Fondaparinux

This page contains recent news articles, when available, and an overview of Fondaparinux but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Fondaparinux
(when available)

Pharmacology and use:
Fondaparinux is a synthetic and specific inhibitor of activated Factor X (Xa) indicated for the prophylaxis of deep vein thrombosis, which may lead to pulmonary embolism. Fondaparinux is also indicated for the treatment of acute deep vein thrombosis when administered in conjunction with warfarin, and the treatment of acute pulmonary embolism when administered in conjunction with warfarin. Fondaparinux does not inactivate thrombin (activated Factor II) and has no known effect on platelet function. At the recommended dose, Fondaparinux does not affect fibrinolytic activity or bleeding time. For the treatment of prophylaxis of deep vein thrombosis.

Mechanism Of Action:
The antithrombotic activity of Fondaparinux is the result of antithrombin III (ATIII)-mediated selective inhibition of Factor Xa. By selectively binding to ATIII, Fondaparinux potentiates (about 300 times) the innate neutralization of Factor Xa by ATIII. Neutralization of Factor Xa interrupts the blood coagulation cascade and thus inhibits thrombin formation and thrombus development.

News Articles on Fondaparinux

Major Bleeding, Mortality, and Efficacy of Fondaparinux in Venous ...  -  ‎Dec 18, 2009‎
Study Question: What is the association between major bleeding and mortality as well as efficacy of fondaparinux versus low molecular weight heparin (LMWH) ... Cardiosource

Dabigatran per il tromboembolismo venoso  -  ‎Dec 9, 2009‎
...l'efficacia in confronto al warfarin ed alle eparine a basso peso molecolare oltre che a fondaparinux, la sicurezza nel lungo termine. 1. ... Pillole.org

Latest European and US STEMI guidelines compared and contrasted  -  ‎Nov 6, 2009‎
Both consider it reasonable to treat STEMI patients who did not undergo reperfusion therapy with either low-molecular-weight heparin or fondaparinux for the ... TheHeart.Org

In the Literature  -  ‎Nov 5, 2009‎
Clinical question: Is there a difference in bleeding risk with fondaparinux and enoxaparin when used with GPIIb/IIIa inhibitors or thienopyridines in ... The Hospitalist Online

Resurgent dollar not all gloom and doom  -  ‎Oct 23, 2009‎
If all goes to plan, Alchemia will move into profitability towards the end of next year after its lead product, a generic blood anticoagulant, fondaparinux, ... WA today

Sensex tumbles as RBI kicks off the 'exit'  -  ‎Oct 30, 2009‎
Fondaparinux, if approved, could provide further upside to our numbers. Ranbaxy Labs was up by 5% during the week, A report released by IIFL stated, ... India Infoline.com

OASIS-5: how do fondaparinux and enoxaparin compare in patients with ...  -  May 31, 2006
The Fifth Organization to Assess Strategies in Acute Ischemic Syndromes Investigators (2006) Comparison of fondaparinux and enoxaparin in acute coronary ... Nature.com

Is fondaparinux safer than enoxaparin for patients undergoing …  -  Nov 23, 2007
Mehta SR et al. (2007) Efficacy and safety of fondaparinux versus enoxaparin in patients with acute coronary syndromes undergoing percutaneous coronary ... Nature.com

Can fondaparinux safely prevent the occurrence of venous …  -  Mar 20, 2006
Cohen AT et al. (2006) Efficacy and safety of fondaparinux for the prevention of venous thromboembolism in older acute medical patients: randomised placebo ... Nature.com

ARIXTRA(R) (Fondaparinux Sodium) Reduced Risk of Death or …  -  Mar 14, 2006
ATLANTA, March 14 /PRNewswire-FirstCall/ -- GlaxoSmithKline plc announced today late-breaking clinical trial results of the OASIS 6 trial that compared its ... RedOrbit

Atlanta health, diet and fitness news | ajc.com  -  Sep 5, 2005
In research presented Monday at the European Society of Cardiology meeting in Stockholm, Canadian-led scientists said that fondaparinux, a synthetic drug ... Atlanta Journal Constitution

GlaxoSmithKline's Arixtra® (fondaparinux Sodium) Receives Positive …  -  Jul 8, 2007
GlaxoSmithKline announced today that the Committee for Medicinal Products for Human Use (CHMP) issued a positive opinion for the once-daily anticoagulant ... Medical News Today - Medical News Today (press release)

Arixtra(R) (Fondaparinux Sodium) Reduced Risk Of Death Or Recurrent …  -  Mar 18, 2006
GlaxoSmithKline plc [LSE and NYSE: GSK] announced today late-breaking clinical trial results of the OASIS 6 trial that compared its antithrombotic product ... Medical News Today - Medical News Today (press release)

… Partner Appointed for Synthetic Heparin (Generic Fondaparinux Sodiu...  -  Apr 26, 2007
The branded version of fondaparinux, Arixtra(R) was introduced into the US market in 2002 by Sanofi and ... The US patents on fondaparinux expired in 2003. ... Free with registration - PR Newswire - AccessMyLibrary.com

Fondaparinux in ST-Segment Elevation Myocardial Infarction The Drug, ...  -  Apr 5, 2006
Antithrombotic therapy has become a major defense against the assault of atherosclerosis on society, and accordingly, "atherothrombosis" has become a ... Journal of American Medical Association - Journal of American Medical Association...

Steve Flecknoe-Brown on heparin guidleines  -  May 20, 2008
Fondaparinux is a synthetic heparinoid which is proven to be safe and effective. ... Why was fondaparinux not given a big push in these guidelines? ... 6minutes

OASIS 5: Efficacy and Safety of Fondaparinux vs Enoxaparin in ACS …  -  Oct 5, 2005
Presenters: Salim Yusuf, MD, DPhil, and Shamir R. Mehta, MD (McMaster University, Hamilton, Ontario, Canada). Heparin binds to antithrombin III and induces ... Medscape

… significant with enoxaparin over fondaparinux for VTE prophylaxis  -  Nov 29, 2008
Prophylaxis in patients at risk for venous thromboembolism (VTE) is more cost-effective with the low-molecular-weight heparin enoxaparin compared with the ... Medicexchange

… Approvable Letter for New Indications for Arixtra(R) (Fondaparinux...  -  Feb 2, 2007
The FDA priority review was completed in six months. GSK will continue to work with the FDA to provide the additional information requested to complete the ... DG News

Fondaparinux shows HIT treatment potential  -  Jan 9, 2008
By Lynda Williams. MedWire News: The selective factor (F)Xa inhibitor fondaparinux may be used to treat patients with acute heparin-induced thrombocytopenia ... Medwire (subscription)

Fondaparinux betters enoxaparin in acute coronary syndrome.( …  -  Nov 1, 2005
STOCKHOLM -- The antithrombotic agent fondaparinux provided similar short-term efficacy compared with enoxaparin, but dramatically greater safety and ... Pay-Per-View - Family Practice News - Factiva, from Dow Jones

FDA Grants Priority Review For Arixtra(R) (fondaparinux Sodium) In...  -  Oct 6, 2006
GlaxoSmithKline plc [LSE and NYSE: GSK] announced today that the supplemental new drug application for its anticoagulant product Arixtra(R) (fondaparinux ... Medical News Today - Medical News Today (press release)

Significant Milestone on Path to Commercialisation of Fondaparinux  -  Dec 17, 2008
Australian drug developer, Alchemia Limited (ASX:ACL), today announced the achievement of a significant milestone towards the commercialisation of its lead ... International Business Times

… give pros, cons for fondaparinux, enoxaparin.(Cardiovascular...  -  May 15, 2006
ATLANTA -- Comparisons between enoxaparin and fondaparinux were perhaps inevitable when findings from two major clinical trials that evaluated the two ... Free with registration - Internal Medicine News - AccessMyLibrary.com

GSK Pharma net down 13% at Rs 249cr  -  Oct 25, 2007
In addition to the launch of Arixtra (Fondaparinux), a new generation blood thinning drug in the second quarter of this year, GSK had launched Carzec ... Business Standard

New Anti-thrombotic Therapy Effective, Safer For Patients  -  Sep 7, 2005
..."The study findings demonstrate that fondaparinux is likely the ... Dr. Yusuf noted that previous studies showed that fondaparinux was superior in ... sciencedaily.com

FDA Grants Priority Review for Arixtra(R) (Fondaparinux Sodium) in...  -  Oct 2, 2006
PHILADELPHIA, PA -- October 2, 2006 -- GlaxoSmithKline plc announced today that the supplemental new drug application for its anticoagulant product Arixtra® ... DG News

Alchemia Patents Granted for Generic Fondaparinux  -  Jun 23, 2008
Alchemia Ltd. (ASX:ACL) announces the granting of the first two patents in the "Synthetic Heparin Oligosaccharide" family of patents. ... Genetic Engineering News - Genetic Engineering News (press release)

Fondaparinux shows bridging therapy promise  -  Mar 9, 2007
The factor (F)Xa inhibitor fondaparinux could offer an effective bridging therapy for patients undergoing surgery, including those with antithrombin (AT) ... Medwire (subscription)

New anti-thrombotic therapy effective, safer for patients  -  Sep 11, 2005
..."The study findings demonstrate that fondaparinux is likely the ... Dr. Yusuf noted that previous studies showed that fondaparinux was superior in ... i-newswire.com

Antithrombotic Arixtra(R) (Fondaparinux) Saves More Lives Than …  -  Apr 7, 2006
GlaxoSmithKline's ARIXTRA(R) (fondaparinux) reduces mortality rates by 17% at one month compared to the more expensive, current gold-standard, ... Medical News Today - Medical News Today (press release)

Key Fondaparinux Patent Allowed by US Patent Office  -  Oct 21, 2008
Australian drug developer Alchemia Limited (ASX:ACL) today announced it had received a 'notice of allowance' for the United States patent application titled ... Genetic Engineering News - Genetic Engineering News (press release)

Fondaparinux bests enoxaparin overall in ACS.(Cardiovascular Medicine...  -  Nov 1, 2005
Fondaparinux bests enoxaparin overall in ACS.(Cardiovascular Medicine) ... find Internal Medicine News articles. STOCKHOLM -- The antithrombotic agent ... Pay-Per-View - Internal Medicine News - HighBeam Research

Fondaparinux cut event, bleeding risk in ACS.(Cardiovascular Medicine)...  -  Dec 1, 2006
BARCELONA -- The selective factor Xa inhibitor fondaparinux proved superior to enoxaparin or unfractionated heparin for the treatment of the full spectrum ... Free with registration - Internal Medicine News - AccessMyLibrary.com

… New Indication for ARIXTRA(R) (fondaparinux sodium) Injection for ...  -  May 27, 2005
FDA Approves New Indication for ARIXTRA(R) (fondaparinux sodium) Injection for Prevention of Venous Thromboembolism in Abdominal Surgery. from PR Newswire. Pay-Per-View - PR Newswire - HighBeam Research

Fondaparinux reduces event rate in ST-segment elevation MI, except in...  -  May 1, 2006
Fondaparinux reduces the risk of death or recurrent MI compared with standard antithrombotic therapy (UFH or placebo) in patients with ST-segment elevation ... Free with registration - Formulary - AccessMyLibrary.com

Ann Intern Med -- Rapid Responses for Fox et al., 147 (5) 304-310  -  Oct 9, 2007
The dose of fondaparinux was chosen following the phase II study in ... Effects of fondaparinux on mortality and reinfarction in patients with acute ... Annals of Internal Medicine

Alchemia gets milestone on fondaparinux.  -  Dec 22, 2008
Alchemia gets milestone on fondaparinux. Australian drug developer Alchemia has announced the achievement of a significant milestone towards the ... $9.94 - Pharma Marketletter - Alacra Store

FDA Approves Fondaparinux sodium for Prevention of Venous …  -  May 27, 2005
By GlaxoSmithKline, [RxPG] The anti-thrombotic drug ARIXTRA(R) is now indicated for use in patients undergoing abdominal surgery, GlaxoSmithKline (NYSE: ... RxPG NEWS

… Approvable Letter For New Indications For Arixtra® (fondaparinux …  -  Feb 5, 2007
The FDA priority review was completed in six months. GSK will continue to work with the FDA to provide the additional information requested to complete the ... Medical News Today - Medical News Today (press release)

Article: Fondaparinux lowers bleeding risk in acute MI: 'its impact...  -  May 15, 2006
Fondaparinux lowers bleeding risk in acute MI: 'its impact is as large as the difference between tissue plasminogen activator and streptokinase.'. Pay-Per-View - Internal Medicine News - HighBeam Research

Aspirin Safe for Emboli Prevention After Knee Replacement in Selected...  -  Mar 7, 2008
...treated with aspirin; 51923 patients treated with adjusted-dose warfarin; and 37198 patients treated with low-molecular-weight heparin or fondaparinux. ... DG News

Article: Fondaparinux betters enoxaparin in acute coronary syndrome.(...  -  Nov 1, 2005
Fondaparinux betters enoxaparin in acute coronary syndrome.(Cardiovascular Medicine) ... find Family Practice News articles. STOCKHOLM -- The antithrombotic ... Pay-Per-View - Family Practice News - HighBeam Research

… give pros, cons for fondaparinux, enoxaparin.(Cardiovascular...  -  May 15, 2006
Researchers give pros, cons for fondaparinux, enoxaparin.(Cardiovascular Medicine) ... find Internal Medicine News articles. ATLANTA -- Comparisons between ... Pay-Per-View - Internal Medicine News - HighBeam Research

A review of antithrombotic therapies in acute coronary syndrome:...  -  Mar 1, 2007
These classes include unfractionated heparin (UFH), direct thrombin inhibitors (bivalirudin), pentasaccharide (fondaparinux), and low-molecular-weight ... Free with registration - Formulary - AccessMyLibrary.com

fondaparinux sodium GlaxoSmithKline registered, EU (prophylaxis of …  -  Feb 14, 2005
Fondaparinux sodium, an antithrombotic consisting of a synthetic pentasaccharide composed of an antithrombin III-binding fragment of heparin, ... Pay-Per-View - R & D Focus Drug News - Factiva, from Dow Jones

… ST-segment elevation myocardial infarction be treated with fondapar...  -  May 24, 2006
The OASIS-6 Trial Group (2006) Effects of fondaparinux on mortality and ... To compare the effect of the anticoagulant fondaparinux with that of standard ... Nature.com

Researchers report progress in treating MI.  -  Oct 24, 2005
Patients in OASIS-5 were randomized to either fondaparinux 2.5 mg (once daily) or ... Major bleeding, however, was lower with fondaparinux, with remarkable ... $9.94 - Drug Topics - Alacra Store

Impact Of Fondaparinux Tested On Most Serious Heart Attacks  -  Mar 17, 2006
ATLANTA, GA (March, 2006) -- The results of a large international cardiovascular trial will shed light on whether the addition of a new drug that prevents ... Medical News Today - Medical News Today (press release)

OnMedica - News: The anti-thrombotic drug Arixtra is significantly...  -  Sep 6, 2005
..."The study findings demonstrate that fondaparinux is likely the anti-thrombotic drug of choice in patients with acute coronary syndromes (ACS)," he said. ... OnMedica

Impact of fondaparinux tested on most serious heart attacks  -  Mar 14, 2006
ATLANTA, GA (March 14, 2006) -- The results of a large international cardiovascular trial will shed light on whether the addition of a new drug that ... eurekalert.org

… Approvable Letter for New Indications for ARIXTRA(R) (Fondaparinux...  -  Feb 2, 2007
Article: Arixtra(R) (fondaparinux sodium) Has Been Approved ... ... Article: FDA Grants Priority Review for ARIXTRA(R) (fondaparinux ... ... Pay-Per-View - PR Newswire - HighBeam Research

… FDA Grants Priority Review for ARIXTRA(R) (fondaparinux sodium) in...  -  Oct 2, 2006
FDA Grants Priority Review for ARIXTRA(R) (fondaparinux sodium) in the Treatment of Acute Coronary Syndromes. from PR Newswire. Pay-Per-View - PR Newswire - HighBeam Research

Arixtra (Fondaparinux) for Acute Myocardial Infarctions (OASIS-6)  -  Apr 26, 2006
Arixtra® (Fondaparinux, GlaxoSmithKline) is a low molecular weight heparin (LMWH) which was studied in patients with STEMI, a market where LMWHs have been ... Gerson Lehrman Group

… Strategies in Acute Ischemic Syndromes -- Effects of Fondaparinux...  -  Apr 12, 2006
An alternative to these therapies is fondaparinux, a synthetic ... Prior studies have demonstrated that fondaparinux is superior to enoxaparin for the ... Medscape

Article: Fondaparinux plus compression prevents VTE.(Gynecologic …  -  May 1, 2006
Fondaparinux plus compression prevents VTE.(Gynecologic Surgery) ... find OB GYN News articles. PALM SPRINGS, CALIF. -- Once-daily fondaparinux 2.5 mg for ... Pay-Per-View - OB GYN News - HighBeam Research

ARIXTRA drug for venous thromboembolism  -  Feb 5, 2006
ARIXTRA drug which is called as FLEXTRA (Flexibility in Administration of Fondaparinux for Prevention of Symptomatic Venous Thromboembolism in Orthopaedic ... MedIndia

fondaparinux sodium GlaxoSmithKline clinical data (phase III)...  -  Mar 27, 2006
...in acute coronary syndrome (ACS) patients with ST elevation myocardial infarction (STEMI). During this study, 12 092 patients were randomized to receive ... Pay-Per-View - R & D Focus Drug News - Factiva, from Dow Jones

Cardiology; Anti-thrombotic medication reduces risk of death for...  -  Apr 12, 2006
There was a tendency to fewer severe bleeding events in the fondaparinux group. "In summary, fondaparinux reduces mortality and reinfarction early, ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Press Release: ARIXTRA(R) (Fondaparinux Sodium) Reduced Risk of …  -  Mar 14, 2006
ARIXTRA(R) (Fondaparinux Sodium) Reduced Risk of Death or Recurrent Heart Attack in Patients With Acute Coronary Syndromes (ST Elevation Myocardial ... Pay-Per-View - PR Newswire - HighBeam Research

The OASIS-6 Trial: Description and Results  -  May 12, 2006
The goal of the trial was to evaluate treatment with fondaparinux compared ... Patients were randomized to either fondaparinux (2.5 mg/day for up to 8 days ... Medscape

Article: Fondaparinux cut event, bleeding risk in ACS.(Cardiovascular...  -  Dec 1, 2006
Fondaparinux cut event, bleeding risk in ACS.(Cardiovascular Medicine)(acute coronary syndrome) ... find Internal Medicine News articles. Pay-Per-View - Internal Medicine News - HighBeam Research

Adolor Corporation; Deal signed to copromote Arixtra in the US  -  Feb 2, 2005
...that the company has signed a 2-year agreement to copromote GlaxoSmithKline's anti-thrombotic agent Arixtra (fondaparinux sodium) in the United States. ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones

STUDY: BLEEDING RISKS LOWER IN ARIXTRA THAN LOVENOX  -  Apr 10, 2006
Arixtra (fondaparinux sodium) reduced bleeding at day nine by 48 percent compared to Lovenox (enoxaparin), noted the study published in the New England ... Pay-Per-View - Daily International Pharma Alert - Factiva, from Dow Jones

Improving Clinical Outcomes by Reducing Bleeding in Patients With Non...  -  Oct 1, 2008
Study Question: What is the incidence of and outcome after bleeding in patients with acute coronary syndromes (ACS) treated with fondaparinux or enoxaparin? ... Cardiosource

B vitamins fail to help heart; Findings debunk a theory that taking …  -  Mar 20, 2006
In the second trial, nearly 12000 heart attack patients receiving clot-busting therapy and heparin also received either fondaparinux sodium or a placebo. ... Pay-Per-View - Los Angeles Times - ProQuest Archiver

The Treatment of Deep Vein Thrombosis in the Pelvis and Leg  -  Jul 1, 2008
The pentasaccharide fondaparinux is a good alternative to heparins for the treatment of ... Fondaparinux should be used with caution in patients with renal ... Deutsches Ärzteblatt

Anti-Thrombotic Medication Reduces Risk of Death for Heart Attack …  -  Mar 9, 2006
There was a tendency to fewer severe bleeding events in the fondaparinux group. "In summary, fondaparinux reduces mortality and reinfarction early, ... newswise.com

New Trials of Antithrombotic Therapy for ACS -- ACC 2006  -  Jul 19, 2006
OASIS-6 compared fondaparinux with either placebo or UFH. ... The trial also compared fondaparinux to 2 control arms: (1) placebo and (2) UFH. ... Medscape

Anti-Thrombotic Medication Significantly Reduces Risk of Death for...  -  Mar 20, 2006
There was a tendency to fewer severe bleeding events in the fondaparinux group. "In summary, fondaparinux reduces mortality and reinfarction early, ... emaxhealth.com

Press Release: Pivotal Study Published in British Medical Journal …  -  Feb 13, 2006
Synthelabo and Organon announced today that Arixtra(R) (fondaparinux sodium) has ... Article: Arixtra(R) (fondaparinux sodium) Has Been Approved by the ... ... Pay-Per-View - PR Newswire - HighBeam Research

Management of hip fracture: the family physician's role.(Medical...  -  Jun 15, 2006
Fondaparinux is a synthetic pentasaccharide that significantly increases an ... The US Food and Drug Administration (FDA) has approved fondaparinux for the ... $4.95 - American Family Physician - ECNext

Anticoagulation in non-ST-Segment elevation acute coronary syndromes ...  -  Sep 1, 2007
Fondaparinux Versus LMWH in Medical Stabilization Fondaparinux is a relatively new antithrombotic agent that selectively binds to AT, catalyzing the ... Free with registration - Formulary - AccessMyLibrary.com

Heparininduzierte Thrombozytopenie unter Fondaparinux  -  Jul 29, 2008
Die Arzneimittelkommission der deutschen Ärzteschaft (AkdÄ) berichtet am 25. Juli 2008 über den Fall einer 48-jährigen Patientin, die nach beidseitigem ... Pharmazeutische Zeitung online

Study on acute coronary syndromes shows new anti-thrombotic therapy …  -  Sep 5, 2005
..."The study findings demonstrate that fondaparinux is likely the ... Dr. Yusuf noted that previous studies showed that fondaparinux was superior in ... PsychCentral.com

ACS, antithrombotics, and the kidney  -  Mar 27, 2006
The study was designed to compare fondaparinux 2.5 mg daily with ... Fondaparinux was as effective as enoxaparin in reducing cardiovascular events in the ... Medscape

Autorizado en la UE el fondaparinux para el síndrome coronario agudo  -  May 9, 2007
La compañía GlaxoSmithKline ha anunciado que la Agencia Europea del Medicamento (EMEA) ha autorizado una nueva indicación para el anticoagulante ... doyma.es

Geringere Mortalität unter Fondaparinux  -  Mar 28, 2008
Verglichen mit einer Heparin-Therapie kann die Faktor-Xa-Hemmung erstmals die Sterblichkeit bei ACS-Patienten senken, ohne dass mehr Blutungs-Komplikationen ... Ärztliche Praxis Gesundheitszeitung

ARIXTRA® (fondaparinux sódico) REDUJO EL RIESGO DE MUERTE O …  -  Mar 16, 2006
Atlanta, Georgia, EE.UU., 16 de marzo de 2006. GlaxoSmithKline ha anunciado los resultados de última hora del estudio OASIS 6 que comparaba su fármaco ... acceso.com

New anti-thrombotic therapy effective, safer for patients  -  Sep 1, 2005
..."The study findings demonstrate that fondaparinux is likely the ... Dr. Yusuf noted that previous studies showed that fondaparinux was superior in ... PsychCentral.com

Studio OASIS-6: Fondaparinux riduce la mortalità ed il reinfarto nei ...  -  Mar 29, 2006
Mercoledì 29 Marzo 2006 - La mortalità nei pazienti con infarto miocardico acuto con sopraslivellamento ST ( STEMI ) rimane alto. ... XagenaSalute

Factor Xa inhibitors: future therapeutic directions in the prophylaxis...  -  Oct 1, 2006
Indirect thrombin inhibitors such as UFH, LMWH, and fondaparinux require ... Fondaparinux, acting indirectly via AT, is highly specific for Factor Xa and ... Free with registration - Formulary - AccessMyLibrary.com

Nuovo 'salvavita' contro l'attacco cardiaco  -  Apr 23, 2008
In sostanza fondaparinux funziona come un “idraulico� che libera il vaso e consente ... Per questo fondaparinux è stato identificato come farmaco di prima ... Il Quotidiano

Factor Xa inhibitors: future therapeutic directions in the prophylaxis...  -  Oct 1, 2006
Indirect thrombin inhibitors such as UFH, LMWH, and fondaparinux require ... The long half-life of fondaparinux allows the convenience of once-daily dosing. ... Free with registration - Managed Healthcare Executive - AccessMyLibrary.com

ARIXTRA®, DE GLAXOSMITHKLINE, RECIBE LA AUTORIZACIÓN PARA …  -  Sep 5, 2007
...“Los beneficios en la mortalidad con fondaparinux comparado con enoxaparina y la autorización europea de fondaparinux pueden permitir a los médicos ... acceso.com

Le fondaparinux, un antithrombotique plus efficace et plus sûr pour...  -  Sep 13, 2005
Une étude internationale (Organisation to Assess Strategies for Ischemic Syndromes, OASIS) menée par le Dr. Salim YUSUF de Mc Master University a permis de ... InformationHospitaliere.com

Factor Xa inhibitors: future therapeutic directions in the prophylaxis...  -  Oct 1, 2006
Indirect thrombin inhibitors such as UFH, LMWH, and fondaparinux require ... Fondaparinux, acting indirectly via AT, is highly specific for Factor Xa and ... $4.95 - Formulary - ECNext

New drugs on the horizon for VTE.(venous thromboembolism)(Editorial)...  -  Jun 1, 2005
Fondaparinux and a relative, idraparinux, are most like LMWH. ... Fondaparinux has been tested for the prophylaxis of major orthopedic surgery. ... Pay-Per-View - Internal Medicine News - HighBeam Research

Il dilemma della terapia antitrombotica nelle sindromi coronariche...  -  Apr 3, 2006
Nello studio OASIS-5 [1] sono stati reclutati 20.078 pazienti con sindrome coronarica acuta, randomizzati a ricevere fondaparinux (2,5 mg/die) oppure ... Pillole.org

Fondaparinux bra vid hjärtinfarkt  -  Mar 16, 2006
Tillägg av antitrobosmedlet fondaparinux är bra för patienter med hjärtinfarkt och ST-höjning. Det visar OASIS-6-studien som presenterades på den nyligen ... Läkemedelsvärlden

Fondaparinux post-intervento paragonabile alla Dalteparina pre- …  -  Nov 22, 2005
Martedì 22 Novembre 2005 - Uno studio, coordinato da G. Agnelli dell'Università di Perugia, ha valutato se Fondaparinux ( Arixtra ), un inibitore sintetico ... XagenaSalute

International Approvals: Tarceva, Arixtra, 1D09C3  -  Jul 18, 2005
Fondaparinux sodium injection was approved for this indication by the US Food and Drug Administration on May 26, 2005. It was previously approved by the FDA ... Medscape

Assessment of a Self-Administration Protocol for Extended Subcutaneous...  -  Jan 31, 2006
The first dose of fondaparinux, a synthetic factor Xa inhibitor (2.5 mg subcutaneous injection; Glaxo-SmithKline, Middlesex, UK) was administered eight ... RedOrbit

FONDAPARINUX, PRINCIPIO ACTIVO DEL ANTITROMBÓTICO …  -  Feb 21, 2005
Madrid, 21 de febrero de 2005. Especialistas en Traumatología, Hematología y Anestesiología de toda España han debatido de manera activa y conjunta, ... acceso.com

Fondaparinux per la prevenzione del tromboembolismo venoso  -  Apr 10, 2006
Fondaparinux è efficace nel prevenire il tromboembolismo venoso asintomatico e sintomatico nei pazienti anziani con patologie di tipo medico. ... Pillole.org

D&B Australasia Pty Ltd acquires Decision Intellect - Oct 08, 2008 -...  -  Oct 8, 2008
Retinopathy PC HyAMP Fungal Infections D Fondaparinux sodium ALCHEMIA Thrombosis NA…Research (AACR) held in Washington D.C. This poster describes the… ... Pay-Per-View - deals - Alacra Store

Heparin-induced thrombocytopenia: A quick review of recent studies.( …  -  Sep 1, 2007
In addition, prophylactic doses of the factor Xa inhibitor fondaparinux may ... Wester and associates12 reported successful use of low-dose fondaparinux as ... $4.95 - Journal of Respiratory Diseases - ECNext

Efficacia di Fondaparinux nella prevenzione del tromboembolismo …  -  Mar 8, 2006
Mercoledì 8 Marzo 2006 - I Ricercatori dello studio ARTEMIS hanno valutato l'efficacia e la sicurezza dell'anticoagulante Fondaparinux ( Arixtra ) nei ... XagenaSalute

Fondaparinux et infarctus du myocarde (IDM)  -  Mar 15, 2006
Les résultats de l'essai OASIS-6 viennent d'être publiés dans le JAMA. Chez des patients avec IDM et sus-décalage du segment ST, le fondaparinux est associé ... Caducée.net

Fondaparinux sódico en el síndrome coronario agudo  -  Apr 25, 2006
El fondaparinux sódico, comercializado por la compañía GlaxoSmithKline (GSK) como Arixtra, reduce la hemorragia mayor y el riesgo de muerte o infarto en ... doyma.es

Un nuevo anticoagulante disminuye el riesgo de hemorragia tras un …  -  Sep 8, 2005
Sin embargo, los que reciben fondaparinux tienen muchas menos ... Por otro lado, los pacientes tratados con fondaparinux tuvieron menos riesgo de accidente ... El Mundo Salud

Anticoagulation in non-ST-Segment elevation acute coronary syndromes ...  -  Sep 1, 2007
Fondaparinux Versus LMWH in Medical Stabilization Fondaparinux is a relatively new antithrombotic agent that selectively binds to AT, catalyzing the ... $4.95 - Formulary - ECNext

LOS RESULTADOS OBTENIDOS EN LOS ESTUDIOS OASIS 5 Y OASIS …  -  Apr 24, 2006
Además, fondaparinux ha demostrado una notable reducción en toda la ... El objetivo principal del estudio consistía en evaluar si fondaparinux era tan ... acceso.com

Discrepancies in ACC-AHA and ESC anticoagulant guidelines criticized  -  May 9, 2008
However, an excess of catheter thrombosis with fondaparinux led the ESC not to recommend its use in invasively managed patients, Eikelboom et al note. ... Medwire (subscription)

Preventing venous thromboembolism in your patients at risk.(Clinical ...  -  Feb 1, 2007
Since fondaparinux has not been associated with HIT, many clinicians will use ... Others include dalteparin, 5000 U SC q12h, and fondaparinux, 2.5 mg/d SC. ... Free with registration - Patient Care for the Nurse Practitioner - AccessMyLibrary.com

APS patient responds to pentasaccharide agent  -  Jul 20, 2006
Fondaparinux therapy was therefore initiated and her platelet count returned ... While noting no other reports of fondaparinux therapy for this indication ... Medwire (subscription)

Brand Names/Synonyms:
Fondaparinux is also known by the following brand names and/or synonymsArixtra; Fondaparinux sodium

Drug Category:
Fondaparinux is categorized under the following by the FDA: Anticoagulants; Antithrombotics; ATC:B01AX05

Dosage Forms:
Solution

Absorption:
100%

Interactions:
[an error occurred while processing this directive]



Chemical IUPAC Name:
decasodium 6-[6-[2-carboxylato-4-hydroxy-6-[4-hydroxy-6-methoxy-5-sulfonatoamino-2-(sulfonatooxymethyl)oxan-3-yl]oxy-5-sulfonatooxy-oxan-3-yl]oxy-5-sulfonatoamino-4-sulfonatooxy-2-(sulfonatooxymethyl)oxan-3-yl]oxy-3-[4,5-dihydroxy-3-sulfonatoamino-6-(sulfonatooxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-oxane-2-carboxylate





Health Home | Conditions | Cancer | Medications | Surgery | Vaccines


The Cancer News Network


Disclaimer:

Contact a physician with regard to health concerns. Email requests for further health information will be discarded.

The materials contained on this Web site are for informational purposes only and do not constitute health or medical advice. Use of information on this site does not create or constitute any kind of agreement or contract between you and the owners or users of this site, the owners of the servers upon which it is housed, or anyone else who is in any way connected with this site.

Many links on cancernewsnetwork.org lead to other sites. cancernewsnetwork.org does not sponsor, endorse or otherwise approve of the materials appearing in such sites. Nor is CancerNewsNetwork.org responsible for dead or misdirected links.

IF YOU NEED A LINK OR TEXT REMOVED FROM THIS PAGE PLEASE CONTACT cancernewsnetwork (at) live.com.
We will do our best to accommodate your request.



COPYRIGHT 2009 CANCERNEWSNETWORK | Privacy