Gabapentin

This page contains recent news articles, when available, and an overview of Gabapentin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Gabapentin
(when available)

Pharmacology and use:
Gabapentin, an analog of GABA, is used as an anticonvulsant to treat partial seizures, amyotrophic lateral sclerosis (ALS), and painful neuropathies. Potential uses include monotherapy of refractory partial seizure disorders, and treatment of spasticity in multiple sclerosis, tremor. mood disorders, and attenuation of disruptive behaviors in dementia. Gabapentin has high lipid solubility, is not metabolized by the liver, has no protein binding, and doesn't possess the usual drug interactions. For the management of postherpetic neuralgia in adults and as adjunctive therapy in the treatment of partial seizures with and without secondary generalization in patients over 12 years of age with epilepsy

Mechanism Of Action:
Gabapentin interacts with cortical neurons at auxillary subunits of voltage-sensitive calcium channels. Gabapentin increases the synaptic concentration of GABA, enhances GABA responses at non-synaptic sites in neuronal tissues, and reduces the release of mono-amine neurotransmitters. One of the mechanisms implicated in this effect of gabapentin is the reduction of the axon excitability measured as an amplitude change of the presynaptic fibre volley (FV) in the CA1 area of the hippocampus. This is mediated through its binding to presynaptic NMDA receptors. Other studies have shown that the antihyperalgesic and antiallodynic effects of gabapentin are mediated by the descending noradrenergic system, resulting in the activation of spinal alpha2-adrenergic receptors. Gabapentin has also been shown to bind and activate the adenosine A1 receptor.

News Articles on Gabapentin

Forecast Insight: Neuropathic Pain - Brighter future for pipeline drugs while ...  -  05 Jan 2010
Two extended-release gabapentin reformulationsXenoPort/GlaxoSmithKline´s Solzira (gabapentin enacarbil) and Depomed/Solvay´s DM-1796 (gabapentin ER) are ... PR-inside.com (press release)

Alternative Treatments in Hormone Therapy  -  05 Jan 2010
Then, there are prescription medications like Gabapentin, selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors ... EmpowHer (blog)

Are alternative treatments for menopausal hot flushes safe?  -  05 Jan 2010
Gabapentin and Clonidine are other drugs used for menopausal hot flushes. Are there alternative therapies that can help? Why are some doctors reluctant to ... Herald.ie

Brain Finding Raises Concerns About Seizure Drug in Children  -  ‎Dec 18, 2009‎
The findings shed light on the pathophysiology of certain neurological diseases and raise concerns about the long-term effects of gabapentin on the ... Psychiatric News

2000 patent applications by MNCs withdrawn, rejected: PPMA  -  ‎Dec 24, 2009‎
He said PPMA has opposed some important molecules including PEG-Interferon, Omeprazole, Gabapentin, combination of Pregablin and Gabapentin, Azithromycin, ... Daily Times

Conquering the Battle Zone in His Mind  -  ‎Dec 27, 2009‎
There was Trazodone, Gabapentin, Oxycodone, Citalopram, Fluconazole, Donepezil and Ranitidine — and, if the pharmaceutical combination did not drive him ... New York Times

2009 Big Pharma DOTY Nominee: Abbott/Solvay and the Foreign Cash Dilemma  -  ‎Dec 17, 2009‎
...disease and gabapentin GR, an extended-release form of gabapentin (Pfizer's Neurontin and generics) for neuropathic pain and post-herpetic neuralgia. ... The IN VIVO Blog (blog)

Breakthrough Treatment for Diabetic Neuropathy Introduced  -  ‎Jan 2, 2010‎
...conventional or newer approaches, including the use of medications like gabapentin, exercise and other adjunctive treatment measures,� Dr. Ajrawat says. ... Melodika.net

Primary insomnia  -  ‎Dec 14, 2009‎
Some medications, including gabapentin, pregabalin and tiagabine, increase the amount of GABA in the brain. These medications have a very low tendency to be ... Dubuque Telegraph Herald

New Inhaled Insulin, Provenge, Top List of 2010 Action Dates  -  ‎Dec 31, 2009‎
On the FDA's February agenda is a NDA for Solzira (gabapentin enacarbil), Santa Clara, Calif.-based XenoPort Inc.'s drug for restless legs syndrome, ... BioWorld Online

Vigabatrin (Sabril®): A New Epilepsy Drug -- With Strings Attached  -  ‎Dec 31, 2009‎
...[1] Vigabatrin joined the 11 antiepileptic drugs that have received FDA approval since 1993: felbamate (Felbatol®), gabapentin (Neurontin®), ... Medscape

Maybe a treatment for hot flashes without hormones  -  ‎Dec 27, 2009‎
A small study conducted by an unbiased group has shown that the generic drug "gabapentin" can work as well as estrogen for hot flashes. ... Hattiesburg American

Medical marijuana attorney Rob Corry: "The future is here"  -  ‎Dec 18, 2009‎
These medications include Copaxone, Gabapentin, Cyclobenzaprine, Meloxicam, Sertraline, Advair, and Mirapex. With the addition of medical marijuana to her ... Westword (blog)

Managing hot flushes in men after prostate cancer-A systematic review - Abstract  -  ‎Dec 28, 2009‎
Gabapentin has an uncertain effect. Clonidine is not proven effective for hot flushes. Long-term effects were not evaluated in any of the studies. ... UroToday

Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market ...  -  ‎Dec 15, 2009‎
13.2.5.6 Xiaflex 13.2.5.7 Eurartesim 13.2.5.8 Gabapentin GR 13.2.6 Approved 13.2.6.1 Cyanokit 13.2.6.2 Fomepizole 13.2.6.3 Xenazine 13.2.6.4 fludarabine ... IT News Online

Antiepileptic Drugs Do Not Trigger Suicidal Thoughts in Victims of Bipolar ...  -  ‎Dec 9, 2009‎
The 11 antiepileptic drugs include gabapentin, pregabalin, topiramate and carbamazepine. "On Jan. 31, 2008, the Food and Drug Administration issued an alert ... MedIndia

Geschönte Ergebnisse  -  ‎Dec 17, 2009‎
Seine kritischen Worte beziehen sich auf das Epilepsie-Medikament Gabapentin. Vor fast genau einem Jahr, im Dezember 2008, berichtete sein Blatt über ... FR-online.de

Modificata la nota 4  -  ‎Dec 13, 2009‎
...terapeutiche: trattamento della depressione maggiore e disturbo d'ansia generalizzato per duloxetina e della epilessia per gabapentin e pregabalin.". ... Pillole.org

Massaging the Data for Neurontin?  -  ‎Nov 12, 2009‎
There's a disturbing article out at the New England Journal of Medicine on studies conducted on Neurontin (gabapentin) for various unapproved indications. ... Corante (blog)

Gabapentin Studies for Off-Label Uses Cooked?  -  ‎Nov 11, 2009‎
Primary outcome measures were apparently a moving target in many company-sponsored studies of gabapentin ... MedPage Today

FDA extends review of XenoPort-Glaxo pain drug  -  ‎Nov 9, 2009‎
XenoPort and GlaxoSmithKline said late Friday the FDA should complete its review of the drug, called gabapentin enacarbil, by Feb. 9, 2010. ... The Associated Press

Pregabalin Can Reduce Hot Flash Frequency and Severity Study finds drug as ...  -  ‎Nov 12, 2009‎
..."Its effects appear to be roughly comparable to what has been reported with gabapentin and with some newer antidepressants." ModernMedicine

Combined Tramadol and Acetaminophen as Effective as Gabapentin for Treatment ...  -  ‎Oct 21, 2009‎
Although gabapentin can provide pain relief, it carries the risk of side effects that range from mild to the potential for compromised breathing and ... DG News

Up-Trend Outlook: RCRC, ANAD, DEPO, MOVE  -  ‎Oct 21, 2009‎
Serada is an extended release version of the drug gabapentin, which is used to treat epilepsy and pain disorders. DEPO recently reported results from a ... Small Cap Network

Key mechanism in brain development seems to have been identified  -  ‎Oct 21, 2009‎
Also, this study is believed to have identified for the foremost time, the biochemical mechanism by which the commonly prescribed drug gabapentin functions. ... HealthJockey.com

Pharmacologic attenuation of pelvic pain in a Murine model of interstitial ...  -  ‎Nov 13, 2009‎
In contrast, the H1R antagonist hydroxyzine, proton pump inhibitors, a histamine receptor 3 agonist, and gabapentin had little or no effect on PRV-induced ... 7thSpace Interactive (press release)

Combo Pill an Option for Diabetes-Related Nerve Pain  -  ‎Oct 20, 2009‎
Gabapentin is an anti-seizure drug frequently prescribed for epilepsy. The drug is also used to treat persistent neurological pain. In general, gabapentin ... ABC News

EpiCept Corporation Reports Third Quarter Results, Provides Business Update  -  ‎Nov 9, 2009‎
...achieved statistically significant pain relief compared with placebo and was statistically comparable in pain relief to the market leader gabapentin. ... WELT ONLINE

XenoPort Reports Third Quarter Financial Results  -  ‎Nov 3, 2009‎
Subjects with a history of inadequate response to gabapentin (N=138) entered a baseline period where they received a dose of 1800 mg/day of gabapentin for ... WELT ONLINE

CORRECTING and REPLACING GlaxoSmithKline and XenoPort Announce Extension of ...  -  ‎Nov 10, 2009‎
Drug User Fee Act (PDUFA) goal date for its review of the New Drug Application (NDA) for GSK1838262/XP13512 (gabapentin enacarbil) to February 9, 2010. ... Trading Markets (press release)

Personal Health The Many Ills of Peripheral Nerve Damage  -  ‎Oct 20, 2009‎
Many with neuropathic pain have benefited from drugs licensed for other uses, including antiseizure medications like gabapentin, topiramate (Topamax) and ... New York Times

GlaxoSmithKline and XenoPort Announce Extension of GSK1838262 (XP13512) FDA ...  -  ‎Nov 6, 2009‎
Drug User Fee Act (PDUFA) goal date for its review of the New Drug Application (NDA) for GSK1838262/XP13512 (gabapentin enacarbil) to February 9, 2010. ... Business Wire (press release)

Serada Half Price Sale: DepoMed's Stock Price Poised to Climb  -  ‎Nov 8, 2009‎
Lyrica, Pfizer's $2 billion dollar blockbuster, is a prodrug of gabapentin, which is the active ingredient used in DM1796. Lyrica is dosed 2-4 times-a-day, ... Seeking Alpha (blog)

Other News To Note  -  ‎Nov 9, 2009‎
Act (PDUFA) target date for Solzira (gabapentin enacarbil) and will now make a decision regarding the drug's approval for restless legs syndrome on Feb. ... Therapeutics Daily (press release) (registration)

Botox also helps relieve pain  -  ‎Nov 10, 2009‎
When given both an anti-seizure drug (gabapentin) and an antidepressant (nortriptyline), patients suffering from neuropathic pain caused by nerve damage or ... Gaea Times

Studie sieht manipulierte Daten zu Gabapentin  -  ‎Nov 12, 2009‎
Unter ihnen befanden sich auch Dokumente zu firmengesponserten Studien, in denen Gabapentin in Off-label-Indikationen eingesetzt wurde. ... Deutsches Ärzteblatt

FDA延後GSK1838262/XP13512æ–°è?¯å®¡æ ¸æ—¥æœŸ  -  ‎Nov 10, 2009‎
...(XNPT) 18.14 : GLaxoSmithKline (GSK)与XenoPort宣布,美国FDA延後处方è?¯ä½¿ç”¨è€…费用法(PDUFA)原定日期至2010å¹´2月9日,以审核GSK1838262/XP13512 (gabapentin ... 凤凰网

'울트ë?¼ì…‹' 당뇨성 신경병ì¦?ì—? 효과 íƒ?월해  -  ‎Oct 20, 2009‎
...트ë?¼ë§ˆë?Œ(tramadol)ê³¼ 아세트아미노펜(acetaminophen) 복합제가 가바펜틴(gabapentin)ê³¼ 비슷한 당뇨병성 신경병ì¦? 완화 효과를 보였다는 연구결과가 ìº?나다 몬트리올 ... 데일리팜

המדדי×? סיימו בגבוה יומי: הד×?ו ×’'ונס ננעל בשי×? שנתי, מניית ט×?ו×?ר עלתה 4%  -  ‎Nov 9, 2009‎
...חברת התרופות הבריטית גל×?קסו-סמית-קליין (סימול: GSK) הודיעה היו×? יחד ×¢×? חברת XenoPort ×›×™ ×”-FDA ×”×?ריך בשלושה חודשי×? ×?ת בחינת התרופה gabapentin לטיפול בכ×?בי×? ... Bizportal

Trigeminus: Schmerzfrei mit Gen-GABA  -  ‎Oct 29, 2009‎
...der aber nur in Kombination mit anderen Medikamenten verwendet wird, und auch modernen Antikonvulsiva, etwa Lamotrigin und Gabapentin. ... DocCheck News

India's Ranbaxy recalls 73 mln Gabapentin pills from US market -...  -  Nov 16, 2007
MUMBAI (Thomson Financial) - In what is possibly the first product recall by an Indian company in the US, Ranbaxy Laboratories is voluntarily pulling out 73 ... Forbes

Depomed reports positive results from Phase II Gabapentin study  -  Feb 12, 2008
NEW YORK (Thomson Financial) - Depomed Inc. Tuesday said data from a Phase II trial evaluating Gabapentin GR for the treatment of women with ... Forbes

Gabapentin to help muscle spasms  -  Jul 25, 2008
We're not sure. Some people with multiple sclerosis (MS) find that gabapentin helps their pain, especially pain from muscle spasms. ... guardian.co.uk

Glenmark gets US FDA nod to market generic Gabapentin  -  Aug 24, 2006
Mumbai, August 24, 2006: Glenmark Pharmaceuticals, Inc., USA [GPI], the wholly owned US subsidiary of Glenmark Pharmaceuticals Limited [Glenmark], ... Business Standard

… District Court Opinions - IN RE GABAPENTIN PATENT LITIGATION (NJ …  -  Aug 25, 2005
IN RE GABAPENTIN PATENT LITIGATION (NJ 2005) IN RE GABAPENTIN PATENT LITIGATION. PFIZER INC., WARNER-LAMBERT COMPANY and GÖDECKE AKTIENGESELLSCHAFT, ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Depomed nerve pain drug fails trial, shares plunge  -  Jul 10, 2007
The Gabapentin GR medicine was tested against postherpetic neuralgia, ... Patients daily received a total of 1800 milligrams of Gabapentin GR in one or two ... Reuters

… pain associated with herpes zoster respond to treatment with gabape...  -  Feb 8, 2006
Berry JD and Petersen KL (2005) A single dose of gabapentin reduces acute pain ... The anticonvulsant agent gabapentin is widely prescribed to relieve the ... Nature.com

Seizure Drug | Gabapentin | Alcoholism | Anxiety | Medications  -  Jun 21, 2008
A new study conducted on mice has shown that a seizure drug, called gabapentin, could act as a potential therapy for alcoholism by reversing cellular ... Oneindia

Does addition of gabapentin to antidepressant therapy improve control...  -  Mar 23, 2007
Loprinzi CL et al. (2007) Phase III trial of gabapentin alone or in conjunction with an antidepressant in the management of hot flashes in women who have ... Nature.com

Survey of management of acquired nystagmus in the United Kingdom  -  May 26, 2006
The most commonly used medical treatment was gabapentin and baclofen. ... Occurrence of side effects noted with baclofen and gabapentin treatments were ... Nature.com

Ranbaxy may tap Shasun for epilepsy drug supply  -  Sep 17, 2005
Ranbaxy Laboratories, which has received US FDA approval to tap the $964 million gabapentin market, is in talks with the Chennai-based Shasun Chemicals and ... Business Standard

Treatment for Postherpetic Neuralgia  -  Jun 19, 2008
Gabapentin (Neurontin) was the first anticonvulsant drug approved for PHN. ... Gabapentin is also showing promise in combination with valacyclovir for ... New York Times

In re Gabapentin Patent Litigation, No. 2006-1572 (Fed. Cir. 09/21/200...  -  Sep 21, 2007
Supreme Court Cases - Research for US Supreme Court Cases, Federal Circuit Court Cases, and Federal District Court Cases. Whether you need decisions in ... $2.95 - U.S. Court of Appeals, Federal Circuit - VersusLaw

Gabapentin May Control Hot Flashes in Women With Breast Cancer  -  Sep 6, 2005
Sept. 6, 2005 — Gabapentin at a dose of 900 mg per day but not 300 mg per day is effective in controlling hot flashes in women with breast cancer, ... Medscape

Gabapentin activates ROMK1 channels by a protein kinase A (PKA)- …  -  Mar 3, 2008
Correspondence: Professor HH Liou, Department of Pharmacology and Neurology, College of Medicine, National Taiwan University, Room 1141, No. 1, Sec. ... Nature.com

… Positive Phase II Trial Results for Once Daily Gabapentin GR(TM)...  -  Dec 12, 2006
Depomed, Inc. (Nasdaq:DEPO) today announced statistically significant efficacy benefits of its Gabapentin GR[TM] extended release tablets for the once daily ... Free with registration - Business Wire - AccessMyLibrary.com

Pfizer gets relief on epilepsy drug as US court reverses ruling  -  Sep 25, 2007
24 Domestic drug companies looking for a slice of Pfizer's 'gabapentin' market, ... And adding to the worries of companies on the generic gabapentin ... Hindu Business Line

IVAX launches gabapentin capsules.  -  Mar 23, 2005
SAN FRANCISCO (MarketWatch) -- IVAX Corp. said Wednesday that it has launched its gabapentin capsules. Gabapentin is the generic equivalent of ... Free with registration - America's Intelligence Wire - AccessMyLibrary.com

Gabapentin for hot flashes  -  May 16, 2008
Gabapentin is an antiseizure (anticonvulsive) medicine that is approved by the US Food and Drug Administration (FDA) for controlling epilepsy. ... WebMD

Depomed Obtains Exclusive License to Gabapentin Use in Hot Flashes.  -  Oct 18, 2006
MENLO PARK, Calif. -- Depomed, Inc. (NASDAQ:DEPO) today announced that it has obtained an exclusive sublicense from PharmaNova, Inc. to a US patent held by ... Free with registration - Business Wire - AccessMyLibrary.com

Thursday's Health Winners & Losers  -  Jun 14, 2007
Gabapentin GR is an extended-release formulation of gabapentin, an FDA-approved drug for the treatment of seizures and postherpetic neuralgia. ... TheStreet.com - TheStreet.com (subscription)

Gabapentin May Control Hot Flashes in Women with Breast Cancer  -  Sep 1, 2005
NEW YORK SEP 01, 2005 (Reuters Health) - The anticonvulsant gabapentin may help reduce the frequency and severity of hot flashes in women undergoing ... Cancerpage.com

Chance Find Puts End to Hot Flashes  -  Apr 4, 2006
Thus, gabapentin was part of the medication prescribed for my unrelenting ... But when I weaned myself from gabapentin last May, the hot flashes returned, ... The Ledger

Japan's Astellas in licensing deal for US XenoPort's painkiller...  -  Nov 30, 2005
XP13512 is a new chemical entity that is designed by XenoPort to improve the pharmacokinetics and therapeutic benefits of gabapentin. ... Forbes

Gabapentin (Neurontin) Eases Chronic Pain in Fibromyalgia  -  Jun 13, 2007
By Judith Groch, Senior Writer, MedPage Today. CINCINNATI, June 13 -- For treating the chronic pain and other symptoms of fibromyalgia, the anticonvulsant ... MedPage Today

Depomed Finalizes Phase III Clinical Trial Protocol for Gabapentin...  -  May 10, 2006
Gabapentin GR extended release tablets are in development for the treatment ... The primary goal is to evaluate 1800 mg twice-daily Gabapentin GR compared ... Free with registration - Business Wire - AccessMyLibrary.com

Gabapentin effective for menopausal hot flushes  -  Mar 12, 2008
...by Sam Lee. The epilepsy drug gabapentin is an effective and well-tolerated treatment for menopausal hot flashes, new research shows. ... 6minutes

Gabapentin + morphine marginally better than either alone for...  -  Jul 1, 2005
Clinical question Is the combination of gabapentin (Neurontin) and morphine more effective for neuropathic pain than either drug alone? ... Free with registration - JAAPA-Journal of the American Academy... - AccessMyLibrary.com

Gabapentin reduces hot flashes in men receiving androgen deprivation ...  -  Jun 5, 2007
North Central Cancer Treatment Group researchers based at Mayo Clinic in Rochester, Minn., have discovered that low doses of a drug used to prevent ... News-Medical.net

Gabapentin as effective as estrogen in treating hot flashes  -  Jul 3, 2006
By University of Rochester Medical Center, [RxPG] University of Rochester researchers, who have been investigating new therapies for hot flashes for several ... RxPG NEWS

Alcohol dependence brain mechanism shown  -  May 29, 2008
They found that gabapentin reduced alcohol intake in rats chronically exposed to alcohol but not in rats that were chronically unexposed. ... United Press International

Alpharma Settles Gabapentin Exclusivity Litigation.  -  Feb 11, 2005
Alpharma Inc. , a leading global generic pharmaceutical company, today announced it had entered into a settlement agreement regarding the Ivax ... Free with registration - PR Newswire - AccessMyLibrary.com

Depomed files for study on Gabapentin GR  -  Mar 12, 2007
By : Agencies. MENLO PARK, Calif. (AP) - Drug developer Depomed Inc. said Monday it asked the Food and Drug Administration to approve further study on its ... ABCmoney.co.uk

… Positive Results of Phase II Clinical Trial for Gabapentin GR(TM)...  -  Jan 5, 2006
For once daily Gabapentin GR, there was also a trend in pain improvement with ... "As we expected, these data strongly support twice daily Gabapentin GR and ... RedOrbit

… Patient In New Phase 3 Clinical Trial Of Gabapentin GR In Postherpe...  -  Mar 27, 2008
Gabapentin GR is an investigational, extended release formulation of gabapentin, ... In 2006, 16.3 million prescriptions for gabapentin were dispensed. ... Medical News Today - Medical News Today (press release)

… District Court Opinions - IN RE GABAPENTIN PATENT LITIGATION (DNJ ...  -  Dec 27, 2005
IN RE GABAPENTIN PATENT LITIGATION (DNJ 2005) 407 F. Supp.2d 607 IN RE GABAPENTIN PATENT LITIGATION. MDL Docket No.: 1384, Master Docket No: 00-2931 (JCL), ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Pfizer Wins Appeal Over Neurontin Epilepsy Drug  -  Sep 21, 2007
The patent, to expire in 2017, is for a process to make gabapentin, the active ingredient in ... The case is In Re Gabapentin Patent Litigation, 06-1572, ... Bloomberg

PERSONAL HEALTH; A Chance Find, and Voilà! Goodbye, Hot Flashes. …  -  Mar 28, 2006
Thus, gabapentin was part of the medication prescribed for my unrelenting ... But when I weaned myself from gabapentin last May, the hot flashes returned, ... New York Times

Side effects of tiagabine  -  Dec 4, 2008
Gabapentin add-on for drug-resistant partial epilepsy (Cochrane review). In; The Cochrane Library. Wiley, Chichester, UK. US Food and Drug Administration. ... guardian.co.uk

Depomed completes enrolment for Phase II clinical trial for Gabapentin...  -  Oct 24, 2005
The primary objective is to assess the efficacy of Gabapentin GR twice daily ... The data showed that Gabapentin GR has an extended, sustained release ... Free with registration - Asia Africa Intelligence Wire - AccessMyLibrary.com

Unexpected and disappointing negative outcomes for Gabapentin GR ( …  -  Jul 12, 2007
Gabapentin has yielded very good results for the treatment of neuropathic pain as documented in the literature, and supported by my personal clinical ... Gerson Lehrman Group

Study Results Lift Depomed  -  Dec 12, 2006
Depomed (DEPO Quote) was jumping after the company said a trial of Gabapentin GR showed the drug to be effective in reducing the pain caused by diabetic ... TheStreet.com - TheStreet.com (subscription)

Ranbaxy drug gets FDA nod  -  Oct 11, 2005
The total sales for oral gabapentin were $2.2 billion, while sales of gabapentin ... Gabapentin is indicated for the management of postherpetic neuralgia in ... Hindu Business Line

… Enrollment in Phase 3 Clinical Trial of Gabapentin GR in Postherpet...  -  Mar 8, 2007
Gabapentin GR is an investigational extended release formulation of gabapentin, an FDA-approved product for the treatment of PHN. ... Free with registration - Business Wire - AccessMyLibrary.com

Narrative Review: The Promotion of Gabapentin: An Analysis of...  -  Aug 15, 2006
Background: Internal documents from the pharmaceutical industry provide a unique window for understanding the structure and methods of pharmaceutical ... Annals of Internal Medicine

Depomed doses first patient in pain drug retest  -  Mar 24, 2008
This test, the second Phase III trial of Gabapentin GR, will enroll about 450 ... Gabapentin GR is an extended-release formulation of the drug gabapentin, ... Bizjournals.com

… Initiates Dosing of Patients in Phase 2 Trial For Gabapentin GR...  -  Jun 13, 2007
Secondary endpoints include, among others, the efficacy of Gabapentin GR relative ... Gabapentin GR is an investigational, extended release formulation of ... Genetic Engineering News - Genetic Engineering News (press release)

… Grants Teva Summary Judgment of Non-Infringement on Gabapentin  -  Aug 23, 2005
Teva Pharmaceutical Industries Ltd. (Nasdaq: TEVA) announced today that the US District Court for the District of New Jersey has granted summary judgment in ... RedOrbit

MEDICINE; When there's little proof a prescription drug will work;...  -  May 15, 2006
...(Pfizer, manufacturer of the gabapentin drug Neurontin, was convicted in 2004 for ... And gabapentin, a seizure drug, is widely prescribed for chronic pain. ... Pay-Per-View - Los Angeles Times - ProQuest Archiver

Report: Soldier died from mix of prescriptions  -  Aug 21, 2008
Ort had acetaminophen, morphine, hydrocodone and gabapentin as well as anti-anxiety drugs Valium and oxazepam in her system, the report said. ... San Francisco Chronicle

Mylan, Ranbaxy eye Shasun's bulk drug unit-report  -  Oct 18, 2007
Shasun's bulk drug business, which includes nizatidine, gabapentin, ranitidine and ibuprofen, accounted for almost half of the company's revenue last year, ... Reuters

Hikal, Crompton Manufacturing in alliance  -  Feb 23, 2005
...“This apart, we are also launching two pharmaceuticals – gabapentin, that is used for epilepsy and bupropion that is used for depression,� Hiremath said. ... Business Standard

… Announces Positive Phase II Results for Once Daily Gabapentin GR  -  Dec 11, 2006
Patients were randomized into one of three treatment groups: 3000 mg Gabapentin GR dosed once or twice daily or placebo. The primary objective of the ... FierceBiotech

… reps encourage doctors to prescribe gabapentin for nonapproved...  -  Apr 23, 2007
A new study published in PLoS Medicine suggests that so-called "detail" visits to doctors made by drug company representatives can involve promotion of ... eurekalert.org

USA diseases: Depomed starts hot flash Phase III for Gabapentin GR  -  Sep 18, 2008
Depomed Inc. initiated the first of two pivotal trials for menopausal hot flashes with Gabapentin GR, an extended-release version of the active ingredient ... $34.00 - EIU Country Analysis - Alacra Store

Lamotrigine, gabapentin both relieve HIV neuropathy pain.(Infectious ...  -  Jul 1, 2005
OAKLAND, CALIF. -- Two anticonvulsants are competing in popularity for treating peripheral neuropathy in patients with HIV infection: gabapentin and ... Free with registration - Internal Medicine News - AccessMyLibrary.com

Neurontin® (Gabapentin) Patent Trials - Pfizer Victory Remains Possi ...  -  Sep 24, 2007
The at-risk product launch by [NasdaqGS:TEVA] Teva of generic equivalents to [NYSE:PFE] Pfizer's Neurontin® (gabapentin) might - and the emphasis is clearly ... Gerson Lehrman Group

Stockpickr Lists: DepoMed Sinks on Drug Trial  -  Jul 11, 2007
...based drugmaker DepoMed(DEPO Quote) sank 60% after it posted disappointing results in a late-stage clinical trial of its Gabapentin GR extended-release ... TheStreet.com - TheStreet.com (subscription)

Depomed Reports Dose Proportionality of Gabapentin GR at the …  -  Jun 26, 2006
MENLO PARK, Calif. -- Depomed, Inc. (Nasdaq:DEPO) announced today that results from two studies of Gabapentin GR support the ability of its improved, ... Free with registration - Business Wire - AccessMyLibrary.com

UPI NewsTrack Health and Science News  -  Jun 11, 2007
Patients taking gabapentin also reported significantly better sleep and less fatigue. "While gabapentin does not have Food and Drug Administration approval ... United Press International

Gabapentin withdrawal.(EVIDENCE - BASED PSYCHIATRIC MEDICINE) …  -  Jul 1, 2008
Gabapentin withdrawal.(EVIDENCE - BASED PSYCHIATRIC MEDICINE) ... find Clinical Psychiatry News articles. The Problem Many of the patients at your long-term ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

'Ranbaxy's epilepsy drug recall may not attract lawsuits'  -  Nov 24, 2007
23 Ranbaxy's recent voluntary recall of epilepsy drug gabapentin in the US is ... The recall of Gabapentin tablets by Ranbaxy was a Class III recall, ... Hindu Business Line

Alpharma expects conclusion to Ivax gabapentin litigation.  -  Feb 2, 2005
As previously disclosed on 21 Dec 2004, Ivax Corp has filed an appeal in the US Court of Appeals for the District of Columbia seeking to reverse a District ... Free with registration - Asia Africa Intelligence Wire - AccessMyLibrary.com

Gabapentin as a Potential Option for Treatment of Sciatica: Case...  -  Jun 11, 2007
A 32-year-old Caucasian man with no significant medical history came to his physician's office with shooting pain in his left leg. ... Medscape

Clonidine and Gabapentin Effective for Hot Flashes  -  Sep 1, 2006
Synopsis: Recent concerns about the adverse effects of hormonal therapy have increased interest in alternative treatments of menopausal hot flashes. ... AAFP News Now

Morphine Plus Gabapentin Better for Neuropathic Pain Than Each Drug …  -  Apr 4, 2006
The combination of morphine and gabapentin achieves better analgesia for neuropathic pain than each drug alone, according to the results of a randomized ... Diabetes In Control

Epilepsy drug may help alcoholics recover from dependence, small...  -  Aug 4, 2008
In all, 30 percent of the patients who received gabapentin during alcohol ... "A possible explanation of these new findings is that the gabapentin might ... Genetic Engineering News - Genetic Engineering News (press release)

… Rules in Alpharma's Favor on Gabapentin Summary Judgment Motion  -  Aug 23, 2005
Alpharma, Teva, Ivax, Apotex, and Eon, in the patent litigation regarding gabapentin, the generic version of Pfizer Inc.'s Neurontin(R) product. ... lknliving.com

Gabapentin reduces hot flashes in breast cancer survivors.(Tips)  -  Mar 15, 2006
Hot flashes are among the most common symptoms reported by women during and after therapy for breast cancer. Conventional therapy for hot flashes using ... Free with registration - American Family Physician - AccessMyLibrary.com

Gabapentin No More Effective Than Placebo for Tinnitus Relief  -  Apr 17, 2007
April 17, 2007 -- Gabapentin was no more effective than placebo in relieving tinnitus, according to the results of an 8-week randomized trial reported in ... Medscape

SPECIAL ISSUE: WOMEN'S HEALTH; CAPSULE; Hot flashes, cold facts  -  May 8, 2006
...and that gabapentin (Neurontin), an antiseizure drug, and clonidine, a drug for high blood pressure, can help too. None is as effective as estrogen. ... Pay-Per-View - Los Angeles Times - ProQuest Archiver

Epilepsy drug beats hot flashes in study  -  Jul 17, 2006
Gabapentin is approved as an epilepsy treatment but has also been used to ... One of the seven authors holds a patent for the use of gabapentin to treat hot ... Pay-Per-View - The Record - ProQuest Archiver

Article: Gabapentin may ease symptoms in patients with fibromyalgia.(...  -  Mar 1, 2007
Gabapentin may ease symptoms in patients with fibromyalgia.(Pain Medicine)(Brief article)(Clinical report) ... find Clinical Psychiatry News articles. Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Dystonia and gabapentin.(Drug-Drug Interactions)  -  Mar 1, 2005
Gabapentin (Neurontin) is an anticonvulsant structurally related to the central nervous system neurotransmitter gamma-aminobutyric acid, and approved for ... Free with registration - Brown University Geriatric Psychopharmac... - AccessMyLibrary.com

Gabapentin cools hot flashes as well as estrogen  -  Jul 1, 2006
University of Rochester researchers, who have been investigating new therapies for hot flashes for several years, report in the July Obstetrics and ... eurekalert.org

New study reveals brain cell mechanism of alcohol dependence  -  May 30, 2008
Gabapentin (known commercially as Neurontin) is structurally similar to GABA and ... In alcoholics, gabapentin has been shown to effectively treat alcohol ... Hindu

Gabapentin Plus Morphine for the Treatment of Neuralgia  -  Aug 1, 2005
Clinical Question: Is the combination of gabapentin (Neurontin) and morphine more effective for neuropathic pain than either drug alone? ... AAFP News Now

Article: Adjunctive gabapentin may help in postherpetic neuralgia.( …  -  Dec 15, 2007
Adjunctive gabapentin may help in postherpetic neuralgia.(Infectious Diseases)(Clinical report) ... find Internal Medicine News articles. Pay-Per-View - Internal Medicine News - HighBeam Research

Gabapentin Appears to Improve Eating Among Colicky Infants and …  -  May 23, 2008
By Ed Susman. SAN DIEGO -- May 23, 2008 -- Doctors have shown initial success in treating young children with gabapentin, a drug shown to relieve ... DG News

Gabapentin for Hot Flushes From Androgen Deprivation Therapy  -  Jul 3, 2007
July 3, 2007 — Gabapentin ( Neurotin, Pfizer) was effective at reducing hot flushes occurring with androgen deprivation therapy (ADT) in men with prostate ... Medscape

Gabapentin Cools Hot Flushes as well as Oestrogen  -  Jul 18, 2006
University of Rochester researchers, who have been investigating new therapies for hot flushes for several years, report in the July Obstetrics and ... Virtual Medical Centre - The Virtual Medical Centre

KCA: Gabapentin Scratches the IL-2 Itch  -  Sep 29, 2008
By John Gever, Staff Writer, MedPage Today. CHICAGO, Sept. 29 -- Pruritus in patients receiving interleukin-2 for metastatic kidney cancer and malignant ... MedPage Today

Gabapentin May Treat Sleep Problems Related to Menopause  -  Jun 18, 2007
June 18, 2007 (Minneapolis) — For the many women in their menopausal years who struggle for good sleep amid the onslaught of hot flashes, a drug indicated ... Medscape

Gabapentin cools hot flashes as well as estrogen  -  Apr 7, 2006
University of Rochester researchers, who have been investigating new therapies for hot flashes for several years, report in the July Obstetrics and ... innovations report - Innovations-Report

… Completes Patient Enrollment in Phase 2 Trial for Gabapentin GR...  -  Sep 19, 2007
Gabapentin GR is an investigational, extended release formulation of gabapentin, ... Published data on the use of gabapentin in menopausal women provide ... Genetic Engineering News - Genetic Engineering News (press release)

Gabapentin Shown Effective for Fibromyalgia Pain  -  Dec 6, 2007
New research supported by the National Institutes of Health's National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) shows that the ... innovations report - Innovations-Report

Gabapentin for pain: balancing benefit and harm.(Cochrane Briefs)  -  Feb 1, 2006
At high dosages, gabapentin is moderately effective for neuropathic pain, although adverse effects are experienced as often as benefit. ... Free with registration - American Family Physician - AccessMyLibrary.com

No change of venue for quadruple-murder trial  -  Sep 8, 2006
The documents also describe items that police found at Schierman's house, such as boxes of multiple knives and an empty prescription bottle for Gabapentin, ... Seattle Times

Depomed starts second test of hot flash drug  -  Oct 20, 2008
The drug, now called DM-5689, but previously called Gabapentin GR, is in another Phase III trial that started in September. ... Bizjournals.com

Sensex in the green; Energy, metal stocks up  -  Aug 24, 2006
1:45 pm: Glenmark Pharmaceuticals Ltd fell 1% to Rs 338.25 even after its US subsidiary received US FDA approval to market Gabapentin oral tablets 600 mg ... Times of India

Hikal posts 37 pc rise in Q1 net profit  -  Jul 30, 2005
According to Mr Jai Hiremath, Vice-Chairman and Managing Director of Hikal Ltd: "Sale of Gabapentin, (an active pharmaceutical ingredient) to the US market, ... Hindu Business Line

Gabapentin for acute and chronic pain  -  Jul 1, 2007
Anticonvulsant drugs have been used in the management of pain since the 1960s. The clinical impression is that they are useful for chronic neuropathic pain, ... Medscape

Gabapentin may help hot flashes in breast cancer.(Women's Health) | …  -  Dec 1, 2005
Gabapentin may help hot flashes in breast cancer.(Women's Health) ... find Family Practice News articles. A 900-mg daily dose of gabapentin was associated ... Pay-Per-View - Family Practice News - HighBeam Research

Gabapentin Improves Opioid Treatment of Neuropathic Cancer Pain  -  Aug 30, 2007
NEW YORK AUG 30, 2007 (Reuters Health) - The combination of gabapentin and an opioid provides better relief of neuropathic pain in cancer patients than ... Cancerpage.com

… Ranbaxy Receives Final Approval for Gabapentin Tablets. - PR...  -  Sep 16, 2005
Ranbaxy Receives Final Approval for Gabapentin Tablets. from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

… to Manufacture and Market Gabapentin Capsules. - PR Newswire | High  -  Oct 11, 2005
Ranbaxy Gains Final Approval to Manufacture and Market Gabapentin Capsules. from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

Nonhormonal Drug Reduces Hot Flashes Linked to Prostate Cancer …  -  Jun 12, 2007
The men who received gabapentin reported fewer side effects than those ... Because gabapentin works on the central nervous system, its function may be ... DG News

Nonhormonal Drug Reduces Hot Flashes in Men Treated for Prostate …  -  May 29, 2007
The men who received gabapentin reported fewer side effects than those ... Because gabapentin works on the central nervous system, its function may be ... newswise.com

XenoPort Announces Positive Phase 2a Results With XP13512 for the …  -  Apr 7, 2005
XP13512 is a Transported Prodrug of gabapentin, a drug that has been sold by ... Of the anticonvulsants, gabapentin is the market leader for the treatment ... RedOrbit

… Circuit Court of Appeals Reports - IN RE GABAPENTIN PATENT, 503 F....  -  Nov 14, 2007
The active ingredient in Neurontin ® is a compound called gabapentin, ... The lactam was shown to be twenty-five times more toxic than gabapentin, ... Pay-Per-View - United States Federal Circuit Court of... - Loislaw

Brand Names/Synonyms:
Gabapentin is also known by the following brand names and/or synonymsAclonium; Gababentin; Gabapentin; Gabapentin [Usan:Ban:Inn]; Gabapentine; Gabapentine [Inn-French]; Gabapentino [Inn-Spanish]; Gabapentino [Spanish]; Gabapentinum [Inn-Latin]; Gabapetin; Neurontin; Novo-Gabapentin

Drug Category:
Gabapentin is categorized under the following by the FDA: Antimanic Agents; Anti-anxiety Agents; Antiparkinson Agents; Antidyskinetics; Analgesics; Anticonvulsants; ATC:N03AX12

Dosage Forms:
Oral tablets and oral Solution

Absorption:
60%, 47%, 34%, 33%, and 27% following 900, 1200, 2400, 3600, and 4800 mg/day given in 3 divided doses, respectively.

Interactions:
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Chemical IUPAC Name:
2-[1-(aminomethyl)cyclohexyl]ethanoicacid





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