aug 23, 2007
GABITRIL(R) (tiagabine hydrochloride), ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II], and NUVIGIL(TM) (armodafinil) Tablets [C-IV]. ... FierceBiotech

Event Brief of Q2 2007 Cephalon, Inc. Earnings Conference Call -...  -  Jul 31, 2007
As expected, ACTIQ sales have declined significantly since the launch of generic oral transmucosal fentanyl citrate (OTFC) last year. 2. ... Free with registration - Fair Disclosure Wire - AccessMyLibrary.com

Journal of Clinical Oncology Publishes Study of Cephalon Medication …  -  Jul 15, 2008
GABITRIL(R) (tiagabine hydrochloride), NUVIGIL(TM) (armodafinil) Tablets [C-IV] and ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II]. ... RedOrbit

Cephalon Provides Update Related to NUVIGIL(TM) New Drug …  -  Mar 30, 2007
ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II], GABITRIL(R) (tiagabine hydrochloride), TRISENOX(R) (arsenic trioxide) injection, and VIVITROL(R) ... Free with registration - PR Newswire - AccessMyLibrary.com

Watson Pharmaceuticals Reports Second Quarter 2007 Results.  -  Aug 2, 2007
Other revenue increased $17.2 million to $18.2 million, due primarily to the addition of commission revenue related to fentanyl citrate and the addition of ... $4.95 - PR Newswire - ECNext

Cephalon's EFFENTORA Receives Positive Opinion from European …  -  Jan 24, 2008
GABITRIL(R) (tiagabine hydrochloride), NUVIGIL(TM) (armodafinil) Tablets [C-IV] and ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II]. ... Free with registration - PR Newswire - AccessMyLibrary.com

Cephalon Receives Approvable Letter for NUVIGIL(TM) (Armodafinil)  -  May 1, 2006
GABITRIL(R) (tiagabine hydrochloride), ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II], and TRISENOX(R) (arsenic trioxide) injection. ... RedOrbit

Cephalon Announces Positive Results from Its Pivotal Study of TREANDA...  -  Oct 23, 2007
GABITRIL(R) (tiagabine hydrochloride), NUVIGIL(TM) (armodafinil) Tablets [C-IV] and ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II]. ... Free with registration - PR Newswire - AccessMyLibrary.com

FDA Extends PDUFA Date for VIVITREX(R) to December 30, 2005; …  -  Dec 30, 2005
ACTIQ(R) (oral transmucosal fentanyl citrate) (C-II) and TRISENOX(R) (arsenic trioxide) injection, and more than 20 products internationally. ... businesswire.com

Cephalon, Inc. Provides Update on Regulatory Status of SPARLON(TM)  -  Jan 25, 2006
ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II] and TRISENOX(R) (arsenic trioxide) injection, and more than 20 products internationally. ... biotech-intelligence.com

Cephalon, Inc. Announces Agreements With Barr Laboratories, Inc. …  -  Feb 1, 2006
...infringement disputes in the United States related to PROVIGIL(R) (modafinil) Tablets [C-IV] and ACTIQ(R) (oral transmucosal fentanyl citrate) [C-II]. ... Free with registration - PR Newswire - AccessMyLibrary.com

Brand Names/Synonyms:
Fentanyl Citrate is also known by the following brand names and/or synonymsActiq; CHEMBANK1683; Dea No. 9801; Duragesic; Duragesic-100; Durogesic; F5886; Fentanest; Fentanil; Fentanil [Dcit]; Fentanila; Fentanila [Inn-Spanish]; Fentanyl; Fentanyl Citrate; Fentanyl Citrate Preservative Free; Fentanylum; Fentanylum [Inn-Latin]; HSDB 3329; Pentanyl; Phentanyl; R 4263; Sentonil; Sublimaze; Sublimaze Preservative Free

Drug Category:
Fentanyl Citrate is categorized under the following by the FDA: Anesthetics; Narcotics; Adjuvants; Analgesics; Opiate Agonists; ATC:N01AH01; ATC:N02AB03

Dosage Forms:
DISC (SUSTAINED-RELEASE); LIQUID; SOLUTION

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
N-(1-phenethyl-4-piperidyl)-N-phenyl-propanamide





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