Glimepiride

This page contains recent news articles, when available, and an overview of Glimepiride but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Glimepiride
(when available)

Pharmacology and use:
Glimepiride, like glyburide and glipizide, is a "second-generation" sulfonylurea agents. Glimepiride is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to insulin. For concomitant use with insulin for the treatment of noninsulin-dependent (Type II) diabetes mellitus; For the treatment of hyperglycemia that cannot be controlled by diet and exercise in conjunction with an oral hypoglycemic agent

Mechanism Of Action:
The mechanism of action of glimepiride in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral tissues to insulin. Glimepiride likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-sensitive calcium channels. This increase in intracellular calcium ion concentration induces the secretion of insulin.

News Articles on Glimepiride

Hypoglycemia Associated with the Use of Levofloxacin  -  ‎Jan 4, 2010‎
The patient's only home medication was a self-reported "sugar pill," later identified as glimepiride. A chest radiograph revealed consolidation in both lung ... Medscape

Nurse acquitted in husband's murder  -  ‎Dec 10, 2009‎
SAVANNAH, TN (AP) - A circuit court jury in Savannah, TN, has acquitted a nurse of murdering her husband by giving him a diabetes drug for which he had no ... WAVE

Modifiche AIC in GU: Glimepiride Exal, Glimepiride Angenerico, Transtec  -  ‎Dec 31, 2009‎
Gazzetta Ufficiale: Modificate le autorizzazioni all'immissione in commercio di Glimepiride Exal, Glimepiride Angenerico, Transtec. ... Pillole.org

常用的糖尿病藥物與心衰竭有關  -  ‎Dec 10, 2009‎
...研究中探討的第2代磺醯尿素類藥物包括:glipizide (商å“?å??Glucotrol)ã€?gliclazideã€?glimepiride (商å“?å??Amaryl)以å?Šglyburide (商å“? ... 臺灣新浪網

Brand Name: Amaryl  -  ‎Nov 11, 2009‎
Amaryl (generic name: glimepiride; brand names include: Diapride / Amyline / Euglim) is an oral anti-diabetic medicine of the sulfonylurea class. ... Pattaya Daily News

Diabetes drugs may leave heart at greater risk  -  ‎Oct 23, 2009‎
One group got standard treatment (with oral drugs such as metformin, glimepiride, thiazolidinedione and often insulin) to get blood glucose levels down to ... Los Angeles Times

매ì?¼ê²½ì œ 홈 > 뉴스센터 > êµ­ì œ  -  ‎Oct 22, 2009‎
Furthermore, total cholesterol and low density lipoproteins were significantly reduced with liraglutide treatment compared to rosiglitazone, glimepiride or ... 매일경제

11월부터 헵세ë?¼-ë°”ë?¼í?¬ë£¨ë“œ êµ?체투여 ì?¸ì •  -  ‎Oct 30, 2009‎
...ë˜?한 Rosiglitazone + Glimepiride 경구제(품명: 아마반정 등)는 ë?™ 복합제를 투여해ë?„ 충분한 혈당조절ì?„ í•  수 없는 경우 Glimepiride 단ì?¼ì œì?˜ 추가투여를 ì?¸ì •하ë?˜ ... 메디포뉴스

헵세ë?¼ì •·바ë?¼í?¬ë£¨ë“œì •, ë‘? 약제 êµ?체투여 ì?¸ì •  -  ‎Oct 22, 2009‎
...'Rosiglitazone + Glimepiride 경구제(품명: 아마반정 등)'ë?„ Glimepiride 추가 투여 시 급여가 ì?¸ì •ë?˜ë?„ë¡? 변경했다. 항악성종양제 'GnRH 주사제'는 허가사항 범위를 ... 메디포뉴스

ì‹?후 혈당 ì¡°ì ˆì?˜ ì›?리와 ì¦?ë¡€ ë¶„ì„?  -  ‎Nov 2, 2009‎
...ì?¸ìŠ?린과 함께 Glimepiride와 Metforminì?€ ê°™ì?€ ì–‘ì?„ 투여하였다. 2개월 후 ì‹?ì „ 혈당 90∼120mg/dL, ì‹?후 2 시간 혈당 250∼280mg/dL, HbA1c 7.8% ì?´ì—ˆë‹¤. ... 코리아헬스로그

Pioglitazone But Not Glimepiride Slows Progression of Carotid Intima-...  -  Nov 14, 2006
By WA Thomasson, PhD. CHICAGO, IL -- November 14, 2006 -- Patients with type 2 diabetes who are treated with pioglitazone experience less atherosclerotic ... DG News

Ranbaxy gets tentative FDA nod for drug  -  Jul 21, 2005
Glimepiride is to be taken, in addition to diet and exercise, ... Glimepiride is also indicated for use in combination with insulin to lower blood glucose ... Rediff

Novo Nordisk says phase 3 Liraglutide trials show very favourable...  -  Dec 11, 2007
In this final study 746 patients with type 2 diabetes were given either one of two doses of liraglutide or 8 mg (maximum dose) of glimepiride, a widely used ... Forbes

Pioglitazone Slows Atherosclerotic Process Better than Glimepiride  -  Apr 1, 2008
...(April 1, 2008 - Insidermedicine) Thiazolidinedione pioglitazone (tradename Actos) is more effective than sulfonylurea glimepiride (tradename Amaryl) at ... Insidermedicine

The groundbreaking diabetes drug that also reduces risk of heart...  -  Mar 31, 2008
It compared a standard glucose-lowering medication called glimepiride with ... The plaque build-up increased 0.73 percent in the glimepiride group but fell ... Daily Mail

… receives tentative approval to manufacture and market Glimepiride ...  -  Jul 28, 2005
Glimepiride is indicated as an adjunct to diet and exercise to lower the blood glucose ... Glimepiride may be used concomitantly with metformin when diet, ... News-Medical.net

Takeda gets EU OK for combination diabetes drug  -  Jan 17, 2007
Tandemact is a fixed combination tablet of Actos, Takeda's top selling diabetes treatment which targets insulin resistance, and glimepiride HC1 which works ... Reuters

… duetact(TM) (pioglitazone HCl and glimepiride) for the Treatment...  -  Jul 31, 2006
LINCOLNSHIRE, IL -- July 31, 2006 -- Takeda Pharmaceuticals North America, Inc. (TPNA) announced that the US Food and Drug Administration (FDA) has approved ... DG News

Liraglutide Effectively Controls Glucose, Reduces Weight in Type 2 …  -  Jun 9, 2008
All patients received metformin and glimepiride. The lead author and presenter of the study was David Russell-Jones, MBBS, BSc, MD, FRCP, clinical director, ... Medscape

Dr Reddy's gets USFDA nod for glimepiride  -  Oct 10, 2005
Hyderabad based Dr Reddy's Laboratories has received approval from the US Food and Drugs Administration for multiple strengths of anti-diabetes drug ... Rediff

Learn about Glimepiride from Consumer Reports Health.  -  Jan 5, 2007
Glimepiride is used with diet and exercise to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control ... consumerreports.org

The Hindu Business Line  -  Oct 9, 2005
Glimepiride is indicated as an adjunct to diet and exercise to lower the blood ... Glimepiride will be launched immediately, and the company will now make a ... Hindu Business Line

… Use of Rosiglitazone Maleate and Glimepiride Combination Tablet in...  -  Jun 21, 2006
49% of patients taking glimepiride and 46% of patients taking rosiglitazone. ... There was a small average weight gain with rosiglitazone and glimepiride, ... DG News

Pioglitazone vs Glimepiride and Carotid Intima-Media Thickness  -  Mar 28, 2007
To the Editor: The CHICAGO (Carotid Intima-Media Thickness in Atherosclerosis Using Pioglitazone) trial by Dr Mazzone and colleagues 1 found a reduced ... Journal of American Medical Association - Journal of American Medical Association...

Glitazones halt atheroma  -  Apr 4, 2008
After 18 months atheroma volume increased by .73% in the glimepiride group and decreased by .16% in the pioglitazone group. In terms of adverse effects, ... 6minutes

Mylan Announces Final FDA Approval for Glimepiride Tablets  -  Nov 29, 2005
PITTSBURGH, Nov. 29 /PRNewswire-FirstCall/ -- Mylan Laboratories Inc. today announced that Mylan Pharmaceuticals Inc. has received final approval from the ... RedOrbit

… FDA approves duetact (pioglitazone HCl and glimepiride) for...  -  Sep 1, 2006
Duetact combines Actos(pioglitazone HCl) and glimepiride, two widely used ... Both ACTOS and glimepiride are widely used medications in the treatment of ... Pay-Per-View - Drug Week - Factiva, from Dow Jones

GLIMEPIRIDE AND ROSIGLITAZONE (Oral route) - GLYE-me-pye-ride, …  -  May 1, 2007
Glimepiride and rosiglitazone combination is used to treat high blood sugar levels that are caused by a type of diabetes mellitus (sugar diabetes) called ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Liraglutide Outperforms Glimepiride as Monotherapy in Type 2 Diabetics...  -  Sep 8, 2008
By Jill Stein. ROME -- September 8, 2008 -- Once-daily liraglutide used alone significantly boosts glucose control in patients with type 2 diabetes compared ... DG News

CHICAGO: Pioglitazone slowed atherosclerosis progression  -  Dec 1, 2006
In the glimepiride group, there were 10 events (one MI, one stroke and eight ... Mazzone T. Effect of pioglitazone compared to glimepiride on carotid ... Endocrine Today

Dr Reddy's launches new diabetes drugs  -  Jul 11, 2007
Glimy MP, a triple drug combination (Glimepiride, Metformin and Pioglitazone) was an ... Glimepiride would work by increasing the insulin secretion, ... Hindu Business Line

Liraglutide superior to glimepiride in lowering HbA1c levels, weight  -  Oct 3, 2008
Liraglutide, a GLP-1 receptor agonist, reduced HbA1c levels, weight, hypoglycemia and blood pressure to levels lower than achieved with glimepiride, ... Endocrine Today

… Gains Tentative Approval to Market Glimepiride Tablets. - PR...  -  Jul 21, 2005
Ranbaxy Gains Tentative Approval to Market Glimepiride Tablets. from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

Pioglitazone HCl Plus Glimepiride Tablets (Duetact) for Type 2...  -  Aug 8, 2006
On July 28, the FDA approved pioglitazone HCl (Actos) plus glimepiride 30-mg/2-mg and 30-mg/4-mg tablets (Duetact, both made by Takeda Pharmaceuticals North ... Diabetes In Control

… Receives Final Approval To Market Glimepiride Tablets. - PR...  -  Oct 7, 2005
Ranbaxy Receives Final Approval To Market Glimepiride Tablets. from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

Aventis Pharma, Themis sign tech deal  -  Jul 26, 2007
Themis Laboratories have signed a technology transfer agreement for fixed-dose combinations comprising glibenclamide (Daonil) and glimepiride (Amaryl). ... Economic Times

Brand Names/Synonyms:
Glimepiride is also known by the following brand names and/or synonymsAmarel; Amaryl; CCRIS 7083; CHEMBANK1624; Endial; Glimepirid; Glimepirida [Spanish]; Glimepiride; Glimepiride [Usan:Ban:Inn]; Glimepiridum [Latin]; Glimepride; HOE 490

Drug Category:
Glimepiride is categorized under the following by the FDA: Immunosuppressive Agents; Hypoglycemic Agents; Antiarrhythmic Agents; Sulfonylureas; ATC:A10BB12

Dosage Forms:
Oral tablets with various strengths

Absorption:
completely (100%) absorbed

Interactions:
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Chemical IUPAC Name:
3-ethyl-N,N-bis(3-ethyl-4-methyl-2-oxo-5H-pyrrol-2-yl)-4-methyl-2-oxo-5H-pyrrole-1-carboxamide





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